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The SelfHacked flagship book that covers the science behind reversing chronic diseases and becoming 100% healthy


Joe Cohen

At the age of 25, with lots of questions and very few satisfying answers, Joe decided to embark on a journey of self-experimentation - something that has since become known as "bio-hacking". 

Thousands of experiments later, he is now a thriving writer/author, entrepreneur, investor and founder of SelfHacked, SelfDecode and LabTestAnalyzer.

His published works include "SelfHacked Secrets" and "Biohacking Insomnia" where he shares some of the most powerful insights from his research.

Joe is still a significant contributor of the content of SelfHacked and is the general magic behind the scenes that makes things happen.

Favorite biohacks: Lectin Avoidance Diet, Sun, Blocking light at night, Circadian rhythm entrainment, Pregnenolone, Microdosing THC, Butyrate, Curcumin, Galantamine, Nicotine, etc…

Roles: Founder and CEO

Joe on facebook: https://www.facebook.com/jmcohen87

Jonathan Ritter, Pharm.D., Ph.D. (Pharmacology)

Jonathan is a scientist who writes SelfHacked. He is an experienced scientist in the fields of pharmacology, neuroscience, developmental neurobiology, and physiology with clinical experience in areas such as pharmacy/therapeutics, natural products, psychopharmacology, oncology, and toxicology. Jonathan received his Pharm.D. in 2006 from Wilkes University and his Ph.D. in pharmacology from Georgetown University in 2012.

Jonathan is committed to helping individuals achieve optimal health and wellness through education and self-empowerment. He believes that personalized nutrition and medicine is the key to unlocking one's maximum potential.

His personal interests include finance, literature, biohacking, nootropics, and brewing sake.


Nattha Wannisorn, PhD

Nattha received her PhD in Molecular Genetics from University of Toronto in 2016.

Aside from having spent 12 years in biomedical research, Nattha is also a registered holistic nutritionist, a certified personal trainer, has a precision nutrition level 1 certification, and is a certified functional diagnostic nutrition practitioner. As a holistic practitioner with a strong science background, Nattha is an advocate of science literacy in health topics and self-experimentation.

Favorite biohacks: Sauna, red/infrared light, and magnesium

Roles: Nattha is the chief scientist at SelfHacked and a consultant for SelfDecode.

Brendan Swan, PhD

Brendan has had a fascination with human genetics from an early age. His PhD was undertaken at the University of Auckland in New Zealand. It involved developing a method for identifying mutations that cause neuro-developmental disorders, with emphasis placed on autism. He then investigated the causative mechanism of the mutations to gain insight to how these disorders arise.

To Brendan, SelfDecode represents the future of health and wellbeing. A tool that provides personalized information about an individual’s genetic variations. A place for people to learn about how they can align their lifestyles with their genetic makeup in order to have longer, healthier, and happier lives.

Favorite biohacks: Fasting (weekly 36-48 hour fasts), Meditation, Cold showers, Standing desk, White noise in the evenings, Outdoor exercise (especially around dusk and dawn), Yoga, Modafinil

Roles: Brendan is a project manager and Chief Scientist at SelfDecode and contributes to SelfHacked/SelfDecode content.

Biljana Novkovic, PhD

Biljana received her PhD in Evolutionary Biology, in the field of Ecological Genetics. Before joining SelfHacked, she was a research scientist with extensive field and laboratory experience.

She is passionate about finding answers to the how and why of health, wellbeing, and life in general. As the understanding of our physical and mental wellbeing is constantly evolving, she believes that SelfHacked is the best place to keep up with all the knowledge, ideas and latest research on these subjects.

Favorite biohacks: Meditation, Tea, Hiking, Sleep, Yoga, Olive Oil, Magnesium

Roles: Biljana is a writer and editor for SelfHacked and SelfDecode.

Ana Aleksic, MSc (Pharm)

Ana holds an MSc in Pharmacy and has many years of experience in clinical research and health advising.

She loves communicating science and empowering people to achieve their optimal health. Ana spent years working with patients who suffer from various mental health issues and chronic health problems. She is a strong advocate of integrating scientific knowledge and holistic medicine.

Favorite biohacks: adaptogens, gut-brain interaction, nootropics, stress reduction

Roles: Chief Editor for SelfHacked

Evguenia Alechine, PhD, ELS

Evguenia received a PhD in Biochemistry in the area of Human Genetics and has a masters in Biomedical Sciences. She was an academic scientist for eight years, and currently she is a certified Editor in the Life Sciences (ELS).

She is passionate about communicating scientific advances both to the scientific community and to the public.

She lives a healthy lifestyle and her mission is to make the world a healthier place by delivering scientific research to a broad audience.

Favorite biohacks: acroyoga, healthy food, sleep, intermittent fasting, ginger, turmeric, echinacea, chamomile, lavender, coconut oil

Roles: Evguenia is a science editor at SelfHacked

Carlos Tello, PhD (Plant Molecular Biology) and MS (Biochemistry and Molecular Biology)

Carlos received his PhD (plant molecular biology) and MS (biochemistry and molecular biology) from the Universidad de Sevilla, in Spain. He has multiple publications of his research at various scientific journals and can speak 4 languages.


Caroline Lam, MS (Molecular Biology) and BS (Biology)

Project Manager of SelfHacked | Science Writer and Editor at SelfHacked

Caroline has a MS in molecular biology from California State University, Fullerton and a BS from University of California, Irvine. She is passionate about getting rid of the barriers to scientific knowledge.

Matt Carland, PhD candidate (2018)

Matt holds multiple degrees in psychology, cognitive science, and neuroscience. He has over a decade of experience in academic research and has published a number of articles in scholarly journals.

He currently works as a neuropsychologist in Montreal, where he performs research on the links between personality traits and the development of clinical disorders such as addiction, compulsive gambling, and disordered eating.

Favorite biohacks: pets, positive thinking, and anti-oxidants from red wine.

Roles: Matt is a science editor and psychometric consultant at SelfHacked.

Matt Lehrer, PhD (2018)

Matt is a PhD candidate at The University of Texas at Austin pursuing an interdisciplinary degree in behavioral health, nutritional sciences, and quantitative methods. He holds an MS in behavioral health and a BS in exercise science. As a scientist, Matt believes his job is not only to produce knowledge, but to share it with a wide audience.

Favorite biohacks: lectin avoidance/ketogenic diet, weight lifting, running sprints, circadian rhythm optimization, sun exposure, meditation

Roles: Matt is a writer for SelfHacked

Yara Khatib, MS, BS

Yara completed her MS degree in Pharmacology from Georgetown University and holds a dual BSc in Pharmacology and Molecular Genetics from King's College London. She is an advocate of improving scientific literacy among the masses and believes that Selfhacked is the key to doing so.

To Yara, both Selfhacked and Selfdecode provide a novel approach to healthcare that will revolutionize the way we treat chronic illnesses. Finally, we can work around our individual differences to live happier, healthier lives.

Favorite biohacks: Niacinamide, sleep, alkaline diet, chamomile, inositol, CBD oil, bergamot, and cinnamon

Role: Yara is a writer and editor for Selfhacked

Randa Laouar, BS

Randa is a graduate of the University of Colorado with a dual bachelor’s degree in Physiology and Biochemistry and will be pursuing a M.S. degree in Biotechnology in the near future.

After observing second hand how debilitating chronic diseases can be, she became interested in researching simple and practical diet/lifestyle changes that one can incorporate daily to prevent and reduce disease risk factors. Knowing how difficult and overwhelming it can be to navigate the vast network of scientific information on the internet, she strongly believes in the importance of providing comprehensible and accurate information to the general public for self-knowledge and empowerment.

Favorite biohacks: Flax seeds, Green tea, Fasting, Cupping

Roles: Randa is a writer for SelfHacked and SelfDecode


Q: What Approach Does SelfHacked Take to Health?

A common theme on this blog is my attempt to not portray things as good or bad.

Biology is complex and a balance is always in play. Different people are physiologically imbalanced in different ways. Everyone has a different set of issues that needs to be dealt with in different ways. Hence, one man's poison is another man's medicine and vice versa.

There's still no scientific consensus if saturated fat is bad or not. There's obviously complexities here. Whether it's bad would likely depend on the dosage, your genetic makeup, what you replace it with, how many calories you're consuming, the other contents of your diet (doesn't go well with fructose), if you're getting into ketosis, your microbiota, etc...

At Selfhacked, I just present information to guide you on your own experiments and give you the tools to understand how things might affect YOUR body. But you've got to do the testing and listen to your own body.

Q: What is the Comment Policy For SelfHacked?

There has been an update to the commenting policy for Selfhacked. Comments that add value will be approved. If it doesn't add value, I won't approve it. This is because people sign up for email updates to comments and if I approve irrelevant comments or long rants that don't add value, it spams people's emails and it discourages people from reading comments.

Comments that are linking to products will be removed if there is a suspicion that there is self-promotion.

If you make a statement that's not common knowledge, you should try to back it up with studies.

Try to keep your comments concise.

Q: Why Did I Start Selfhacked?

I started SelfHacked because I was sick of:

-Mainstream doctors telling you that you’re perfectly healthy when you obviously aren’t - or even worse recommending you go to a psychiatrist because a few basic blood tests couldn’t find anything life threatening.

SelfHacked is bringing back the basic science, paired with the spirit of self-experimentation, to offer you cutting-edge health information.

100% BS free.

Q: What is the Goal of Selfhacked?

SelfHacked's aim is to help you understand exactly why your body isn’t functioning optimally, and what to do about it.

Our purpose here at Selfhacked is to introduce cutting-edge ideas to upgrade the human condition. I think people have a right to feel great in mind, body and 'spirit'.

Current technology has made this more possible than ever before. Whether you have a chronic issue, disease or just feel you want to improve some aspect about yourself, you're in the right place.

We favor combining attitudes, principles, and knowledge from Science, Quantified-self and Buddhism.

Our overarching philosophy is to simplify and achieve more with less.

In forming ideas, we look to traditional and cultural knowledge, mechanistic studies, animal studies, human studies, expert opinions, anecdotes and our own experimental results. We prefer large, double-blind placebo-controlled trials.

We don't recycle the same old garbage as other blogs do. We offer unique, creative and effective solutions.

We're not committed to using only "natural" solutions, but for various reasons, natural is often better (but not always).

We favor a self-hacking approach where we provide the information and you experiment with various changes to see if they work for you. Personal experience trumps any science with regard to your health. Science can only say what works for a given set of people.

Selfhacking is the process by which I healed and upgraded myself. This approach, combined with good information, can be used by everyone to feel optimal.

Q: What Kind of Studies Are Included in SelfHacked?

I consider Selfhacked science-based. All of my knowledge about the body and how it works is science-based. I don't use traditional ideas from Ayurveda or Chinese medicine when I want to know how a supplement works. I solely use scientific studies. When it comes to treatments or how supplements interact with the body, I also use science.

I often get attacked for including low-quality studies, animal studies, mechanistic studies and sometimes test tube studies.

The reason I include these is because I use studies as clues, not definitives. Sometimes a clue is a weak one, but I don't think we should be ignoring any clues. Of course, I will put more weight on the clues with stronger evidence. If a test tube study says one thing and a clinical trial says something else, I will go with the stronger clue (clinical trial). I will weight clues (studies) that are replicated, conducted better or that are published in higher impact journals. So I fully appreciate that clues have different levels of evidence behind them, but I think we should bring down any clue that has relevance.

I use the best information in a complex world, realizing that a lot of it will be wrong.

The clues are then a template for self-experimentation, which is the end goal.

Anecdotes and traditional/evolutionary ideas can also offer clues that are worth self-experimentation, but they can also be wrong often.

If you want to improve, you start experimenting with the ideas with the best evidence and you keep experimenting with ideas that have less evidence behind them.

Q: Why is SelfHacking Important?

Why This Blog Is Important

A comprehensive study done in 2013 looked at 702 occupations and found that 47% are at risk of being computerized. These are the jobs with less cognitive demand.

Even if your job doesn't disappear, cognitive performance will dictate how successful you are. Intelligence has always been important for the modern economy, but as technology advances and takes away repetitive jobs, we have to up our skills.

As technology develops, economies become more competitive and more reliant on higher intellectual ability. Simultaneously, we have many technologies to improve performance that we never had before.

Every year, we have greater access to new technologies that is allowing people to heal themselves better than ever before. Access to information is also unprecedented.

Think about how much the internet has developed in the past 15 years. Scientific studies are increasing at an incredible rate. Devices like LLLT, for example, are ubiquitous and cheap. The number of dietary supplements hitting the market is also astounding. There's perhaps dozens of different types of bioavailable curcumin, whereas 15 years ago the supplement didn't exist in the marketplace. The supplements that were available were much more expensive as well. Quality control in the industry has also gotten better, especially after the passing of cGMP laws.

Drug developments have also been promising. Blood, genetic and other kinds of tests have been developed and have become significantly cheaper.

These breakthroughs will only increase in time and maybe even accelerate. We are at an exciting time period and you don't have to be rich to take advantage of the technology we have in the 21st century to upgrade yourself.

Q: What is The Problem with Doctors?

I must say it's unfortunate that today's medical doctors don't begin to understand the full range of options because it simply wasn't taught to them and they usually aren't enterprising enough to read the literature directly.

The medical system selects for a specific type of person. This person will be good at memorizing lots of information and diligent in studying it, without selecting for people who actually know how to apply it properly and think outside the box. And if these doctors did think out of the box, this litigious society would sue the sh*t out of them.

Most doctors go to school for a long time and then just see patients afterward without being proactive in constantly learning new information. If a doctor went to med school 10 years ago, they are clueless about all of the studies that came out in the past 10-15 years.

The few doctors who do read the literature directly are stifled by an ultra-conservative philosophy that if something isn't studied and replicated by massive double blind, placebo controlled trials (which only the drug companies can afford) and published in prestigious journals then it has absolutely no value.

Instead of looking at problems with a risk/benefit analyses they are stifled by their parochial view. On the other hand, there's way too much dogma and quackery in the alternative health sphere.

Don't get me wrong - the doctors aren't the problem. Most of them are normal well-meaning people. I just think the system is broken. The medical system is dominated by bureaucracy. Instead of going to school for 10 years and completely stopping like it's done now, it would make more sense to go to school for a few years and thereafter go to school for 3 months out of the year for the rest of their lives.

There's obviously a lot more problems, but it's out of the scope of this post.

Q: Is There is a Silver Bullet?

I think the nature of disease is woefully misunderstood.

The usage of drugs by conventional medicine indicates an approach to disease that is highly targeted. For some diseases that happen because of a very specific cause, this is a good approach, but for chronic disease, it's usually not optimal or effective.

This is simply because chronic disease - whether it be depression, anxiety, cancer, obesity, schizophrenia or heart disease- has multiple causes that contribute to the disease.

Multiple things need to go wrong in the body by the time we realize something is seriously wrong. The body is good at adapting when one or two things go awry.

These multifactorial diseases can't successfully be treated with a drug that only addresses one of the issues.

In practice, this is what's called treatment resistance - a continuation of disease despite one or more treatments.

You see, when one factor in the body goes awry, the body adjusts through homeostasis and tries to work around the imbalance to function normally. When multiple things go bad, a new homeostasis is created and at that stage even if someone tries to fix one of the underlying issues, the body will get back to its new diseased homeostatic state.

We see this with every chronic disease. This is why it's so hard to treat any chronic disease and most of our attempts are futile. We can give drugs for depression but it barely makes a dent. There might be a small decrease in depression for a few weeks, but after a few months depression takes hold again.

Cancer chemotherapy drugs are often clinically insignificant because cancer comes about as result of multiple dysfunctions. Once it takes root, it's the new homeostasis. I don't think herbs or alternative medicine is the cure, either. A combination of drugs, herbs, diet, lifestyle and various new technologies to kill the tumor more specifically is the best bet.

If one is in a diseased state, they must attack it from multiple angles that address all of the underlying causes of the disease. Some of these causes we aren't aware of yet, but our knowledge is progressing quickly and we learn more daily.

Finesse and balance are required for attacking the disease in multiple ways. If one treatment is targeted too much, as is the case of many drugs, an imbalance will occur and the person may have side effects that are worse than the disease itself. So the treatment must target every cause significantly but not so much that it causes tremendous harm to the body.

One must always remember , though, that any treatment - diet, exercise, supplements or anything else - always comes with a trade-off.

The older someone is the less wiggle-room they have and their condition becomes significantly harder to treat. I view chronic disease mostly as just a manifestation of aging, where we eventually succumb to one diseased state or another if we live to be old enough.



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