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This post is a summary of a few other posts, in a more readable format.

causes-of-obestiy

132 Different Mechanisms for Weight Modulation

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See the following posts, which have the 132 different mechanisms that’re listed here:

Now, most of these have more complex effects, but I was hoping to simplify it and mention on the whole what it does.

References are in the full posts and also contains the full names for these.

Some mechanisms are better established than others.  Seeing the full post explores more of the specifics.

Pro Weight Gain

Pro Weight Loss

Mixed Effects

  • AMPK activation in the hypothalamus cause weight gain, but in the muscle causes fat burning (R).
  • DHEA might have gender specific effects – men lose and women gain weight (R).
  • Serotonin has tissue-specific effects – it causes weight gain in the body but weight loss in the hypothalamus (R).
  • mTOR activation has tissue-specific effects. Activation in the hypothalamus reduces food intake, while in fat cells, it increases fat mass.
  • Acetylcholine causes mixed effects. Acetylcholine helps weight loss through nicotinic receptors but can cause weight gain through muscarinic receptors.
  • LXR has mixed effects on weight (R).

Genetic variation in PFKP, KCNJ11, PTER and SEC16B were associated with obesity (R).

Health Tools I Wish I Had When I Was Sick

At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.

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  • SelfHacked VIP – an area where you can ask me (Joe) questions about health topics

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  • Ted

    Great article- a lot of it makes sense to me as a lay person. These trade-offs of weight gain and weight loss due to the way each of us are dissimilar, and process vitamins, hormones,enzymes, proteins, fats and other stuff, all make sense- otherwise there would be easy solutions to our common problems of weight gain, inflammation, heart disease, high blood pressure and diabetes- among other maladies. I think the author is on the right trail to getting us answers for our unique discrete metabolisms.

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