PPAR alpha is a very important protein for metabolizing fat and for weight loss.
If you want to interpret your genes, you can put them into SelfDecode.
- Intro to PPAR-alpha
- The Benefits of PPAR Alpha
- Males vs Females: PPAR Alpha Increases Th2 Immunity and Suppresses Th1 Immunity
- PPAR Alpha Negatives
- How to Increase PPAR Alpha
- PPAR alpha inhibitors
- PPAR Alpha Gene
- Circadian Control of PPAR Alpha (Technical)
- Health Tools I Wish I Had When I Was Sick
Intro to PPAR-alpha
I’ve spoken about PPAR gamma. This post is about its related kin PPAR alpha, which has somewhat different effects.
PPAR-alpha is a protein (transcription factor) that increases fat breakdown in the liver and elsewhere. Good metabolism is important for energy production.
PPAR-alpha alters the expression of a large number of genes.
PPAR-alpha is mainly found in the liver and brown fat, followed by the heart and kidney. Lower PPAR-alpha expression levels are found in the small and large intestine, muscle and adrenal gland.
The Benefits of PPAR Alpha
Activation of PPAR-alpha promotes uptake, utilization, and breakdown of fatty acids by increasing genes involved in fatty acid transport, binding, activation, and oxidation.
PPAR alpha helps with the detoxification of drugs and toxins (R).
Males vs Females: PPAR Alpha Increases Th2 Immunity and Suppresses Th1 Immunity
PPAR Alpha Negatives
As mentioned, PPAR alpha can increase Th17 dominance (R).
How to Increase PPAR Alpha
- Pathways to activate PPAR alpha: SIRT1 (R), PGC-1a (R),
- Cold (R),
- Exercise (R),
- Sun/UVB (skin) (R)
- Fasting (R) – fasting increases SIRT1 via activation of PPAR-alpha in mice (R).
- DHEA (R)
- Zinc (R)
- Fish oil/DHA (R)
- R-Lipoic Acid (R)
- Hydroxytyrosol (R)
- Resveratrol (R)
- Cinnamon (R)
- EGCG (R, R)
- Bitter melon (R)
- Epimedium/Icariin (R, R2),
- Nicotinamide Riboside – NAD+ helps activate both PPAR-alpha and SIRT1 (R).
- Oregano –carvacrol (R), Biochanin A (R)
- Carnitine (R)
- Naringenin (R)
- PQQ (R)
- Genistein (R),
- Palmitoylethanolamide (PEA) (R)
- Lion’s Mane (R)
- Leukotriene B4
- Gynostemma (R)
- Anandamide (R)
- Fenofibrate (drug)
PPAR alpha inhibitors
You must buy 23andme to see if you have these genes.
Circadian Control of PPAR Alpha (Technical)
Bottom Line: Circadian rhythm disruptions will cause problems with PPAR alpha.
PPAR alpha has a circadian rhythm in several organs, including the heart, muscles, liver, and kidney (R).
PPAR alpha directly regulates the gene activity of Bmal1 and Rev-erb alpha. Per2 interacts with nuclear receptors including PPAR alpha and Rev-Erb alpha and serves as a co-regulator of nuclear receptor-mediated transcription (R).
Drugs that increase PPAR alpha also increase the production of and reset circadian expression of Bmal1, Per2, and Rev-erb alpha in mouse livers. These drugs can phase advance the rhythmic expression (cause it to start earlier) of Bmal1, Per2, and Rev-erb alpha in several mouse peripheral tissues (R).
Health Tools I Wish I Had When I Was Sick
At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.
That’s why I decided to create tools that will help others cut down the guesswork:
- Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
- SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
- SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
- SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
- Selfhacked Inflammation course – a video course on inflammation and how to bring it down
- Biohacking insomnia – an ebook on how to get great sleep
- Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
- BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
- SelfHacked VIP – an area where you can ask me (Joe) questions about health topics
The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.
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