Bacterial infections can cause a lot of health problems. Most people suffer from infectious issues that often aren’t acute enough to cause fever or the like. If you feel like you are suffering from chronic health issues, inhibiting quorum sensing by bacteria may help your issues.

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What is Quorum Sensing?

Quorum Sensing is when bacteria “sense” or try to communicate with other bacterial cells to coordinate with each, which improves survival.

When many bacteria gather in one place, enough to form a “quorum” as in the number of members needed to vote on an issue in parliamentary procedure, they are able to communicate with one another via chemical messages, or “quorum sensing” (QS).

For example, in order to form a biofilm, bacteria need to communicate with each other.

So when you “jam” these communication signals, it’s harder for bacteria to form biofilms and survive.

Quorum sensing allows the bacteria to work as en masse (as though together they made up one organism), to change their behavior and adapt to their present environment (R).

Basically, QS operates as “strength in numbers” for the bacteria to expand their territory, construct biofilm shields, defend against antimicrobial agents, and make any changes necessary to improve their chances of survival (R).

Why is it Important to Inhibit Quorum Sensing?

Autoimmunity

With the increased use of conventional antibiotics in modern medicine, there is an increasing problem of antibiotic-resistant bacteria (R).

The failure of the antibiotic paradigm has led to concern over whether antibiotic medicine has reached its end (R).

An additional major cause for concern is the fact that conventional antibiotics are unable to effectively address the biofilm and quorum sensing aspects of chronic infections (R, R2).

Biofilms are collections of bacteria protected by self-produced shields. These shields are not necessarily hard, but are actually more glue-like and referred to as “slime”. This slime protects the bacteria from most antibiotics and other natural antimicrobials and from the immune system of the host, making it difficult to eradicate the bacterial infection (R).

Breaking down biofilms and disrupting quorum sensing is clearly key to truly eradicating bacterial infections and restoring normal immune system function.

Then the immune system can work as it was designed to –keeping the body in homeostasis and defending against invaders.

Quorum Sensing Inhibitors

Following is a list of scientifically proven quorum sensing inhibitors (QSIs). Many of them are whole plant sources and others are compounds that have been isolated from the naturally occurring sources to create a more potent bacterial adversary.

  1. APOB/LDL Cholesterol (R)
  2. Curcumin (R, R2, R3, R4)
  3. Resveratrol (R)
  4. Holy basil/Tulsi (R)
  5. EGCG (R, R2R3, R4)
  6. Pomegranate (R) and Ellagic acid (found in pomegranate) (R)
  7. Quercetin (RR2)
  8. Naringenin (R, R2)
  9. Amla (R)
  10. Berries: Strawberry (R,  R2), Wild Blueberry (R), Raspberry (R),Cranberry (R, R2), Blackberry (R)
  11. Oregano (R, R2, R3, R4, R5)
  12. Basil (R, R2)
  13. Rosemary (R, R2)
  14. Thyme (R, R2)
  15. Clove (R, R2, R3, R4, R5)
  16. Allspice (R)
  17. Sage (R)
  18. Ginger (R)
  19. Kale (R)
  20. Garlic (R, R2)
  21. Tannic acid (R, R2, R3)
  22. Rutin (R, R2, R3)
  23. Epicatechin (EGCG, Tea, Chocolate) (R, R2)
  24. Cruciferous veggies (R, R2)
  25. Vanilla (R) and Vanillic acid (R)
  26. Proanthocyanidins/grapeseed extract (R, R2)
  27. Kaempferol (fruits and veggies) (R)
  28. Apigenin (fruits and veggies) (R)
  29. Chlorogenic acid (coffee) (R)
  30. Kynurenic acid (honey) (R)
  31. Daidzein (soy) (R)
  32. Hydroxycinnamic acids (cinnamon(R)
  33. Cinnamaldehyde (cinnamon) (R, R2)
  34. Furocoumarins (grapefruit) (R)
  35. Limonoids (found in lemon) (R)
  36. Flavanones  (i.e., naringenin, eriodictyol, and taxifolin) (R)
  37. Salicylic acid (willow bark or aspirin(R)
  38. Some apples (R)
  39. Cider (R)
  40. GABA (R)
  41. Rose essential oil (R)
  42. Geranium essential oil (R)
  43. Lavender essential oil (R)
  44. Rosemary essential oil (R)
  45. Alfalfa (R)
  46. Clover (R)
  47. Witch Hazel (R)
  48. Dimethyl-esculetin (artemisia) (R)
  49. Flavan-3-ol catechin (R)

Others:

  1. Lotus (R)
  2. Sassafras (R)
  3. Urolithin A and B (R)
  4. Peas and yam beans (R)
  5. Iberin (horseradish) (R)
  6. Pyrogallol (R, R2)
  7. Chaparral (R)
  8. Extracts of L. nobilis (Bay Laurel), S. oleraceus (Sow Thistle), T. capensis (Cape honeysuckle), J. sambac (jasmine), P. alba (Silver poplar tree) and P. nigra (Black poplar tree) (R, R2)
  9. Extracts of: Delisea pulchra (red algae), Medicago truncatula (barrel cover), Ananas comosus (pineapple), Musa paradiciaca (banana), Manilkara zapota (sapodilla), Hypericum connatum (a flower) (R)

Health Tools I Wish I Had When I Was Sick

At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.

That’s why I decided to create tools that will help others cut down the guesswork:

  • Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
  • SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
  • SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
  • SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
  • Selfhacked Inflammation course – a video course on inflammation and how to bring it down
  • Biohacking insomnia – an ebook on how to get great sleep
  • Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
  • BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
  • SelfHacked VIP – an area where you can ask me (Joe) questions about health topics

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

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