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Apple Polyphenols have various health benefits on Inflammation, Heart diseases, and Cancer. Much of these benefits can be obtained especially when you have your apple with its skin on! Continue reading to know the various health benefits of this dietary polyphenol.



Polyphenols are organic compounds found in fruits and vegetables. Polyphenols in plants are secondary plant metabolites and can be categorized as flavonoids and non-flavonoids. Apple polyphenols are known to have beneficial effects on cancer, inflammation, and antioxidation. They are found in the apple itself, but most polyphenols are found in the apple peel.

Health Benefits of Apple Polyphenols

1) Apple Polyphenols Are Anti-Cancer Agents

Apple polyphenols for Cancer

In a theoretical study of apple compounds, apple extracts may have chemo-preventative effects, especially in colorectal cancer (R).

Polyphenols in apple increased cell death in adenoid cystic carcinoma cells (R).

Polyphenols in apple may reactivate tumor suppressor genes in colorectal cancer cells (R).

They caused tumor cell death by activating capase-3 (R).

In a human colon carcinoma cell line, these polyphenols induced cell death (R).

2) Apple Polyphenols Have an Anti-Inflammatory Effect

In rats, these polyphenols suppress pro-inflammatory cytokines and improve the antioxidant system (R).

3) Apple Polyphenols Benefit the Cardiovascular and Muscular System

Apple polyphenols for heart

In young adult rats, an 8-week diet supplemented with apple polyphenols had improved muscle endurance (R).

In rats, polyphenols in apple decreased atherosclerosis and reduced liver inflammation after a 12-week diet (R).

In rats, an increased apple polyphenol intake increased muscle endurance and increased fatigue resistance (R).

In mice, after chronic cardiac stress, these polyphenols helped decrease electrophysiological disturbances (R).

In human subjects, a supplement of apple juice, containing polyphenols AND vitamin C, mildly increased cardiometabolic markers in comparison to apple polyphenols alone (R).

In rats, polyphenols in apple protected against contraction-induced muscle injuries (R).

4) Apple Polyphenols Benefit the Hormone and Gastrointestinal System

In rats, polyphenols in apple increased insulin sensitivity, which benefits diabetes management (R).

In rats, apple polyphenols had a protective effect against damage caused by aspirin taken on an empty stomach (R).

In rats with colitis, polyphenols in apple improved colon damage (R).

In mice, these polyphenols had a protective effect against blood toxicity and antioxidant effects in the liver (R).

5) Apple Polyphenols Have Neuroprotective and Immunoprotective Effects

neuroprotective effects of Apple polyphenols

In rats, polyphenols in apple had neuroprotective effects against aluminium-caused toxicity (R).

In mice infected with the H1N1 virus, polyphenols in apple reduced stress caused by immune functions and improved recovery and survival rates (R).

6) Apple Polyphenols Help with Weight Management


In rats, polyphenols in apple have anti-obesity effects by regulating genes that produce fat cells (R).

In rats fed with high fat and sucrose diet, those given with apple, cinnamon, and birch polyphenols had lower weight gain and better insulin resistance than those fed without (R).


  • They also prevent the expression of ErbB receptors, which are used in cancer cell development (R).
  • Polyphenols in apple increased GSTT2 genes, which may contribute to chemoprevention of colon cancer (R).

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