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“It is not that I’m so smart. But I stay with the questions much longer.”

― Albert Einstein

Dogs Have Brain Fog Too

Supplements For Brain Fog

Before you proceed, make sure you read: Brain Fog Treatment, Part 1: Diet and Lifestyle

Also, some people are Th1 dominant, while others are Th2 dominant.  If you want more information, our All About Inflammation Course covers Th1 and Th2 dominance, as well as how to balance your immune system if you suffer from one of these.

If the dosing information isn’t written, it means that you should follow the standard instructions on the label.

Brain fog is almost always caused by inflammation, immune imbalance, and mitochondrial dysfunction.

How to Know If Something Is Worsening or Helping with Your Brain Fog

This post is a list of suggested remedies for you to try because brain fog is different for everyone, so some of this will help you while others don’t.

I find that most of my brain fog clients have trouble telling if something is somewhat helpful with their brain fog. They would be able to tell if a supplement or device completely takes away the brain fog, but not if it partially improves their brain function. Brain fog is a complex problem and most people will need multiple interventions to completely fix it. Therefore, I recommend using Brain Gauge to quantify if any supplements, devices, or lifestyle changes help with your brain function to any degree, so that you can create your own brain fog protocol that works.

You can read about Brain Gauge here and get yours here. Use code SELFHACKED to save 15% off any Brain Gauge device.

Mitochondrial Enhancers to Reverse Mitochondrial Breakdown


These have all been tried and tested by me.  I’ve tried every mitochondrial enhancer on the market and these are the best.  They work.

These dosages are meant to be taken individually.  If you’re stacking, then cut everything in half.

Supplements to Reduce Th1 Dominance


Supplements to Reduce Th2 Dominance

I realize many people just want the bottom line.  Here it is:

  1. Sun/UVB (R) – UVB decreases IFNy in Th1 dominance but increases it in Th2 dominance.  So it’s balancing.  It also decreases IgE responses. UVA in sun also decreases Th2 dominance. (R)
  2. ProbioticsDecreases Th2: L Reuteri (R) (probiotic), L. Plantarum (R) (probiotic), L. salivarius (R) (probiotic), L. lactis (R) (probiotic)….Increases Th1S Boulardii? (R), L. Sporogenes (R), L Acidophilus (R), L casei (R), Lactobacillus rhamnosus GG (R), Lactobacillus paracasei (R), Lactobacillus salivarius (R), B Longum (R), L Brevis (R), L fermentum (R)
  3. NAC/Glutathione sufficiency decreases Th2 (R) and increases Th1 (R).  1 cap 2X a day with breakfast and lunch.
  4. Licorice -18/β-glycyrrhetinic acid+LicoA (RR2).  Glycyrrhizin increases IFNy and decreases the Th2 response. (R, R2).
  5. Gynostemma (R).  This is a Th1 immune stimulant and reduces allergies.  Gynostemma is recommended also because it’s a powerful mitochondrial enhancer.
  6. Ginger or juice the root (R, R2).  Recommended because it has anecdotal support in addition to the research, but also because you can get it everywhere, it has a long history of use and for its multitude of other benefits.   My mother who is Th2 dominant finds this very helpful for her allergies.
  7. Reishi  (R).  Recommended because it’s a medicinal mushroom, which has unique health properties.  It works in many ways.  It’s a favorite substance of mine but I don’t take anymore so that I don’t stimulate my immune system.
  8. Tinospora (R).  This has a clinical trial backing it, with some anecdotal support.
  9. Quercetin (R)

The Most Effective Devices for Treating Brain Fog



These are all very important.

Take Note

Take note that I am limited in that this is a general protocol and not tailored to an individual.

For example, people with candida experience brain fog, but this protocol isn’t meant for them.  Candida is caused in part by lower immunity instead of increased immunity.  Candida sufferers should not take NAG since it’s used by candida to grow and become more virulent (R).  Mannose can also cause candida to grow (R) and probably sialic acid as well.  However, only a small percentage of brain fog cases are from candida in my experience and the effects are different than other types of brain fog.

The dosage that you should take depends on your case and other things you are taking.

Each case is different.  With no knowledge of the individual, this is the best I can recommend.  You’ll just need to experiment more with what works for you.

Also, keep in mind that brain fog, like every other chronic disease, has multiple causes and is resistant to treatment by a single intervention.

This is why it is so difficult to cure depression, anxiety, cancer and any other chronic condition.

Once a disease takes hold, it’s the norm and while interventions can temporarily fix these problems, the body has a knack to adapt to its former diseased state.

Focusing on a single approach will not work, but it can help a little.  Chronic issues need to be addressed from all angles and then once the body develops a new homeostasis, adjustments can be made.  The more severe your brain fog is the more of these tools you’ll need to use.

It can take a few months for the full effect to take root, but improvements will be felt along the way.

If you take everything in one shot it will probably be too dramatic, so I encourage you to introduce one supplement at a time.

If the effects are too strong, then simply reduce the dosage or reduce the total supplement load. This is an important concept. Also, after you realize the brain fog is disappearing you can start to withdraw some of the treatments.

Don’t allow this long and comprehensive list to scare you into inertia or think some of the treatments aren’t significant.

If you can only try some, then it’s better than nothing.

Additionally, don’t use supplements as a crutch and neglect other important aspects of this regimen.

Realize that staying away from food allergens – gluten and casein, general diet, exercise, stress management and good sleep are at the core of this plan to banish brain fog.

Additional Supplements for Infection Derived Brain Fog

People who suddenly started experiencing brain fog after an infection must use additional tools to fight off the infection.  The same mechanisms are at play and therefore the regime doesn’t change, but the root cause is different and therefore some additions are required.

Possibly some pharmaceuticals should be added if this is the case.

The regimen already includes many antimicrobials and immune boosters, which would go a long way.

Brain Fog Caused by Heavy Metals

If your brain fog is caused by oxidative stress from heavy metals, then I would suggest Modified Citrus Pectin and lots of kombucha.

MCP binds to only the harmful heavy metals in the body while leaving alone the beneficial minerals.

Kombucha is loaded with gluconate, which binds to heavy metals.

If you have issues with mercury in particular, then add in Stabilized R-Lipoic Acid.  RLA is very good at excreting mercury within your cells.

Video: How The Mitochondria Makes Energy

Health Tools I Wish I Had When I Was Sick

At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.

That’s why I decided to create tools that will help others cut down the guesswork:

  • Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
  • SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
  • SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
  • SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
  • Selfhacked Inflammation course – a video course on inflammation and how to bring it down
  • Biohacking insomnia – an ebook on how to get great sleep
  • Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
  • BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
  • SelfHacked VIP – an area where you can ask me (Joe) questions about health topics

Disclaimer and Caveats

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.


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  • gil

    wait Joe, are you that ignorant ? no parasites in the western world ? you did not see the National Geographic about: monsters inside me… makes me think the rest of your info has to be taken with a big grain of salt

  • Doug

    Cian, my brain fog has not responded to anything. PQQ produced no tangible effects (cognitive or otherwise) so I stopped.

  • Cian Bennett

    Hi Doug, did your brain fog resolve after a certain time of treatment with PQQ as I’m also having the same issue!

  • Doug

    Cutler protocol also mandates lipoic acid on a strict dosing schedule. In his view anyone with a significant toxic metals burden should never take LA once or twice a day.

  • Doug

    Joe, why would mito enhancers like PQQ temporarily increase brain fog? Thanks.

    1. Nattha Wannissorn, PhD

      You can join VIP to ask him directly.

  • Louis Tourtellotte

    “MCP binds to only the harmful heavy metals in the body while leaving alone the beneficial minerals.” Any references on that? Thanks!

  • Sam

    Hi. Great article. I make my own fermented Kefir. Currently doing water kefir, but have also done Milk based Kefir in the past which I think is better for me plus has more probiotic strains. I have seen kombucha promoted as a fermented probiotic drink. It seems similar to water based kefir, Can it be substituted for kombucha for the purpose of this article?

    I am suffering from bad brain fog, apathy after doing the Marshall protocol to see if it would help me with getting over CFS, I had brilliant health on phase 2 of it, but in phase 3 when I added the ABx Clindamycin I started to go down hill. My cognition/ability to make decisions suffered badly and I also had a lot of trouble with sleepiness after meals (esp starches & grains). I am Th1 dominant. I am already taking some of the supps recommended

  • Sean

    I have brain fog from fibromyalgia and postural orthostatic tachycardia syndrome (POTS) . Add vitamin C to your pqq, it converts it to pqqh2 and crosses the blood brain barrier much better. It’s like amphetamine without the jitters. Take it with magnesium threonate or it can give you a “hangover”. if your brain gets deprived of oxygen often as with pots your brain deactivates your NMDA receptors via a redox switch to protect itself from excess calcium release. pqqh2 will reset the switch and magnesium L-threonate will help control calcium release. Pqq boosts immune system. Pqq also increases nad+ in your cells, activating DNA telling your cells to produce more mitochondria. Boost nad+ with Niagen (b3 in the form your body actually uses) take niagen with a methylation protocol to keep your body balanced. Niagen also really helps my fibromyalgia tender point pain. NAC is metabolized into homocysteine which is toxic. Without proper methylation your body can’t neutralize and recycle homocysteine wich can cause brainfog and inflammation on its own. Hope this helps someone.

  • Health Vibed

    Hey Joe, i bought some of the supplements for brain fog on your main (first list), but i only got 4 of them as i want to test things “slowly”. i’m using butyrate, pqq, suma, and jiaogulan. Question is, do you recommend i still half the dosage from what you said, even though it’s not the whole stack??

    Thanks man!

  • Jen

    I am so glad i found this blog. thank you so much for all the information you have put together! i have been losing hope the past few months,… i have been ill for years and have little money/ motivation left! but finding this blog and all the wealth of information is giving me new hope. i tihnk i am TH1. i have ordered as many of the supplements listed here as i can afford, i couldn’t get the more expensive ones for the time being.

    I would really appreciate it if you could take a minute just to tell me which of these supplements that im already taking .. should i keep taking, or stop taking? i have been taking these for months, i am not seeing much improvement. my main symptoms are cfs….post exertional malaise, light and sound sensitivity and brain fog. these are my current supplements:

    Multi Vitamin
    Omega oils
    Magnesium & Zinc
    D Ribose,
    L Carnitine
    Multi-Mineral powder,
    Bentonite clay (sometimes orally, sometimes foot bath)
    Vit C powder,
    Oil of Oregano,
    co enzyme 10
    Olive Leaf Extract

  • luke

    What do you think of uridine, DHA, b6, and b12? It seems pretty promising; I’m surprised you haven’t talked about it. I’m somewhat biased because I think I have dopamine damage from too many stimulants, which it might help.

  • Uros Stojanovic

    Dear Joe, PLEASE HELP !!! I will be brief. I am 22 years, student of Faculty of Forestry, University of Belgrade (Serbia) and beacuse of my endless curiosty in searching for the best nootropic I bougth Pramiracetam and Noopept. I took it only 3 days and felt horrible negative effects as people wrote in topic “Piracetam, Aniracetam and Noopept Dangers and Risks (And Other Racetams)”. 2 months later these effects (extremely poor concentration, disgusting memory problems and anxiety/depression) have not disappeared. When I read your topics, I ordered ALCAR, ALA, Curcumin, NAC, Probiotics, PQQ, L-Theanine, L-Tyrosine, Ashwagandha. When it comes I will try and I pray to God to make me feel better. \
    Before taking Pramiracetam and Noopept I was brilliant student, full of self-confidence and enjoy in training (gym). My questions are: 1) Will I ever recover from these drugs ? 2) What would you recommend to me ? In addition, I am waiting for results of hormone levels …

  • Francis George

    Magnesium at night will cause sleep problems, as also do the B vitamins.

  • Abrin


    I see that you recommend Oil of Oregano as a natural antibiotic but looking around I haven’t found much science to support it. Have you used it personally and have had good luck with it? The only reason I ask is because my budget is very limited.

    I am in love with your awesome site. Thanks for all the hard work you’ve put into it. \(°□°)/

  • alberto

    I have interesting information too Joe. I am living in central america.
    Sorry if my english is not that good…it is not my native language.
    I also went to many many doctor$ and they thought that I was crazy, insane, etc.
    I almost die.
    They tried to put me on antidepressant drugs. I refused them.
    I also found many things you have described here. At this moment I´ve spent more than US $ 65000 in my health (from 2012 to now)
    I can´t tell now how much $ my fathers and myself have spent on my health since I was born.
    Improvements have been marked however due to the mf lack of good laboratories and the right tests I still don´t know all the stuff I´m allergic too. The other problem is stress.
    Right now my doctor is using bioresonance technology with me
    This device can create a medicine based on your frequency (Hz) and made stress reduction possible of taking it on a pill.
    Remember all is information and energy. We´re energy.
    Along many herbs you´ve described here I´m also using Omura BDORT (ring test) to detect the right dose of each herb and the specific dose of created medicine with ps1000 device.
    Also using a pendulum and homeopathy.
    I´m 37 now and found astrology works. Also have heard of jon kabat zinn full catastrophe living and read Eckhart Tolle power of now, a new earth. Also asisted to jusuits school to realize now Induism and Buddhism have many many things right and many things in catholicism are darkened not to properly show the spirit of the actual teaching. I realized through astrology we are more than this and disease is only a way to reach superior planes.
    I see you´re younger than me and believe many things you´re describing here are quite right.
    As now I can see many things that were hidden to me, I´m pretty sure you can see many things too.
    This type of things are not easily reveled to the common eye.
    would like to write more to you…maybe later.
    The friends and family around me don´t understand many things and don´t see many things. But everything is as should be.
    Hope to hear from you.

    1. alberto

      not all the supplements are to be taken together and even taking some of them how do you manage to protect kidneys from an overcharge of toxins moving out and cleaning blood?

      here´s a peptonum from an Argentina lab

      they offer this ID peptonum:

      Inmuno Desensibilizante





      Indicado en todos los estados alérgicos. Coadyuvante en el tratamiento del asma. Rinitis crónicas. Alergias alimentarias.

      and for kidneys:




      Protector del nefrón. Hiperuricemia. Glomerulonefritis crónica. Nefrosis. Nefroesclerosis. Nefritis focal. Lupus sistémico. Hipertensión arterial. Edemas renales. Coadyuvante en antibioticoterapia. Pielonefritis crónica. Litiasis renal.

      you may want to use google translate

  • Mike

    Are you familiar with David Perlmutter’s book “Grain Brain”?
    His explanation of brain inflammation being caused by a shitty diet (I think) aligns quite well with yours

    Apart from diet, sleep and exercise, his suggested supplements for a good functioning brain are
    – DHA,EPA
    – Vitamin D3
    – Resveratrol
    – Turmeric/ Curcumin
    – Probiotics
    – Lipoic Acid
    – Coconut oil

    Am I right to say that:
    – you would agree with taking DHA and Resveratrol,
    – you would take D3 only if you don’t get enough sun?
    – you are not a fan of coconut oil’s benefits
    – your view is that Turmeric and probiotics are only for the guts, but not so much for the brain

    what is your view about Lipoic Acid?
    Did I get this summary right?


    1. Mike

      “- you are not a fan of coconut oil’s benefits”
      I guess what i meant is that you don’t buy into the claims related to coconut oil’s benefits, and you even think it creates some insulin resistance?

      1. Joe

        yes, outside of ketosis

    2. Mike

      I guess that the best way to know if you need to take or not vit D3 supplements is by having a medical check and see what the levels are?

    3. Joe

      Yes to all. LA=good.

      1. Mike

        Thanks for your reply!!!

        your only big discrepancy is in coconut oil’s use
        and when to benefit from vit D3, curcumin an probiotics


  • Aidan

    I’ve gotten on zinc, cinnamon, and magnesium and toned down the calories/mostly eat natural foods.

    I wake up better than ever. Actually jump out of bed. Going to give the other recommendations a go

    1. Joe

      Thanks 🙂

  • John

    Why did you put a line through Niagen?

    1. Joe

      Didn’t, was a broken link. Fixed.

  • dan

    When is the best time to talk lithium? Also what is the recommend dosage for hypothalamus glandular (-was it 1 or 5 g)? Why under tongue?

  • MattSade

    Would you say that 4g Sunflower Lecithin is a normal amount to take when experiencing brain fog (+ not eating eggs) or is it too excessive?

    1. Joe


  • (@paleodietru)

    Is there any _specific_ externally validated reason for Longvida vs Life Extension?

    The reason I am asking is that after researching longecity I was under impression that LEF has the best scientific evidence while Longvida looks more like a shady scam.

    1. Joe

      I tried 10 versions,including LEF, and it’s the only one that enters the brain. My experiments support this research. NOT A SCAM.

  • (@paleodietru)

    Hi! I have not received a response to the last comment, have you seen it? Thank you very much!

  • ChicPammy

    Could brain fog come from parasites?

    1. Joe

      Extremely unlikely in the Western world and unlikely anywhere.

  • (@paleodietru)

    Thank you very much for all the information you are sharing here!

    For someone who is generally healthy what would be your “top 3” and “top 5” supplements lists in terms of biggest impact on brain fog AND energy and in terms of lowest long-term risks? From any category (mitochondria, inflammation, etc).

    I would really appreciate if you could answer this. If you could also briefly elaborate on “why” than I would be grateful beyond any measure!

    1. Joe

      No clear answer, but here ya go:

      Longvida curcumin,
      Grapeseed extract,
      Jasmine tea.

      Hope that helps. All can be found in my toolkit.

  • Claude

    How much Tamarind paste do you put in the tea? I tried a whole teaspoon and it ended up tasting bad.

    1. Joe

      ~1/2 tsp

  • MattSade

    Any reason for taking Lipoic Acid off the list after it has been there for so long? What is it?

    1. Selfhacked

      There’s better for BF, that’s all.

  • Andrew

    can you write more about your experience with C60?

    1. Selfhacked

      Sure…. eventually…

  • Paul

    Have you looked into HMD for metal toxicity?

    Seems interesting, and good alternative for people with heavy metals.

    1. Selfhacked

      All I see is overpriced chlorella. Chlorella may be effective, but it gave me inflammation.

  • Jean

    Hey man!
    I have tried 10g of Soy Lecithin + 5g of turmeric powder. I mixed it so much so that really blended together and everything dissolved into the water. It did not hit the brain. I just tried coconut oil + 5g of turmeric with some black pepper and I must say that I feel more “sharp minded” and I don’t think it’s placebo. What do you think?

  • Paul

    Nice change in supplements. Would you recommend transdermal or oral Pregnenolone?

  • Jean

    Alright! Great.
    One last question.

    I checked the Longvida curcumin and it’s crazy expensive. Do you think this could work as an alternative or have you already tried this?

    I could go for a trial amd revoew it if you haven’t tried it. Any other cheaper alternative out there that you suspect could work?

    I tried New Chapters turmeric force before which has got great reviews, but I didn’t feel like it hit my brain.

    Thanks in advance.

    1. Selfhacked

      Tried it

  • Jean


    Citicoline vs Lecithin. Isn’t like 640mg Phosphatidylcholine still equivalent of < 100 mg of Choline? It's basically nothing if I've understood this right. Feels like an egg would be a better source if this is the case.

    1. Selfhacked

      Eggs are fine, too

  • Fredoz

    I am glad that you listed BF supplements in two different categories based on their function. I found that my BF gets worse whenever I drink kombucha, take PQQ and ESPECIALLY have Gotu Kola. On the other hand, BF got completely alleviated with Curcumin, Cinnamon, Licorice, sun and especially tea (which works like magic in large doses).

    Does it make sense? why? should I avoid taking mito-enhancers?

    1. Selfhacked

      Of course! That’s why I separated the two. You do worse on the mito’s in the short term, but they’ll help you in the long term. You probably hav a lot of inflammation

  • Jean

    Thank you.
    Much appreciated.

    Prescript-assist is out of the list then. I will invest the money in some other supplements/colostrum.

  • Jean

    Joe, when it comes to budget and you’d have to choose (yes, I’m a poor student), which one would you invest your money on each month: Colostrum or Prescript-Assist?

    Thanks in advance.

    //Jean from Finland

    1. Selfhacked

      Depends what you’re trying to accomplish. For BF, colostrum, but there’s better than colostrum.

      1. derek

        If colostrum is better than Prescript Assist for BF so why is colostrum not listed and Prescript assist is?

        1. Selfhacked

          I probably should take prescript assist off because it’s not really for BF. It may bring down inflammation, but the other recs are better. Colostrum also only helps for BF in specific cases.

  • Paul

    How effective do you believe pregnenolone and NAG are for cognitive performance?

    I have been through a string of diagnoses and multiple doctors. Having bloating, constipation, weight, craving and brain fog issues for as long as I remember, I have, through my own research, and through an open minded but ill knowledgeable doctor, diagnosed myself with hypogonadism and gluten-casein intolerance. I am currently being treating for low Testosterone. No real cognitive benefits, but libido and strength considerable better. One of the main things I have found throughout my whole life, is that I am running at around 10-20% cognitive capacity since the beginning of high school. Even though I was top of the class in math and physics, recieving awards and dux etc, I always felt I have never been close to my potential with regard to brain function. So I guess my main goal, as with everyone on this site, is to finally experience mental clarity, something that is completely foreign to me. When you explained your experiences as a child and teenager I couldn’t believe the resemblance.

    I am in the process of an elimination diet currently, week 3, and feeling the depression and anxiety alleviating, but brain fog as not improved as of yet. Currently studying intense courses in electrical engineering and physics, I need my concentration and memory to improve a fair bit because I am struggling with information retention even though I am highly intelligent.

    I do know that within two-six months on the diet I will benefit significantly, but in the mean time I need some cognitive boost to help with symptoms. So I’ll be trying to get a subscription of preg (live in Australia) and buy NAG. I also am supplementing with longvida curcumin, PQQ, ALA, vit D etc for about 1.5 months but not have really improved.

    So if you have any other quick recommendations that aren’t already suggested in your articles I would like to hear them.

    I will try to organize a consultation once of receive more funds.


    1. Paul

      Found some prescription modafinil that I had a year ago. Took 200mg and feeling MUCH better today. Can focus and concentrate better. Anxiety and depression GONE. Enjoying the little things in life etc. However my brain fog is terrible, as always, and unchanged.

      Would be it ok to use modafinil while on your brain fog protocol ?

      Will it inhibit the way your protocol works, and delay the process of healing?

      On a side note, seeing as it seems that ALA, NAV, longivda curcumin, PQQ, inositol have had no effect on me I decided to take much larger doses of each on separate days to see how I feel. I took 500mg of ALA, 2gm of curcumin, 80mg PQQ, 3gm of NAC, 12gm inositol on separate days, but felt no different at all. I know these supplements are meant for long term, but doesn’t this seem a little odd?

      1. Selfhacked

        This means there’s nothing wrong with your hypothalamus, but some other issue with our brain ie you don’t have BF, but something else.

        1. Paul

          I see. Have had multiple tests done for thyroid, adrenal and androgen status. Will discuss once I organise a consultation.

          One question, why did you decide to remove licorice from the supplement list??

          1. Selfhacked

            It has its use but I felt it’s too potent to recommend generally.

            reply icon
  • DoomSword

    Thanks for the reply. Yeah, I didn’t clarify that I don’t use these supps for cognitive enhancements (except the ALCAR), just for well-being.

    I’ve had a look around the site, but the list of stuff is endless. If I started experimenting with all these I’d go broke! Anyway, I did learn about PQQ and CoQ10 from this article, so I’ll be looking into them, although they are quite expensive… would you recommend them at all? how about the L-Glutamine and Glycine. I’ve seen them in your list of supps as well. Do they provide any assistance with memory, cognition, etc?

    What do you think about the Taurine and Melatonin supps? not for cognitive enhancement, generally.

  • DoomSword


    that’s a whole lot of supplements!

    anyway, I can’t say I suffer from brain fog. I may have the occasional blur if I’m tired or stressed etc, but my regular state is one of adequate mental clarity. I’d like to severely improve my memory and concentration though. Both are lacking, especially the memory… it is quite selective!

    at the moment I’m supplementing as follows,

    1g ALCAR in the morning
    2400iu Vit-D3 in the morning
    400mg super bio-curcumin (by LEF) after a morning snack, with my coffee
    4 capsules of LEF super omega-3 (ttl 700mg EPA, 500mg DHA, 300mg polyphen oil olive extract, 10mg sesame seed lignans) with a glass of dissolved 300mg vit-C tablet in water. before or after lunch.

    planning to add also some taurine and melatonin (3mg pills by LEF). Also been looking into L-glutamine but not sure yet about it (is this supposed to be supplemented with Glycine?)

    I don’t follow a particular diet (ie. I eat everything in moderation….mostly 🙂 ) and I do very mild workouts due to lack of time (no cardio unfortunately… some weights, crunches, pushups, pullups and some muay thai techniques, all at home at this stage). Also I usually supplement during weekdays, breaking off from most or all of these on weekends.

    As it is, I do feel a snappier memory and alertness. But I think there is certainly room for improvement. I guess the only ambiguous item in my supplements is the ALCAR, but I feel it is helping.

    anything I should add or remove to obtain added results in memory, concentration and overall cognitive enhancement? (i’ve tried some aniracetam and those Onnit Alpha Brain pills but without any result to write home about, waste of money…)

    thanks for any input!

    1. Selfhacked

      I would be surprised to see any cognitive enhancement from the supps you listed. Look around the site and you’ll see some of my recs. Maybe the ALCAR is helping you a bit, but I don’t generally recommend it.

  • Fredoz

    Any reason why citicoline is no longer recommended?

    1. Selfhacked

      It is, it’s just not as high priority as the others.

  • Fritz.Harber

    Also, what is the recommended daily dose for black cumin seed oil?

    1. Selfhacked


  • MattSade

    Any reason for taking NAC from your recommendations ?

    1. Selfhacked


    2. Selfhacked
      1. Fritz.Harber

        So basically,NAC could potentially cause stronger autoimmune to some individuals?

        1. Selfhacked


  • eggdmc

    That’s fair enough Joe, understood. Thanks for the pointers. I’ll try and get a consultation going with you soon.

  • eggdmc

    So, following your recommendations will improve my circadian rhythm, is this what you believe will improve the defective serotonin receptor issue in my hypothalamus?

  • Hannah

    Ah, forgot the most important concern with pregnenolone: do you think it will interact negatively with a mild birth control?

    1. Selfhacked

      5 mg shouldn’t do anything

  • Hannah

    I’ve really enjoyed following your posts over the past few months, have found the resistant-starch diet to be immensely beneficial given my dietary restrictions, and am ultimately pleased by your rigorously self-explorative, independent research. I have a question about pregnenolone. Is it unsafe to take as a young graduate student and as a female (it is, afterall, steroidal)? I have exhaustively explored other lifestyle shifts, but my current schedule requires that I sleep less, study & write constantly, and is generally demanding of my memory and cognitive reserves. For whatever reason, pregnenolone seems like an interesting thing to try, especially to boost overall energy and memory (I do have a problem with brain fog and recall memory). I currently and daily take PQQ, NAC, Rhodiola, and a generous volume of various teas.

    Thank you!

    1. Selfhacked

      Thanks Hannah for your feedback and kind words.

      I was scared to take pregnenolone for years, but there’s nothing to worry about. I say try it and if it helps then you know it’s needed – and I think it will help. I found 10mg is the minimum effective dosage for me.

  • Ash

    And what do you think of ALCAR with lipoic acid?

    1. John Macgregor

      From my Cutler chelation years:

      Cutler recommends alpha lipoic acid (not R-lipoic).

      ALCAR (or L-carnitine fumerate) cause extremely unpleasant meltdowns in a minority of people.

  • Ash

    If I take 2 TBSP of Bragg’s ACV before each meal should I still take enzymes?

    1. Selfhacked


  • eggdmc

    Would you suggest I add NAG to my supplement regimen? I also have taurine and glutamine laying around, would they be useful to add in my situation?

    1. eggdmc

      Ok, will do Joe. So, following your recommendations will improve my circadian rhythm, is this what you believe will improve the defective serotonin receptor issue in my hypothalamus?

  • Stuart Lynn

    “When I have an autoimmune reaction I chew 8 of these, which equals 4g. It’s miraculous.”

    How can you tell if you have an autoimmune reaction?

    1. Selfhacked

      I get tired and/or arthritis or other symptoms depending on the autoimmune condition.

  • Amir Golan

    You wrote the following about NAG in your toolkit: “Never realized anything remarkable from it, but I’m keeping my eye on it.”

    How is it one of the most important supplements now>

    1. Selfhacked

      Didn’t know how to use it. As in I never used it during an autoimmune attack. Knowing how to use things is critical.

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