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Any kind of chronic inflammation will make you fatigued all of the time, so it may be hard to differentiate.

However, the first thing I look for is Th2 dominance, which is the immune profile in CFS. Discover our favorite biohacks in our ebook, SelfHacked Secrets. You can download the first chapter absolutely free here.

What Causes CFS?

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It seems like CFS is a result of a viral infection and the body’s inability to control it.  The result is oxidative stress.

This isn’t a post on how to combat CFS, but the general idea is to rebalance your immune system by increasing Th1, decreasing oxidative stress and reducing some kinds of inflammation.

This means that the mechanisms to control viruses are low and other kinds of inflammation might be high.

Your Doc Won’t Order These Tests

The problem is no doctor or will order these tests.  As I understand it, doctors are under pressure from insurance companies and insurance companies are out for profit.

They don’t want to shell out thousands of dollars on tests if they don’t see a clear way to benefit from these tests.

People with CFS show elevated:

One must keep in mind that one test will not tell you if you have CFS.  You need to take many of these tests to put a picture together.

People with CFS show decreased:

  • EPA (R)
  • Zinc  (R, R2)
  • DHEAS (R) -contradictory (R)
  • Glutathione/GSH (cortical) (R)
  • Natural Killer Cell Activity/Cytotoxic activity of NK and CD8+T cells (R)
  • LPS-stimulated TGF-b (R)
  • HDL (R)
  • CD56bright NK cells (R) – CD56 Bright NK Cells are  also lower in Coronary Heart Disease, Asthma, Rhinitis (R)
  • Granzyme A and granzyme K (R)
  • CD11b  (R)
  • CD69 activation marker on T cells (CD3+, CD3+CD4+, and CD3+CD8+) and on NK cells (CD45+CD56+) – Since induction of CD69 surface expression is dependent on the activation of the protein kinase C (PKC) activation pathway, it is suggested that in CFS there is a disorder in the early activation of the immune system involving PKC. (R)
  • DPPIV/C26 expressed on T cells and NK cells (R)
  • Neutrophil respiratory burst (R)
  • White matter in midbrain (R)
  • PM Cortisol and 24hr urine free cortisol (R)
  • Folinic acid/Folate/Methylation (R, R2)
  • Bilateral white matter volumes (R)


Gut Dysfunction -altered intestinal microbiota, mucosal barrier dysfunction (R)

Lesions in frontal white matter (R).

Corticotropin-releasing hormone (CRH) and neurotensin (NT), secreted under stress, activate mast cells (MC) necessary for allergic reactions to release inflammatory mediators that could contribute to CFS symptoms.  (R)

No difference in GPx. (R)

“Almost every adolescent with CFS had orthostatic tachycardia (Stewart et al.,1999), but this was not the case with adults (Natelson et al., 2007) where rates appear to be lower ranging from 10% (Naschitz et al., 2006) to 27% (Hoad et al., 2008) with the higher rate found in UK patients who reported having the diagnosis of CFS rather than being directly diagnosed. In our own study of adult patients (Natelson et al., 2007), orthostatic tachycardia was not common, occurring in only 11% of patients, not significantly different from rates in healthy controls.” (R)

“Finding subgroups of CFS suggests different underlying pathophysiological processes responsible for the symptoms seen.”(R)

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  • Kristi

    I would LOVE a post on how to beat CFS… been struggling for too long!!!

  • Tur

    Joe have you ever written a post on how to beet CFS?

  • Michael Attanasio

    Why liposomal vitamin C? Regular vitamin C (ascorbic acid) is up to 98% absorbed (normally 70-90%) and is incredibly inexpensive.

    1. Joseph M. Cohen

      You can take higher dosages of liposomal in a shot, which is antimicrobial

  • Joseph M. Cohen

    For now I recommend following the guidance of this post.

    Not perfect, but for the mean time.

    It will likely take me 6-12 months to write a post on CFS. If someone donates 30 bucks, I’ll speed it up to within a few weeks.

  • david

    Nice post. I’m eager to hear your recommendations to those who are suffering from cfs as myself. Much gratitude to you Joe as I don’t know where I would be health wise if it wasn’t for your work and this site. Btw I believe you set the wrong link for increasing th1, it brings me to decreasing it.

    1. Joseph M. Cohen

      Thanks, fixed.

  • Marco

    How to treat severe CFS?

    1. Joseph M. Cohen

      Dif post

      1. Marco

        Will you write or or is it there already?

        1. Joseph M. Cohen

          Will write…it could take a while, though. There’s a backlog….

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