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Coffee May Cause Inflammation

Compared with coffee nondrinkers, people who consumed more than a cup of coffee/day had:

  • 50-54% higher interleukin 6 (IL-6) (R),
  • 28% higher TNF (R),
  • 30-38% higher C-reactive protein (CRP) (R),
  • 12-28% higher serum amyloid-A (SAA) (R),

The findings were significant even after controlling for age, sex, smoking, body mass index, physical activity status, and other covariates. (R)

It can be argued that people with inflammation are more likely to drink coffee, but it’s widely enough consumed that I wouldn’t guess this to be the case, but it’s certainly possible – even though they controlled for important factors.

The effects on IL-6 seem to be confirmed in a randomized control trial in people with diabetes, which showed a similar 60% increase. (R)  On the upside, they increased adiponectin, which is a generally good thing for people who are obese/diabetic.

Various studies show that people who drink the most coffee have a 23-67% lower risk of getting diabetes (R, R2, R3, R4, R5).

According to a review that looked at data from 18 studies with a total of 457,922 individuals, each daily cup of coffee was associated with a 7% reduced risk of developing type 2 diabetes (R).

Coffee seems to also help lower risk of dementia/Alzheimer’s. (R, R2)

As far as risk of death from all causes, coffee is associated with both slightly increased or decreased risk from death, depending on the dosage (R).   For example, in men, 5-7 cups per a week increased death risk by 2 %, while 2-3 cups per a day decreased death risk by 3%.  However, 6 cups and over decreased death risk by 20%.  Risks in women were different, but a bit better.

Coffee has pros and cons. The research is mixed as to its effects.  While coffee has a lot of benefits, but we shouldn’t gloss over the negatives.

Coffee isn’t good or bad, as it effects everyone differently.  It didn’t work for me, but try it for yourself.

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2 COMMENTS

  • Rose

    F

  • Traci

    Hi Joseph,

    What about this one from 2016? https://www.nature.com/articles/nm.4267

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