CYP11A1 is necessary for the production of steroid hormones, such as estrogen, testosterone, aldosterone and cortisol. It converts cholesterol into pregnenolone, a precursor of all other steroid hormones. This enzyme also acts as an anti-inflammatory agent. However, it may increase susceptibility to allergies. Read on to learn more about CYP11A1 function, gene variants and factors that increase or decrease its activity.
This enzyme is also called the cholesterol side-chain cleavage enzyme or P450scc.
It is one of the cytochrome P450 monooxygenases (CYPs) (R). CYPs eliminate toxins and drugs from the human body. However, some like CYP11A1, are not involved in detoxification but in steroid hormone production.
The activity of this enzyme is age and sex dependent (R).
However, it is also active in the brain, skin, lungs, gut, bone, breast and prostate (R)..
Furthermore, it plays a function in the thymus and immune cells (R).
CYP11A1 The Good
This enzyme is involved in steroid hormone production. It is necessary for testis development, pregnancy-related processes, and mating-related behavior (R).
CYP11A1 The Bad
CYP11A1 Gene Polymorphism
People with partial or complete enzyme deficiency have adrenal insufficiency (R). This is a condition in which the adrenal glands do not produce adequate amounts of steroid hormones.
They also have sexual development disorders (R).
Lifelong hormone replacement therapy is necessary for this condition. Without therapy the disease is lethal (R).
The condition is rare. So far, only 19 patients with CYP11A1 complete deficiency-causing mutations have been reported worldwide (R).
rs11632698 was associated with aromatase-inhibitor-related bone loss (391 breast cancer patients) (R).
Increasing or Decreasing CYP11A1
These increase CYP11A1
- Ginseng (Panax ginseng) (R).
- UVB and UVC (R).
- Bisphenol A (BPA) (R).
- Pemirolast, clobenpropit, desogestrel, dexmedetomidine, and tizanidine (R).
These decrease CYP11A1:
Health Tools I Wish I Had When I Was Sick
At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.
That’s why I decided to create tools that will help others cut down the guesswork:
- Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
- SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
- SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
- SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
- Selfhacked Inflammation course – a video course on inflammation and how to bring it down
- Biohacking insomnia – an ebook on how to get great sleep
- Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
- BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
- SelfHacked VIP – an area where you can ask me (Joe) questions about health topics
The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.
HOW WOULD YOU RATE THIS ARTICLE?