Monocytes are the largest of all white blood cells and play an important role in the defense against germs and in inflammation. Read on to learn about these cells, the health effects of having higher or lower levels of monocytes, and how to keep your monocytes in a normal range.
Monocytes play a role in controlling and mitigating the effects of Th1/Th2/Th17 dominance, which is an important factor in chronic inflammation, leaky gut, and more.
If you ever felt like you should be getting more out of your lab results, now you can. Using Lab Test Analyzer, you can get up-to-date scientific information about your lab results. In addition, you get both lifestyle tips and natural solutions to help you optimize your health. You can also rely on our science-based Optimal Ranges to prevent potential health issues and maximize your overall wellbeing.
- Monocyte Production in the Body
- Optimal Reference Range for Monocytes
- High Levels of Monocytes (Monocytosis)
- Health Effects of Having a High Monocyte Count
- Low Levels of Monocytes (Monocytopenia)
- Health Effects of Having a Low Monocyte Count
- Ways to Increase Monocyte Levels
- Ways to Decrease Monocyte Levels
- Lab Test Analyzer: The Future of Personalized Health
Monocytes are the largest type of white blood cells (leukocytes). Approximately 2 to 10% of white blood cells are monocytes [R].
Monocytes protect against viral, bacterial, fungal, and protozoal infections [R].
Monocyte Production in the Body
In adults, blood cells are produced mainly in the bone marrow [R].
The process of monocyte production is called myelopoiesis [R].
Factors that control this process are:
- Transcription factor PU.1 [R, R, R, R]
- Cytokines: SCF (stem cell factor), GM-CSF (granulocyte-macrophage colony-stimulating factor), M-CSF (macrophage colony-stimulating factor, CSF1), IL-3, IL-6, and IFN-gamma [R, R, R, R]
After Monocytes Fulfill Their Job, What Happens Next?
Monocytes live for an average of 3 days before undergoing programmed cell death [R].
Optimal Reference Range for Monocytes
People go to their doctor to get their monocytes tested as part of a standard panel. Almost always, the results are not scrutinized, even though we know that you can be healthier and live longer when your results lie within optimal ranges. When I used to go to doctors and tried to discuss my results, they had no clue what these meant from a health perspective. All they cared about was whether I was gonna die in the next year.
This is why we created Lab Test Analyzer, a tool that easily lets you know which lab results you need to be concerned about, and how to bring these in the optimal range.
Our Lab Test Analyzer can help you keep your monocytes in the optimum range by allowing you to keep track of your levels, identifying causes of low or high levels, and giving you evidence-based lifestyle, diet, and supplement recommendations.
High Levels of Monocytes (Monocytosis)
In monocytosis, the number of monocytes circulating in the blood is increased to more than 0.8×109/L in adults.
Conditions Associated with Monocytosis
- Hematologic malignancies (myelodysplastic disorder, acute monocytic, chronic myelomonocytic leukemia, Hodgkin and non-Hodgkin lymphoma) [R, R, R]
- Infections (tuberculosis, viral infections, bacterial endocarditis, brucellosis, malaria, syphilis) [R, R, R, R, R, R]
- Autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease) [R, R, R]
- Sarcoidosis [R]
- Cancers (ovary, breast, rectum) [R, R]
- Heart attack [R, R]
- Appendicitis [R]
- HIV infection [R, R]
- Depression [R]
- Childbirth [R, R]
- Obesity [R]
- Severe pneumonia [R]
- Alcoholic liver disease [R]
Health Effects of Having a High Monocyte Count
Lab Test Analyzer is your digital health advisor that helps you understand your lab tests and makes recommendations based on your results. So if you have high levels of monocytes, we can tell you how to bring them down. Our recommendations could differ based on what your other lab results show.
Always know your optimal ranges. Click here to download our free Blood Test Reference Guide.
1) Monocytosis Increases the Risk of Atherosclerosis
As hardening of the arteries progresses, the number of monocytes in the blood rises [R].
2) Monocytosis May Increase Inflammation in Diabetes
Monocytes may induce inflammation in diabetes.
3) Monocytosis Is Associated with Increased Risk of Death in the Elderly
An increased number of monocytes is associated with an increased risk of cardiovascular and cancer-related risk of dying in the elderly [R].
4) Monocytosis Facilitates Healing Process After a Heart Attack
Low Levels of Monocytes (Monocytopenia)
In monocytopenia, the number of monocytes circulating in the blood is decreased to less than 0.2×109/L in adults.
Conditions Associated with Monocytopenia
- Aplastic anemia [R]
- Leukemia (hairy-cell leukemia,
- MonoMAC syndrome (monocytopenia and mycobacterium avium complex syndrome) [R]
- Severe burn injuries [R]
- Rheumatoid arthritis [R]
- Systemic lupus erythematosus [R]
- Vitamin B12 deficiency [R]
- Corticosteroid therapy (transient monocytopenia) [R]
- Administration of INF-alpha and TNF-alpha [R]
Health Effects of Having a Low Monocyte Count
Our Lab Test Analyzer can help you keep your monocytes in the optimum range by allowing you to keep track of your levels, identifying causes of low or high levels, and giving you evidence-based lifestyle, diet, and supplement recommendations. If you have low levels of monocytes, we can tell you how to bring them up.
1) Monocytopenia Lowers the Risk of Cardiovascular Disease
Out of all white blood cells, monocyte count has the strongest relationship with overall cardiovascular disease development in people with no symptoms.
Lower levels of monocytes are associated with lower cardiovascular risk [R].
2) Monocytopenia Increases Susceptibility to Infections
Low monocyte counts increase susceptibility to infections.
3) Monocytopenia Is Associated with a Risk of Hematologic Disorders
Monocytopenia is associated with a high risk of development of hematologic disorders (cancers of blood cells) such as myelodysplasia, acute myelogenous leukemia, chronic myelomonocytic leukemia, and lymphomas [R].
4) Monocytopenia Increases Risk of Cervical Cancer
Ways to Increase Monocyte Levels
Everyone is different, and our bodies can be complex. If you want to increase your levels, it’s best to put them in Lab Test Analyzer so that it can compute based on this and other results what you could do to become optimal.
1) Acute Strenuous Exercise
3) Cold Exposure
Prolonged cold exposure increases the number of monocytes through the “fight or flight” (sympathetic) nervous system activation [R].
Sauna and cold exposure are also great ways to stimulate the vagus nerve. Listen to our Free Vagus Nerve Audio Course to learn more about its health benefits.
4) Growth Hormone
7) Vitamin B12
Vitamin B12 helps increase white blood cell count (including monocytes) in rats with protein deficiencies. However, supplementation with vitamin B12 does not change white blood cell count in rats that ate normal levels of protein [R].
9) Vitamin C
10) Calcitriol (Vitamin D3)
Garlic increases total white blood cell count. Rats fed garlic had significantly more monocytes, neutrophils, and lymphocytes than rats not fed with garlic [R].
12) Chronic Alcohol Drinking
Alcohol consumption causes leaky gut, which allows lipopolysaccharides from gram-negative bacteria in the gut to cause inflammation. Acute alcohol consumption initially mitigates the inflammation from LPS. However, chronic alcohol consumption can lead to a gradual increase of monocytes and inflammatory proteins, contributing to a general body state of inflammation [R].
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Ways to Decrease Monocyte Levels
Everyone is different, and our bodies can be complex. If you want to decrease your levels, it’s best to put them in Lab Test Analyzer so that it can compute based on this and other results what you could do to become optimal.
1) Acute Alcohol Intake
Acute alcohol exposure influences immune functions, particularly monocyte function [R].
Studies suggest that acute alcohol consumption decreases inflammation in response to LPS in the gut [R].
These mechanisms may contribute to the beneficial effects of moderate alcohol use on atherosclerosis.
2) Regular Exercise
Regular exercise is anti-inflammatory. Monocytes significantly decreased after a 6-week course of moderate intensity cycling in overweight sedentary women.
3) Weight Loss
4) Omega-3 Fatty Acids
People taking fish oil supplements were less likely to have inflammation in the blood vessel walls caused by monocytes. This effect was not as pronounced in people already taking medication to treat peripheral artery disease [R].
5) Mediterranean Diet
The Mediterranean diet is comprised of foods such as seeds, nuts, vegetables, fruits, whole grains, and monounsaturated fats from olive oil.
6) Cortisol and Glucocorticoids
A single dose of cortisol decreased monocytes by 90% at 4 to 6 hours after treatment. This reduction persisted for about 24 hours. Subsequently, monocyte levels returned to normal 24 to 72 hours after treatment [R].
This decrease is thought to be a consequence of the redistribution of monocytes.
7) Estrogen and Progesterone
Infliximab kills monocytes, which may help reduce inflammation in patients with chronic inflammatory diseases [R].
Lab Test Analyzer: The Future of Personalized Health
If you got your blood test results and you’re not sure what to make of them, you need to use our cutting-edge tool: Lab Test Analyzer.
We built this tool to do the heavy lifting for you. No need to do thousands of hours of research on what to make of your blood tests.
People don’t realize that their blood results contain a goldmine of information that is waiting to be unearthed. Unfortunately, layers usually need to be dug to uncover this information gold.
But we make it super simple, so that even if you don’t have any background in science, you will understand what your results mean, and what you can do to get them in the optimal range.
Everything written in Lab Test Analyzer is backed by science and researched by a team of PhDs, professors and scientists.
By using Lab Test Analyzer, you will learn how to optimize your health, tailored to your unique biology.
We’re all unique, so we deserve therapies that treat us that way.
The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.
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