VEGF plays a role in heart disease, cancer, chronic inflammation, depression, tissue oxygenation, cognitive function, kidney disease and macular degeneration. VEGF can be harmful at high or low levels.
- Introduction to VEGF
- The Good
- The Bad
- VEGF May Increase Inflammation by Activating Microglia
- VEGF Leads To Holes In Blood Vessels To Make Them More Leaky
- VEGF Contributes to the Spread of Cancer
- VEGF Worsens Some Autoimmune Diseases
- VEGF Makes Diabetic Retinopathy and Macular Degeneration Worse
- VEGF Causes Kidney Damage
- VEGF Contributes to Depression
- VEGF Activates Matrix Metalloproteinases (MMPs)
- Inhibiting VEGF
- Increasing VEGF
- VEGF on SelfDecode
- Health Tools I Wish I Had When I Was Sick
Introduction to VEGF
VEGF (Vascular Endothelial Growth Factor) is a protein that initiates blood vessel formation.
VEGF Helps Oxygenate Tissue (by Creating New Blood Vessels)
VEGF leads to creation of blood vessels in the unborn baby (R).
VEGF makes blood vessels bigger which means more blood flow (R).
Part of the mechanism by which it leads to new blood vessel formation is by increasing MMPs (R).
VEGF Can Benefit Heart Disease (by Creating New Blood Vessels)
The VEGF gene can be injected into cells to make them produce more VEGF (R).
This will make new capillaries grow, and will help bypass blocks in blood vessels caused by plaque (R).
VEGF Helps Immune Function
VEGF outside the blood vessels attracts immune fighter cells (R).
VEGF builds lymph vessels, which are important for immune cells as they move through your body, looking for dangerous bacteria, viruses, and fungi (R).
The negative to this is that it can increase inflammation.
VEGF Protects the Brain
VEGF can help prevent brain impairments by improving neuron function and viability (R).
VEGF May Increase Inflammation by Activating Microglia
VEGF Leads To Holes In Blood Vessels To Make Them More Leaky
VEGF removes molecules that makes blood vessel cells stick to each other (like different sections of a pipe are held together with screws). This makes blood vessels leaky (R).
VEGF can increase permeability of the blood brain barrier (R).
VEGF Contributes to the Spread of Cancer
By making it easier for cancer cells to grow, it makes it harder to destroy cancer cells (R).
VEGF Worsens Some Autoimmune Diseases
VEGF causes fluid to leak out of blood vessels by making them leaky (R).
Blood levels of VEGF correlate with disease activity in a large number of autoimmune diseases and fall with the use of standard therapy.
VEGF Makes Diabetic Retinopathy and Macular Degeneration Worse
These new blood vessels are fragile, and can burst, leading to blood leaking out and damaging the back of the eye where light is transformed into a picture (R).
VEGF Causes Kidney Damage
VEGF builds blood vessels in the kidneys (R).
Kidney cells, which are filters through which fluid from blood is sieved through eventually cannot take that much fluid coming through them and are destroyed (R).
This leads to everything going through the filter as it is now destroyed (R).
This kills kidney cells, and makes the urine have things it shouldn’t have like protein (R).
VEGF changes can indicate early-onset pre-eclampsia which can cause miscarriages (R).
VEGF Contributes to Depression
This is due to the fact that VEGF influences the level of neurotrophins in the brain. VEGF can also mimic the actions of antidepressants, causing them to not work (R).
VEGF Activates Matrix Metalloproteinases (MMPs)
- Andrographis (in-vitro) (R)
- Curcumin (R)
- Tea/EGCG (found in green tea) (R)
- Anthocyanins (found in berries, grapes, eggplants, sweet potato, mango, etc.) (R)
- Fish oil/DHA (R)
- Polyphenols (found in tea, olive Oil) (R)
- Luteolin (found in broccoli, pepper, thyme, etc.) (R)
- Lycopene (found in tomatoes, beans, asparagus, etc.) (R)
- Ubiquinol (R)
- Naringenin (found in grape fruit) (R)
- Myricetin (found in sweet potato, currants, cranberries, etc. ) (R)
VEGF on SelfDecode
Genes for VEGF
- RS10434 (VEGFA)
- RS1570360 (VEGFA)
- RS2146323 (VEGFA)
- RS25648 (VEGFA)
- RS3024994 (VEGFA)
- RS3025000 (VEGFA)
- RS3025010 (VEGFA)
- RS3025020 (VEGFA)
- RS3025035 (VEGFA)
- RS3025039 (VEGFA)
- RS833061 (VEGFA)
- RS833068 (VEGFA)
- RS833069 (VEGFA)
Health Tools I Wish I Had When I Was Sick
At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.
That’s why I decided to create tools that will help others cut down the guesswork:
- Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
- SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
- SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
- SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
- Selfhacked Inflammation course – a video course on inflammation and how to bring it down
- Biohacking insomnia – an ebook on how to get great sleep
- Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
- BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
- SelfHacked VIP – an area where you can ask me (Joe) questions about health topics
The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.
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