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In this podcast interview, Dr. Gundry exposes the dangerous truth behind lectins and how they relate to inflammation, autoimmune diseases, and obesity. Most importantly, he shares his vast experience and research on why lectins are so harmful to the body, and how to reverse the damages they cause.

Anyone who reads SelfHacked knows I am very ‘anti-lectin’ for people with autoimmune/inflammatory issues. Dr. Gundry, originally a very famous heart surgeon, discovered how dangerous lectins are and altered his career to help people reverse autoimmune disease through his matrix diet. He has completed the only human study related to lectins and is now the most knowledgeable on the subject. His second book “the Plant Paradox” is coming out on April 25th, 2017.

About Dr. Gundry


Dr. Gundry is internationally recognized as an inventor, researcher, and one of America’s top doctors.

He is a former researcher at Yale University and has held a director role numerous times including Head of the Division of Cardiothoracic Surgery. Dr. Gundry has written more than 200 articles and books about cardiac surgery, the nutritional reversal of heart disease, high cholesterol, diabetes, and hypertension.

Currently, Dr. Gundry is the Director of The International Heart and Lung Institute in Palm Springs, California, and the Founder/Director of The Center for Restorative Medicine in Palm Springs and Santa Barbara.

In this podcast, Dr. Gundry exposes the dangerous truth behind lectins and how they relate to autoimmune disease. Most importantly, he shares his vast experience and research on why lectins are so harmful to the body, and how to reverse the damages they cause.

[1:59] Dr. Gundry’s opinion on gut health and its relationship to disease

[7:38] LPS (i.e. little pieces of shit)-what they are and how they hurt us

[10:25] What gut-healing protocols are missing

[15:55] Lectins and the cause of disease

[19:23] A new case study of autoimmune disease…and how all participant’s markers of inflammation returned to normal

[22:48] Is it possible to get rid of reactions to other non-lectin foods (nuts, seeds, fruits, etc.)?

[29:00] Preventing LPS from reaching the gut

[31:05] Resistant starch and other foods for our good bacteria

[32:36] Why pressure-cooked tomatoes are a ‘no’ food

[33:30] A recap of Dr. Gundry’s protocol

[34:40] 20% of food poisonings in the US according to the CDC…

[35:20] ‘A carb is not a carb’

[38:00] Tribes like Okinawan absorb a ‘high fat diet’ through short-chain fatty acids

[41:00] We should eat 0 of this food

[41:55] The oil with the highest amount of alpha-linoleic acid

[43:00] Roundup + meat

[45:47] The relationship between histamine intolerance and lectins

[47:10] Why eating only anti-inflammatory foods is like trying to douse a fire with a thimble of water

[49:27] My research on the cannabinoid receptor 1 gene in relationship to food sensitivities and autoimmunity

(see if you have this CNR1 gene using SelfDecode: our gene analysis company using data from 23andme)

[51:40] The player of Adiponectin

[54:40] Probiotics for restoring the gut, including one that grows hair in experimental animals

[57:55] How polyphenols change bacterial behavior

[1:01:07] The Keto-Plant Paradox Intensive Care

[1:04:00] Protein’s influence on MTOR, IGF-1, and glycoprotein

Anyone who reads SelfHacked knows I am very ‘anti-lectin’ for people with autoimmune/inflammatory issues. Dr. Gundry, originally a very famous heart surgeon, discovered how dangerous lectins are and altered his career to help people reverse autoimmune disease through his matrix diet. He has completed the only human study related to lectins and is now the most knowledgeable on the subject. His second book “the Plant Paradox” is coming out on April 25th.

For more resources:

The SelfHacked Lectin Avoidance Diet Cookbook

Due to frequent queries about how to implement a lectin-free diet, I have released the Lectin Avoidance Diet Cookbook. This cookbook may help you overcome autoimmune issues, irritable bowel syndrome, inflammatory bowel disease, chronic fatigue syndrome, histamine intolerance, chronic inflammation, or simply make you feel optimal.

While I and Dr. Gundry both agree that lectins can cause health problems, we have different opinions about how the diet should be implemented. Therefore, the SelfHacked Lectin Avoidance Diet is not a cookbook for Plant Paradox. My version is more restrictive as it is meant to guide you through an elimination diet, in order to identify foods that you can eat without increasing inflammation. In addition, I designed the diet in order to drastically reduce other plant substances that can activate the immune system.

In the Lectin Avoidance Cookbook, we have 51 93 recipes and counting. We’ve also added the Lectin Avoidance Diet Companion Guide which answers the most frequently asked questions about lectins and lectin avoidance. The price is $37.

Health Tools I Wish I Had When I Was Sick

At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on PubMed to figure out how the body worked and how to fix it.

That’s why I decided to create tools that will help others cut down the guesswork:

  • Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
  • SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
  • SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
  • SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
  • Selfhacked Inflammation course – a video course on inflammation and how to bring it down
  • Biohacking insomnia – an ebook on how to get great sleep
  • Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
  • BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
  • SelfHacked VIP – an area where you can ask me (Joe) questions about health topics

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.


1 Star2 Stars3 Stars4 Stars5 Stars (6 votes, average: 4.00 out of 5)


  • Barbara Tadokoro

    I still have a hard time you knowing for sure that heart trouble is positively caused by lectins and really only lectins. How do u see that n the hearts of everyone?

  • Roselyn Banrogo

    I suffer Hypertension to the highest BP 175. Is hypertension caused by lectins?

  • Jose

    I just want to say thank you Dr Grundy. I am 79 (just)..have great constitution ie no health issues usual for my age group. .fit & active. BUT for years have been seeing naturopaths re my dugestion issyes which gave only gotten worse iver the years in spite of 100’s $ spent. Until now finding you I have never heard of lectins or polyphenols. I am now seriously dedicated to your advised way of worry to me as love vegies & dont care what I go without if ut means I am going to feel/be truly consistently well. Thank you.

  • anna burns

    I got Dr. Gundry’s new book that just came out. He has definitely evolved in his thinking since his first book. I was absolutely blown away and excited by the depth of understanding and knowledge he has of lectins. I have been scouring the internet for years on lectins and never have read anything like what Dr. Gundry talks about. I have removed a large portion of lectins from my diet. Not completely though. It’s hard to find animal protein that has not ingested grains. I also have started his recommended green smoothie avery day. He promised in his book that if you follow his recommendations, that cravings for
    sugar and carbs will go away. I didn’t believe him, but it’s true. My gut is very happy with all the greens so available by blending them. I also have added some high quality fats. I still have tweaking to do in my eating, but I am feeling the benefits. Way to go Dr. Gundry! Thanks Joe, for sharing his video on your website.


    I am a health care provider and have been helped tremendously by Dr. Gundry’s Vital Reds and Prebio Thrive and cured with his Plant Paradox diet. This video made me aware of you, Joe Cohen, and I look forward to visiting your website and your wealth of knowledge. I already have my family aware of you and Dr. Gundry!

  • Diego Redondo

    For removing lectins in potatoes when pressure cooking, does the water have to cover the potatoes, or is just a cup of water at the pots base to get them steam cooked right?

    1. Anna Burns

      Please explain why we need to use a pressure cooker to remove lectins from foods. I don’t understand that. Thanks, Anna

    2. Craig

      Time is likely the the main factor. I would be inclined to cook them for an hour in the pressure pot.

  • Diego

    Good podcast, Im willing to buy the book, but Im still not convinced about this Dr. wont be another lowcarb promoter trying to cover a dogmatic anti-carb view with falacies or speculation to trick the reader.

    OK. Ill give him the benefit of the doubt. He says Okinawan/kitavans are actually absorving a “high fat diet” because all those sweet potatoes they eat, get converted to SCTs by the gut bacteria. So, we can get this checked out with a simple glucose test. We can compare a isocaloric carb intake of sweat potato, and plain potato. If he’s right the glucose meter in the readings should reflect the sweat potato intake more like a fat meal, and potato intake like a carb meal.


  • Anna Burns

    I just received Dr Gundry’s first book that he wrote, Diet Revolution. I have to say that I’m disappointed in it. I have not actually read it, but flipped through it, checking it out. I did not
    see any mention of lectins in this book at all. Another thing, he encourages at least 1/2 cup of
    raw nuts a day. I love nuts, but when they are raw, unless they have been sprouted and then
    dehydrated, are very high in certain enzymes that are bad for you. The sprouting interrupts those
    enzymes. I wanted to learn about lectin avoidance, but it was not in this book. He has some good
    ideas, but I think I will not read his book now. Maybe the new one is better. Don’t know that I want to spend anymore money on books that are not meaningful to me,

    1. Tess

      I feel the same way – leafed through the book and was disappointed in what I saw.

    2. Doni Zahn

      His first book is almost 10 years old and was more geared to weight loss. A lot has changed. The new book is excellent and very much worth the read.

      1. Kayla

        I agree, The Plant Paradox is amazing. Very informative! I’m doing it!

  • Tess

    So, Dr. Gundry has a different eating plan than in his first book which I just bought???

    1. Nattha Wannissorn, PhD


  • Timothy

    I’m starting a strict diet based on the LAD and could use some advice since it’s hard to source certain things here. 1) Besides fish I can’t find animals which aren’t grain fed here, best I can do is organic corn-fed/free rage; can this be a problem for a starter who doesn’t know what their sensitive to? I am European if it makes a difference.

    And 2) I can’t find any local Conjac noodles without a little oat fiber in them for some reason. Do those contain many lectins?


    1. Nattha Wannissorn, PhD

      Beef is usually okay. You can try it. In the US there are online grassfed butchers that will ship.

    2. Doni

      For those of us who follow Dr. Gundry’s eating plan, the beef that you mention would NOT be ok. It goes by the principle that “you are what you eat, eats”, meaning if the cow was fed corn you’d be eating corn as well. Many of us go off beef and chicken entirely, but if you can’t find what you need locally there are online stores that people order from and have shipped to them. Best not to eat the oats. Many of us use (and Dr. G recommends) Miracle Noodles as a noodle substitute.

  • Brett

    Great podcast! So Dr. Gundry is not big on animal protein (esp. beef, lamb) which is a big part of the Selfhacked Lectin Avoidance diet. At least it’s the only way I can keep my calories up on it to thrive. What does he suggest we eat?

    1. Nattha Wannissorn, PhD

      His food list on his diet (in his new book, not ours) is a bit different from our list so there are opportunities to add calories there. If you suffer from autoimmunity, going strict first is the way to go and then you can figure out what caloric foods you tolerate so you can play it up. If anything, there’s Hi-Maize cookies in our cookbook.

  • anna burns

    I just listened to Josephs interview of Dr. Gundry. It was so interesting and mind expanding. It appears that I need to make some major changes to what I thought was a reasonably healthy diet. I wanted to recommend to folks to listen to it. I feel like I have to listen to it several times to really glean everything he said.

  • Kyle

    Really enjoyed the interview! Hope for there to be more interviews done and posted. Its an easier way for me to process this information. I also like Joes interviews more than other people in the health podcast world because he spends less time working to simply promote other peoples philosophies. I would love for him to interview Chris Kresser.

  • Tori Sammy

    Is mild amounts of regular, organic maize starch suitable for a lectin-free diet?

    1. Nattha Wannissorn, PhD


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