Sunifiram is an experimental drug currently marketed as a brain enhancer. Sellers and users claim it improves mental focus, decreases depression, and even revs up your sex drive, but is there any truth behind the hype? Read on for a rundown of the science behind 3 possible uses of sunifiram that are supported by evidence.
Note: By writing this post, we are not recommending this drug. Some of our readers who were already taking the drug requested that we commission a post on it, and we are simply providing information that is available in the scientific literature. Please discuss your medications with your doctor.
- Potential Uses of Sunifiram
- Side Effects
- Limitations and Caveats
- Drug Interactions and Stacks
- User Experiences
- Health Tools I Wish I Had When I Was Sick
Sunifiram, or DM-235, is an experimental drug designed to improve cognitive function for Alzheimer’s disease treatment [R].
Research on sunifiram was discontinued due to a lack of funding and the patent lapsed. Although it was never tested on humans, the long-term toxicity is unknown, and it hasn’t been approved for use in any country, sunifiram is currently sold as a smart drug (nootropic) [R].
Sunifiram is similar in structure and function to piracetam. Piracetam-like drugs make the nervous system more sensitive to stimulation while having low toxicity and no serious side effects. However, sunifiram is about 1,000 times more potent than piracetam, making it effective at much lower doses [R].
Potential Uses of Sunifiram
1) Sunifiram May Improve Memory
Sunifiram supplementation (0.01mg/1kg) increased the rate at which mice learned to avoid shocks (passive-avoidance test). Also, at a higher sunifiram dose (0.1 mg/kg), rats recognized partners more quickly (social learning test) [R, R].
However, another study found that sunifiram had no effect on the learning ability of rats [R].
Mechanism of Action
The full mechanism of sunifiram remains unknown. However, research indicates that like other drugs in the racetam class, it probably works on multiple targets within the body [R].
The drug scopolamine blocks the neurotransmitter acetylcholine, which transmits signals between cells in parts of the brain that deal with memory and learning. In mouse studies, sunifiram increased acetylcholine release in the brain [R, R].
Blocking AMPA receptors induced amnesia in mice. Sunifiram reversed the amnesia, indicating it activates AMPA receptors [R].
Sunifiram also stimulates the glutamate receptor, NMDA. It increases the rate at which glutamate (a neurotransmitter) is delivered between brain nerve cells. This can help restore memory function in damaged or surgically altered brains [R, R].
The brain uses glucose delivered by red blood cells for energy. The drug pentobarbital inhibits glucose movement across cell membranes. In low doses, sunifiram reversed this effect. However, at higher doses, it prevented glucose from existing red blood cells. Sunifiram increases glucose uptake in the brain at low doses and decreases uptake at higher doses [R].
2) Sunifiram May Improve Learning
Long-term potentiation, which is when specific synapses are strengthened after frequent stimulation, is the underlying mechanism of learning [R].
When sunifiram was given to mice with surgically impaired memory and long-term potentiation, it restored both factors [R].
3) Sunifiram May Decrease Pain Sensitivity
Sunifiram supplementation delayed mice’s response to heat, indicating that sunifiram has pain relieving properties. The strongest pain-relieving effect was observed at middle doses (0.01 mg/kg), with higher and lower doses having less of an effect [R].
Mice were given a drug (pentobarbital) that induced sleep. Sunifiram supplementation reduced the amount of time they slept, suggesting it may have energizing effects. However, there are no other studies that address sunifiram’s potential energizing effects [R].
Sunifiram was never tested on humans, so long-term toxicity is unknown. However, it is structurally most similar to piracetam-like drugs, which generally show very low toxicity [R].
Users have reported a range of side effects, including:
Reports of unpleasant side effects appear to increase when users take large doses (10 mg or more) or mix sunifiram with stimulants.
Limitations and Caveats
Sunifiram has never undergone any clinical trials or been approved for human use. People have been using it without any verifiable reports of serious injury. However, users should be aware that its long-term effects are unknown [R].
There’s a lot of variability in the experiences of users, ranging from zero effect to laser-like focus or even uncomfortable levels of energy. Given this variability, sunifiram may or may not give you the desired effects.
Users taking larger doses (10 mg or more) or using sunifiram every day for extended periods of time report developing a tolerance, which reduces the effectiveness.
Drug Interactions and Stacks
Sunifiram can be used in stacks, meaning that it can be combined with other supplements and drugs for greater cognitive benefits that can be achieved with sunifiram alone. It can be stacked with:
Stacking sunifiram with noopept has resulted in mixed reviews. Some report excellent focus, motivation, and improved mood while others have reported a drastic reduction in positive effects with continued use.
Users have also reported unpleasant and long-lasting side effects when mixing sunifiram with caffeine, modafinil, and other stimulants.
Based on effective doses found in animal studies and user experience, 4-8 mg is generally cited as a safe and effective dose.
There is a lot of variability in the experiences reported by users of sunifiram. Some people experience no effects at all, while others report dramatic changes in cognitive function. Some additional effects reported by users include:
- Improved focus
- Reduced need for sleep
- Enhanced enjoyment of music
- Upbeat Mood
- Food tasting better
- Mental clarity
- ‘Sharp’ visuals
Although some users have reported that sunifiram alleviated their depression, mouse studies found that it didn’t have any antidepressant effects [R].
Other users claim that sunifiram increases sex drive and intensifies sexual experiences; however, this has never been studied in humans or animals.
Users have compared it to noopept, but with a quicker onset.
Health Tools I Wish I Had When I Was Sick
At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.
That’s why I decided to create tools that will help others cut down the guesswork:
- Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
- SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
- SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
- SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
- Selfhacked Inflammation course – a video course on inflammation and how to bring it down
- Biohacking insomnia – an ebook on how to get great sleep
- Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
- BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
- SelfHacked VIP – an area where you can ask me (Joe) questions about health topics
The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.
HOW WOULD YOU RATE THIS ARTICLE?