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The pregnane X receptor plays an important role in the body by helping the body handle foreign substances. While it decreases inflammation and helps liver function, it also has its cons. It’s important to try and figure out whether you are a high or low PXR producer – and we can figure that out by genes, symptoms and blood tests.

Read more below to learn about PXR.

Introduction

The pregnane X receptor (PXR) is implicated in fatty liver, vitamin D homeostasis, bile acids homeostasis, steroid hormones homeostasis and inflammatory bowel diseases (R).

The pregnane X receptor (PXR) has a significant role in how the body handles any foreign substances, especially manmade chemicals (R).

PXR is one of several cell receptors that are activated by components of the liver’s bile (R).

In newborn mice, exposure to PXR activators directed the genes responsible for the metabolism of extra compounds and fats (R).

Enzymes produced by PXR (such as CYP3A4) that help us detox are reduced in inflammatory states (R).

This is one reason why people suffering from chronic inflammation often feel like they are reacting to all drugs that they take.

Why Do You Not Feel Same Effects The First Time You Take a Drug?

PXR can explain why you don’t feel the same effects from a drug/herb if you take it daily.

When you take a drug that activates PXR (many do), then it will produce a bunch of enzymes that then can eliminate the drug quite effectively (R), which is probably why you won’t notice the same effects from the same dosage.

Pros of PXR

1) PXR Helps Clear Toxins

PXR functions as a defense mechanism against toxic insults (R).

PXR induces genes that help with all three stages of detoxification.

PXR increases CYP3A4, an important phase I oxidative enzyme that is responsible for the metabolism of many drugs.

In addition, PXR increases phase II enzymes such as glutathione S-transferase and phase III transport uptake and efflux proteins such as OATP2 and MDR1 (R).

2) PXR Decreases Inflammation

PXR is responsible for decreasing the amount of inflammation that occurs during an infection in mice (R).

By modifying the concentration of various enzymes within the intestinal lining, PXR is responsible for maintaining the gut during inflammation (R).

Activation of PXR in humans inhibits the activity of NF-κB, a key regulator of inflammation and the immune response. In  mice without PXR, the expression of NF-κB target genes is substantially increased in multiple tissues, and small bowel inflammation is significantly increased (R).

Furthermore, PXR-deficient lymphocytes produce more IFNgamma and less of the anti-inflammatory cytokine IL-10 (R), which suggests that PXR suppresses Th1 inflammation.

3) PXR Helps Liver Function

Fetus exposure to PXR-activators helps regulate gene activity related to lipid metabolism in the liver (R).

Using humans, a mouse model, and cultured cells, scientists found a connection between the PXR pathway and decreased the activity of key enzymes involved in nonalcoholic fatty liver disease (R).

PXR-mediated lipid accumulation is required for liver regeneration [R], suggesting that PXR is essential for normal progression of liver regeneration by modulating lipid homeostasis.

4) PXR Helps Detox Bile, Bilirubin

PXR helps detox products such as bile and bilirubin (R), so if you have Gilbert’s Syndrome, you may not have enough PXR.

Removing bile can help prevent cholestasis (R).

PXR has been shown to induce the expression of multiple key components in the clearance pathway of bile and bilirubin, including UGT1A1, OATP2, GSTA1 and 2 and MRP2 (R).

Consistent with the pattern of gene regulation, activation of PXR in mice has been shown to prevent experimental hyperbilirubinemia [R].

5) PXR Helps Protect Against Colitis

Ulcerative Colitis (UC) has a bunch of detox genes that are not expressed well that can be increased by PXR (such as ABCB1/MDR1).

PXR was significantly reduced in the colon of patients with UC but was unaffected in patients with Crohn’s disease.

With less PXR, animals had a lowered ability to remove toxins in the gut, which likely contributes to UC (R).

Activation of PXR in humans inhibits the activity of NF-κB, a key regulator of inflammation and the immune response. In mice without PXR, the expression of NF-κB target genes is substantially increased in multiple tissues, and small bowel inflammation is significantly increased (R).

The PXR gene was identified as a gene strongly associated with the susceptibility to IBD in humans (R).

In patients with IBD, decreased expression of PXR and PXR target genes was also noted [RR].

In mouse models of colitis, treatment with the PXR activators protected against colitis [R]. PXR may work by increasing SCD1 and increased production of unsaturated fatty acids (R).

Cons of PXR

1) PXR Can Inhibit Anti-Cancer Medication

PXR plays a role in the genes that oversee drug resistance. This can complicate treatment in some forms of cancer (R).

Suppressing PXR by way of inhibitory drugs can enhance the effect of anticancer medications for ovarian cancer. This helps the body overcome the treatment difficulties brought on by drug resistance (R).

In human colon cancer cells, PXR was shown to inhibit a crucial tumor-suppressing gene. This can cause tumors to grow bigger (R).

PXR can increase the recurrence of colon cancer tumor cells. It also stops programmed cell death in colon cancer cells (R).

2) Activation of PXR Can Interfere With Drug Metabolism

Chemicals in industrialized areas that produce plastic can be potentially toxic activators of the pregnane X receptor (R).

New brominated flame retardants and their byproducts activate PXR. This possibly causes undesirable interactions between drugs, interfering with the normal metabolism, or the body’s ability to maintain healthy hormone levels (R).

PXR is sensitive to metabolites produced by microbes, especially those that infect the intestine (R).

3) PXR Reduces Vitamin D

Vitamin D is essential for the maintenance of calcium homeostasis and for the development and maintenance of bones (R).

PXR increases two enzymes (CYP24, CYP3A4) that break down 1,25 D3/Calcitriol, the active form of vitamin D in humans (R).

This suggests that activation of PXR by some drugs may be responsible for the acceleration of vitamin D breakdown through increasing CYP3A4 and CYP24, leading to vitamin D deficiency and, eventually, to bone loss (R).

4) PXR Decreases Fat Burning and Inhibits Ketogenesis

Activation of PXR in the livers of mice resulted in an increased deposit of triglycerides in the liver (R).

The activation of PXR was also associated with an inhibition of pro-fat burning genes, such as PPARa, thiolase, Cpt1a and Hmgcs2 (R).

On the other hand, it increases the fat-storage/increasing genes PPARy and Scd1 (R).

Thus, activated PXR increasing triglyceride synthesis, while decreasing β-oxidation and ketogenesis in the fasting mice (R).

5) PXR Increases Adrenal Hormones (Cortisol/Aldosterone)

Activation of PXR in mice markedly increased plasma concentrations of cortisol and aldosterone [R].

The increased levels of corticosterone and aldosterone were associated with activation of adrenal enzymes, including Cyp11a1, Cyp11b1, Cyp11b2 and 3β-Hsd [R].

The PXR-activating mice also exhibited overgrowth of the adrenal cortex, loss of cortisol circadian rhythm, and a lack of cortisol responses to psychological stress [R].

It could contribute to Pseudo-Cushing’s syndrome, which is most seen in alcoholic, depressed or obese subjects [R].

6) PXR and Colon Cancer

PXR may promote colon cancer in a certain model by inhibiting p53, a tumor suppressor gene (R).

7) PXR and Oxidative Stress Responses

PXR seems to have mixed effects on oxidative stress (R).

Activated PXR in transgenic female mice resulted in a heightened sensitivity to an oxidative toxicant (R).

The PXR-induced sensitivity was associated with decreased activities of superoxide dismutase and catalase, enzymes that scavenge superoxide and hydrogen peroxide, respectively (R).

PXR Genes

SelfDecode has 3 SNPs on the PXR gene:

  1. RS1523127 (PXR)
  2. RS2472682 (PXR)
  3. RS6785049 (PXR)

SelfDecode is the most powerful genetic reader of SNPs and gives a detailed analysis of them.

PXR Activators/Agonists

PXR ligands are structurally diverse and include prescription drugs, herbal medicines, dietary supplements, environmental pollutants and endobiotics (R).

Drugs:

  • Valproic acid (R)
  • Finasteride (R)
  • Dexamethasone (R) and Prednisolone
  • Lovastatin (R) and simvastatin
  • Paclitaxel
  • Phenobarbital
  • Fenbendazole
  • Rifampicin, Clotrimazole, Ritonavir (R)
  • Cyclophosphamide, taxol and tamoxifen (R)
  • Troglitazone (R)
  • Nifedipine and spironolactone (R)
  • Glutethimide and phenobarbital (R)

Toxins

  • Organochlorine pesticides (R)
  • Polybrominated diphenyl ether flame retardants (R)

PXR Inhibitors

  • Ketoconazole  (R)
  • Sesamin (from sesame)
  • Fucoxanthin (R)
  • LPS (R)
  • Nf-kB (R)
  • FGF21 (R)

PXR Increases:

  • CYP3A4 and MDR1 (R)
  • Mrp3, Oatp2, Cyp3a11 and Cyp2b10 (R)
  • Cd36 (R)
  • CYP4F12, CYP2B6, UGT1A1 and P-glycoprotein (R) (regulates)

Health Tools I Wish I Had When I Was Sick

At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.

That’s why I decided to create tools that will help others cut down the guesswork:

  • Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
  • SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
  • SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
  • SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
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  • Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
  • BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
  • SelfHacked VIP – an area where you can ask me (Joe) questions about health topics

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The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

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