Print Friendly, PDF & Email

Why Alcohol May Make You Feel Better Temporarily

Some clients say that after a night of drinking, they have a relief of various symptoms (it makes me feel worse).  It’s reached a point where enough people are telling me that to pique my curiosity.

Alcohol increases endorphins (R), cortisol, uric acid and decreases the Th1 immune system.  It also increases CRH activation, which causes its euphoric feeling (R).   All of these can theoretically help in the short term.

Alcohol also increases Slow Wave and REM sleep in the first half of your sleep (by increasing adenosine, which lowers excitatory glutamate). (R)  Low doses of alcohol (1 beer) are sleep-promoting by increasing total sleep time and reducing awakenings during the night.  In insomniacs, moderate doses of alcohol actually improve sleep maintenance.  So for some people with impaired sleep, alcohol might help them a bit in the short term, even if it’s harmful to them in the long term.

How Long Does It Take For Resistant Starch to Have an Effect?

When I ingest Hi-Maize, I’ve recorded that it takes about 22 hours for it to reach my large intestines, or at least for me to start noticing an effect.   Obviously, it depends on other factors but 22 hours seems to be the norm for me.

Why does the timing matter?  Because butyrate is acidic and has wakeful and circadian rhythm effects.

Butyrate also synergizes with ketosis and if you cycle ketosis the way I suggest, then you want to get it right.

The acidity makes it ill suited to have when you do long-lasting exercise, so you don’t want it to hit while you’re playing sports or exercising a lot..

I find it wakeful promoting and not conducive to sleep so I don’t want it to hit right when I am falling asleep or during sleep – though others differ.

Right now, I’m experimenting taking it at 9 or 10 AM so that will hit at 7 or 8 AM, just when I want to get up.  I took it at about 9AM yesterday and it hit at 7 AM – a perfect time for me.

Butyrate does interact with our circadian rhythm.  Here’s how:

Butyrate is a ‘pan HDAC inhibitor’, which means it inhibits all HDACs.  It prefers to inhibit HDAC 1,2,3 and 8. (R) Anyway, HDAC 1 and 2 help form a complex that represses gene expression by circadian proteins (CLOCK and BMAL1).  By inhibiting HDAC 1 and 2, it will keep the circadian gene expression going.

Right now, this Hi-maize from Australia seems to be the only one available in a pound.  Mix 50g in water.

Einstein Quotes

Albert-Einstein-Quote-Reading (1) Just-albert-einstein_4e4166_3605229 einstein-quote

Lose Fat and Improve Health By Having an 8-12 Hour Eating Window

There have been many studies on limited eating windows over the years.

I recommend a 12-hour eating window from 8AM-8PM, assuming you wake up at 7AM.  I recommend waking up 7 or earlier and going to bed early as well- I’m trying to keep this more.   If you wake up later then just adjust it accordingly.  Essentially, this means you don’t eat 3 hours before bed.

I like the 12-hour eating window because the benefits are almost the same and your sleep will be better than if you did the 8 hour one.

The study synopsis:

In the new study, nearly 400 mice, ranging from normal to obese, consumed various types of diets and lengths of time restrictions.

They found that the benefits of time-restricted eating showed up regardless of the weight of the mouse, type of diet and length of the time restriction (to some degree).

Regardless of whether their diets were high in fat and sugar or just fructose, mice that were given time restrictions of 9 to 12 gained less weight than the controls, even though they ate the same amount of calories.

12-hour  eating window periods didn’t differ significantly from 9 hours.

It made no difference if the mice ate whatever they want on the weekends and broke the 12-hour eating window structure.

The time-restricted mice also had more lean muscle mass. (R)

See this video.

Health Tools I Wish I Had When I Was Sick

At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.

That’s why I decided to create tools that will help others cut down the guesswork:

  • Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
  • SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
  • SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
  • SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
  • Selfhacked Inflammation course – a video course on inflammation and how to bring it down
  • Biohacking insomnia – an ebook on how to get great sleep
  • Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
  • BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
  • SelfHacked VIP – an area where you can ask me (Joe) questions about health topics

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.


1 Star2 Stars3 Stars4 Stars5 Stars (No Ratings Yet)


  • cross.chrono

    You know they are releasing a new drug for treating multiple myeloma called Farydak (panobinostat) and it is also a pan-HDAC inhibitor. Do you think butyrate is related to that? Or could butyrate be used in some way for multiple myeloma?

    1. Joseph M. Cohen

      Interesting. Good chance…

  • MachineGhost

    Ehhh, isn’t a “molecular hydrogen machine” just new marketing fiction for a water alkalizer or is it something entirely different?

    1. Joseph M. Cohen

      entirely different

  • forgotmypreviousnick

    Whaat do you think about yerba mate? I am now drinking it and I have elaborated a strategy of drinking that works to me: I drink about 100ml of herb of various grades (my favoirute: pajarito, colon, fede rico bezcause of a low temperature needed to infuse the herb(70-75C) and lasting long taste and effect – with quite modarate stimulation). The efect lasts about 12h after drinking (so it is best to drink it after breakfast).
    The pros is that, it gives me creative flow is best in a few first hours (5-6), I can do really weird things (like writing an email to my professor about inpact of decrease of atmospheric N when we could introduce plants that efficiently assimilates N from atmosphere (by introducing genes).

    The cons are that, later I am still very creative and efficient, but also nervous. I need to get a 1 day off, before taking next session. But the best recovery is after 2-3 days with yerba off.

    I am pretty sure, with my shitty lifestyle and diet I cant get my top mental and physical efficiency, but I am only a poor student and I have no time and space for making better food or training. I try to overcome this with taking suplements (inosine, Zn, Mg, docosahexaenoic acid, eating 90% chocolate, somtimes eating a valuable food (eggs, meat) and everyday some fruit) and with yerba.

    I have low blood pressure, so I am drinking everyday herbs that decrease my inflammation (Leonurus cardiaca (for hearth), yerba mate, Crataegus monogyna, Viscum sp, Rosmarinus officinalis, Ginkgo biloba) – all are herbs, 50g of each mixed in one jar. It is enough for about 2-3 months, when taking it 1-2x per day (one large spoon). Some day I want to take an advice from you about my lifestyle (I am also obsessed with this topic) but I need to earn some.

    You see what yerba mate does. I write this post when I was going to just say “get interested about yerba”.

    (sorry for typos, googletranslate refuses to check it)

    1. Joseph M. Cohen

      Wait till book comes out

  • Leave a Reply

    Your email address will not be published. Required fields are marked *

    This site uses Akismet to reduce spam. Learn how your comment data is processed.