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Since the beginning of time we’ve put health concepts in tiny bins and labeled them as “good,” or “bad,” like high-fat diets, or antioxidant supplements…until we realize these little cubbies aren’t always so black and white.

Ozone has suffered similar treatment.  

There are two main points to remember when someone categorizes ozone as evil: all ozone isn’t the same (atmospheric ozone is not the same as pure, therapeutic ozone), and it’s the dose that makes the poison (which can be said about most beneficial therapies).

By grouping atmospheric ozone gas and ozone therapy together, we’ve turned our backs on the beneficial effects ozone therapy has on certain health disorders.

I think we’ll see more people jumping on the ozone therapy bandwagon, following in the footsteps of Healthcare in Europe.

Ozone Snapshot


  • Powerful: inactivates viruses, fungi, protozoa, and carcinomas in diseased cells by destroying their outer membrane
  • Reactivates antioxidant system and moderates immune system
  • Improves circulation
  • Decreases inflammation
  • Comes with complimentary Skype set-up consultation
  • Side effects are minimal and avoidable


  • Good to take a break from treatments 1x a week
  • Can cause ear discomfort if ear insufflations are used too often (usually subsides within a day or a few days
  • Can create a “die-off” effect
  • Can cause lung discomfort if ozone is breathed in directly (don’t do this, can be avoided). If you do this by accident, take a large dose of vitamin C. Large amounts of ozone breathed in directly can be harmful to the lungs over time.

First of all, bursts of oxidative stress from ozone therapy is very different from other oxidative stressors.

In targeted amounts, oxidative stress from ozone therapy is able to spike a hormetic response, while activating immunocompetent cells, increasing NAD+, SOD, and glutathione peroxidase.

What is Ozone?

Ozone is an inorganic chemical compound made up of 3 oxygen molecules bonded together. Ozone is most well-known for its presence in the stratosphere, acting as a barrier against highly damaging UV rays from the sun (blocking anywhere from 93%-99% UV radiation), allowing advanced life to exist.(R)

While ozone is most common at high altitude in the stratosphere, it can be found in low concentrations in the entire atmosphere. (R)

At ground level, ozone is produced from the burning of fossil fuels reacting with sunlight. Here, ozone is composed of part smog and is harmful to human health. (R)

However, studies show therapeutic ozone, when it is pure, and when it has not been mixed with the atmosphere’s smog, has therapeutic effects on the human body at low concentrations. It is able to boost antioxidant systems, treat wounds, relieve pain, and act as an antibacterial among other benefits. (R)

In small doses, ozone becomes medically active and is therapeutic, triggering several useful biochemical mechanisms and reactivating the antioxidant system, without any toxicity or side effects. (R)

Health Effects of Therapeutic Ozone

1) Ozone Therapy Inactivates Viruses, Fungi, Protozoa, Carcinomas

Ozone therapy is able to inactivate viruses, fungi, protozoa, and carcinomas in diseased cells by destroying their outer membrane. (R)

Ozone is powerful, and helps with many chronic infections, even possibly treating Ebola (from what Dr. Robert Rowen experienced). There aren’t scientific studies relating to Ebola, only his experience, but his story is intriguing.

2) Ozone Therapy Treats Uveitis 

Application of ozone therapy effectively treated inflamed eyes (uveitis) in rats. (R)

The ozone treated group had significantly reduced inflammation compared to a control group and had reduced messenger proteins that trigger inflammation compared to the control. (R)

3) Ozone Therapy Regenerates Damaged Nerves

Ozone therapy successfully regenerated facial nerves in rats by activation of the body’s antioxidant systems. (R)

Nerves manually crushed in the laboratory prior to the ozone treatment showed improved nerve health in comparison to the control rats treated with saline, with thicker fatty insulation (myelin sheath) and greater sensitivity (not by a significant figure, but still shows promise of potentially improved health). (R) With further treatments, improvements may have been much greater.

4) Ozone Therapy Heals Ulcers Resulting From Diabetes

Ulcerous lesions in the foot (necrotic lesions, common in diabetics) can be successfully treated with ozone therapy. (R)

Ozone treatment accelerates the healing process of the ulcer compared to antibiotics, and overall improves wound appearance. (R)

5) Ozone Therapy Could Increase Oxygenation in Most Hypoxic Tumors

Tumor hypoxia is an adverse factor for chemotherapy and radiotherapy. (R)

Despite being administered during a short period, ozone therapy improved oxygenation in most hypoxic tumors. This suggests the potential use of this therapy as an adjuvant in chemo-radiotherapy. (R)

6) Ozone Reduces Potential Oxidative Kidney Damage from Kidney Stone Treatment

Ozone successfully reduces potential oxidative stress and kidney damage resulting from a common uncomplicated kidney stone treatment Extracorporeal Shockwave (ESW) lithotripsy. (R)

Ozone therapy prevented the buildup of free radicals in the kidney from ESW and significantly reduced physical damage sustained by the kidney compared to a control. (R)

7) Ozone Treats Herniated Disks

Ozone therapy may help treat long-term herniated disks normally only treatable by surgery (Non- spontaneously regressing disks). (R)

8) Ozone Combats Hindered Bone Regeneration Caused by Diabetes

Ozone therapy is useful in boosting bone regeneration that is typically slowed by diabetes. (R)

In rats with diabetes, ozone (plus a bone transplant) spurred bone healing, growth and recovery. (R)

9) Ozone Therapy Treats Chronic Kidney Disease (CKD)

Ozone therapy reduces inflammation that can lead to chronic kidney disease (tubulointerstitial inflammation/tubulointerstitium inflammation injury). (R)

In rats, inflamed and injured kidneys appeared to be healed by ozone, improving kidney structure to normal standards and increasing their efficiency. (R)

10) Ozone Therapy Accelerates Early Healing Process in Gingival Grafts

Ozone therapy is useful in healing gingival grafts. (R)

In 33 patients receiving gingival grafts, total healing time significantly decreased compared to a control (gingival graft only) when applying ozone therapy to the graft. Ozone significantly increased blood flow to the graft area 8 days after surgery. (R)

The wound appearance noticeably improved, as well as the overall quality of life of the patient in comparison to the control after 8 days. (R)

11) Ozone Therapy Protects Cells From Hypoxia

Ozone therapy successfully treated testicular ischemia-reperfusion (tissue damaged from return of blood supply after prior lack of oxygen) injury in rats. (R)

General testicular health was overall improved in the ozone treated group, increasing instances of apoptosis and reducing communication protein activity (NO synthase activity). Application was most successful when directed applied locally. (R)

12) Ozone Reduces Liver Damage Caused by Obstruction in the Biliary Tract 

Ozone therapy successfully and significantly reduces liver damage (Hepatic fibrosis) caused by liver obstruction in rats. (R)

Lower levels of liver fibrosis and inflammation (including perioral inflammation) were observed in the ozone treated group compared to the sham and control groups. There were also no traces of cirrhosis. (R)

13) Ozone Therapy Treats Recurring Canker Sores

Ozone treatment is highly effective at treating recurring canker sores. (R)

69 patients with sores were either exposed to ozone, or to a regular air control. The ozone treatment group had significantly reduced ulcer pain compared to an air control, reduced ulcer size after 2 days, and overall reduced ulcer duration. (R)

14) Ozone Therapy Treats Acute Distal Colitis

A rat model demonstrated ozone’s effectiveness in treating acute distal colitis (ADC). (R)

Proteins that affect inflammation (TNF-α and IL-1β), and other proteins (MDA and MPO) increased in activity from the ozone treatment as compared to the non-treatment and control. (R)

Then in comparison with colon therapy group and control group, ozone therapy plus colon therapy resulted in more rapid alleviation of symptoms and better histological improvement without any adverse effects. (R)

15) Ozone Therapy Relieves Lower Back Pain

Ozone treats lower back pain that may result from herniated disks. (R)

A review of controlled studies on low back pain using ozone therapy shows ozone therapy as reducing short-term and long-term pain associated with the condition. (R)

16) Ozone Activates the Body’s Antioxidant System

Ozone may help activate the body’s immune system by being absorbed in blood cells and soft tissues and is spread throughout the body as messengers. (R)

The reactivation of the body’s antioxidant system is thought to be important in treating chronic renal failure (seen in rat study). (R)

The rats given ozone had fewer lesions, lower arterial pressure, and generally hindered the progression of disease compared to the control. (R)

17) Ozone Therapy Preconditioning Helps to Prevent Intestinal Tissue Damage from Chemotherapy Drug

Methotrexate (Mtx) is a chemotherapeutic agent. Gastrointestinal toxicity is the drug’s major limiting factor, mainly from oxidative damage.

It was proposed that ozone is an activator of antioxidant enzymes.

Ozone preconditioning showed a preventative effect in small intestinal tissue by decreasing tissue damage and increasing antioxidant enzyme activity in an experimental model of Mtx-induced intestinal injury. (R)

18) Ozone Therapy and Ozone Oils Treat Skin Diseases 

Ozone treats a variety of wounds and ulcers and is an excellent disinfectant. (R)

No resistance to O3, so far, has been demonstrated, and ozonated products can be used 3-4 times daily for external genital areas, for venereal infections, and several anorectal affections. (R)

As for oral infections (apthae, HV-I, opportunistic superinfections, or acne), prompt application of ozonated ointments reduces swelling, destroys the pathogen, and allows rapid healing. (R)

Others have managed their rosacea with ozone therapy. (R)

Ozone Therapies

The most common ozone therapies include:

  • Rectal Insufflation
  • Vaginal Insufflation
  • Ozonated Water
  • Ear Insufflation
  • Ozone oil breathing (which creates ozone oil as a byproduct that can be used on the skin). Ozone compositions (oils) have the capacity to deliver active O2 and/or useful species deep within lesions without causing primary skin irritation.

Other Ozone Therapies Include:

  • Ozone Sauna

Ozone Therapies in-clinic Include:

  • MAH (Major Autohemotherapy): involves the injection of medical grade ozone into blood drawn from a person
  • O3UV: MAHT and ultraviolet blood irradiation are performed together.

There may be some vein-related issues when doing ozone therapy through IV. Many people have found that IV therapies may be more effective initially (show relief of symptoms faster). However, they may opt to do home therapies instead (ear insufflation, rectal and vaginal insufflation, oil breathing, and ozone water) to avoid the high cost of in-clinic therapies, and avoid side effects. Home therapies usually take a bit longer than IV therapies to show an effect but are usually just as effective.

Side Effects of Ozone Therapy

Ozone’s effects are with minimal and preventable side effects. (R)

In Germany, where ozone therapy is commonplace (over 7,000 doctors in Germany use it daily), there are very few incidences of side effects. Ozone generators are also used in ambulances for treatment of stroke victims. The incidence of permanent paralysis is less common in Ozone patients than in similar non-ozone patients.

When doing the common treatments of ear insufflation, rectal, vaginal and ozone water, the main side effects are with ear insufflation. Ear insufflation, when done often (15 minutes a day, 3-4x a week), can sometimes cause ear discomfort. Usually, this can be avoided as before any signs of slight pain occur, you will first feel ear pressure. When this happens, ear insufflation treatments are avoided for 1 or 2 days (or up to 2 weeks if necessary) until all side effects are gone. This side effect always resolves, and when it does you may continue ear insufflation therapy.

Of course, you should always talk to your doctor before starting ozone sessions.

Health Tools I Wish I Had When I Was Sick

At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.

That’s why I decided to create tools that will help others cut down the guesswork:

  • Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
  • SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
  • SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
  • SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
  • Selfhacked Inflammation course – a video course on inflammation and how to bring it down
  • Biohacking insomnia – an ebook on how to get great sleep
  • Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
  • BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
  • SelfHacked VIP – an area where you can ask me (Joe) questions about health topics

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.


1 Star2 Stars3 Stars4 Stars5 Stars (11 votes, average: 4.00 out of 5)


  • John

    Does running an ozone generator machine in one’s bedroom constitute ozone therapy as it is referenced in this article?

  • caz carter

    Where is the source for ten pass causing strokes, heart attacks ect?

  • Jason Klinger

    I wouldnt do the 10-pass treatments. They are very dangerous and this method is not well researched. People have died and gotten strokes and ebolisms from this. single pass ozone with UVB along with medicine and herbals is the best approach. American doctors are pushing 10 pass cause they know they can charge a fortune and believe me the certainly do

  • Caroline Carter

    10 pass ozone therapy is very powerful and is killing Borrelia (Lyme disease) and it is available in the US. The problem with the treatment is the cost which ranges from 900 – 1100 per 10 pass session.

  • Iwonka

    I wasn’t feeling well, my blood test were coming back perfect and my doctor didn’t know what to do.
    I went to Poland for ozon therapy. I had a drop of blood put under microscope where I could see myself bacterias moving in that drop. There were two diferent ones, thin moving with wiping motion and motionless that look like croissants. Doctor prescribed IV ozone and test me for Lyme.
    I was tested positive for Lyme and after 3 weeks of ozone therapy my blood was free of bacteria it was there before. I retested for Lyme and it was still there, ozone didn’t help. In Poland IV ozone cost $20/treatment. I have to admit I felt much better duding therapy.

  • Green

    Yes, Ozone therapy is Legal in Nevada, Alaska and Arizona in the USA today, that I’m sure of.
    The FDA is not God, the be all end all for answers. The Germans used Ozone treatment as far back as The Great War. Do the home work there is a mountain of clinical history and study out there from around the World. Look at the Science, Don’t get sucked into the Politics and prejudices, it’s Your Health Your Life.

  • Caroline Carter

    I have treated clients successfully with ozone for many years. Since the beginning of 2017 and the inclusion of 10 pass ozone, we are achieving amazing results and reversals with Lyme disease.

  • JJ

    Any sort of Ozone treatments is “BANNED” in US & Canada because I lived in Canada & I saw on this Ozone website. It is commonly used in Germany, Swiss & Europe of course and cured people of Lyme Disease and Cancer with additional IV treatments, Hyperthermia, etc. Do some research on the Establishment where you are getting your Ozone Treatment at to make sure the Doctor is Licensed or have Good Reviews. I wanted to get a Nose Insufflation constant recurring Sinus Infection (biofilms) for 15 yrs that lead to Vag & Gut & other problems now. After the Ozone Sauna day 1, I felt good. 3 days later I went for Rectal Ozone the Doctor was suppose to come check on me; which he didn’t ” my stomach swelled up like 10 months pregnant I thought I was going to die I pulled the plug and ran to the bathroom for 3 hrs” I would not go back to a Doctor like that!!! It makes me wonder why people died while getting “Mis-Treated”. Ozone works.

  • Karen

    I activated a OI dysautonomia SNP and vitamin B1 deficiency unknowingly while doing ozone baths it caused oxidative stress from heat and my lack of SOD function does not help mop up oxidation. It caused pusedo-hypoxia and POTS and coughing. Not everyone is a candidate as cited in the post above.

  • Tim

    Hi selfhacked, so which ozone product do I buy?

    1. Nattha Wannissorn, PhD
  • Gary

    You have no idea what you were talking about Jacob. I did ozone therapy for 14 years as a treatment instead of medication. Had I not done Ozone, I would be dead now. Ozone is a fabulous wonderful therapy and it works very very well. I am also a realist and know that ozone will not cure everything. My issue was a vile viral problem. Ozone only works on non aerobic cancers as well. Aerobic cancer that thrives in oxygen environment would get worse. I can only assume that you’re in the medical profession somewhere and natural medicine it’s something you don’t believe in from your comment that you wrote

  • om

    I have gone to a guy that claims he is injecting ozone into you…is there health benefits to this? inferior, superior? thoughts

    1. jacob

      Yes ozone may make you feel better and may treat certain ailments, but I would be very cautious about using it. The FDA has banned the use of ozone therapy and ozone is not approved by any states as a treatment. Don’t buy the argument that ozone is persecuted because it doesn’t make money for the pharmaceutical industry. On the contrary, ozone is pushed hard on the internet by people who sell the equipment and services who are hucksters trying to take advantage of sick people. Naturepaths sell ozone services because they do not have a significant degree (Naturapathic schools are notoriously easy to get into and self-accredited) and as a consequence are not allowed to administer real treatments and are taught bogus methods such as homeopathy. I question some of the studies cited above, look at them carefully yourself. Additionally, ozone is a strong oxidizing agent, clearly this should indicate that it is bad for you. Also, it is found in these questionable places and clinics but not in any serious location.

  • dennis

    what is the difference between chlordioxid and ozone ?

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