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I recommend reading How to do an elemental diet.  This post was initially part of that one.

The Point of An Elemental Diet


I’ve made a lectin avoidance diet, which is pretty limited and strict, but is doable for some people who are committed. However, even the lectin avoidance diet has lectins in there.

An elemental diet is meant to be kept for a few weeks to determine how much of your issues are from food.

I would recommend this diet to help people determine if they’re sensitive to lectins or other proteins in food.

If you are, indeed, sensitive then I’d recommend the lectin avoidance diet for the longer term and using supplements when you have to break it or while on it if you are extremely sensitive.

Indications For An Elemental Diet

If you have autoimmune issues or other inflammatory conditions then you are probably getting inflammation from food.

I reckon that up to 40% of the population has some level of lectin sensitivity, but maybe only 25% have it to a level that causes significant discomfort.  This 25% of the population I recommend keep to this diet.  The other percentage can do the resistant starch diet.

Lectin sensitivity is on a spectrum, where people are sensitive to varying degrees.

The more symptoms you have the higher the likelihood of lectin sensitivity.

  • Immune imbalances (see if you’re Th1 dominant or Th2 dominant) or any autoimmune condition-  very common.
  • Bloating— very common
  • Gut problems: Gas/Abdominal discomfort/Irritated GI tract – very common
  • Fatigue in the day – even with 8 hours of sleep. Especially post-meal fatigue – very common
  • Brain fog – very common
  • Excessive anxiety, perfectionism, procrastination, paranoia, OCD and an inability to let go.  These are indicative of low serotonin.
  • Skin problems (not acne) – indicative of an immune imbalance.   Skin problems can include various fungus, eczema, psoriasis, etc.. – very common
  • Not handling glucose or carbs well (getting hypoglycemic often)
  • Joint discomfort
  • Pain in random places like backaches, etc…. (that aren’t a result of a serious injury, obviously)
  • Weight problems: Inability to put on weight or stubborn weight loss
  • Water retention, puffiness around the eyes, extremities
  • Some types of headaches/migraines
  • Sleep and circadian issues

Scientific Indications/Benefits of An Elemental Diet

The benefits of an elemental diet I believe are achieved by staying away from lectins and other proteins.  I believe that the vast majority of gut and autoimmune issues starts with lectins, which go on to cause a range of food sensitivities and eventually full blown autoimmune disease.

By staying away from lectins and other inflammatory proteins, as well as starving bad bacteria is what can explain the benefits.

Other conditions caused by lectins and inflammatory proteins would have similar results.

You’ll notice that the cure rate isn’t 100% and that’s because we don’t know anything else about the people in the study.

For example, most people are stressed like hell and have a shitty lifestyle.  Most people don’t get enough sun or exercise.  Yet we still see amazing cure rates with just a single treatment.

Imagine what would happen if you combine this with lifestyle modifications, superior nutrition, supplements, devices, etc…

1) Autoimmune disease in general.

A study was done on 800 people with autoimmune conditions who ate a diet that consisted of avoidance of grains, sprouted grains, pseudo-grains, beans and legumes, soy, peanuts, cashews, nightshades, melons and squashes, and non-Southern European cow milk products (Casein A1), and grain and/or bean fed animals.

Most of these people had elevated TNF-alpha.  The result after 6 months was a normalization of TNF-alpha in all patients who complied with the diet.

The study concluded that elevated Adiponectin is a marker for lectin and gluten sensitivity, while TNF-alpha can be used as a marker for gluten/lectin exposure in sensitive individuals. (R)



An elemental diet has an 80% cure rate for people with SIBO when done for 14 days and 85% cure rate for people who continued for 21 days (R).  93 people with confirmed SIBO (via lactulose breath test) and IBS experienced a 66% improvement (R).  There are multiple studies that show benefits with IBS/SIBO. If this were done with supplements and for longer, I believe the cure rate would be close to if not 100%.

3) Crohn’s Disease.

An elemental diet was at least as effective as steroids for Crohn’s disease (R).  The study was done with 12 males with a median age of 30 and last for 2 weeks.  In a 4 week study, there was a 71% remission rate and inflammatory markers normalized (R).  There are multiple studies that show benefits with Crohn’s disease.  The same benefits aren’t achieved with colitis (R).

In a different study testing the effectiveness of an elemental diet for Crohn‘s, it found that increasing levels of fat made the remission rate ( the rate at which symptoms disappear) worse.  The remission rate after 4 weeks in each group was 80%, 40% and 25% for patients in the low-, medium- and high-fat groups, respectively (R).  Therefore, people with Crohn‘s should take Vivonex.  However, I can’t access the study to see the long chain fatty acids they used in the study.

Don’t think that an elemental diet is all or nothing.  People with Crohn‘s who had half of their calories from an elemental diet and the other half whatever they wanted had a 30% lower relapse rate (R) than the people who just ate whatever they wanted.

4) Rheumatoid Arthritis


A pilot trial with 21 people showed a significant improvement in 72% of people, in comparison to 78% for a standard drug (prednisolone). The study concludes: “An elemental diet for 2 weeks resulted in a clinical improvement in patients with active rheumatoid arthritis, and was as effective as a course of oral prednisolone 15 mg daily in improving subjective clinical parameters. This study supports the concept that rheumatoid arthritis may be a reaction to a food antigen(s) and that the disease process starts within the intestine.” (R)

I believe that there would’ve been a bigger improvement had the trial gone on longer and better nutrition was supplied.  In addition, supplements would also help.

5) Type 1 refractory celiac disease

Out of 9 people who completed the trial, 8 showed reductions in inflammation (R).

6) Eosinophilic esophagitis, an autoimmune condition.

“Elemental diet resulted in striking improvement in both symptoms and histologic evidence of disease in children and adolescents with EoE, as identified by strict diagnostic criteria.” (R)

7) Dermatitis herpetiformis, an autoimmune condition


“We conclude that 1) there is a significant improvement in clinical disease activity on an elemental diet, independent of gluten administration, 2) small bowel morphology improves rapidly on an elemental diet” (R)

Besides the listed conditions, food intolerance has been found to be associated with:

Health Tools I Wish I Had When I Was Sick

At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.

That’s why I decided to create tools that will help others cut down the guesswork:

  • Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
  • SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
  • SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
  • SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
  • Selfhacked Inflammation course – a video course on inflammation and how to bring it down
  • Biohacking insomnia – an ebook on how to get great sleep
  • Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
  • BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
  • SelfHacked VIP – an area where you can ask me (Joe) questions about health topics

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  • Alan

    Hi Joe,

    Is it necessary to take a dopamine decarboxylase inhibitor (like EGCG) along with 5-HTP if I want to take the latter to raise my serotonin levels?

    1. Joseph M. Cohen


  • mixy


    I have occasional brain fog, and following some experimentation I believe the issues might be related to Wheat and Barley consumption.
    I am not celiac but i might have a gluten sensibility

    I have done a strict elimination diet to check the symptons out, and I am in the crucial moment of reintroducing food back to the diet

    My question is:
    – Reintroducing wheat , what food has the highest concentration of wheat? Bread?
    – Reintroducing barley, what food has the highest concentration of barley? I dont want to drink beer because i could be confused by the effects related to alcohol consumption


    1. Joseph M. Cohen

      Irrelevant regarding concentration

      1. mixy

        Thanks for your reply Joe.

        OK, so any food with barley or wheat will do.

        I dont want to use beer to avoid adding another variable: alcohol or yeast effects… but i think you can buy barley flakes in health shops


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