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This is the stack that I use to quickly recover from cannabis.  All of the methods have been vetted by me and they work (on me at least). I experimented with these because of the underlying mechanisms made sense and they worked quite effectively.

Every one of these recommendations uniquely counteract an area of physiology that is negatively changed by cannabis and can quicken your recovery.

I initially figured these out by simply paying attention to the changes in my brain and thinking what chemicals would counteract it.  It’s kind of like when a cook imagines what added ingredients would go well with a recipe.

Once I noticed they were helpful, I started looking into why they were helpful.

How to Counteract The Negative Effects of Cannabis/Marijuana

1-2) Forskolin and Exercise

Cannabis (both CB1 and CB2 receptors) causes a decline in cyclic AMP by inhibiting adenylate cyclase (R).

Cyclic AMP is important for tons of bodily processes, including energy and cognitive performance.

Exercise is the best lifestyle approach to increasing cyclic AMP.  However, you’re probably feeling sluggish and not in the mood to exercise, which is why Forskolin can help.

Forskolin is the top supplement to increase cyclic AMP and combat the negative effects of pot.

When I smoke cannabis, it seems to cause a phase delay in my circadian rhythm, which means that I am more tired in the morning and more awake at night – and I tend to go to sleep later.

Cyclic AMP is critical to setting the circadian rhythm and when I take forskolin upon awakening, it reduces most of the negative effects with regard to the circadian rhythm.  Indeed, Cannabinoids lessened the ability of the circadian clock to entrain to light (phase advance) (R).

Forskolin also increases thyroid hormones, which are decreased by cannabis.

3) Caffeine

Caffeine can modulate the effects of cannabis on cognitive function (R).

Activation of the CB1 receptors work through the Adenosine 2a receptors to put you in a trance.  If you block the Adenosine 2a receptors with caffeine, you will be taken out of the trance-like state that cannabis causes.  Blocking these receptors also blocks the addictive effects of cannabis (R).

Interestingly, cannabis counteracts the negative effects of caffeine for me.  When I drink caffeine the day after smoking cannabis, I don’t get tired or anxious, and I believe this has something to do with CB1 activation lowering glutamate in the striatum by activating the A2a receptors there (R), whereas caffeine increases striatal glutamate and dopamine by blocking the A2a receptors (R).

4-5) Galantamine and Nicotine

Nicotinic receptors (Alpha 4β2 and Alpha 7 nicotinic receptors) are blocked by THC, CBD and anandamide (R, R, R, R), and these receptors help with working memory (R, R, R).  This is probably the biggest reason why your working memory is not as good while on and after cannabis.  Both nicotine and galantamine activate both of these receptors.

When I take some nicotine the day after cannabis, it restores most of the cognitive decline from cannabis.

6) Pregnenolone

Pregnenolone is like steroids for the brain.

Pregnenolone is strongly increased by THC via CB1 activation in order to prevent cognitive harm. This negative-feedback mechanism could explain why cannabis overdoses never seem to occur (R).

Pregnenolone limits the negative effects of cannabis – on addiction and on cognitive function (R).

Inhibition of pregnenolone synthesis in mice increased THC-induced sluggishness (R).

Conversely, pregnenolone administration blocked the increase in food intake induced by THC in rats as well as THC-induced memory impairments in mice (R).

Furthermore, the inhibitory effect of THC of glutamate release in the Nucleus Accumbens was reduced by pregnenolone application (R).

Pregnenolone influenced not only these behavioural and cellular effects of THC but also its addictive properties ( by reducing the dopamine increase in the VTA and Nucleus Accumbens in rats) (R).

Pregnenolone reduced THC-induced decreases in mitochondrial and cellular respiration, without affecting THC-induced reduction of cyclic AMP production (also inhibits ERK 1,2 and MAPK phosphorylation) (R).  This means that you will also have to take forskolin.

Interestingly, pregnenolone is used as a treatment for schizophrenia and cannabis is known to induce symptoms of psychosis and schizophrenia.

7) LLLT on Thyroid

Cannabis decreases the release of thyroid hormones, and if your thyroid is already somewhat low, this can be problematic.  LLLT on the thyroid is the best way to increase thyroid hormones.

I put LLLT on my thyroid for 15 minutes.

8) Sun

The half-life of THC is 25-36 hours when orally consumed.

UV from the sun will speed up THC conversion to Cannabinol (CBN), which is much weaker than THC  (R, R2).

9) Sun  or LLLT on Your Testes

THC decreases testosterone (R), and Sun or LLLT on your testes can help increase testosterone. I put LLLT on my testes until the device gets too hot and it becomes uncomfortable.

I don’t notice as significant effects as I do with the others, but I just like to make sure my testosterone is at a good level.

Health Tools I Wish I Had When I Was Sick

At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.

That’s why I decided to create tools that will help others cut down the guesswork:

  • Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
  • SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
  • SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
  • SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
  • Selfhacked Inflammation course – a video course on inflammation and how to bring it down
  • Biohacking insomnia – an ebook on how to get great sleep
  • Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
  • BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
  • SelfHacked VIP – an area where you can ask me (Joe) questions about health topics

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.


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  • Jason

    Cox inhibitors ameliorate the memory effects in mice. Ibuprofen? Turmeric?

  • Sean

    If you are using it for pain mix it with emu oil and apply topically. No head high and I find it works better and longer than smoking. Don’t use butane extracts, butane is selective for thc. I’ve used kief that had had butane run through it and it will actually sober you up because of the cbd left behind. In regards to the previous question… ~=== smoke more 8) ===~

  • Andrea Adams

    id like to knowthe aswer to the above question to…lol

  • Lorn

    Would there be a way to prolong the “negative” effect?

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