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It goes without saying that if you have a serious problem with candida, you should try to get a doctor to treat it.  This post is meant for people with candida that want to treat it themselves, in which case it’s probably not very serious or your doctors aren’t helpful.

What Causes Candida?

Candida comes from an immune deficiency, particularly a deficiency in Th17 cells [R] and Th1 cells [R] and an increase in Th2 cells [R].  For this reason, you’d want to focus on supplements that increase the Th1 immune response and decrease the Th2 immune response.

Environmental triggers include refined carbs, stress, low stomach acidity (could be from antacids) and antibiotics. Anybody with brain fog after antibiotic treatment and/or a particularly stressful period should look into candida as being the cause, although it isn’t certain that candida is the cause.

Refined carbs make candida grow by feeding it directly and stomach acid suppresses candida growth.  Antibiotics cause candida indirectly by killing off bacteria that suppress candida.  Stress also increases candida indirectly by suppressing the immune system.

People with candida or bacterial infections will often have a chronic type of brain fog.  The mechanism fits in with the mechanism for almost all other types of brain fog: inflammation and oxidative stress.  Candida increases TNF-alpha and IL-1 [R] (as well as IL-6 [R]), which are inflammatory cytokines and this leads to OS. Watch this video demonstrating how this takes place.

Candida can infect many areas of the body and supplements that inhibit candida in one place may not inhibit candida in another location.

The Following Exhibit Activity Against Candida

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I’ve had clients who mentioned they had a resistant strain of candida and that’s why they didn’t want to take fluconazole.  If this is the case it doesn’t mean fluconazole won’t help, it only means it won’t completely kill the infection by itself.

Candida can usually be cured through conventional and alternative means.  I recommend getting a reliable test to confirm this diagnosis before going crazy with these supplements.

Eventually, when I get enough time, I will break down the mechanism’s by which each substance kills candida and formulate a protocol to encompass all of the ways to kill candida.  Also, these lists aren’t comprehensive.

As always, consult with your doctor.

Most Highly Recommended

  • Nystatin (drug) – doesn’t cross the gut barrier
  • Fluconazole (drug)
  • Voriconazole (drug) [R]
  • LLLT  [RRR] – place this on your gut
  • Coconut oil [RR] This is a super candida destroyer because it contains many types of fatty acids that inhibit candida: Capric acid [R], Saturated Fat [R], Lauric acid [R] and MCT oil [R].
  • Probiotics (Swanson) and Prescript assist B longum [R], L Rhamnosus [R], L Reuteri, Acidophilus …. Acidophilus converts-thiocyanate to hypothiocyanite which is more toxic [R].
  • Saccharomyces Boulardii [RR].
  • Undecylenic acid [R]
  • Berberine -synergistic with AmphoB and Fluconazole [RR].
  • Raw honey [R] and Propolis [R].
  • Lactoferrin [R]
  • Sodium Butyrate [R]
  • Clay [R]
  • Lectins like ConA [R] by consuming whole grains, legumes, nuts, seeds, tubers.  N-acetyl galactosamine, mannose, and sialic acid binding lectins [RR].
  • Elecare Jr – in conjunction with probiotics.  By only consuming glucose without too much fat, no carbs will go to your small intestines.
  • Uva Ursi (commonly used)
  • Cat‘s Claw (commonly used)
  • Pau D’arco (commonly used)
  • Gymnema (commonly used)
  • High-dose biotin (commonly used)
  • Tulsi [RR], – also has Eugenol [R]
  • Reishi  [R]
  • Bacopa  [R]
  • Noni [R]
  • Bromide [R] (plenty in fish),
  • Potassium iodide [R] 
  • Oregano oil/Carvacrol [R]
  • Kombucha
  • Apple Cider Vinegar [R] – has Acetic acid [R]
  • Increase stomach acidity via HCL supplements [R] or Chewing Gum
  • Ginseng [R]
  • Garlic /Allicin -synergistic with Fluconazole [RR],- haven’t found any garlic supps better than raw garlic
  • Onions [R]
  • Amla [R]
  • Grapefruit seed extract [R] – mainly because of anecdotal reports, but be careful with the quality of this supplement is suspect.
  • Peppermint [R]
  • Cruciferous vegetables such as Cabbage [R].  These also have I3C, which is active against candida [R]
  • Xylitol
  • Thiocyanate
  • Colostrum  [R]
  • Lycopene [R], in tomatoes

I recommend using a lot of spices on your food such as Curry and Italian seasoning.  Turmeric/Curcumin [RRR], Cinnamon [R], Black Pepper, Basil, Black Cumin Seed Oil [R], Cumin [R], Cayenne [R], Rosemary [R], Anise [R] and  Clove [R] have all been found to inhibit candida.  Just use them on your food.

Less Highly Recommended

The main reason most of these are less highly recommended is because they simultaneously decrease the Th17 immune response.

  • Baicalin [R]
  • Tea tree oil [R] – less recommended because I wouldn’t recommend for internal use at this stage of my knowledge.
  • Pine bark [R]
  • CLA [R]
  • Grapeseed extract-synergistic with AmphoB [R]
  • Thymol [R]
  • Geraniol [R]
  • Linalool [R]
  • Papaya [R]
  • Agaricus brasiliensis [R]
  • Sesame seed [R]
  • Honokiol-synergistic with Fluconazole [R]
  • Baicalein -synergistic with Fluconazole [RRR]
  • EGCG-synergistic with AmphoB [RR]
  • Resveratrol [R]
  • Echinacea [R]
  • Glutamine
  • Olive leaf extract
  • Itraconazole (less tolerated than fluconazole, voriconazole).
  • Licorice by the immune system [RR]
  • Tribulus [R]
  • Lavender [R]
  • Lemongrass [R]
  • Chlorhexidine acetate [R]
  • Sodium hypochlorite [R]
  • Calcium hydroxide [R]
  • Candicidin for vaginal [R]
  • Abafungin [R]
  • Solanu chrysotrichum [R]

The Following Increase Candida

  • Glucose [R]
  • Corticosteroids [R]
  • Antibiotics [R]
  • Sugars that bind to lectins: NAG, Mannose [R] and maybe sialic acid [R].

How The Immune System Detects and Kills Candida/Fungi

How Fluconazole and Other Azoles Kills Candida and Fungi

How Amphotericin B Kills Candida and Fungi

Amphotericin is dangerous and should be a last resort, though taking a lower dosage and combining it with other substances should be explored.

Conventional Treatment of Candidiasis

Health Tools I Wish I Had When I Was Sick

At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.

That’s why I decided to create tools that will help others cut down the guesswork:

  • Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
  • SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
  • SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
  • SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
  • Selfhacked Inflammation course – a video course on inflammation and how to bring it down
  • Biohacking insomnia – an ebook on how to get great sleep
  • Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
  • BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
  • SelfHacked VIP – an area where you can ask me (Joe) questions about health topics

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20 COMMENTS

  • Sophie

    Hiya I have Candida I’ve been taking priobiotics and capyrlic acid since beginning of June, I’m chronically bloated every day and not hungry. I haven’t noticed a difference as yet taking these supplements does it take a whole or?

  • BPip

    My personal experience with consuming honey is that it made internal fungus worse. I developed extremely itchy toes within 2 days of converting from processed sugar to replacing with honey. The itchy toes didn’t go away until i quit honey. It was an extremely severe itch that was constant and all i could do to relieve the feeling was to ignore it – it’s the type of itch which gets itchier the more you itch it! Toes burning, blisters appearing – i wanted to chop my toes off to get rid of the feeling!

    My boyfriend experienced the same, and also developed jock itch from consuming honey so i’m not convinced at all that honey doesn’t feed fungus. Our experience shows it’s worse than processed sugar!

  • josh

    Hey Joe,

    For the past 6 months I’ve had a thick white coating on my tongue and an itchy rectum…
    checked stools for major parasites and all green – candida therefore should be the culprit?

    i have P.O.T.S and I’m lectin sensitive.

    what foods should i watch out for on this particular diet? as i know having candida would limit my food options even more.

    Thank you,

    Josh.

  • Sebastian Achter

    Hey Joe,
    I really like your blog and i just discovered it. I’m 24 and I suffer from brain fog since I’m 22(but it got a bit better now with the dietary change) and I had IBS since I was 16. My IBS went away with the high fat lectin free diet I started a year ago which was advised to me by my NP. I always had a white coated tongue and now I have jock itch which I had before, when my IBS started after an infection. Now my NP gave me calcium undecynate against the candida, but I read here that the oil form from thorne is better : https://www.candidaplan.com/1101/undecenoic-acid-or-calcium-undecylenate/
    Do you have experience with this?. I started using it yesterday but I want the most potent product to get rid of it. I now use PURE Encapsulations AC Formula for the fungus.
    My energy levels are good now but I still have brain fog, but I’m so lucky I found an experienced NP. You are very brave man, trying everything alone. I’m sure there is an opportunity for me to get rid of brain fog and the thyroid condition

    Best regards from Austria;) (not Australia hehe)

  • Frederik Emil Hanfgarn

    Hey Joe.

    I was wandering, isn’t nicotine an anti-fungal that could be used to kill off candida?

  • Jake

    Anybody want to throw a plan for Ulcerative Colitis, Histamine and Salicylate Intolerance, stage 3 adrenal fatigue, and Candida? Symptoms include GI distress (obviously) like bloating, cramping, pain, no diarrhea though, and no SIBO, sensitive to just about every food, dizziness, hives, itchy, congestion (last 3 are from histamine for sure). I’m worried that an elemental diet would exacerbate Candida, and I wonder about the regulation of osmolarity inside the intestines as concentrated nutrients flood them.

  • akismet-e2f924dd01bf1e587f51cd89152785f3

    What kind of diet do you suggest for Candida and Bacterial Owergrowth ?

  • Oskar

    I think that biofilm destroying enzymes would be helpful as well.

    1. Joseph M. Cohen

      I would rather get this

      1. Ted Hu

        Doesn’t have lysozyme. Egg-derived enzyme, potent biofilm breaker.

    2. Emmy

      Oskar, did you have results with Biofase ?

  • Phil

    Would you recommend taking molybdenum to minimize candida die-off? I’ve read elsewhere this is a good idea as well as adrenal support. Also milk thistle.

  • Mark

    Where’s the Manuka UMF honey?

    1. Joseph M. Cohen

      Study showing it’s better than regular raw honey?

  • Mike

    Is raw honey really effective? Others say this could also feed the candida while others also agree that it does help inhibit. Does it matter when blended with other fruits/vegetables?

    1. Joe

      I don’t know, but you need some source of carbs and honey would be the best option it seems

  • Aleksandra

    Hi Joe!
    Does addidng spices to your food act by increasing stomach acid production and hence killing the yeast, or is there anything more to this?

    1. Joe

      They’re directly antimicrobial

  • dawnofeverything

    If you went to school, would you study biology? Seems like it would be a good fit for you.

    1. Joe

      I took the premed courses

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