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Glutathione, often referred to as “the mother of all antioxidants,” is one of the most talked-about supplements in the healthcare industry…and for good reason. Glutathione is produced and used by every single cell in the human body and, therefore, has a very wide range of scientifically-proven health effects.

In this article we will explore the science surrounding the biological benefits of glutathione supplementation, and the best measures you can take to ensure your glutathione levels are optimally balanced.

What Is Glutathione?

Glutathione is a peptide containing 3 important amino acids that have several important roles in the human body [R].

Demonstrating glutathione’s importance for humans, researchers have suggested that cellular glutathione levels are a great predictor of life expectancy [R, R].

Like vitamin C & E, glutathione is an important antioxidant in the body. What’s special about glutathione is that it is positioned within the cell, making it perfectly placed to carry out its job.

Glutathione is an important antioxidant in animals, plants (especially avocados), fungi, and some bacteria, where it prevents damage to important cellular components caused by reactive oxygen species [R].

By removing oxygen radicals from the body, glutathione protects many different body systems from disease and deterioration [R].

Glutathione is a defensive agent against the action of toxic xenobiotics (drugs, pollutants, carcinogens) [R].

Because of its wide range of uses in the body, it is essential to prevent glutathione levels from becoming low.

Glutathione deficiency manifests in increased susceptibility to oxidative stress, the resulting damage of which is thought to be involved in a plethora of diseases, such as cancer, Parkinson’s, and Alzheimer’s disease [R].

Therefore, regulation of glutathione metabolism is a critical part of strategies to ensure optimal health [RR].

Glutathione Snapshot

 Pros

  • Great antioxidant
  • Good detoxifier
  • Positive effects for prevention of glaucoma and cataracts
  • Helps liver function
  • Promising for a variety of conditions

 Cons

  • Tastes really bad
  • Absorption and bioavailability is poor unless taken in liposomal form
  • If health is very poor, must start slow and work to a higher dose

Health Benefits of Glutathione

1) Glutathione Fights Oxidative Stress in the Body

Glutathione reduces the amount of reactive oxygen species (ROS) and oxidative stress in the body, which would otherwise cause damage to cells and DNA [RR, R].

Glutathione protects against chronic oxidative stress that can cause cancer, neurodegeneration, and a range of other diseases that we will discuss below [R].

As well and neutralizing reactive oxygen species (ROS), glutathione is important for the regeneration of other antioxidants, such as vitamins C and E [R].

2) Glutathione May Control Inflammation

Glutathione inhibits the production of most inflammatory cytokines [R].

Glutathione deficiency caused inflammation in the airways of mice. This inflammation was reduced when the mice were given glutathione [R].

Also, glutathione inhibits NF-κ, a transcription factor that increases the transcription of various inflammatory genes [R].

A number of pulmonary diseases are caused by excessive inflammation. In many of these diseases, restoring glutathione to a healthy level is protective, indirectly supporting the idea that glutathione is anti-inflammatory [R].

3) Glutathione Is Anti-Aging

With less glutathione, free radicals can harm the body and cause aging [R].

Replenishing glutathione levels may slow the aging process [R].

Imbalances in glutathione levels affect immune system function and are thought to play a role in the aging process [R].

Multiple studies have demonstrated that the body makes less glutathione as it ages [R].

Glutathione drops off during menopause, which may be part of the reason for the dramatic aging that occurs during this time in a woman’s life.

By maintaining glutathione levels, aging individuals may prevent age-related cognitive decline [R].

Decreased levels of glutathione in aging subjects caused oxidative stress, which can cause bone breaking and osteoporosis [R].

Myricitrin, a drug used in preventing age-related osteoporosis, may work by increasing levels of glutathione [R].

4) Glutathione May Prevent Depression and Stress

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Studies show low glutathione levels in patients with depression [R, R].

Also, glutathione is able to prevent shock-induced behavioral depression in animals [R].

A study on mice showed that alprazolam, a drug used to relieve stress, increased levels of glutathione in the mice [R].

5) Glutathione May Limit Neurodegeneration

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The cells of the human brain consume about 20% of the oxygen utilized by the body but make up only 2% of the body’s weight. Reactive oxygen species are continuously generated during oxidative metabolism. Therefore, the detoxification of reactive oxygen species is an essential task within the brain. Glutathione plays a key role in this process [R].

Alzheimer’s Disease

Alzheimer’s disease is in part caused by the oxidative stress that antioxidants neutralize, as demonstrated by clinical studies showing that oral vitamin E (powerful antioxidant) intake slowed the progression of Alzheimer’s [R].

To make matters worse, Alzheimer’s is characterized by accumulation of TDP-43 (a DNA binding protein) in the nervous system, which further lowers glutathione levels [R].

In mice, a protein that increases glutathione levels in the body was found to increase memory in subjects with Alzheimer’s [R].

Parkinson’s Disease

Parkinson’s disease is caused, in part, by oxidative stress in the nervous system. Glutathione combats this oxidative stress.

Parkinson’s disease involves the loss of dopaminergic neurons in the substantia nigra part of the brain. Studies have noted that people in pre-clinical stages of Parkinson’s have low glutathione levels in the substantia nigra [R].

A study showed that a drug, named 3,4-dihydroxybenzalacetone, helped prevent Parkinson’s disease by increasing levels of glutathione [R].

Huntington’s Disease

Huntington’s disease is caused by oxidative stress and mitochondrial dysfunction [R].

Studies have shown that a special form of curcumin successfully helped improve mitochondrial health by increasing glutathione levels [R].

6) Glutathione May Help with Infections

Viral Infections cause abnormal amounts of oxidative stress in cells due to inflammation and a reduction of glutathione levels [RR].

In many diseases (e.g., AIDS, COPDcystic fibrosisinfluenza, and alcoholism), lowered immunity and increased risk of infections correlate to low glutathione levels [R].

Patients with tuberculosis have been shown to have low glutathione levels [R].

Glutathione depletion lowers the anti-infection activity of macrophages, while NAC (glutathione precursor) increased intracellular killing of mycobacteria [R].

Another study showed that the maintenance of cysteine levels, and thus glutathione levels, is important for enhancing mycobacterial killing activity [R].

7) Glutathione May Heal the Gut

Patients with IBS have decreased activity of enzymes involved in glutathione synthesis, as well as lower levels of glutathione’s precursor, cysteine [R].

Glutathione peroxidase is an important enzyme for the normal renewal of the gut wall [R].

Glutathione protects the intestinal mucosa. Administration of glutathione may protect the gut wall which, when weakened, can lead to leaky gut (R).

8) Glutathione May Treat Autism

Children diagnosed with autism have lower levels (20 to 40% lower) of reduced glutathione than considered normal levels [R, R].

Other abnormalities have been found in the transsulfuration pathway (the pathway where glutathione is produced) in children diagnosed with autism [R].

This includes lower levels of cysteine, the rate limiting substrate for glutathione production [R].

Oral and transdermal glutathione are currently being used to normalize glutathione levels in autistic children. Early studies indicate that this may improve some of the transsulfuration metabolites often low in autistic children [R].

9) Glutathione and Cancer

Glutathione is a major factor in the regulation of life, proliferation, and death of cancer cells [R].

Glutathione deficiency, or a decrease in the glutathione/glutathione disulphide (GSSG) ratio, leads to increased damage from oxidative stress involved in the progression of cancer [R].

There is significant correlation between increased glutathione intake and decreased risk of oral and throat cancer [R].

Furthermore, glutathione plays a key role in repairing damage done by cancer drugs on cells in chemotherapy patients [R].

Glutathione is crucial in the removal and detoxification of carcinogens. However, it should be noted that, by conferring resistance to a number of chemotherapeutic drugs, elevated levels of glutathione can actually protect tumor cells. Perfect balance is imperative [R, R].

10) Glutathione May Treat Psychiatric Disorders

Schizophrenics have low levels of glutathione. NAC, which increases glutathione levels in the brain, was shown to improve the symptoms of schizophrenia in human subjects [R].

Patients with OCD have low levels of glutathione in certain parts of their brain (e.g., lower posterior cingulate cortex) [R].

High levels of free radicals were found in the blood of patients with OCD. Reducing these levels by introducing glutathione may help reduce the severity of OCD symptoms [R].

Furthermore, glutathione may help to reduce stress, which is a major symptom, and possibly contributing factor, of OCD [R].

Multiple drugs used to treat bipolar disorder work by increasing glutathione levels [R].

11) Increasing Glutathione Levels May Help ADHD

Subjects with ADHD have been shown to have low glutathione and high levels of oxidative stress [RR].

Pycnogenol, a glutathione booster, was found to normalize antioxidant levels in children with ADHD [R].

12) Glutathione May Help in Preventing Heart Disease

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Low activity of glutathione peroxidase, as well as low levels of systemic and cardiac glutathione, is linked with an increased risk of heart attack [R, R, R].

Cardiovascular disease is largely caused by oxidative stress in heart tissues. Perhaps this is why insulin resistance, impaired glucose tolerance, and diabetes (3 conditions that cause oxidative stress), are linked to heart attacks [R, R].

Glutathione can help in reducing these reactive species and, in turn, limit the risk of stroke or heart attack [R].

13) Glutathione May Treat Diabetic Complications

Diabetes II and high blood sugar cause the reduction of glutathione in the body [R].

Free radical accumulation causes many of the complications associated with diabetes type 2, such as cardiovascular problems and neurodegeneration [R].

Studies show introducing extra glutathione into the body prevents or limits these complications [R].

14) Glutathione May Prevent Kidney Disease

Oxidative stress in the kidneys can cause kidney failure [R].

Studies in rats have shown that the precursor of glutathione, NAC, can prevent kidney disease due to aspartame [R].

A study, which investigated 20 patients suffering from chronic renal failure and undergoing hemodialysis, found that supplemental glutathione resulted in a marked improvement in kidney function (as measured by red blood cells, plasma reduced glutathione, hematocrit, and hemoglobin) [R].

15) Glutathione Protects Against Liver Damage

Liver disease is caused by oxidative stress. Glutathione keeps the liver healthy by helping in reducing this oxidative stress in the liver [R].

Glutathione plays an important role in the liver in detoxification reactions and in controlling the thiol-disulfide status of the cell [R, R].

The liver upregulates glutathione synthesis to combat the effects of a high-fat diet.

Oral administration of reduced glutathione (300mg/day) is effective at preventing non-alcoholic fatty liver disease, which can eventually lead to cirrhosis and liver cancer [R].

16) Glutathione May Help Prevent Addiction

Consumption of cocaine, methamphetamines, and alcohol lead to an increased production of reactive oxygen species (ROS).

These species can alter proteins involved in neuronal and behavioral pathways, causing the subject to become addicted. By reducing the presence of these reactive species, glutathione may decrease the development of addictive behaviors [RR].

This may also be applicable to overeating disorders [R].

17) Glutathione May Reduce Consequences of Drugs or Alcohol

Chronic alcohol use causes oxidative stress and reduces liver levels of glutathione [R].

Glutathione can reduce the effects of chronic use by decreasing the presence of reactive oxygen species (ROS) [R].

Glutathione improved liver function of alcoholics, but only when they abstained from alcohol use.

Chronic alcohol ingestion causes oxidative stress in the lungs which can often lead to respiratory infections such as pneumonia. Glutathione can protect the lungs by reducing oxidative stress [R].

18) Glutathione Controls Cell Death

Glutathione depletion is a key signalling event that controls the activation of cell death pathways. For example, S-glutathiolation in important for protein modulation and apoptotic (cell death) initiation [R, R].

Cells depleted of glutathione are susceptible to damage, especially from arachidonic acid. Studies show that low glutathione levels cause a series of events, which ultimately result in cell death [R].

19) Glutathione Can Help with Respiratory Issues

Screen Shot 2016-07-03 at 13.35.13

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048347/

One study showed that low levels of glutathione increased inflammation and caused asthma in the airway [R].

The same study showed that increasing levels of glutathione decreased inflammation and reduced asthma in the airway [R].

Chronic Obstructive Pulmonary Disease (COPD) is a lung disease caused by long-term oxidative damage to lung tissue, the damage of which results in inflammation of the lung tissue, causing shortness of breath and coughing [R].

Glutathione supplements can decrease this oxidative damage and tissue damage within the lungs , thereby reducing the risk of developing COPD [R].

20) Glutathione Can Treat Sleep Apnea

Sleeping

Patients with sleep apnea have very high levels of oxidative stress and, consequently, depleted glutathione levels [R, R].

A study showed that glutathione levels were low in subjects who were diagnosed with sleep apnea, and that increasing those levels of glutathione to normal improved sleep quality in these patients [R].

21) Glutathione May Treat Acne

High levels of oxidative stress lead to low levels of glutathione in acne patients [R, R].

A decline in antioxidative activity, especially a decrease in glutathione quantity, may play a key role in the development of acne [R].

Increasing glutathione levels may help reduce acne by decreasing oxidative stress levels.

22) Glutathione May Help Treat Rheumatoid Arthritis

Studies have shown that antioxidant mechanisms can be impaired in subjects with rheumatoid arthritis. Glutathione levels were shown to be significantly lower in these patients [R].

Patients with rheumatoid arthritis have increased levels of glutathione peroxidase as a response to high levels of oxidative stress. It makes sense to supplement glutathione to ensure that these individuals can match this high demand for glutathione [R].

23) Glutathione Helps Prevent Glaucoma and Cataracts

Glaucoma and cataracts can gradually cause loss of vision. Both of these conditions are in part caused by oxidative stress to the ocular nerve, which glutathione may reduce [R].

24) Glutathione Encourages a Healthy Pregnancy

In pregnant women, low glutathione levels caused by depression may lead to impaired brain development in the unborn child [R].

Increased amounts of reactive oxygen species in a fetus have been linked to preterm labor. Thus, by reducing these oxygen species, glutathione can delay the onset of labor to a biologically healthier time [R].

25) Glutathione May Treat AIDS

A study showed that older AIDS patients produced lower levels of glutathione in their mitochondria [R].

NAC (glutathione’s precursor) blocks the stimulatory effect of TNF on HIV replication [R].

AIDS sufferers with glutathione deficiencies have decreased insulin sensitivity, and muscle strength. Introducing adequate glutathione effectively treats these issues [R].

Glutathione deficiency weakens the immune systems of AIDS patients with already weak bodies. Studies have shown that giving these individuals additional glutathione can rebalance their immune systems [R].

Introducing glutathione into the body decreases the chances of AIDS sufferers developing tuberculosis [R].

26) Glutathione May Treat Cystic Fibrosis

People with cystic fibrosis have low glutathione levels [R].

Cystic fibrosis causes the release of oxidative reactants in to inflammatory cells. Making matters worse, cystic fibrosis reduces levels of glutathione able to scavenge these reactants [R].

Studies show that patients treated with inhaled glutathione have increased lung capacity and function [R, R].

Glutathione inhalers can restore oxidant-antioxidant balance and reduce inflammation in those with cystic fibrosis [R].

More broadly, certain forms of buffered glutathione have been found to lower the symptoms of cystic fibrosis [R].

27) Glutathione Is a Skin Lightening Agent

Studies have shown that glutathione can increase lightness of the skin in healthy women [RR].

This is because glutathione causes the production of a different type of melanin in skin cells [R].

Glutathione Metabolism and Administration

Glutathione is made in the body from 3 amino acids: glutamate, cysteine, and glycine (making it a “tripeptide”). The glutathione produced in the body is broken down by an enzyme, GGT, on the surface of the cells before it can be trasnported to the inside of the cell [R]

However, when we ingest glutathione as a supplement, it has to pass the liver before it reaches the bloodsteam. The liver can contain high amounts of GGT, which can break down glutathone. This means that most oral forms of glutathione may not acheive the desired effects [R].

There are several ways to bypass this limitation, such as [R]:

  • Liposomal glutathione [R]
  • Sublingual glutathione (absorbed directly into the bloodstream) [R]
  • Slow-release tablets dissolved in the mouth (orobuccal) or lozenges [R, R]
  • Inhaled glutathone [R]
  • Methyl glutathone, where another compound (the methyl group) is attached to glutathone, so GGT cannot degrade it [R]
  • Coated glutathone tablets [R]
  • IV glutathone is also available, but the safety has not been established [R]

New formulations of glutathione are being researched every day in the hopes of maximizing its concentration in the body.

Taking glutathione with vitamin C may also increase its absorption [R].

Safety

People with asthma should not inhale glutathione.

Taking glutathione supplements during pregnancy or breastfeeding is not recommended.

Thirty-eight participants aged 21 to 62 were given oral glutathione (1,000mg a day) for 4 weeks. Side effects were limited, but included: Increased flatulence and loose stools (5 patients), flushing (2 patients), and weight gain (1 patient) [R].

Another study that gave glutathione to patients with cystic fibrosis found the following side effects: Chest tightness, diarrhea and fever. Of course, these results may not apply to the general population [R].

Also, these studies are relative exceptions; to date, glutathione supplements are known as safe. More research is undoubtedly needed on high-dose and long-term glutathione supplementation.

Glutathione Side Effects (If You Have Chronic Inflammation)

Glutathione promotes immune system function. It enhances T cell growth and activates mTOR [R].

When studies deplete glutathione, it reduces the inflammatory response, because it reduces the immune system response [R].

However, under inflammatory conditions, it often becomes more important to reduce the damage with an antioxidant like glutathione.

So glutathione can both be good and bad if someone has chronic inflammation. If you get negative side effects, it could be that it’s stimulating your immune system too much.

Glutathione in Food

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The picture above shows a number of foods that contain glutathione precursors. These are great additions to your diet, but I usually recommend supplementation to get a therapeutic and reliable dose.

Garlic, asparagus, and cruciferous vegetables such as broccoli and kale boost glutathione levels as a result of their sulfur components.

Animal foods, which are higher in cysteine and methionine, can also help increase glutathione levels.

Increasing Glutathione with Supplements

Cysteine

Out of three amino acids that glutathione is made from, cysteine is the most important; the amount of cysteine governs the speed and quantity of glutathione that can be made inside the cell. Here are some options for increasing cysteine:

NAC – dose usually 500 to 1,000mg/day

Selenium

Selenium is important for maintaining healthy glutathione levels as it becomes a component of glutathione peroxidase in the body – the enzyme that helps neutralize free radicals.

Alpha Lipoic Acid (ALA)

R-Lipoic acid is one of the main boosters of glutathione levels in cells [R].

Methionine

S-adenosyl-methionine is a supplement that contains methionine and can help boost glutathione levels.

Buying Glutathione

Are You Struggling With Chronic Health Issues?

If you are struggling with chronic health issues – the way I used to – you probably have piles of lab tests that can potentially tell you a lot about your health. However, doctors never had enough time to explain it properly. They will only notice it if the lab flags your test results as outside of normal. But what if all your results are coming back normal, yet you know you are feeling nowhere near healthy? They may even tell you there is nothing wrong with you, and that it’s all in your head – I’ve been there.

Lab Test Analyzer is the tool I wish I had when I was dealing with all my health issues. Instead of normal, it will tell you the optimal values for lab tests. And if you are outside the optimal range, it will give you actionable tips and recommendations that will help you get there.

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

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63 COMMENTS

  • Alyssa

    I have asthma and I dont agree that you shouldnt nebulize Glutathoione becasue I do and it helps alot with decreasing asthma attacks etc. I take a capsule and then put two vials of saline solution in the nebulizer and it does help.

  • Dave

    Sulforaphane increases glutathione in the brain
    https://www.karger.com/Article/Abstract/487639

  • PHILIP

    I was diagnosed with COPD , four years ago now. I moved to USA two years ago in the hope my health would improve
    and my doctor has given me Seebri Breezhaler, it’s an inhalation powder 44 micrograms. I take it once a day in the morning, but it was unable to help me breath properly. Earlier this year my sister who lives in New Delhi India Purchased COPD herbal remedy from BEST HEALTH HERBAL CENTRE and they told her that their COPD herbal remedy only takes six weeks to reverse COPD completely, which she didn’t’ believe, but she had no choice than to purchase, because she knew breathing was so difficult for me. When I received the herbal remedy, I only used it for six weeks, it was so shocking to see the outcome, I was able to breath normal, no more shortness of breath, no more dry cough, chest pressure stop and my COPD was fully reversed.
    I know is hard to believe but am a living testimony, There is no harm in trying natural herbs supplements.

  • philip

    HERBAL FORMULA

    I was diagnosed with COPD , four years ago now. I moved to USA two years ago in the hope my health would improve
    and my doctor has given me Seebri Breezhaler, it’s an inhalation powder 44 micrograms. I take it once a day in the morning, but it was unable to help me breath properly. Earlier this year my sister who lives in New Delhi India Purchased COPD herbal remedy from BEST HEALTH HERBAL CENTRE and they told her that their COPD herbal remedy only takes six weeks to reverse COPD completely, which she didn’t’ believe, but she had no choice than to purchase, because she knew breathing was so difficult for me. When I received the herbal remedy, I only used it for six weeks, it was so shocking to see the outcome, I was able to breath normal, no more shortness of breath, no more dry cough, chest pressure stop and my COPD was fully reversed.
    I know is hard to believe but am a living testimony, There is no harm in trying natural herbs supplements.

  • Fifi

    Can Glutathione help treat fibroid tumors?

  • Mirpam

    Is glutamine a precursor of glutathione. And is it equally effective?

  • Dilrajj Kaur

    Sir ..I am from Bombay India , I wanted to improve my skin colour as well my ageing spots. .wrinkles. .my skin is sagging very much. so I am worried about my looks. Bcoz I have to make my doughter’s marriage in year so please guide me to which Brands Glutathione is good for getting good results.

  • Jun Gilbert Bautista

    Hi im jun.. May i suggest you to use Aim global glutathione products. It is very effective.. It is made in the Philippines with international standard. Internationalized brands. Thanks

  • Mr Tunde

    Kim, I will like to know more about Protandim. Kindly shed more light on its workings. Thank you.

  • Kim Chomiak

    The absolute best “brand” of Glutathione is what your own body makes!!! When you activate your Nrf2 pathway, your body will start producing your own antioxidants and your own glutathione. There is only one activator that I know of and it’s called Protandim. There are numerous studies published on PubMed on this product and it definitely does what it says, it will activate your Nrf2 and reduce your Oxidative Stress by an average of 40% in the first 30 days.

  • Japhet Nyakudya

    Where can I get Glutathione esp anti-ageing? I am based Johannesburg, SA.

  • Jael

    How does one activate Nrf2 pathway ? Whats the best brand of l glutathione & whats the dosage required. Thank you

  • Strobelight

    Veronica,
    I just read that we have it wrong on these autoimmune diseases…they are pointing to creepy crawler no see ‘ems, you have to get rid of those and their toxins, ravages the body, try to learn natural path, I had so many issues and I am knocking them gone one by one including stage 3 kidney disease (I am 100% normal now in that dept). We need western meds but we need natural path, too! We can reverse and most of the time cure our issues mainly with food, minerals and supplements if you can’t chow that food. Had horrible headaches as I aged where they were 24/7, no more, cured them by trace mineral drops, our dirt has no more nutrients, I presently hooked on medical medium.com, he is funny and he is getting higher up help! Also, just google “natural path cure for ________your issue. 20 years I have had miserable hip pain, google said piriformis syndrome (little muscle that attaches legs to pelvic) found what exercises to do, summers are marvelous but winters I still die so going to medicalmediulm to see what his take is on this problem is! Good luck!

  • jonath

    Good info thanks

  • Kim Chomiak

    FYI – when you activate your Nrf2 pathway, your body will increase it’s glutathione production by 300%
    That is way more powerful than anything that you can buy!

    1. Deb Bose

      The key here is the presence of cofactors and attention to counter-productive SNPs such as CBS. B2 / B6 / Serine / Se / Vit C are needed to glutathione systhesis. If you activate Nrf2 pathway and you don’t have necessary cofactors present, you essentially will going to face increased oxidative stress.

      So fix any issues with your transsulfuration pathway and then activate Nrf2 slowly. Nrf2 pathway actually causes small amount of oxidative stress to train cells for upcoming stress and cell reacts by upregulating CBS in order to increase glutathione. If you have CBS 699T, you want to ensure transurfuration pathway produce glutathione instead of ammonia and sulfites.

      1. Reduce thiol foods
      2. Take Moly for sulfite
      3. Take Yasko’s CBS RNA + for ammonia
      4. Follow this for 4-6 weeks
      5. Take small amount of lean meat
      6. Slowly introduce glutathione cofactors along with moly.
      7. Induce nrf2 via curcumin or ginger
      8. Take liposomal glutathione

  • Kim Chomiak

    Hi Rick, I take a product called Protandim. It activates the Nrf2 pathway, which in turn lower your oxidative stress by approx 40% in the first 30 days. There is an ABC Investigative report that was aired once in 2005, gives a great overview of the company and how Protandim works.

  • Rick

    Kim, how do you increase your Nrf2 pathway?? Thanks for the information!

  • Veronica White

    Thank you. I take this product and pray it helps with my Lupus diagnosis. Very informative. I’ve learned a lot of valuable information. Trying to eat a better diet. Thanks again for sharing.

  • Becca Ashely

    Thanks for the imformation

  • Japhet Nyakudya

    Which glutathione should I buy and where can I buy it from.

  • Keeble Rose

    Daniel , the main purpose is to reduce or eliminate black/dark spots not so much in making a naturally dark skin lighter, though some people may use it with that intention.

    People of all races get dark spots on their skin for various reasons … usually due to an injury or a special disease condition. So glutathione can be used to reduce or eliminate these dark spots.

  • Dave Clark

    Studies have shown that ozone therapy will raise Nrf2 and glutathione levels in the cells, and that the effects are long lasting. Rectal ozone insuflation is a viable home treatment once ozone equipment is procured,

  • Daniel Gill

    Steve, forgive my ignorance – could you please elaborate on the health benefits of having lighter skin (#27)? Its almost as if you’re saying the lighter your skin is, the better you off are…but I could be reading this ridiculous and offensive statement all wrong.

  • mario roca

    This comment is 300% truth

  • mario roca

    Check immunocal I’m working with this company products and I’m getting great results fitting cancer and all types of inflation and helping. On chronic fatigue.if you need more information please send me a request.at facebook .I will help you on how to take this. Depending on you problem you treating.

  • John

    Please share your company/site/info regarding increasing glutathione.

    Thanks

  • Iyke

    Glutathion is relatively new in Nigeria. Better publication is necessary.
    Can this reverse Dianetics 11 to normal.

  • roy

    Really glutathione can cure fibrosis?

  • Dominique

    I would like more information please

  • Matthew

    Interesting article. Though I’m a bit confused by your cautionary remark regarding chronic inflammation. Many studies, including one cited elsewhere on this site, state that NAC significantly inhibits mTOR. In this light, and given the fact that many autoimmune sufferers have depleted glutathione levels, it would seem very wise to supplement with NAC.

  • Kim Chomiak

    I agree with you Jamie and I believe it is far better for your body to make its own glutathione. I am really curious what company you are with. If you are interested in peer reviewed studies, the company that I am with has 24 peer reviewed studies so far and 12 patents on a product that will reduce oxidative stress by an average of 40% in 30 days (plus it increases your glutathione production)
    Let me know if you would like more information.

  • Kim Chomiak

    The best way to increase your Glutathione is for your body to produce its own. When you activate your Nrf2 pathway you turn on your survival genes and your body will make SOD, catalase and glutathione. This will help to reduce oxidative stress (free radical damage) and inflammation. All chronic diseases are linked to an increase of inflammation in your body. If you want to delay the onset of, or possibly reverse symptoms of a chronic illness, it is imperative that you reduce both oxidative stress and inflammation.
    Activating your Nrf2 pathway will help you stay on top of the aging process while delivering the mental clarity and overall well-being you need every day to get the absolute most out of life.

  • Michael Spadaccini

    Mahraj21 send me a friend request via FB & I will msg you info on the glutathione breakthrough. Jamie Hawley, no this is not GXL. I’d be happy to share the science with you if you are interested. Cheers Michael Spadaccini

  • Oleh

    I would be interested in getting your views about how to increase glutathione levels in my body.

  • ULYSSES COLON

    What brand do you recommend

  • KB

    Taking glutathione 250mg + Vit C 1000mg, will improve over all health?

  • Jamie Hawley

    It is physiologically impossible to raise glutathione 300%. I’m assuming this is MAX and NAC. If so will send me one double blind peer reviewed study entered into a prestigious medical journal on the benefits derived from your product specifically. If you send one I’ll bring my entire group over to your company. I’ve been in this industry fro 21 years with one company with a proven glutathione precursor and would love to find a company with more credibility than mine. If you can’t perhaps you’d bring your group over to our company? Please just one actual peer reviewed study on you glutathione enhancer

  • Jamie Hawley

    John glutathione is not absorbed into the cells. It has to manufactured in the cell. These people who claim they have a product (MAX GXL) that can raise glutathione 300% are totally daft. Check this out John:
    Dr. Jim Gutman MD, Professor of Emergency Medicine, McGill university Medical Research Center and expert on “Glutathione” speaks about Max GXL the legendary product these folks are claiming raise glutathione.

    Pardon my English but do not pay attention to the cr_p coming from the company.

    As I mentioned – this company has not – nor will it ever produce a study that will be published in a peer reviewed journal. As such their product is for all intents and purposes a commodity and will remain that way. A composition product means little and is very easy to circumvent.

    NAC is the main ingredient of Max and as a drug it spikes glutathione levels temporarily. It also has NO ability to raise glutathione 300% because this is physiologically impossible.
    “NAC fools the body into thinking that it has an oxygen shortage,” said Gaston.

    “We found that a NAC product formed by red blood cells, know as a nitrosothiol, bypasses the normal regulation of oxygen sensing. It tells the arteries in the lung to ‘remodel’; they become narrow, increasing the blood pressure in the lungs and causing the right side of the heart to swell.”

  • Mahraj21

    Hello Michael, can you please share the info on what you have mentioned.

  • John O'Mahony

    Hi. I am confused about whether the entire gluthathione molecule can be absorbed into cells.
    Some say its only the components that get absorbed.
    Some say certain cells like brain can.

  • Michael Spadaccini

    Glutathione as the bodies master endogenous antioxidant is a phenomenal molecule. It is massively vital for optimal cellular health. There is now a proven precursor that allows each cell to make glutathione by a huge 300% more than any other method, Safely, significantly & naturally. Invented by a world leading medicinal chemist & 25 years in the making I do not like to spam or spruik the virtues of anything on these types of forums, but I will happily share obligation free info on this wonderful breakthrough. Best of health to all

  • Sheri

    Thank you for this extremely informative post about glutathione. I am interested in increasing my levels to improve relatively uncontrolled asthma, largely due to a severe anaphylaxis reaction to an antibiotic a couple months ago. I read that taking glutathione orally raises a viability question due to it potentially being destroyed by stomach acids. Is it better to take NAC instead? Or perhaps take NAC, selenium and ALA as you recommend above, along with a glutathione supplement? I’m also wondering if it is possible to have too high a level of glutathione in one’s system due to supplementing?

  • Karen Todd

    Interesting comment. I’ve never seen a comparison. Are there any Liposomal studies on healthy subjects?

  • Anna Burns

    Maybe a better question is what can reverse diabetes?

  • Suleman Labbo

    Can glutathione reverse diabetes?

  • JG

    The authors information is at right top of the article. His name is Joseph Cohen. Hope this helps.

  • anna burns

    It’s not a shot, it’s an IV that takes awhile. I used to get them, once a month. It was a little intense while it was going on, but I felt soooo good afterward. I think it was mostly from the glutathione. It made me feel so calm. All my anxiety was just gone. I don’t know why it did that, but it did. They cost a lot also. If you can get them, do it.

  • Lanie

    Hi! There is a Glutathione IV with Vitamin C being offered by an Aesthetic Clinic. The doctor told me that it is very beneficial for aging people because it boosts the immune system. How many times in a month should i take a shot to help me as a 50 year old woman. Thank you!

  • RB

    The references ARE included. See the blue R in parentheses? Click on it. There are your references you’re so concerned about.

  • Paula

    Whoever is the author here please always state your sources, so everyone would know your information are reliable. Thanks.

    1. Nattha Wannissorn, PhD

      Which one do you need to know?

  • Tt

    I’ve heard you can’t take glutathione, only take a glutathione precursor?

  • Maddy

    What are your thoughts on bulletproof brand of liposomal glutathione? Are there any studies on if it reduces TNF-a and IL6.

  • Joseph M. Cohen

    I’ve taken it before http://amzn.to/2e1Jz1j

    1. anna burns

      Joseph, What is your opinion of the Setria L glutathione?

      1. Joseph M. Cohen

        Fine, but not as good as liposomal

  • Ted

    Your chart says it. Glycine is required precursor to form glutathione. My child has cbs mutation and overproduce taurine and underproduces glutathione in his transsulfuration pathway. Suspects song piece is glycine.

  • anna burns

    hello, the glutathione that you take…it’s a product in your store? I was wondering if you test it for how much is actually encapsulated?

  • Louise

    Hi, What do you think about Glutathione IV being bad for someone with mercury poisining because it is a weak chelator? I had flu like symptoms and headache after IV and thought it was a herx but now I am thinking it was due to mercury re-distribution. I am nervous to have Glutathione now.

    1. Joseph M. Cohen

      It’s possible.

    2. Brett

      I’ve seen a few ancedotal web reports, on health forums, where people (who appeared to have extremely high levels of biotoxins such as metals) got significantly worse after supplementing glutathione. In some cases they reported to get catastrophically worse. It doesn’t seem to be a common reaction, but if you read reviews and forums you’ll find reports.

    3. Steve

      I only get IV with colonics

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