Print Friendly, PDF & Email

Oxaloacetate is a relatively understudied compound with a high potential. Studies have shown that Oxaloacetate supplements can help reduce aging, help with brain injuries and neurodegenerative diseases, and help with treatment of Cancers. For info on my handpicked favorite substances check out my book SelfHacked Secrets. To receive the first chapter absolutely free click here.


Oxaloacetate is a part of many metabolic reactions in the body.

Not much research has been conducted on this molecule and more research is definitely needed.

This is because the molecule has proven hard to stabilize in its isolated form [R].

However, the studies that have been done are promising.

Studies in rodents and humans have shown that Oxaloacetate can help reduce damage to the brain.

Studies have also shown that Oxaloacetate can reduce the effects of aging and even increase lifespan.

Oxaloacetate has also been shown to help treat cancer and help manage blood glucose levels.

Health Benefits of Oxaloacetate

1) Oxaloacetate Can Reverse and Prevent Brain Damage Caused By Exposure To Pesticides

Pesticides contain organophosphates. These cause high levels of glutamate in the brain [R].

A high level of glutamate in the brain leads to brain damage [R].

Oxaloacetate works to reduce levels of glutamate in the brain to reduce the damage [R].

Studies in rats have shown that oxaloacetate can prevent and reverse neural damage in the brain caused by organophosphates [R].

2) Oxaloacetate Can Help Protect The Brain After a Traumatic Brain Injury

High glutamate levels after a traumatic brain injury cause cell death in many brain cells [R].

A study done in rats showed that introducing high levels of oxaloacetate could reduce glutamate levels and decrease cell death after injury [R].

3) Oxaloacetate Can Help Reduce Neurodegenerative Effects Caused by Strokes

A study in rats showed that oxaloacetate reduces the levels of glutamate in the brain to allow for cells to survive and recover after a stroke [R].

Another study done in 365 human stroke victims confirmed this [R].

4) Oxaloacetate Can Help Prevent Neurodegenerative Diseases

Diseases such as Alzheimer’s and Parkinson’s are in part caused by decreasing amounts of mitochondria in the brain [R].

Studies in rats have shown that oxaloacetate can help encourage the making of new mitochondria in the brain to prevent these diseases [R].

5) Oxaloacetate May Help Increase Lifespan

A study done in worms showed that oxaloacetate supplements increased lifespan [R].

Oxaloacetate worked using similar mechanisms as a caloric diet [R].

6) Oxaloacetate May Help In Reducing Aging

Methylglyoxal causes aging by causing organelle and cellular dysfunction [R].

A study done in worms showed that oxaloacetate decreased methylglyoxal levels and reduced aging effects [R].

Oxaloacetate can also reduce aging by protecting mitochondrial enzymes from oxidative damage [R].

7) Oxaloacetate May Help in Treating Brain Cancer

High levels of glutamate increase brain cancer growth and decrease patient prognosis [R].

A study done in rats showed that oxaloacetate could reduce glutamate levels in the brain and decrease brain tumor growth [R].

The lives of the rats in the study were also significantly prolonged [R].

Oxaloacetate may be a good complimentary treatment to pair with chemotherapy.

8) Oxaloacetate May Help Cancer

Glutamine is an important growth element for pancreatic cancer cells [R].

Studies have shown that reducing glutamine levels can stop cell growth of multiple forms of cancer [R].

Oxaloacetate has been shown to reduce glutamine levels and decrease cancer cell growth rates in mice [R].

It has also been shown to make chemotherapy and radiation treatment more effective [R].

9) Oxaloacetate May Help in Reducing Blood Glucose Levels

Studies in humans have shown that oxaloacetate may reduce blood glucose levels in Diabetics and in healthy subjects [R].

Human studies have also shown that oxaloacetate may improve insulin resistance [R].

This may reduce the risk of type II Diabetes.

10) Oxaloacetate May Help Reduce Risk of Heart Disease

It has been shown in animals that by acting similarly to reducing caloric intake, oxaloacetate may help to reduce the risk of heart disease [R].

It does this by increasing levels of NAD+, which causes the production of proteins that reduce the risk of heart disease [R].

11) Oxaloacetate May Help Reduce Risk of Kidney Disease

By acting similarly to reducing caloric intake, oxaloacetate may also help prevent kidney disease [R].

12) Low Oxaloacetate in Early Months of Infant Development May cause Death

Very low levels of oxaloacetate in an infant may lead to early death due to the nervous system failing [R].

13) Oxaloacetate May Help Increase Regulation of Blood Glucose Levels

Blood glucose levels can vary significantly even in healthy individuals [R].

This can affect daily productivity levels [R].

A human study showed that oxaloacetate could help reduce variations in glucose levels and could help maintain productivity [R].

14) Oxaloacetate May Increase Energy Levels and Endurance

A study done on rats showed that oxaloacetate might improve endurance and energy levels [R].

It can do this by activating more mitochondria to increase energy production [R].

This may be especially helpful in elderly subjects or athletes.

15) Oxaloacetate Can Help Reduce Effects of Diet Rebound

After dieting, the metabolism in your body changes and this often causes a fast increase in weight.

Oxaloacetate can reduce the effects of diet rebound by reducing the body’s ability to store fat.

Dosing and Side Effects

Oxaloacetate can be found in some foods.

However, the levels of the supplement found in foods are too low to make a difference.

For effects regarding heart disease, kidney disease, aging, or endurance, relatively low doses of 100 mg can be taken per day.

For effects regarding brain trauma, brain cancer, or other forms of cancer, large doses of up to 1000mg should be taken immediately following the incidence or during treatment.

A maximum recommended dose has not been found at this point in research studies.

Studies have not discovered any side effects regarding oxaloacetate even when administered at very high doses.

Buy Oxaloacetate Capsules

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.


1 Star2 Stars3 Stars4 Stars5 Stars (6 votes, average: 4.50 out of 5)

Why did you dislike this article?



  • Neylson

    I’ve heard from some people that Oregano is a rich source of Oxaloacetic Acid. Is it?

  • Marta

    Hi Larry,
    Do you know how we can get this from China?

  • Jessica

    thank you Nattha!

  • Jessica

    If you are on a low oxalate diet to prevent kidney stones, would this supplement be prohibited? Is Oxaloacetic Acid the same thing?

    1. Nattha Wannissorn, PhD

      It’s a different thing altogether, but talk to your doctor.

  • Larry D.

    Go to Alibaba and search for Oxaloacetic Acid

  • Drum Point

    Do you have a name of the manufacturer in China?

  • Larry D.

    By the way, this is available from the manufacturer in China for about $10/kg! I wonder if any of the US companies selling it are manufacturing it themselves, or are they just buying it in bulk from China and repackaging it at a tremendous mark-up. 30 capsules of 100 mg each goes for $50 if you just buy one bottle. That’s 60 mg per dollar. If you can buy 1 kg for $10, that’s 100,000 mg per $. In other words, retail is a markup of 1,667%! Nice work if you can get it.

  • john seville

    As a side note for those interested in using this for cancer purposes or just like to take a lot, they also market the SAME EXACT product under the trade name CRONAXAL. It is the designated product for BRAIN CANCERS. I guess they made it a separate product due to some FDA policy or something. It is exactly the same in all respects, you also have the option of bulk purchases to save money, since the cancer patients use higher levels for treatment. They offer a 12 pack for $300, including shipping, so it comes to $25 per bottle,a bit of a savings. Personally I use this product for issues of brain fog due to an autoimmune issue, really makes a difference. Before using it I had issues with short term memory, now things are much improved, would not go without it. Hope this helps someone.

    1. Ilene Piazza

      John –

      What dose do you take? I’ve seen recommendations that range all across the board, so don’t want to begin with too much or too little. Thanks!

      1. mhatfie

        100 mg is the standard dose.

      2. john seville

        Have not been one due to business issues, sorry. As the other reader stated 100mg is a good point to start at, it may be all you need. I really never felt much of a difference when I upped my dose as high as 1000mg, which is what the brain cancer patients use. I now use 200mg daily and my blood sugar is normally in the 70’s which is great and no more brain fog. One thing I would like to stress, whatever problem you have can more or less be linked to the gut biome, learn about it and the use of probiotics, I did and now my Sjogren’s is basically eliminated and I am working long hours again, lol. The secret to health is in your gut. Best of luck.

  • Leave a Reply

    Your email address will not be published. Required fields are marked *

    This site uses Akismet to reduce spam. Learn how your comment data is processed.