Fisetin is great for reducing inflammation and all things related to brain function. There’s a variety of health promoting and disease-preventing benefits.
- What is Fisetin?
- The Fisetin That I Take
- Health Benefits of Fisetin
- 1) Fisetin is Good For Your Brain
- 2) Fisetin May Treat Depression
- 3) Fisetin Has Anti-Inflammatory Properties
- 4) Fisetin May Prevent and Treat Cancer
- 5) Fisetin Improves Blood Flow & Lowers Blood Pressure
- 6) Fisetin May Help Treat Diabetes
- 7) Fisetin May Extend Lifespan
- 8) Fisetin May Lower Body Weight
- 9) Fisetin Lowers Pain
- 10) Fisetin Protects Bone
- 11) Fisetin Protects Skin From Sun Damage
- 12) Fisetin Prevents Toxicity
- 13) Fisetin Helps Maintain Energy Levels
- 14) Fisetin Can Treat Infections
- 15) Fisetin is a Mast Cell Inhibitor and Can Help Histamine Intolerance
- Buying Fisetin
- Natural Sources of Fisetin
- Health Tools I Wish I Had When I Was Sick
What is Fisetin?
The Fisetin That I Take
Below, I give a a few ways you can get fisetin, but some people want to to know which one I recommend.
Health Benefits of Fisetin
Note that there are very few trials of fisetin with humans and nearly all of the studies listed here are done on animals.
1) Fisetin is Good For Your Brain
Fisetin Encourages New Brain Growth
Out of a number of studied flavanoids, fisetin was found to be the most effective at causing new brain growth (R).
One of the reasons fisetin possesses so many brain-boosting effects is because it is able to cross the blood brain barrier (R).
Fisetin Improves Memory
Fisetin Protects Against Brain Degeneration
Fisetin has been shown to regulate a number of pathways (e.g. antioxidant & mitochondrial function) that are implicated in age-related decline in brain health (R).
One mechanism by which fisetin might protect against degenerative brain conditions is by activating certain transcription factors such as Nrf2 that increase the cellular levels of glutathione – a key cellular antioxidant that has protective effects on nerve cells (R, R1).
Moreover, Fisetin limits the accumulation of harmful compounds (phosphorylated tau) that accumulate in the brain and cause Alzheimer’s disease (R).
Fisetin is a potentially useful supplement for decreasing inflammation in microglia – immune cells that exert neurotoxic effects and are often activated in neurodegenerative conditions (see Dr Younger speak about Microglia) (R).
Fisetin Decreases Brain Damage After Stroke
Another study confirmed that fisetin helps to protect whichever part of the brain is starved of blood flow during a stroke (R).
Ten flavonoids including fisetin were tested for their ability to protect brain cells against glutamate toxicity. Fisetin was one of four that were found to increase antioxidant defenses enough to limit toxicity (R).
Fisetin Minimizes Brain Damage From Injury
Traumatic epilepsy is a condition of repeated seizures after a head injury. One study showed that epileptic rats experienced less brain damage from their seizures when given fisetin – probably because Fisetin inhibits oxidative stress (R).
Rodents given high dose (50mg/kg of bodyweight) fisetin had significantly better neurological function and reduced brain swelling after brain injury – maybe because fisetin inhibits TLR 4/NF-κB mediated inflammatory pathways (R).
Fisetin is Neuroprotective
Fisetin promotes nerve cell survival from trophic factor (helping molecules that allow neuron to develop and maintain connections with its neighbours) withdrawal by the enhancement of proteasomal activity (R).
2) Fisetin May Treat Depression
3) Fisetin Has Anti-Inflammatory Properties
Treatment with fisetin suppresses activation of mast cells, demonstrating its potential use as an anti-inflammatory (R).
High blood sugar in diabetics can cause inflammation of the blood vessels and lead to serious damage. These inflammatory processes are inhibited by treatment with fisetin (possibly via inhibition of the HMGB1 signaling pathway) (R, R1).
Fisetin was found to be an effective treatment for Eczema in animals as it reduced the presence of inflammatory cytokines, eosinophils, mast cells and T-cells (CD4+ & CD8+) that are typically found in atopic dermatitis skin lesions (R).
4) Fisetin May Prevent and Treat Cancer
The following studies are performed in animals and/or cells…Speak to your doctor if you have cancer.
Fisetin inhibits the pathways responsible for cell growth and survival that are overactive in cancer patients (R).
Fisetin inhibits the ability of cancer cells to invade healthy tissues (R).
Treatment with fisetin was able to kill acute monocytic leukemia cells by increasing levels of nitric oxide and Ca(2+) and activating pathways of apoptosis (cell death) (R).
Aflotoxin is one of the most potent carcinogens known to man. Fisetin was found to reverse oxidative damage in the livers of rats with aflotoxin-induced cancer (R).
Treatment with fisetin reduced tissue lesions and lipid peroxidation in the lungs of mice exposed to Benzo(a)Pyrene (a carcinogenic chemical) (R).
A diet rich in fisetin might help prevent and treat prostate cancer (by inhibiting urokinase plasminogen activator, altering genes that regulate cell cycles, and causing cancer cell death) (R, R1, R2).
Fisetin is such a promising anti-cancer agent because it appears to inhibit and kill cancers without severely affecting the surrounding normal cells – probably because it is able to identify the unique cell-signaling pathways used by cancer cells (R, R1,R2).
5) Fisetin Improves Blood Flow & Lowers Blood Pressure
Fisetin lowers the clumping together (coagulation) of blood cells in mice and, thus, lowers the chance of blockages (R)
By inhibiting Ca(2+) signaling, Fisetin helps reverse vasoconstriction caused by the release serotonin and phenylephrine (R).
Fisetin was able to reverse bad circulation in mice caused by a high fat diet (R).
A rodent study found that Fisetin relaxes drug-induced contraction of blood vessels and, thus, lowers blood pressure. This action occurs regardless of blood vessel function (R).
6) Fisetin May Help Treat Diabetes
Diabetic mice fed a diet high in Fisetin stayed diabetic, but the kidney abnormalities normalized (R).
Fisetin administration normalized the increased levels of lipid content in blood, liver and kidney in drug-induced diabetic rats (R).
In diabetic mice, Fisetin reduced the expected formation of cataracts (R).
Fisetin reduced anxiety-related behaviors in diabetic mice.
Fisetin improved mitochondrial function in diabetic rats (R).
Fisetin regulates carbohydrate metabolism by modulating the key regulatory enzymes in the liver and kidney tissues of diabetic rats (R).
7) Fisetin May Extend Lifespan
Dietary supplementation with a strawberry extract (which is said to have the highest levels of fisetin) improved the performance of rats in a rodent model of accelerated aging (R).
8) Fisetin May Lower Body Weight
In mice, fisetin supplementation reversed the weight gain caused by a high fat diet (R).
Mice that underwent fisetin treatment had less weight increase than mice that did not undergo treatment (R).
9) Fisetin Lowers Pain
10) Fisetin Protects Bone
In mice with estrogen deficiency or inflammation, the consumption of fisetin resulted in less bone density loss. Bone mineral density and bone markers positively correlated with the amount of fisetin consumed (R).
Therefore, fisetin might be an effective tool for preventing age-related or inactivity-related (e.g. when injured) loss of bone density.
11) Fisetin Protects Skin From Sun Damage
Fisetin inhibits UVB-induced collagen degradation – a key factor in skin aging (R).
12) Fisetin Prevents Toxicity
As such, it might be a wise idea to take fisetin if you are taking any substance that affects the kidneys, such as: pain medications, alcohol, antibiotics and laxatives (R). (Speak to your doctor.)
13) Fisetin Helps Maintain Energy Levels
14) Fisetin Can Treat Infections
One study found that fisetin was antifungal and might be a useful therapeutic treatment for cryptococcosis infections (R).
Fisetin inhibits the Listeria infection (R).
Fisetin inhibits arginase, a key enzyme in the Leishmania amazonensis infection and, therefore, could be used as a food supplement in Leishmaniasis treatment (R).
15) Fisetin is a Mast Cell Inhibitor and Can Help Histamine Intolerance
Doctor’s Best make a relatively pure source of fisetin:
Life Extension make a good product that combines fisetin with other life-extending ingredients:
Natural Sources of Fisetin
As shown in the picture above, you can find small amounts of fisetin in many fruits and vegetables, with the highest natural source being strawberries. However, to get a truly therapeutic dose I recommend supplementation.
Health Tools I Wish I Had When I Was Sick
At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.
That’s why I decided to create tools that will help others cut down the guesswork:
- Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
- SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
- SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
- SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
- Selfhacked Inflammation course – a video course on inflammation and how to bring it down
- Biohacking insomnia – an ebook on how to get great sleep
- Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
- BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
- SelfHacked VIP – an area where you can ask me (Joe) questions about health topics
The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.
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