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I’ve been getting more and more people with outstanding infections.

Helping people who have chronic infections can be tricky because they are most likely to react to supplements, which is why such people often require a ‘slower’ approach (one that lessens reactions).

Identifying infections can also be really tricky.  Is it bacterial, fungal, parasitic or viral?

Biofilms make the equation more complex, because even if someone took an anti-microbial that would kill their infection, biofilms can prevent this from happening.


What Are Biofilms

Biofilm formation occurs when free-floating microorganisms attach themselves to a surface and create a colony (R).

They secrete materials (extracellular polymers) that provide a structural matrix that adheres to surfaces (R).

About 80% of human infections affecting the gut, mouth, sex organs, lungs, heart, teeth, eyes, ear, and skin are caused by biofilm-associated microorganisms (R).

Antibiotics can actually induce biofilm formation (R).

Biofilms may be a reason why some people suddenly do worse for no apparent reason – because after biofilms grow, they disperse.

Biofilms also might be a reason why people herx from herbal supplements.

For example, if you take a supplement that breaks up biofilms, some of the bacterial products can be released, which can cause an immune reaction.

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Why Are Biofilms Bad?

Currently, there is a large sum of money and research aimed at the use of and protection against biofilms (R).

Because biofilms protect the bacteria, infections are often more resistant to traditional antimicrobial treatments, making them a serious health risk (R).

Biofilm bacteria generally tolerate antibiotic treatment (R).

This is because antibiotics can’t pass through the biofilm enough (R).

Biofilms are known to be involved in many chronic infections such as in a chronic wound, lung, ear, heart and nose infections (R).

Most people (59%) with chronic sinus infections were found to have a bacterial biofilm, whereas none of the controls (people who didn’t have a sinus infection) had bacterial biofilm (R).

The most common biofilm that you might be familiar with is the plaque in your teeth (R).

Most, if not all, antibiotics and antiseptics fail to eradicate mature biofilms, and today, the poor efficiency of available antibiotics is a major challenge for the successful treatment of chronic infections (R).

At present, the most efficient treatment for biofilm infection is to mechanically remove the infected area or body part.  This is sometimes possible if the focus is a catheter, an implant, or an infected organ that is eligible for transplantation (R).

So far, the two main strategies for preventing or suppressing bacterial biofilm infections are (1) early aggressive antibiotic treatment before the biofilm is formed or (2) chronic suppressive antibiotic treatment when the biofilm is established if it cannot be removed physically (R).

There are more than one million cases of catheter-associated urinary tract infections reported each year, many of which can be attributed to biofilm-associated bacteria (R).

Catheters have a surface that is conducive for biofilms to form, which is why infections are so common.

In the body, when biofilms form, they form a protective layer by which bacteria evade the immune system and antimicrobials.

Bacteria become tolerant to antibiotics and most other antimicrobial agents (R).

So if you have a fungal or bacterial infection that’s coated with a biofilm, normal antibiotics and antifungals won’t kill the infection.

If you have a bacterial infection that persists despite antibiotic therapy and you have a high level of proinflammatory cytokines, then you either have a biofilm or a nonbacterial infection (R).

How to Inhibit Biofilms: Natural Biofilm Disruptors

When bacteria form biofilms, they don’t lump together by chance.

In order to form biofilms, bacteria need to communicate with each other (R).

One way to disrupt biofilm formation is to interrupt bacterial communication, also known as quorum sensing (QS) (R).

Quorum Sensing Inhibitors interrupt bacterial communication signals, which prevent them from aggregating (R).


  1. Linoleic acid (omega-6) (R, R2, R3),
  2. Oleic Acid/Olive Oil  (RR2),
  3. Honey (R)….Better if you have an infection: Raw Honey+Royal Jelly+Propolis+Bee Pollen (IHERB)
  4. Propolis (candida biofilm) (R),
  5. Apple Cider Vinegar (IHERB) (R) -physiologically tolerable concentrations of acetic acid can completely eradicate bacteria in mature biofilms vitro.
  6. Caprylic acid (G+,-, fungal) (R),
  7. Stevia (R),
  8. Xylitol (R),
  9. Garlic (R, R2),
  10. Manuka (R),
  11. Ginger (R) (G+,-),
  12. Cranberry (R)

Non-Herbal Biofilm Disruptors

  1. Ozone (R, R2)
  2. Chitosan (R, R2, R3),
  3. NAC (IHERB) (R),
  4. Lactoferrin (R, R2),
  5. EDTA (R)….EDTA likely exerts antimicrobial activity by chelating magnesium and calcium – minerals necessary for growth and membrane stability and may also display anti-biofilm activity by reducing biofilm material (EPS) production and/or enhancing the detachment of bacterial cells from the biofilm.  Magnesium, calcium, iron, zinc, and manganese appear to stabilize the biofilm matrix of a variety of organisms by enhancing structural integrity through electrostatic interactions that serve to cross-link the matrix (R).
  6. Zinc (R)
  7. Iron (R)
  8. Manganese (R).
  9. High alkalinity (magnesium)? (R)
  10. Monolaurin (IHERB) (R) (G+),
  11. Colloidal Silver (IHERB) (R),
  12. Zeolite (Acidithiobacillus thiooxidans) (R)
  13. L Reuteri (R).
  14. Citrate? (R) – Calcium Citrate, Magnesium Citrate
  15. Norspermidine (found in chlorella) (R),


  1. Trypsin (R) – found in pancreas glands, Wobenzyme
  2. Serratiopeptidase (R),
  3. Nattokinase (R),

Herbal Biofilm Disruptors

  1. Andrographis (R),
  2. Curcumin (R, R2)
  3. Berberine (R, R2)
  4. Cinnamon/Cinnamaldehyde (R, R2) and Cinnamon essential oil (R),
  5. Black cumin oil/Thymoquinone (R),
  6. Boswellia (R),
  7. Vanilla
  8. Ginkgo
  9. Oregano Oil (carvacrol+thymol) (R),
  10. Quercetin (R),
  11. Apigenin (R),
  12. Naringenin (R),
  13. St John’s Wort (R),
  14. Kaempferol (R),
  15. Rosmarinic acid (higher concentrations) (R),
  16. Baicalein (R, R2),
  17. Neem (R, R2)
  18. Gentian violet (R),
  19. Mangosteen (streptococcus) (R)
  20. Alfalfa (R)
  21. Eugenol (R, R2, R3) – found in Tulsi, clove essential oil and cinnamon essential oil,


  1. Farnesol (R),
  2. D-Amino Acids (R),
  3. Reserpine (R),
  4. Rifampicin (R)

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The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.


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  • Ivan

    The references are in brackets (R)

  • Tasman

    In my experience biofilms do develop a resistance to individual biofilm disruptors. So I am currently rotating between 3 different disruptors, which seems to manage that issue.

  • Katharina

    Sounds to me like you have cytoliytic vaginosis, which has the exact same symptoms as a yeast infection, but is caused by an overgrowth of lactobacillus instead of yeast and thus also responds negatively to an antifungal treatment. Your acidic ph is both reason and result of the overgrowth since lactobacilli strive in an acidic environment. If the cream is too expensive for you in the long-term, you could also try baking soda baths on your vagina, since baking soda is very basic and has been used as a sage home remedy for ages.

  • Mary C.

    In the book “The Ultimate Candida Diet” Lumbrokinase and NAC as well as some others were used to breakdown biofilms. They work but it takes a lot of wisdom of how, what, when sometimes and endurance.

  • Lauren Gordon

    Do you have advice on treating biofilm for babesia or bartonella infections? And do you have articles or info on treating babesia and bartonella?

  • Johanna

    I have chronic BV symptoms, except no smell. I have never tested positive or been diagnosed with BV or yeast or anything. Doctors have treated me for Yeast- everything gets worse. I’ve taken antibiotics for BV, nothing improved, ended up with stomach issues.

    Over the years I have found that my symptoms link directly to my PH level. If it’s very low (which is my norm) then you can I am symptomatic. Normal-high normal and I am usually comfortable. The product “Pre-Seed,” is a gel lubricant with high PH that is made to aid couples in getting pregnant. High PH protects the sperm during travel to the egg. Anyway, for me, it takes away the itching/burning/intensely painful “fire crotch” as I call it. It helps immediately, and over the course of a day, I am usually close to symptom free! It’s pricey but lasts me months- and it’s worth it, I believe.

  • Roger

    Trying to find out if biofilm can become resistant to biofilm disrupters? I understand that bacteria, fungus and viruses can. I am trying to find a good protocol to breakdown biofilm as I also work on candida. This is the third time for candida and I honestly believe the reason is that prior protocols didn’t address biofilms. I have to say the research has been pretty overwhelming since there are soooooo many opinions on the correct protocol. I understand everyone is different but wow! Is it overwhelming especially when dealing with the brain fog. I have seen some good suggestions here and am very hopeful for solid guidance. Thanks very much in advance!

  • Duncan Green

    You missed dietary nitrates. Nitric oxide has been shown to inhib and disperse certain biofilms (see Pubmed). Beetroot and green, leafy veg a great option.

  • Anonymous

    Any opinion on Garden of Life Enzymes for {Specific Gender), homemade Gc-maf yogurt, high doses of D3 related to what Doctor Cal Streeter says? Rumor of a Massive Staph MSSA Pneumonia/Sinus infection Outbreak in the US? Unbelievable tax dollars are being stolen by welfare queens (healthcare losers/workers, and SWISS Bank accounts) and many people have to pay out of pockets experimenting with supplements, either way great site

  • Lolita Cleaves

    Avoiding nightshades and sugar, taking vit D and liquid b-12 complex, Oregon grape root tincture, bentonite clay (1t internal- do not use as mask, it will cause toxins to surface causing the psoriasis to spread out and cover a larger area!), SUN EXPOSURE, COFFEE ENEMAS (this has been one of the most important components and works wonders!), and using Eucerin Intensive Care 5-10+x/DAY(!),

    OMG! My doctor cured me of psoriasis permanently! He told me that it is a over-reaction of my immune system due to ingesting too much protein. I told him I didn’t want to stop eating meat, and he said for me to reduce my intake to 3 days a week (not more). I am now part vegetarian and have never had any more flare ups. It has been 10 years….

  • Katie

    Wonderful article on biofilm inhibitors. I would love to see an article on biofilm enablers!

  • Jerry Morrison, ND

    Potentially helpful article. Do you have any references to validate the various foods and herbs that are claimed to be biofilm disruptors?

  • Ernest

    Have you tried LDN…Low Dose Naltrexone, for auto-immune problems?

  • Dr. Durben

    My cousin struggled with biofilms and it complicated her Lyme disease as the Lyme would hide in the biofilm. To break up the biofilms she used a combination of borax water (1/8th teaspoon mixed in 1 liter of water and sipped on it throughout the day), liposomal turmeric extract (she used Nature’s Essentials due to their combination of clinical study dosages with liposomal delivery combined with beta cyclodextrin for solubility and cell permeation), Cinnamon (she used the Cinnamon from the same company for the same reasons), then Oregano Oil twice per day. She took activated charcoal to absorb some of the die-off and reduce the herx reaction (but make sure this is taken at least two hours before or after others or it will reduce the effectiveness). Now she is cured completely and she takes the Curcumin and Cinnamon daily in the morning and evening to keep the biofilms away and support her brain function.

  • Maria

    Yes it does. Thermal imaging would show the inflammation or possible Biofilm infection. The other concern is metal toxicity. Candida and metals are like peas in a pod.

  • Ozzy

    Biophoton modality is the best approach for MRSAs in my experience.

  • nomen nescio

    This website says that allicin breaks down quickly and pretty much can’t be stable in a pill: [phytochemicals]

    Thanks for the tip, though, as I can always add garlic to my meals.

  • Carole Bryant

    Any feedback/research on what is the best treatment for MRSA (Methicillin Resistant Staph Aureus)?

  • djoliba


    Hi @astroff this is a repost since I don’t think the 1st one stuck!

    20+ years ago I cured myself of psoriasis, by following directions in the book, ‘Healing Psoriasis’ as well as fasting, sun exposure, avoiding nightshades (such as tomatoes, potatoes, sweet and hot peppers, and eggplant), wheatgrass juice implants and drinking it, and colonics. Proper spinal allignment is important as misalignment can put extra strain on the liver and other eliminative organs. Yoga and chiropractic treatments were helpful also. All of this is explained in the book, which I highly recommend.

    Now, 20+ years after though, I had a fall and it’s starting to rear its ugly head again 🙁

    But I’m prepared, as I’ve done it before! This time I’m finding relief doing:
    Avoiding nightshades and sugar, taking vit D and liquid b-12 complex, Oregon grape root tincture, bentonite clay (1t internal- do not use as mask, it will cause toxins to surface causing the psoriasis to spread out and cover a larger area!), SUN EXPOSURE, COFFEE ENEMAS (this has been one of the most important components and works wonders!), and using Eucerin Intensive Care 5-10+x/DAY(!), especially any time the affected area’s come into contact with water. I also try to find several moments each day for deep breathing and relaxation. My symptoms are clearing within 5 days of following this regimen! Some areas were clear in 2 days!

    Armed with the knowledge and confidence of having cured it before, I know I’m well on my way now!

    I know just how frustrating going through this can be! I’m so pleased to have found relief (it can drive you nuts!). I pray you are on your path to relief and find healing, as well!

  • vincenzo di Leonardo

    Hello is it useful according to your experience? I red it was developed by doctores hulda Clark against parasites: can you give a feedback?

  • Tim

    There’s a new supplement called Allicin Max, it’s a stable for of Allicin from garlic. It’s been the most potent antifungal I’ve ever taken (I’ve taken them all!) and it’s a proven biofilm buster.

  • Yonder

    What do the G+/- additions signify?
    (see ginger, caprylic acid, monolaurin)

    1. April Hall

      Gramme positive/ negative bacteria I believe.

  • Chris

    Great article but missed one of THE BEST herbal biofilm disrupters with high broad spectrum antibiotic activity. Oil of Melaleuca alternifolia or Tea Tree Oil. Way past due that this should be near the top of any list. Powerful dispersing agent. Highly active germicide. Well tolerated by skin.

    1. zeropoint

      how about taking it internally or in a sinus rinse?

      1. Matt

        Do not ever drink it. It will kill you.

        1. zeropoint

          Thanks, Matt. My thoughts exactly.

  • Camille

    Thanks so much for this excellent article! Extremely helpful info! 🙂
    Would L-Cysteine work in the same way as NAC?

    1. Nattha Wannissorn

      Not exactly I’d think.

  • Maria

    I think it is worth mentioning that people with any type of biomedical implants are predisposed to Biofilm infection. Biofilm quickly forms are foreign objects in the body and the $2 Trillion Life Sciences Industry is well aware of this problem. The real reason for antibiotic resistant bacteria, and the consequent deaths are biomedical implants placed inside the human body. Crimes against humanity aren’t a problem if the public isn’t informed, right?

    ..clinical and laboratory profile of symptomatic women with silicone breast implants.

    Among 176 breast implant patients examined by doctors at the Hospital for Joint Diseases, Orthopedic Institute in New York City, the most frequently reported symptoms were chronic fatigue (77%), cognitive dysfunction (65%), severe joint pain (56%), dry mouth (53%), dry eyes (50%), hair loss (40%), and difficulty in swallowing (35%).

    Pathogens in Medical Implants!po=34.4444

    Biofilms linked to human implants play a large part in antibiotic resistant bacteria (chronic infections)

    1. Willow

      I have screws in my jawbone. Does the same idea apply?

  • matt

    i’am on a 108 day grape juice fast it also removes biofilms in the intestines. 7 days in im feeling alot better and you dont want to know about the nightmares that have come out of me.

  • Ted Hu

    grapefruit seed extract?

    1. Will I Am

      LOL, What part of ‘Grape’ Juice is beyond your understanding lol…
      No one, on this planet is going to go on a grapefruit seed extract diet for 108 days lol
      Not that it would not have its benefits but….
      Matt is Feasting on “Grape Juice.”

      1. L

        Do you realize that Ted Hu submitted his comment a month before matt?

  • Mark


  • Kate

    Has anyone found a supplement or enzyme that can disrup BV biofilm ?

    1. Bv is the devil

      Biofilm defense… it’s a supplement I ordered yesterday online. I’ve been struggling with humiliating bv for years also. I saw a post on…. it says it should be taken with a round of antibiotics… I hope this is our answer. Good luck, God bless.

      Here’s on iHerb:, and Amazon:

      1. Carly

        hi, has your BV been cleared since using the biofilm defense? i seen the article on as well and wanted to purchase the product as well.
        well wishes!

      2. Bren Ludlow

        hi. best of luck to you! taking about 15 chewable vitamin C by naturemade, 500 mg each, spread out throughout the day made a HUGE difference. I can’t say it was the only thing I tried…I tried probiotics, grapeseed oil as lub because the pH was like 4, apple cidar vinegar mixed with hydrogen peroxide as a douche…i struggled for YEARS.

    2. Bren Husher

      Thyme, cinnamon, lavender and tea tree essential oils. Also douche with rock rose essential oil

  • Vanda Sherman

    Read Walter Last The Ultimate Cleanse. That’s all you need. I’m on borax and DMSO, colloidal silver, H202, olive leaf extract, slow build up so herx reaction not overwhelming. Turps my next stop. Prosthesis badly implanted and prob infected from jaw infection from crap dentistry. The source of most evils esp if u have root fillings. I have had chronic fatigue for years and am starting to feel normal. It is almost a miracle. W Last a hero in my opinion. Oh and I’m researching Rife/Clark zappers (a minefield and can be expensive…I’m erring on the side of Eastern Europe and Russia science. Patience with this as it takes time; several frequencies oscillate to disrupt a particular pathogen. I’m doing staph and strep to start. If anyone has purchased one , do post on results or not

    1. Kelly

      I just bought a Zapper to kill SIBO. My local computer store makes it. I’ll have to report back.

  • Alba

    Has anyone yet tried botanical combinations such as Byron White? I’m considering trying; would appreciate some feed-back.

  • pc

    A new study on coconut oil reducing candida in the gut, doesn’t mention bio films but still interesting:

  • astroff

    what is non bacterial infection exactly? you mean its one
    of the other 3 groups?
    bacterial, fungal, parasitic or viral, what are the differences
    and how that effect the strategies to be employed?
    will it be addressed in future posts.?

    when i was little i wasnt breast fed and i had a lot of sicknesses as a baby and child and asthma as well.
    i also have allergy issues and stress issues.
    also i seems to have low processing speed.
    lately i had psoriasis. i wonder if all of it connected to infection/s or i just force one cause on it all?

    i wonder..

    just how many of those bastards i have/had? and how much can be caused by it out of everything that happened?

    1. Suzanna Adams Cantley

      Not being breast fed means you did not get the natural immunity of your mother in breast milk so you need to develop your own in other ways. yes the skin problem are a sign of reduced immunity defense. Using as many of the items in his list will help build your immunity. Be consistent and patient- it will happen.

    2. matt

      try a very good colostrum. i believe goat colostrum is best for humans do your own research. but i will tell you it does work i have auto immune problem and i took colostrum. and my auto immune raged out of control because it improved my immune system so much. took me a bit to recover from it.

  • Walter

    Very interesting article. I thought zeolite would also be a potential anti-biofilm agent. ( )

    1. Joseph M. Cohen


  • Matrixik

    Hmmm, so it looks like essentials oils blends like e.g. “OraWellness HealThy Mouth Blend” can really help with infections in mouth.

    Organic and wildcrafted essentials oils of:
    ~ cinnamon
    ~ peppermint
    ~ spearmint
    ~ clove
    ~ myrrh
    ~ manuka
    in a base of Organic almond oil

    Did you maybe found anything about other essential oils included in this recipe (peppermint, spearmint, myrrh, almond oil because of Linoleic acid and Oleic Acid?)?
    Could they also help with biofilms?

    Maybe I could make something similar myself because I did not found anything similar in Europe.

  • LQ

    Also lumbrokinase and Cistus incanus. My dental health has improved since I started swishing with Cistus incanus tea. Far less plaque. Also good results from combining monolaurin and olive leaf extract, which caused die-off reaction from some undetermined infection. Also Eva Sapi has found that stevia helps biofilms related to Lyme.

  • laurashafferchristensen

    Thank you for the great article! For those of us with Lyme, biofilms are a big issue. Glad to know I am already using lots of the biofilm-busters you listed and glad to learn about new ones!

    1. Joseph M. Cohen
  • Bart Sherbon

    What about cannabis oil?

    1. kathleenhearts

      It would interesting to find out if it can break the biofilm. Good thought.

    2. matt

      it would work all plants destroy biofilms. if not bacteria would kill all plants.

  • Nick

    What is your experience or thoughts on activated charcoal? Do you think it affects biofilms?

  • Mr Banks

    Hey Joe. Thanks for this article. I love the innovation you bring to the biohacking scene.

    1. Joseph M. Cohen

      Thanks 🙂

      1. Julie Cohen

        Have you looked into restore for life as a gut rebuilder and creating a tighter junction to keep the stomach biofilm at bay and ridding candidad ?

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