Acetylcholine is a hot topic within the realm of memory enhancement. It is a neurotransmitter that is critical for the everyday functioning of the brain, particularly in the areas of movement, learning & memory, and sleep quality. Check out this post to learn how to promote balanced acetylcholine in your body and function at your very best.
- Benefits of Acetylcholine
- Negative Effects of Acetylcholine
- How to Change Your Levels of Acetylcholine
- Health Tools I Wish I Had When I Was Sick
Acetylcholine is a neurotransmitter that is used for many things: from stimulating muscles to memory and sleep.
Acetylcholine is synthesized in nerve terminals from acetyl-CoA (which is synthesized from glucose) and choline in a reaction that is catalyzed by choline acetyltransferase [R].
Acetylcholine controls movements by activating skeletal muscles and causes muscle contraction [R].
It also schedules and promotes REM sleep [R].
Benefits of Acetylcholine
1) Acetylcholine Prevents Memory Loss
Too little acetylcholine in the hippocampus has been associated with dementia and Alzheimer’s [R].
Acetylcholine may enhance memory by helping encoding new memories and increasing the modification of synapses [R].
2) Acetylcholine Improves Attention
Acetylcholine helped improve attention and improves decision-making skills [R].
3) Acetylcholine Helps You Sleep Better
4) Acetylcholine Regulates Gastrointestinal Activity
Presynaptic nicotinic acetylcholine receptors (nAChRs) help release acetylcholine in the gut.
These receptors mediate a positive feedback with respect to ACh release from motor neurons, and therefore plays an important role in the regulation of gut flow [R].
5) Acetylcholine Protects Against Infections
Acetylcholine can modulate inflammatory responses. Acetylcholine was shown to have the ability to inhibit biofilm formation during a fungal infection (Candida albicans). Also, it inhibited inflammation-induced damage to internal organs [R].
6) Acetylcholine Affects Hormone Secretion
Negative Effects of Acetylcholine
2) Acetylcholine is Related to Myasthenia Gravis
In myasthenia gravis, antibodies either block, alter, or destroy the receptors for acetylcholine at the neuromuscular junction, preventing muscle contractions.
It is a defect in the transmission of nerve impulses to muscles. However, it is unclear if antibodies against receptors in the brain can directly cause the disease [R].
How to Change Your Levels of Acetylcholine
Supplements for Acetylcholine Deficiency
When it comes to the herbs listed, they increase acetylcholine by inhibiting the enzyme that breaks them down – acetylcholinesterase. Most common herbs have some inhibitory activity against the enzyme.
- Foods with Choline (Eggs, Liver)
- Choline supplements
- Bacopa (R)
- Huperzine A
- Epimedium (R),
- Caffeine (R),
- Blueberries (R),
- Zinc (R),
- Copper (R),
- Grape seed Extract (R),
- Cinnamon (R),
- Tulsi (R),
- Gotu Kola (R),
- EGCG [R].
- Curcumin [R].
- Manganese, in the presences of citrate, increases acetylcholine synthesis [R].
- DHA and dietary fish oils [R].
- Luteolin enhances choline, which in turn increases acetylcholine in the body [R].
- Quercetin (high dose) (R),
- Fo-ti (R),
- Saffron (R)
- Reishi (R),
- Carvacrol (R),
- Rhodiola (R),
- Rehmannia (R)/Catalpol (R)
- Noni (R),
- Schisandra (R),
- Magnesium (potentiates) (R),
- Andrographis (weak) (R),
- Fenugreek (R),
- Melatonin (R),
- Ginger (R),
- Danshen (R),
- Licorice (R),
- Sulforaphane (R),
- Ginseng (R),
- Propolis (R),
- Muira (R),
- Insulin (R),
- Fasting (R),
A lot of drugs can inhibit acetylcholine, either by imitating it or inhibiting choline [R].
- Lipoic Acid (in certain situations)
- Glycine in certain situations (R),
- Mercury compounds
Health Tools I Wish I Had When I Was Sick
At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.
That’s why I decided to create tools that will help others cut down the guesswork:
- Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
- SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
- SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
- SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
- Selfhacked Inflammation course – a video course on inflammation and how to bring it down
- Biohacking insomnia – an ebook on how to get great sleep
- Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
- BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
- SelfHacked VIP – an area where you can ask me (Joe) questions about health topics
The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.
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