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If you are struggling with chronic health issues – the way I used to – you probably have piles of lab tests that can potentially tell you a lot about your health. ACTH may be one of them. However, doctors never had enough time to explain it properly. They will only notice it if the lab flags your test results as outside of normal. But what if all your results are coming back normal, yet you know you are feeling nowhere near healthy? They may even tell you there is nothing wrong with you, and that it’s all in your head – I’ve been there.

Lab Test Analyzer is the tool I wish I had when I was dealing with all my health issues. Instead of normal, it will tell you the optimal values for ACTH and many other lab tests. And if you are outside the optimal range, it will give you actionable tips and recommendations that will help you get there.


Adrenocorticotropic hormone (ACTH), also known as corticotropin, is a hormone secreted by the pituitary gland. It is often produced in response to biological stress.

It increases production of the stress hormone cortisol when physical or mental stress occurs [R].

ACTH is regulated by corticotropin-releasing hormone (CRH), which is from the hypothalamus.

Benefits of ACTH

ACTH Prevents Cortisol Deficient-Related Diseases

Addison disease or primary adrenal insufficiency can be caused when there is not enough ACTH (R).

Secondary adrenal insufficiency causes severe fatigue, loss of appetite, weight loss, nausea, vomiting, diarrhea, muscle weakness, irritability, and depression (R).

Pituitary insufficiency – the front of the pituitary gland stimulates ACTH production and so an insufficiency would lead to a consequential ACTH insufficiency (R). The hypothalamus controls the pituitary gland, which regulates ACTH production. An insufficiency limits ACTH production (R).

Defects in enzymes involved in cortisol synthesis prevents enough production of certain important hormones. In children, congenital adrenal hyperplasia (enlargement of the organ) regular formation of genital formation especially, can be stunted but can be treated with proper medication (R).

If you’re confused by all this information, Lab Test Analyzer is your digital health advisor that helps you understand your lab tests and makes recommendations based on your results.


ACTH acts as an anti-inflammatory and decreases inflammatory cytokines (R).


ACTH also enhances transcription of mitochondrial genes that encode for subunits of mitochondrial oxidative phosphorylation systems.

These actions are probably necessary to supply the enhanced energy needs of adrenocortical cells stimulated by ACTH (R).


ACTH can help bone forming cells by increasing VEGF. This response might be important in maintaining osteoblast survival under some conditions (R).

If this is physiologically important, it probably functions in conditions with short-period or intermittent ACTH signaling, since with continual exposure of osteoblasts to ACTH, the effect was lost in a few hours.


ACTH has protective actions against heart disease, atherosclerosis, and stroke (R, R).

Drawbacks of ACTH

Too Much ACTH Causes Cushing Syndrome

Cushing syndrome causes swelling, thin skin, weight gain, fatigue, decreased libido, irregular menstruation, overgrowth of hair (R).

Cushing disease is caused by a benign tumor that causes the pituitary gland to produce too much ACTH, which causes overproduction of cortisol by the adrenal glands, and causes Cushing syndrome (R).

ACTH-producing tumor causes slightly less intense of symptoms as regular Cushing syndrome (R).

Ectopic CRH (corticotropin- releasing hormone) causes headaches, hypertension that cannot be alleviated by regular therapy and excessive sweating as part of Cushing Syndrome (R).

Adrenal cortisol-producing tumor also causes Cushing Syndrome (R). Adrenal hyperplasia (non-ACTH dependent, autonomous cortisol-producing adrenal nodules) enlarges of adrenal glands (R).

ACTH Can Increase Blood Pressure and Anxiety

ACTH increases blood pressure in humans [R].

ACTH acts on the Serotonin pathway to increase anxiety [R].

Irregular ACTH Levels?

If you have not yet tested your ACTH levels, I recommend that you ask your doctor to do it. If you already have your blood test results and you’re not sure what to make of them, you need to check out Lab Test Analyzer. It does all the heavy lifting for you. No need to do thousands of hours of research on what to make of your various blood tests.

People don’t realize that their blood test results contain a gold mine of information that’s waiting to be unearthed. Unfortunately, not everyone has the time or the inclination to sift through dozens of research papers.

It’s super-simple, so that even if you don’t have any background in science, you will understand what your results mean and what you can do to get them in the optimal range.

Lab Test Analyzer gives you up-to-date scientific information about your lab results. In addition, you will get both lifestyle tips and natural solutions to help you optimize your health. You can also rely on our science-based Optimal Ranges to prevent potential health issues and maximize your overall well-being.

All of the content is backed by science and researched by a team of PhDs, professors, and scientists.

We’re all unique, so we deserve solutions that treat us that way.

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