American Ginseng is a potent herb that has many health benefits. It acts as an antioxidant, enhances brain function, protects against cancer, and is anti-diabetic. Keep reading to learn more about its effects.

What is American Ginseng?

American ginseng (Panax quinquefolius) is a herb that grows mainly in North America. This particular ginseng is in such high demand that it has been declared a threatened or endangered species in some states in the United States. People take American ginseng for stress, to boost the immune system, and as a stimulant (R).

Ginsenosides are the active components of ginseng and are usually found in the root extracts. Ginsenosides have antioxidant properties and can also help protect the brain (R).

Health Benefits of American Ginseng

1) American Ginseng Has Antioxidant Effects

Ginseng and ginsenosides have an anti-oxidant effect that is manifested as a decrease in oxidative stress.

Ginsenosides Rg2 and Rh1 protect from oxidation-induced impairment of red blood cell membrane properties. Ginseng polysaccharide is effective in the regulation of energy metabolism and protection of mitochondria (R).

2) American Ginseng Enhances Brain Function

American ginseng and ginsenosides enhanced cognitive performance and mood.

Administration of American ginseng to healthy young adults enhanced working memory, calmness, and mood (R).

Ginseng and ginsenosides can rescue nerve cells by increasing cell survival, extending neurite growth, and rescuing neurons from death both in human patients and cell cultures (R).

Ginseng and ginsenosides also showed beneficial effects on disease models of Parkinson’s and Alzheimer’s diseases (R).

Long-term ginsenoside administration to mice prevented memory loss or impairment (R).

3) American Ginseng Protects the Heart

In the United States, American ginseng is a popular herbal supplement for patients suffering from heart disease (R).

The antioxidant properties of the herb may be producing its protective effects. American ginseng extract had a stronger antioxidant activity than Asian ginseng root. The root and berry extracts both showed antioxidant and protective effects in cultured heart cells (R).

4) American Ginseng Has Antidiabetic Effects

Insulin resistance and impaired insulin secretion can cause Type 2 diabetes.

Both American and Asian ginseng root lowered diabetic effects in mice (R).

In healthy humans, it also lowered diabetic nerve and heart damage (R).

5) Cancer

American ginseng has anti-tumor properties (R).

Ginseng extract enhanced the chemopreventive effect of a cancer drug in human colon cells. It also improved cancer-related fatigue and produced radioprotective potential in the cells of healthy individuals (R).

6) American Ginseng Has Anti-Inflammatory Effects

Several ginsenosides such as Rd, Rg1, Re, Rg3, Rh2, and Rb1 can control brain inflammatory responses in cultured brain cells. The anti-inflammatory effects might be related to the antioxidant property of ginseng (R).

It also suppresses inflammation in the colon and prevents DNA damage from occurring (R).

7) American Ginseng Ameliorates Withdrawal Symptoms

Ginseng can reduce the behavioral and physiological responses to addictive drugs and ameliorate the withdrawal symptoms.

Pseudo Ginsenoside-F11, a saponin contained in American ginseng, effectively reduced anxiety, depression, and memory deficits and alterations of monoamine contents in mouse brains (R).


American ginseng may cause insomnia, birth defects, and cause hormone levels to fluctuate (R).

It also interferes with the effects of warfarin and might cause blood sugar to plummet drastically if taken in conjunction with diabetes medicine (R).

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