Ashitaba has long been used in cuisine and traditional medicine for infections, healing wounds, and improving digestion. Research shows that ashitaba may have a vast array of health benefits beyond these traditional uses, including reducing weight, reducing blood pressure, improving heart health, and more. Read on to find out the benefits and dosage of ashitaba.
- What is Ashitaba?
- Mechanism of Action
- 15 Health Benefits of Ashitaba
- 1) Ashitaba Helps with Weight Loss
- 2) Ashitaba May Reduce Liver Damage from Alcohol
- 3) Ashitaba May Help Fight Cancer
- 4) Ashitaba May Help with Diabetes
- 5) Ashitaba May Help Reduce Blood Pressure
- 6) Ashitaba May Prevent Memory Loss
- 7) Ashitaba Reduces DNA Damage
- 8) Ashitaba May Help Fight the Flu
- 9) Ashitaba Reduces Inflammation
- 10) Ashitaba Increases Antioxidant Levels
- 11) Ashitaba May Reduce Blood Clotting
- 12) Ashitaba Is Antibacterial
- 13) Ashitaba May Protect the Liver
- 14) Ashitaba May Have Antidepressant Effects
- 15) Ashitaba and Cholesterol
- Side Effects
- Limitations and Caveats
- Forms of Supplementation
- User Experiences
What is Ashitaba?
Ashitaba (Angelica keiskei) is a green, leafy herb and is part of the carrot (Apiaceae) family. It is also called “tomorrow’s leaf” because of its rapid growth and regenerative properties. All parts of the plant, including the roots, are edible.
Native to the coastal regions of Japan, Ashitaba is commonly used for food and medicine on the Izu Islands and the Izu Peninsula. Ashitaba is a cold-hardy plant that also easily is grown in partially-shaded garden beds.
Ashitaba is eaten as a fresh vegetable, dried into leaves for teas, entrees, and soups, and ground into powder for supplementation. Tea is made after 15 minutes of steeping dried leaves in hot water. The plant was traditionally used to treat the flu, hepatitis, arthritis, indigestion, fever, and infections [R].
- Chalcones, including isobavachalcone, xanthoangelol, and 4-hydroxyderricin
- Alpha-carotene and beta-carotene
Mechanism of Action
Ashitaba has many diverse effects, including:
- Increasing levels of the hormone adiponectin, which reduces glucose levels and increases fat breakdown [R].
- Decreasing levels of a receptor called PPAR–γ, which plays a key role in fat cell creation (adipogenesis) [R].
- The causing of programmed cell death (apoptosis) in cancer cells [R].
- Blocking the activity of the angiotensin-converting enzyme (ACE), which lowers blood pressure [R].
- Increasing levels of the antioxidants glutathione peroxidase and superoxide dismutase, reducing inflammation [R, R].
- Reducing depression by blocking the activity of monoamine oxidase (MAO), an enzyme that breaks down dopamine and serotonin [R].
- Decreasing levels of the protein plasma plasminogen activator inhibitor-1 (PAI-1), which decreases the risks of blood clotting [R].
15 Health Benefits of Ashitaba
1) Ashitaba Helps with Weight Loss
In a study (DB-RCT) of 15 healthy weight and 25 overweight people, ashitaba reduced waist width and body weight after 8 weeks. The overweight people also had reduced stomach fat (visceral fat) [R].
A pilot trial found that ashitaba reduced stomach fat (visceral), total body fat, BMI, and body weight in people with metabolic syndrome at both 4 and 8 weeks [R].
Ashitaba increased a hormone that may benefit weight loss (adiponectin) in mouse fat cells [R].
2) Ashitaba May Reduce Liver Damage from Alcohol
In a study (DB-RCT) of 82 heavy alcohol drinkers, 12 weeks of supplementation with ashitaba reduced gamma-glutamyl transferase (GGT), a marker of liver damage [R].
3) Ashitaba May Help Fight Cancer
Ashitaba prevented tumor growth, increased survival time, and prevented the spread of cancer to other sites (metastasis) in mice [R].
4) Ashitaba May Help with Diabetes
Ashitba reduced blood sugar levels, insulin, and triglycerides in rats fed a high-sugar diet [R].
Two of the active compounds in ashitaba (4-hydroxyderricin and xanthoangelol) reduced blood sugar and insulin levels in mice fed a high-fat diet by increasing adiponectin, a hormone that improves insulin sensitivity [R].
5) Ashitaba May Help Reduce Blood Pressure
Ashitaba reduced blood pressure in rats by blocking the activity of ACE [R].
6) Ashitaba May Prevent Memory Loss
Ashitaba improved short- and long-term memory in mice with drug-induced memory loss [R].
7) Ashitaba Reduces DNA Damage
An ashitaba-based juice (240 ml daily) over 8 weeks reduced DNA damage in 20 smokers in an open-label study [R].
A cell study found that ashitaba protected DNA from compounds that cause mutations (mutagens) [R].
8) Ashitaba May Help Fight the Flu
Ashitaba prevented the flu virus from replicating in a cell study [R].
9) Ashitaba Reduces Inflammation
- Tumor Necrosis Factor-alpha (TNF-alpha)
- Interleukin 6 (IL-6)
- Cyclooxygenase 2 (COX-2)
- Mitogen-Activated Protein Kinases (MAPKs)
- Nuclear Factor Kappa Beta (NF-kB)
- Endothelin 1
10) Ashitaba Increases Antioxidant Levels
In a pilot study of 10 healthy adults, ashitaba powder increased antioxidant levels [R].
- Superoxide dismutase (SOD)
- Glutathione peroxidase (GSH-Px)
- Total antioxidant capacity
11) Ashitaba May Reduce Blood Clotting
Fibrin is a protein that is involved in blood clots.
Ashitaba extract reduced levels of plasma plasminogen activator inhibitor 1 (PA-1), a compound that prevents the breakdown fibrin clots (fibrinolysis) [R].
Platelets are one of the main components of blood clots and the grouping together of platelets is one of the key steps in the clotting process.
In a cell study, 4-hydroxyderricin and xanthoangelol reduced the grouping together of platelets (platelet aggregation) [R].
12) Ashitaba Is Antibacterial
13) Ashitaba May Protect the Liver
In cell study, ashitaba extract protected liver cells from acetaminophen (e.g. Tylenol) toxicity [R].
14) Ashitaba May Have Antidepressant Effects
Drugs that block the activity of the enzyme monoamine oxidase (MAO) are widely used as antidepressants.
In a cell study, xanthoangelol and 4-hydroxyderricin achieved similar potency in blocking the activity of MAO as the common antidepressant drug iproniazid [R].
15) Ashitaba and Cholesterol
Yet, moderate and high amounts of ashitaba powder did not improve blood cholesterol in rats fed a high-fat diet [R].
There are no reported side effects of ashitaba. However, some users have reported mild stomach upset.
Limitations and Caveats
Most of the research for ashitaba is conducted in cells and animals and there are few clinical trials. Caution should be taken when applying this research for use in humans.
Forms of Supplementation
Ashitaba leaves, stems, and the roots can be eaten either raw, cooked, or dried. Ashitaba extracts are available in tablet, capsules, tea, and powder form for supplementation.
Doses ranging from 200 to 500 mg of ashitaba extract have been used in clinical trials.
Users of ashitaba found improvements in blood pressure, well-being, energy, and digestive pain.
Lactating mothers had improvements in breast milk supply. Others found that it kept them from getting gout symptoms.
As a tea, users state that it tastes nutty, like green tea, or has a pleasant taste. Others find it is bitter in taste.
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