B. coagulans is a promising probiotic that can lower insulin levels, improve cholesterol, IBS, and arthritis. This bacterium was recently shown to stimulate muscle recovery in athletes.

What is Bacillus coagulans?

Bacillus coagulans is a Gram-positive, spore-forming bacterium. It can also produce lactic acid and is therefore often misclassified as Lactobacillus sporogenes.

Health Benefits of B. coagulans

1) B. coagulans Decreases Insulin

B. coagulans containing symbiotic decreased blood insulin levels, HOMA-IR and HOMA-B in pregnant women [R].

2) B. coagulans Improves Blood Lipid Profile

B. coagulans containing a synbiotic reduced TAG, VLDL and elevated GSH levels in pregnant women [R].

B. coagulans reduced total blood cholesterol, LDL-cholesterol, and marginally increased HDL-cholesterol in a small-scale clinical study [RR].

3) B. coagulans is Beneficial in Diabetes

Consumption of synbiotic bread with B. coagulans reduced insulin levels, improved blood lipid profile and increased good cholesterol (HDL-C) in type 2 diabetes (T2D) patients [RRR].

Similarly, consumption of the synbiotic bread with B. coagulans improved NO and MDA levels in T2D patients [R].

Synbiotic containing B. coagulans improved insulin, hs-CRP, uric acid and plasma total GSH levels in diabetic patients [R].

B. coagulans, inulin and beta-carotene coadministration decreased insulin, HOMA-IR, HOMA-B, triglycerides, VLDL-cholesterol levels and total-/HDL-cholesterol ratio. This treatment also elevated plasma nitric oxide (NO) and glutathione (GSH) [R].

4) B. coagulans Enhances Muscle Recovery

B. coagulans enhances protein absorption, and thereby indirectly improves recovery and training adaptations [R].

B. coagulans in combination with protein reduced muscle damage and soreness, improved recovery and maintained physical performance in athletes after strenuous exercise [R].

Increase in vertical jump power was noted following 8 weeks of full body workouts 4-times per week daily while ingesting B. coagulans [R].

5) B. coagulans Ameliorates Rheumatoid Arthritis

Adjunctive treatment with B. coagulans was safe and effective for patients suffering from rheumatoid arthritis. B. coagulans improved pain, improved self-assessed disability, reduced CRP levels, and improved the ability to walk 2 miles, reach, and participate in daily activities [R].

B. coagulans significantly inhibits fibrinogen (Fn), blood amyloid A and pro-inflammatory cytokine production in arthritic rats [R].

6) B. coagulans is Beneficial for the GI Tract

B. coagulans Beneficially Modifies Gut Microbiota

B. coagulans elevates beneficial bacteria (Faecalibacterium prausnitzii, Clostridium lituseburense, Bacillus spp. and Eubacterium rectale) levels in volunteers. This, in turn, results in elevated concentrations of butyrate, acetate, and propionate [R].

Daily consumption of B. coagulans in elderly increased populations of beneficial bacteria and anti-inflammatory cytokines [R].

B. coagulans spores beneficially modulate GI microbiota, by increasing lactic acid bacteria (LAB) and decreasing Enterobacteriaceae in rats [R].

B. coagulans decreased coliform counts and increased both Lactobacilli and Bacillus spore counts in rats [R].

B. coagulans Alleviates abdominal pain

B. coagulans + fructooligosaccharide (FOS) decreased abdominal pain duration and frequency in children with GI disorders [R].

B. coagulans synbiotic seems to be effective in the treatment of childhood functional abdominal pain [R].

B. coagulans significantly improved abdominal pain and the quality of life in adults with postprandial intestinal gas-related symptoms and no GI diagnoses [R].

B. coagulans Ameliorates Constipation

B. coagulans symbiotic effectively improved bowel movements and fecal properties in functionally constipated persons [R].

B. coagulans added to mineral oil can increase the improvement in the constipation symptoms of children without specific side-effects [R].

B. coagulans May Improve GI Inflammation

B. coagulans improved survival and modestly attenuated the colonic pathology (crypt damage, edema, leukocyte influx) in mice with C. difficile-induced colitis [RR].

B. coagulans Ameliorates IBS

B. coagulans decreased bloating, vomiting, diarrhea, abdominal pain and stool frequency and increased the quality of life in patients with diarrhea-predominant irritable bowel syndrome (IBS) [RRRR].

A combination of simethicone and B. coagulans reduced bloating and discomfort in patients with IBS [R].

7) B. coagulans May Improve Feeding Tolerance in Infants

Preterm infants supplemented with B. coagulans had improved feeding tolerance [R].

8) B. coagulans May Boost Immunity

B. coagulans metabolites stimulate the maturation of antigen-presenting cells [R] and increase T-cell production of TNF-alpha in response to adenovirus exposure and influenza A exposure in healthy adults [R].

B. coagulans ameliorates parasite infection, hepatic and intestinal damage, in Schistosoma mansoni infected mice [R].

9) B. coagulans Ameliorates Urogenital Infections

B. coagulans reduced vaginosis symptoms in women when co-administered with antibiotics [R].


B. coagulans is safe for chronic human consumption [R]. Probiotics, in general, are considered safe but should be avoided in patients with organ failure, immunocompromised status, and dysfunctional gut barrier mechanisms.

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