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Cannabidiol (CBD) is emerging as a powerful supplement, a safe anti-inflammatory that can help several previously untreatable diseases. CBD oil can help fight cancer and irritable bowel disease, improve schizophrenia symptoms, relieve anxiety and help you get more sleep.

I’ve personally helped over 1,000 clients suffering from issues like brain fog and headaches, all the way to chronic autoimmune disorders and infections. CBD oil is one of the most beneficial substances I’ve found that has worked for people across a spectrum of different illnesses.

What is CBD?

Cannabidiol (CBD) is one of over 100 cannabinoids, natural compounds found in Cannabis sativa — the marijuana plant [R, R].

CBD and THC (delta-9-tetrahydrocannabinol) are the 2 main active compounds found in the cannabis plant and the most well recognized and studied.

Unlike THC, CBD is not psychoactive. This means it won’t cause all the negative effects linked to THC, like paranoia, anxiety, and memory problems. Instead, it seems to naturally protect against the marijuana high [R, R].

CBD has shown promising benefits for a variety of conditions, many of which are otherwise not treatable [R].

Although CBD counters the THC high in normal doses, large amounts of CBD could enhance the effects of THC (in monkeys). High doses of CBD may mimic serotonin, which seems to boost THC’s psychoactive effects [R].

Health Benefits of CBD/Cannabidiol

1) Anti-Cancer Properties

CBD and other chemicals from cannabis show promising cancer-fighting properties. Although THC has similar cancer-fighting effects, its use in high doses causes too many psychoactive side effects.

In fact, cannabinoids similar to THC were first used to reduce nausea, pain, and improve appetite in cancer patients. Some synthetic cannabinoids are still used for this indication. But only recently did researchers uncover more about natural cannabinoids like CBD and their ability to combat various types of cancers [R].

Overall, CBD is safe, non-psychoactive, and has strong anti-tumor effects. It could be used to improve the efficacy of standard treatments, or potentially even as an anti-cancer substance on its own [R].

CBD prevented cancer cell growth and killed cervical cancer, leukemia, lung, thyroid, and colon cancer in cells [R, R, R, R, R, R].

It also decreased human brain cancer (glioma) cell growth and invasion, which offers hope for combating this hard-to-treat and deadly type of cancer [R, R].

CBD holds promise for fighting breast and prostate cancer, since it directly reduces tumors, alleviates pain, and can improve the effectiveness of conventional drugs [R, R, R].

Although these studies are exciting, most of the research so far is limited to cells. It’s unknown if taking CBD will help combat cancer in humans.

Anticancer Mechanisms:

  • CBD decreases energy production in cancers, triggering their death [R]
  • CBD makes cancer cells more sensitive to tumor-killing white blood cells (lymphokine-activated killer cells) [R]
  • It makes cancer cells kill themselves (apoptosis), stopping both cancer growth and spreading (R)
  • CBD may act on new non-cannabinoid cancer pathways (R)
  • It also blocks a newly discovered cannabinoid cancer pathway (GPR55) (R, R)

2) Inflammation and Autoimmunity

CBD is a very promising remedy for a variety of inflammatory and pain-associated conditions. It acts on the body’s cannabinoid system to reduce inflammation, balance the immune system, and protect from oxidative stress [R].

Our immune system has sensors for the cannabinoids our own body produces, as well as for those we take in. This internal cannabinoid system can become unbalanced in autoimmune disease and inflammation, which was something scientists had no clue a couple decades ago [R].

CBD acts on the immune cells to trigger a host of anti-inflammatory and antioxidant reactions:

CBD Can Blunt Th1 and Th2 Dominance

CBD reduced both Th1 (IL-6 and TNF-alpha) and Th2 (IL-4, IL-5, IL-13) responses in rats with asthma [R].

CBD reduced inflammation and pain in mice [R].

It also decreased the production of inflammatory substances in immune cells (Th1: TNF-alpha, IFN-gamma, and IL-6; Th2: IL-4 and IL-8) [R].

CBD Helps with Th17 Dominance

CBD can help suppress Th17 dominance, which means that it can help with some Th17-dominant autoimmune diseases [R].

CBD also switches neutrophils to their anti-inflammatory state [R, R], along with reducing other inflammatory immune products (Macrophage Inflammatory Protein-1) [R]

If you’re looking to learn more about ways to reduce inflammation and stress in your daily life, check out our Free 6 part eCourse to get you started biohacking to better health.

3) Neurodegenerative Diseases

CBD protects brain cells. It countered the effects of toxic substances and oxidative stress in brain cells, which would be important for recovering from stroke or other forms of brain damage [R, R].

In a small study (open-label) of 5 patients with movement disorders, CBD reduced uncontrollable muscle twitching, higher doses having a stronger effect. The patients received 100 to 600 mg of CBD per day over a 6-week period. 2 of the included patients with Parkinson’s disease did not do well with doses over 300 mg per day, however [R].

A combination of CBD and THC consistently relieved muscle spasms in patients with multiple sclerosis in one study of 219 participants [R].

However, CBD combined with THC did not improve symptoms in a study of 17 patients (DB-RCT) with Parkinson’s disease [R].

CBD protected from brain damage in animals (reducing beta-amyloid toxicity), which could potentially help in Alzheimer’s and Parkinson’s disease [R, R]. It was able to reverse poor cognitive function in animals with Alzheimer’s disease [R].

CBD also protected the brain from the effects of stroke and reduced blood flow in animals [R, R].

CBD is a stronger antioxidant than vitamin C (ascorbic acid) or vitamin E (α-tocopherol) in cells [R].

Due to its anti-inflammatory and antioxidant properties, CBD holds promise for helping those with Amyotrophic Lateral Sclerosis (ALS) and possibly prolonging their life[R].

Overall, it seems that CBD may protect the brain from damage and inflammation, but does not beneficially affect all movement problems that are a result of brain damage.

4) Multiple Sclerosis Symptoms

Cannabinoids may relieve symptoms of multiple sclerosis (MS). In a study (open-label) of 66 patients with MS and chronic pain, a combination of CBD and THC reduced pain over 2 years. The patients determined the dosage by themselves, taking as much as they felt was needed to alleviate the pain [R].

A combination of CBD and THC helped with muscle tightness, pain, sleep disturbances, and bladder control in 189 people with multiple sclerosis over 6 weeks (DB-RCT). The CBD/THC combination was tolerated well [R, R, R].

In another study of 50 MS patients, a CBD/THC combination somewhat reduced muscle tightness and helped with sleep. Lower doses had a weaker effect, so some patients with MS may need higher doses to get relief [R].

5) CBD Potentially Benefits Schizophrenia

Unlike its cousin THC, CBD may be beneficial for preventing psychosis and reducing symptoms in schizophrenia [R, R].

While the psychoactive THC in cannabis seems to trigger psychotic episodes, especially in those with schizophrenia, CBD has opposite, antipsychotic effects. More and more studies are pointing to CBD as a natural alternative to antipsychotic drugs, but with far fewer side effects [R].

People who experience psychosis may produce too much or even too little cannabinoids (from overactive dopamine receptors). CBD is milder than our internal cannabinoids and helps to re-establish a balance of cannabinoids in the brain. CBD also helps lower inflammation, which is often increased in schizophrenia. THC, on the other hand, is stronger than our internal cannabinoids (anandamide and 2-AG), this way potentially triggering psychosis [R+, R].

In 42 patients with acute schizophrenia (DB-RCT), CBD (up to 800 mg daily) improved all symptoms after 4 weeks. It worked as well as a strong antipsychotic (amisulpride) but was much better tolerated. Interestingly, CBD also reduced the breakdown of anandamide (by blocking FAAH), which was linked to the beneficial effects [R, R].

Many animal studies also support the antipsychotic benefits of CBD [R+].

It seems the cannabinoid system is not that straightforward, and we have yet to understand much about it. In the meantime, the evidence for CBD helping hard-to-treat schizophrenia symptoms is promising.

6) CBD May Reduce Seizures

CBD may help reduce seizures in people with epilepsy who do not respond to other drugs ( treatment-resistant epilepsy) [R, R].

In a 3-month study (observational) of 23 children and young adults (3-26 years of age) with treatment-resistant epilepsy, a purified 98% oil-based CBD extract reduced seizures by half in 39% of the participants. The maximum used dose was 25 mg/kg/day, which would be 1750 mg per day for a person weighing 155 lbs.  [R].

CBD also reduced seizures in another trial of 214 children and adults with epilepsy (open-label). CBD was safe even at the maximum dose, which was double of the previous study (50 mg/kg/day) [R].

In one survey, parents of children who suffer from treatment-resistant epilepsy and use CBD were asked about the benefits. 19 parents were included, 84% of which said that CBD reduced the frequency of seizures. Two parents said that CBD completely resolved seizures. Parents also reported improved alertness, sleep, and mood. Some side effects were drowsiness and fatigue [R].

In 15 patients with epilepsy who didn’t respond to drugs, 200-300 mg of cannabidiol per day over 4.5 months reduced seizures. 7 out of 8 patients who took CBD improved (while only 1 patient in the placebo group did) [R].

7) CBD Reduces Anxiety

A single CBD dose of 400 mg reduced anxiety in a brain imaging study of 10 people with seasonal affective disorder (DB-S). CBD reduced blood flow to parts of the limbic system that are often overactive in anxiety. It increased blood flow to another region important for cognition and motivation (the posterior cingulate cortex) [R, R].

In a study of 10 healthy volunteers (DB-CT), 300 mg of CBD reduced anxiety after a stressful task (public speaking) [R]. In 24 patients with social anxiety (DB-RCT), 600 mg of CBD given before public speaking reduced anxiety and discomfort while improving cognition [R].

In 8 volunteers, CBD prevented anxiety from THC use (DB-CT)[R].

With more studies, the benefits of CBD could be expanded to people with various types of anxiety (including panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder) [R].

P.S. Want to learn more about reducing stress, anxiety, chronic inflammation, and getting better sleep? Check out our free 6-part eCourse to begin your biohacking journey.

Download Our FREE eCourse on BioHacking Your Health

8) CBD Relieves Pain

Many studies suggest that cannabinoids could be a potent new class of “painkillers” for helping millions of people with chronic pain [R, R].

We have receptors for cannabinoids in the whole body, but the first type — CB1 — are very dense in the pain pathways of the brain, spine, and nerves. The second type — CB2 — is more important for the immune system but is also involved in inflammation. By gently acting on both pathways, our internal cannabinoids and CBD can balance both pain and inflammation [R+].

In a large analysis (SR of 18 RCTs and 766 participants), cannabinoids strongly and safely reduced various types of chronic pain (neuropathic, arthritis, fibromyalgia, HIV and multiple sclerosis pain). In another (SR-MA) of almost 2000 participants, the benefits of using cannabis-based medicines to combat pain outweighed any risks [R, R]

A CBD/THC combination reduced pain in several studies of patients with MS and chronic pain (open-label and DB-RCT, 66 and 189 participants). It was tolerated well and used regularly for up to 2 years [R, R, R, R].

Cannabidiol/THC combinations show promising results for postoperative pain, chronic pain, cancer pain, rheumatoid arthritis, and neuropathic pain [R, R, R, R, R].

CBD offers benefits compared to synthetic cannabinoids, and even THC, because it’s not psychoactive. Many people want to avoid the “high”, paranoia, and drowsiness that THC can cause [R].

Although both CBD and opioids relieve pain, CBD did not act on opioid pathways in mice [R]. CBD decreased both chronic inflammation and neuropathic pain in rodents [R].

And importantly, neither CBD not THC seem to cause tolerance long-term (after 2 years), unlike opioids and most other painkillers  [R].

Since cannabinoids like CBD don’t mix well with water, they have to be formulated as oils. However, the amount of CBD that’s absorbed from the gut can vary, and large amounts can remain unabsorbed. New products like CBD/cannabinoid patches, nose sprays, and lozenges are being developed for better absorption [R].

9) CBD May Be Beneficial for Rheumatoid Arthritis

As natural anti-inflammatories and antioxidants, cannabinoids may provide relief of joint pain and swelling. They could also help decrease joint destruction and disease worsening in inflammatory diseases like rheumatoid arthritis [R, R].

A CBD/THC combination (Sativex) reduced arthritis symptoms (including pain) in the first study of patients with rheumatoid arthritis (DB-RCT, 58 participants). Over 5 weeks, this combination reduced pain on movement and at rest, improved sleep quality, and inflammation with no serious adverse effects [R].

CBD protected the joints from damage, reduced inflammation, and improved symptoms in mice with arthritis [R].

10) Cannabidiol May Relieve Nausea and Increase Appetite

THC is an approved drug used to treat nausea and vomiting (dronabinol) in humans, but the clinical evidence for CBD is limited [R]. CBD did reduce nausea and vomiting in rat studies [R].

Typical CBD doses decreased nausea and vomiting produced from toxic drugs in animal studies. But given to the animals in very high doses, CBD could increase nausea or lose its effects [R, R].

For cancer patients, a balanced THC/CBD combination may be the best option for increasing appetite and reducing nausea. The “high” of THC is usually too strong, and CBD can help reduce these psychotropic effects but doesn’t reduce the appetite stimulation  [R].

CBD oil helped me greatly reduce my food sensitivities. If you struggle with food sensitivities, I’d recommend experimenting with CBD oil as well as the Lectin Avoidance Diet, a diet specifically designed to help you pinpoint the exact foods that give you a reaction so you can start eating worry free.

11) Cannabidiol May Lower Diabetes Risk

Although marijuana use is known to increase appetite and calorie intake, it has been linked to lower BMI, less obesity, and reduced chance of diabetes [R].

In one study (observational) of 4,657 adult men and women, past and current marijuana users had lower fasting glucose and insulin levels (by 16%), lower waist circumference and BMI, lower insulin resistance (by 18%), and higher HDL. Since all these factors are connected to the onset of diabetes, marijuana seems to offer protection [R].

Cannabidiol prevented diabetes in young diabetes-prone mice. Only 30% of the CBD-treated mice got diabetes, compared to 86% in non-treated mice [R, R].

Cannabidiol could prevent and delay the destruction of insulin-producing cells in the pancreas in a mouse study. It could also reduce inflammatory cytokines in these diabetic mice, shifting the immune response from Th1 (autoimmune) to Th2. This would be especially important for type I diabetes, which has a strong autoimmune basis [R].

CBD is known to be safe in humans. But it may be used to prevent both type 1 and type 2 diabetes, especially at the early disease stages, if more clinical studies confirm these findings [R].

12) Cannabidiol May Protect the Heart

So far, some animal and cellular studies suggest that CBD could protect the heart by relaxing blood vessels, reducing inflammation, and combating oxidative stress.

CBD relaxed the arteries and protected blood vessels from damage in animal models of heart disease [R].

CBD reduced damage to the heart and brain from clogged blood vessels and helped reduce irregular heart rhythms in various animal models. This way, it protects from heart attacks and stroke [R, R].

It could also lower the heart rate and blood pressure in response to anxiety or stressful situations in rats [R, R].

CBD can influence different blood cells. In platelets, it reduced the clumping that can contribute to the clogging of blood vessels. In white blood cells, it reduces inflammatory processes. Both add to its heart-protective effects [R, R].

However, more studies would need to show if CBD can prevent heart disease in humans.

13) Cannabidiol May Reduce Depression

According to researchers, CBD has antidepressant effects in mice [R, R].

These depression-reducing effects of CBD in mice were fast, maintained over time, and as strong as a standard antidepressant (a common tricyclic medication imipramine, also known as Tofranil) [R, R].

14) Cannabidiol May Help with Inflammatory Bowel Disease

So far, several animal and cellular studies point to CBD as beneficial for inflammatory bowel disease (IBD). This is not surprising, having in mind its proven anti-inflammatory effects that can be extended to the gut. Human studies have yet to confirm these benefits, though.

CBD prevented gut inflammation in animals with IBD [R, R, R].

The combination of CBD and THC reduced inflammation and IBD-causing symptoms in tissue models of IBD. It may help with as abdominal pain, diarrhea, and reduced appetite [R].

CBD normalized gut motility and inflammation in mice with IBD [R, R].

In cells, CBD could reduce gut inflammation by acting on an important inflammation-reducing and metabolic pathway (PPAR-gamma) [R, R].

15) Cannabidiol May Protect Against Bacteria

CBD showed some microbe-killing activity against methicillin-resistant Staphylococcus Aureus (MRSA), which often causes tricky, difficult-to-treat, hospital infections [R].

16) Cannabidiol May Protect Against Mad Cow Disease

Studies show cannabidiol inhibits prions, the proteins that cause fatal brain diseases (such as mad cow disease). It increased the survival time of infected mice by almost a week [R].

17) Cannabidiol May Enhance Bone Growth

Although much less known, our bones also have little-researched receptors for cannabinoids.

CBD could enhance the healing of broken limbs in mice. Both CBD and THC were tested, but only CBD activated genetic pathways that also increase collagen structure [R].

18) CBD May Help Movement Disorders (Dyskinesia)

Dyskinesia is a type of movement disorder and causes involuntary movements. These movements can become so severe that it makes daily life difficult. It’s most common as a side effect of Parkinson’s disease or schizophrenia therapy. Sometimes the mood disorder is not connected to any other disease.

CBD did not improve movement disorders based on the studies mentioned in the Neurodegenerative Benefits (4th) section of this post.

CBD did reduce the symptoms of dyskinesia in mice, though [R].

Mechanisms:

  • CBD reduces the production of inflammatory markers
  • CBD decreased enzymes that contribute to dyskinesia [R]

CBD (together with a TRPV-1 antagonist) reduced dyskinesia via the cannabinoid system (CB1) and inflammation pathways (activating PPAR gamma, reducing COX-2 and NF-kB)[R]

19) Cannabidiol May Help with Insomnia

Research suggests taking CBD before bed improves sleep in people with insomnia. It helped a 10-year-old girl struggling with insomnia, anxiety and PTSD [R].

It could help with sleep due to its relaxing, anxiety-reducing effects [R].

It actually appears to have benefits over THC, which can worsen sleep quality long-term [R].

In fact, cannabis users with insomnia prefer strains much higher in CBD as a sleep aid and are less likely to become dependent (according to a survey of 163 adults purchasing medical cannabis)[R].

Can’t fall asleep at night and wake up feeling more tired in the morning than you did the night before? Biohacking Insomnia is the only sleep resource guide that looks at all the possible factors you’re missing out on restorative sleep and works to get you sleeping better from a holistic viewpoint.

20) Cannabidiol May Help with Substance Use Disorders

In those suffering from chronic pain, cannabis use, in general, reduces the use of opioid painkillers [R].

There is a lack of effective and safe treatments for the growing number of people suffering from opioid use disorder. CBD is a promising, safe alternative [R].

CBD reduced addictive behavior in a rat study. It could interfere with the brain’s reward system in response to the opioids morphine and heroin [R, R].

21) Cannabidiol May Help with Quitting Smoking

Research suggests that inhaling CBD may help reduce or quit smoking. In a pilot study of 24 smokers (DB-RCT), cannabidiol reduced the number of cigarettes smoked by about 40%, without increasing cravings for nicotine [R].

22) Cannabidiol May Reduce Acne

CBD decreases the production of oils (sebum) by the skin’s oil-producing glands and reduced the number of these glands in a study on human skin (tissue study). It also had anti-inflammatory effects, all of which would be very beneficial for acne. We’re hoping to see more research and more CBD-based skincare products soon [R].

23) Cannabidiol May Play a Role in Psoriasis

CBD reduces excessive division of skin cells (keratinocytes), which could be beneficial for psoriasis [R].

Mechanisms

  • CBD activates the serotonin system (activating 5HT1A receptors, and to a lesser extent, 5HT2A receptors) [R]
  • CBD reduces nausea and vomiting, depression, appetite, anxiety, sleep and addictions via activating 5HT1A receptors, [R, R, R]
  • CBD protects the brain from lack of oxygen, at least in part, via 5HT1A receptors [R]
  • CBD plays a role in the perception of pain and inflammation by activating the TRPV-1 receptor [R]
  • CBD has the ability to increase anandamide (activates cannabinoid receptors) by blocking the FAAH enzyme, which helps for anxiety and depression
  • Balancing intracellular calcium and brain cell activity, CBD can reduce seizures [R, R]

Side Effects & Safety

CBD is generally well tolerated, and safe at high doses, and with chronic use in humans [R].

CBD decreased the activity of T and B cells, which may increase the risk of infections and worsen HIV, tumor growth, metastases, and asthma [R].
The oil may decrease the activity of liver enzymes called cytochrome P450, responsible for metabolizing more than 60% of prescribed drugs [R, R].
CBD may also cause mild low blood pressure, dry mouth, lightheadedness, and sedation [R, R].

When CBD is combined with THC, it can interfere with reward learning and motivation [R].

At very high doses, CBD may actually cause anxiety (via activation of TRPV1 receptors) (R).

Joe’s Experience With CBD

I have 2 T alleles for the SNP rs1049353 in my cannabinoid receptor (CNR1) gene.

Lower functioning cannabinoid receptors are a fundamental issue of mine. I believe they were chief contributors to my food sensitivities, so fixing those are my top priority.

In addition, I suspect there are other pathways and epigenetic factors that make it work even less well. This may be why I do well on CBD.

Since taking CBD regularly, I have been able to introduce some foods back into my diet without any inflammatory symptoms.

Dosage

CBD dosage can vary anywhere from 100 mg up to even 3 g per day, depending on the health issue being targeted.

For protecting the brain (such as in Alzheimer’s) and reducing inflammation and muscle twitching (MS), doses of 100 to 600 mg of CBD were used in clinical studies. In some studies, patients took as much CBD oil as they needed to feel pain or muscle spasm relief.

Doses up to 800 mg CBD daily were used for psychosis and schizophrenia.

The highest CBD doses used in studies were up to 3.5 g of CBD oil daily for very severe drug-resistant seizures in children and young adults with epilepsy.

300 mg per day was enough to reduce anxiety in clinical studies.

Joe recommends taking 150 mg of CBD oil 2X a day for anxiety and inflammation relief.

Overall, at higher doses (somewhere over 400mg), CBD becomes less effective for anxiety but better for pain relief. At higher doses, CBD activates TRPV1, which can cause anxiety and increased body temperature, while also decreasing pain (R, R).

Sativex is a THC/CBD combination spray approved in Canada. It contains 2.7 mg delta-9-tetrahydrocannabinol (THC) and 2.5 mg cannabidiol (CBD) per spray (100 µL). The typical starting dose is 2 X per day, and the maximum 12 X per day. It’s used to relieve pain, as well as to reduce muscle spasms in MS.

P.S. I delve deeper into the cannabinoid system and how CBD oil has helped me and thousands of my clients live their healthiest lives in SelfHacked Secrets, my compilation of everything I’ve learned biohacking my way to better health. As a thank you to my readers, for a limited time I’m offering a Free Preview of SelfHacked Secrets. Don’t miss out, download your copy today!

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The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

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93 COMMENTS

  • Sam

    Hello there, I was wondering if there are differences in hemp oils, e.g. quality? I read an article which claims hemp oil reduces eczema and psoriasis. Would you know if this is the case and it could be applied to babies?

    1. Ana Aleksic

      Hi Sam, various oils do vary in quality and CBD content. However, you could use CBD cream on the skin rather than the oil. There is some evidence that it reduces psoriasis and acne, but this is still limited to animal and cellular studies. No clinical trials have yet tested CBD on babies, so we advise caution.

  • Annmarie Kostyk

    I bought CBD oil and tried only 1 drop for 4 days sublingually as I’m super sensitive to everything. I got so tired, I couldn’t function. I have a compound pharmacy by me that sells another kid of CBD oil and the pharmacist said it was half the strength of the one I had tried. He also said to start with 1 drop but add it to my liquid fish oil. Tried for 3 days. Same thing happened.

    I have asthma, allergies, GERD, histamine intolerance and ulcerative colitis – all under control with diet and supplements. Thanks Selfhacked! But I want more. I’m a big ball of inflammation.

    Why does this happen? Suggestions? Is it just not for me?

    1. Caroline Lam

      Hi Annmarie, unfortunately, due to the high volume of questions we receive, we are not able to advise or respond to individual questions in the comments. If you’d like, you can join the VIP membership program, where you can ask your questions directly to Joe. Hope that helps!

  • Geraldine Tate

    Please share your dosages and strengths of your cbd experiences! Thank you.

  • Julie Luckham

    I have sarcoidosis, arthritis, and scoliosis, all of which causes constant chronic pain. I’m now in a wheelchair as walking is total agony. I’ve found these articles very interesting as I’ve been considering trying this oil. I live in UK and would love to know where to get it!

    1. Susan Murray

      Hi there Julie,
      You can get this on a site called “Just Vitamins” in the UK.
      Just Vitamins are a supplement company that I have been using for my general
      health for over a year now.
      I find them trustworthy and free delivery on all their products.
      They are also very good on refunds if needed for any reasons.
      This CBD is a new line just been released to them and you will find them listed.
      If you require any help they are always pleased to help in any way.
      Hope you give this a try it may help you tremendously.
      Best of luck,
      Bediveare.

  • Marc

    I’m confused with all the studies posted above by Carol Close showing harmful effects of CBD oil. Can anyone shine any light on these? They’re in complete contradiction to the benefits I’ve read?

    1. LG

      Lots of the supposed benefits of CBD oil are based on studies in cell cultures not on living human beings. We are trying CBD and TCH for our son going thru cancer treatment, but must be very careful of drug interaction. It’s really kind of the wild west right now for medial cannibus, so try at your own risk.

  • Justin Kenp

    Great Stuff.. It seems, you have researched a lot before posting the blog. Thank you for sharing such a important information, as rarely people know this use of CBD. I know about CBD but not aware the CBD can be use in this way as well.

  • Rachel

    After reading this article on selfhacked a few months ago I decided to try Elixinol for my anxiety and OCD. It helped my anxiety and OCD some, which was encouraging, since no other supplement ever really worked for me. About a month or so later, a teacher I work with gave me a bottle of an organic, full spectrum cbd oil from www. hempworx . com/products so far I’ve been using this oil for 3 months and I’m pretty much OCD free and my anxiety has been drastically reduced. I’m not sure why this other brand has worked so much better for me, but very happy that it does. I thank selfhacked for writing this article, because I had never even heard of CBD oil until I read about it here. Now I’m mostly OCD free after 12 years and my anxiety doesn’t even bother me now. So if you have OCD or chronic anxiety, definitely give this a try. I take 10 to 15 drops twice a day.

  • Bella Dushner

    Hi Mom here, I have a son who’s been diagnosed with childhood epilepsy syndrome, this means their epilepsy has specific characteristics. These can include the type of seizure or seizures they have, the age when the seizures started and the specific results of an electroencephalogram (EEG).An EEG test is painless, and it records the electrical activity of the brain. In my son’s case, he has “benign” which means they usually have a good outcome and usually go away once the child reaches a certain age. And as a mom, I don’t want my son to suffer this kind of illness for a very long time. He’s 5 yrs old now and he is doing great in school. That’s why I am searching the best solution for my son and as along the way, I read this https://www.worldwide-marijuana-seeds.com/blogs/marijuana-news/50937669-epileptic-girl-challenges-mexico-medical-marijuana-ban that cannabis can be the solution to my problem. But I did not try it yet. So am just asking if it safe for my son? Any reply will highly appreciate. Thanks in advance.

    1. Nikki Reed

      Im assuming someone answered you about this! I hope you are using CBD for him by now 😉 If not, I offer full spectrum CBD oil with Biolief. Patented cold pressed. We do not add anything to it but the MCT carrier oil and hemp seed oil. It meets organic farming standards.

  • Jay L

    That’s a lot of great info. I use CBD to help with inflammation in my back. Wellspring is the CBD source, where I get my dabs and capsules. Vaping gets me quicker, but shorter relief than capsules. I hope everyone finds relief with this amazing compound!

  • Sharon Thyden

    Guess I should of read the small print. I did not wish to buy the stuff I don’t have chronic health issues. I need a number to call so I can talk to someone about sending it back and getting my money back please. My email is below.

  • Estelle

    How to sensibly buy LEGAL cbd oil? Because I got a letter saying customs has confiscated my package two times already and I’m pissed.

  • clark simmons

    i have COPD stage 4 . would this help me.

  • Sandy

    How does cbd help with COPD? Should it be taken orally or vape? My husband in on Advair, ProAir and a Nebulizer…helps some but he still gets out of breath with excertion.

    1. Anna S

      I’d suggest either as a pill, or a tenture. Or even gummies.

  • Maria Armstrong

    How to digest CBD mix with food or drinks?

    1. Anna S

      certain companies make CBD gummies and CBD infused water. If you have an Instagram account just search CBD in the tab key and you’ll find a ton of options. Then go to their actual website and research the company 🙂

  • Maria Armstrong

    I’m not sure how to use this CBD oil or how much to take.Im taking it for depression/Alzheimer’s.I could really use your input and make sure I’m doing the right thing

  • Maria Armstrong

    How did you take it I’m not sure how to go about this.I do have Local organic home grown oil. Just not sure what’s the right way?

  • Maria Armstrong

    Just got my organic locally grown CBD OIL ~ lm alttle skeptic to try CBD oil for my ALziemers . After reading about so many people’s bad experience with this stuff. I’m going to try it anyway but not sure how much to take?

  • Maria Armstrong

    I’m 62yrs old and have been diagnosed with Alzimiers disease.I have heard good things about CBD that it can help with this disease. I have the oil but not sure how to use it for this condition .I need to learn how to use the correct way.

    1. Anna S

      I hope you figured it out. But if not so a couple of drops under your tongue.

  • frank freire

    Do you ingest the oil or rub it on your skin? All this is new too me.

  • Kathleen

    I have a Autoimmune Disease called Sjogrene Syndrome. Would it help it ?

  • Philip Young

    I have jjust started taking the oil how much should I take? I have cironic pain

  • rich bourne, phd

    So many of my daughter’s chiropractic patients are getting relief with Hempworx CBD Oil….from muscle aches and back pains to reducing anxiety and actually getting rid from one of her patients sleep apnea after three months on it. Organic and no GMO’s.

  • George

    Agreed with Joe. CBD is best to treat anxiety, depression, pain, chronic pain, inflammation, Alzheimer’s and many more diseases. I’ve experienced good qualities of CBD. I was suffering from the chronic pain for a very long time. One of my friends suggested me to take CBD oil which can treat my pain. I took it for a few weeks twice a day and the pain was totally gone. I felt more relaxed and calm than ever before. I love CBD and I recommend it to people.

  • Roy

    Just a quick word to say I had a stroke in Feb 2015 so after smoking a joint someone gave I noticed my arm felt like it moved so after doing searches online to find out what it was an yes it was the dope so more looking at bits online I came across CBd oil found where to buy it an thought I will give it a go now I still suffer from lack of movement on one side of my body but my fingers move on demand so hey I’m over the moon to see something that looks like I’m going to make a recovery an maybe get back to living my life yip yip yipee

  • Hanna

    I have just started on my CBD journey. This is day 3. My knees do not hurt and I am definitely able to tell the difference when things were off. The nights are pain-free. I have a job that I spend a lot of time on my feet, and easily do over 14000 steps just for my job. My feet use to hurt so bad by the end of the night, that I actually would cry on the drive home. This allows me to have much less pain, and an easier time falling and staying asleep.

  • Lindsey

    Although everyone is different i personally dont experience that side effect. I know a lot of people taking CBD ouik((?

  • Gibby White

    Is it possible CBC could help with alcohol addiction?

  • Susan barclay

    Does it make you feel hungry all the time?

  • Lisa Kay

    I’m glad so many of you have been helped; I tried it upon recommendation from accupuncturist to help with anxiety & funny mood in the afternoon. The first night I woke up in the middle of the night and couldn’t get back to sleep, and had the most horrible constant headache for the 3 days after I took it (and I hadn’t had a headache in months). Also had the anxiety/funny mood all day long. And burning eyes.

    Has this happened to anybody else? I couldn’t find much on these reactions so I came here.

    Carol Close, thanks for all the info. Any insight appreciated.

  • ZionMedicinals

    Wow, one of the most science-minded posts I have read on the subject of CBD.
    I am surprised that no one mentioned how powerful the ‘entourage effect’ is when combining low THC and high CBD.
    Each cannabinoid in hemp or marijuana has its own set of healing properties, so it only stands to see that a ‘full spectrum’ product would be more beneficial in the medical sense, right?

  • James

    Maddy, I read here someplace where THC is taken out of this product. I thought was interesting.

  • Robert Geffers

    Thank you all for the abundance of information on CBD. I just ordered mine from Amazon, it’s a product of Colorado. I read it’s important to make sure your CBD was processed in the USA.

  • Maddy

    Hi, Joe references how his cannabinoid receptor issue contributed to food sensitivities….I have a kid with food sensitivities and I’d like to understand more about that mechanism…

  • Maddy

    Carol, thanks for your long and detailed post, and the links. In your paragraph where you reference various effects, you write “cannabis” several times. There are several components of “cannabis”, THC is the more psychoactive component – and current varieties have been bred/engineered to have ever increasing concentrations of this. CBD is another component, which has different and in some cases opposing effects vs. THC. Are the statements you made about effects of “cannabis”, do they center on THC, consumption/use of the whole plant, or have they broken out a purified CBD product and tested the impacts of just that component. Earnest question.

  • sami

    Emily why would you start with 90 ml in the first place? Is it to say something negative? Of course you would have a reaction to it at that amount….I read to start low and slow and build up to where you would have a comfortable level. Sorry about your experience but my experience is awesome.

  • Ron Ferruzza

    CBD increased tumor cell death in leukemia and colon cancer (R, R2, R3)

    Is this correct, an increase?

    1. Helen

      Hi Ron, yes, it increases cancer cell death according to those references.

  • Dean Justus

    It is about time. There is hope for chronic pain sufferers, kids with epilepsy, opioid addicted individuals who are struggling. Get behind this legislation, do the research, find out for yourself what the real facts are with this herb. Its been around since the beginning of time. There has never been anyone who had died from it. Get rid of the alcohol it will kill you. Support this issue…Its good for West Virginia. I think it could even save West Virginia, its people and its beautiful landscape from the ravages of Washington

  • THR Technologies

    Great Article. Very helpful post, it has helped me to understand for benefits of CBD oil for health. Thank you for share the information.

  • Cory Warfield

    Selfhacked – you guys always put out such create content!! This was such a great scientific-based explanations, and concise, actionable ways to take advantage of the benefits of this specific cannabinoid. My 100-lb mastiff’s life was saved by using RxCBD dog treats, and I know someone else who’s grandfather has now enjoyed an additional year of life beyond docs’ projections, seemingly due to their ‘Ginger Snap cookies’. I’m an evangelist for #rxcbd, and #cbd in general (obviously). So glad it’s legal in all 50 states, and I appreciate seeing people as awesome as selfhacked shining light on it. Good on you guys!!

  • Every Day Optimal CBD

    Great article. CBD is truly a “self-hack” that more people need to be aware of. Although some of our competitors (some of which who are commenting on this article) have recently been found to have almost ZERO actual CBD in their products…many REAL hemp-derived CBD products are powerful and effective for a wide variety of issues.

  • Julie

    Yes Lesley, they sell it in Holland and Barrett

  • steve

    Have you ever heard of CW Simply by The Stanley Brothers in Colorado?
    That’s the one I’m going to try first-the capsule version

  • Kari

    Hi Carolyn,
    My mom takes it daily for her arthritis, she uses oil 3X a day and said she has not been pain free until now. We live in Canada so it is prescribed. The main thing is to start at around 2.5mg and go from there as you build a tolerance. Also make sure it’s not affecting other medications you are taking. It has the same side effect as grape fruit does with certain pharmaceuticals.

  • Lara Wiliams

    After Legalization of medical use of CBD, It will become the prime focus. Various different CBD products, Specially CBD Oil is in more demand. CBD Oil contains Hemp seed oil and Kosher-Grade Vegetable Glycerin. CBD Oil Can help to cure Anxiety, Alzheimer, Insomnia, Parkinsons’ disease and many more diseases. CBD Oil Can use as a best pain controller.

  • carol close

    This is for Christie September 27, 2017
    Since pot increases alpha and theta sleep, it inhibits delta sleep, so it also inhibits growth hormone and klotho, the anti aging hormone. You may unknowingly be putting your body into a catabolic state speeding the destruction of your connective tissue and breaking down your connective tissue at a faster rate thus aging you faster, instead of building up stronger connective tissue which is your goal in getting healthy, normal, plus staying young.

  • carol close

    This is in reply to Christie… September 27, 2017.
    Ehler Danlos has recently been found to be caused by hereditary alpha tryptasemia with mast cell activation. You are born with extra copies of the alpha tryptase gene. Tryptase levels can be lowered by lactoferrin found in the supplement colostrum. Also, supplement with luteolin which inactivates mast cells. The cells of connective tissue include fibroblasts, adipocytes, macrophages, mast cells and leucocytes. Histamine activates mast cells increasing inflammation which attacks connective tissue, so eat an anti-histamine diet which lowers inflammation. To lower histamine levels, eat only fresh foods- eggs, chicken, rice, gluten free pasta/crackers, cream cheese, butter, coconut oil, olive oil, non-citrus juices, milk, herbal teas (not coffee, black tea), fresh/frozen fish, fresh/frozen fruits and vegetables, especially prebiotics like onions, garlic, bananas, jicama, raw asparagus. No tomatoes, strawberries, vinegar, matured cheeses, pickled/canned foods, shellfish, salami and other cured meats, sausages, ham, bologna, etc. No beans, nuts chocolate, peanut butter, ready meals, deli food because its been sitting, energy drinks, as these are all high in histamines. The key to low histamine is fresh. Eat knox gelatin daily with vitamin C which strengthens connective tissue. Gelatin is high in the amino acids- glycine, proline and lysine which are needed for collagen production in connective tissue. No aspirin, alcohol, high sugar, fructose, or high carbs to heal leaky gut. In fact, inflammation throughout the body can be mediated by the gut bacteria, and loss of gut bacterial diversity can threaten the gut lining, so then that leakiness of the gut, or intestinal permeability, then mechanistically leads to inflammation. Bacteria from the gut leaks into the bloodstream causing inflammation. Then where does that inflammation go and what part of the body gets damaged from it? Connective tissue. Inflammation is the cornerstone of basically every degenerative condition you don’t want to get. Check your progesterone levels which should be normalized. Progesterone’s role in the health of the body’s connective tissue or collagen is well understood. As progesterone strengthens collagen and increases the turnover of cells, the skin becomes softer and stronger. 70% of the skin is collagen, as is 20% of the entire body- tendon, ligament, blood vessels, skin, cornea, cartilage, bone, blood, blood vessels, gut, intervertebral disc, brown and white adipose tissue. https://www.niaid.nih.gov/research/hereditary-alpha-tryptasemia-faq

  • Someone

    Please look into DCA for her, it’s is proven to shrink tumors.

  • Martin Jones

    Agreed with this blog. CBD is best to treat anxiety, depression, pain, chronic pain, inflammation, Alzheimer’s and many more diseases. I’ve experienced good qualities of CBD. I was suffering from the chronic pain for a very long time. One of my friends suggested me to take CBD oil which can treat my pain. I took it for a few weeks twice a day and the pain was totally gone. I felt more relaxed and calm than ever before. I am wondering that how CBD can cure this much effectively? I love CBD and I recommend it to people.

  • Aaron middleton

    CBD is awesome. I use it to treat my back pain and anxiety and I must say it works 🙂

  • Misty Goodman

    I’m working with a company. That is going global. I can send you info through email.

  • Martha Brown

    CANNABIS OIL CURED MY MOM ALZHEIMER’S

    My name is Martha, My mom has dementia and Alzheimer’s disease, I took care for my mum. We were managing until these awful vigorous shaking seem to have took over her body, she can’t even hold a cup when it is at its worst and sleep is out of the question which leads to utter exhaustion. We were told that the medication she was on for her restless legs which was something totally different was making the shaking worse. But yet the shaking is part of the dementia. I was making research online on any possible solution that could help my mom and I came across how cannabis oil have helped a lot of people around the world to cure Alzheimer’s and Dementia. I was so happy and relief when I saw this and I knew there was hope for my mom to be well again. I contacted Medicinal Marijuana Resources to get the high quality THC cannabis oil for treatment and prescription on how to use the cannabis oil for treatment of Alzheimer’s and Dementia. My mom started using the cannabis oil for treatment as directed by Medicinal Marijuana Resources physician expert team. Now the Alzheimer’s and Dementia are gone and my mom is well, healthy and strong again

  • Christie

    This is an amazing product! I have Ehlers Danlos type 3 & 4. I have been living with chronic pain since my early twenties. I am now 41 yrs old and can say that today, because of Rapid Releaf and their incredible people, I feel better than I have in a long time. After 31 surgeries for various skeletal problems(I have three total joint replacements)I just assumed my life would always include pain and anxiety medication. I called Rapid Releaf and was helped by Josh. He took as much time as I needed to explain their product and how he thought it could help me. Three days after starting the CBD oil regimen, I am almost completely off of the narcotics. I have stopped taking all of my anxiety meds( I took Xanax and Valium for almost 15 years) and am currently working a program designed specifically to my needs and situation. I have slept more and feel rested in the morning. I can’t say thank you enough for giving me a life back! No more every day doctor visits or trips to the pharmacy. I am living a life that I never dreamed could be mine. I am living a normal everyday life under extraordinary circumstances! Thank you for the time you have dedicated to me and my situation. I know I couldn’t be almost drug free within days of starting your program otherwise. It truly is a miracle to be able to go day to day, unrestricted by pain and the tie downs that come with prescription medications. I have more time and energy than I thought would be possible as I transition from a twenty year opiod dependent life, to one having nothing to hold me back.

  • Cindi

    Can you put it in a vape and just hit it all day or is there a limited amount to ingest ?

  • Amanda

    How to sensibly buy LEGAL cbd oil online? Because I got a letter saying customs has confiscated my package two times already and i’m pissed.

    1. Nattha Wannissorn, PhD

      Depends on where you are.

  • Dianna Goforth

    How does CBD Oil help Alzheimer’s?

  • April

    I just want to share how CBD changed my life. I am using water soluble CBD to calm the autoimmune response. It works to reduce inflammation, seizures, nerve pain, and in reducing tumors. It’s truly God-sent! – April

  • Carolyn Doull

    I am a senior who would like to try CBD for inflammatory bowel problems, but where to start? Capsules? Tinctures? Liposomes? How do I know what dosage to take? I find it confusing and need a guideline.

  • Lesley

    Can u get this in the uk

  • Rose Baumann

    I have just started on my CBD journey. This is day 3. My knees do not hurt and I am definitely able to tell the difference when things were off. The nights are pain-free. I have a job that I spend a lot of time on my feet, and easily do over 14000 steps just for my job. My feet use to hurt so bad by the end of the night, that I actually would cry on the drive home. This allows me to have much less pain, and an easier time falling and staying asleep

  • carol close

    Regarding your comment on CBD and colitis or inflammatory bowel disease. Immune cells patrol the gut to ensure that harmful microbes hidden in the food we eat do not sneak into the body. Cells that are capable of triggering inflammation are balanced by cells that promote tolerance, protecting the body without damaging sensitive tissues. When the balance tilts too far toward inflammation, inflammatory bowel disease can result. Now, researchers have found that a kind of tolerance-promoting immune cell appears that carry a specific bacterium in guts called Lactobacillus reuteri that is the normal part of the gut microbiome, and tryptophan, part of a protein-rich diet, soothes the inflamed gut because it increases the development of a population of immune cells that promote tolerance. Further, the bacterium needs tryptophan — one of the building blocks of proteins — to trigger the cells’ appearance, and the more tryptophan in the diet to feed the gut bacterium, Lactobacillus reuteri, the more of these immune cells there are.

    https://www.ncbi.nlm.nih.gov/pubmed/28775213 Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells

    Regarding Cannibis and Klotho and Cannibis and the Endocrine System
    Cannabis and alcohol both increase alpha and theta sleep and decrease delta sleep. Cannabis and alcohol inhibit delta sleep needed for the night time brain housekeeping duties and increase luteinizing hormone so core body temperature does not drop for brain cells to shrink for 60% more space between brain cells for the cerebral spinal fluid to wash out toxins. Since pot inhibits delta sleep, it also inhibits growth hormone and also dehydrates you, so klotho is reduced. Cannabis causes kidney stones by reduced klotho. Klotho is anti tumor, anti dementia, inhibits arteriosclerosis, osteoporosis, and skin atrophy, so since cannabis inhibits klotho, aging is increased. Cannibis decreases sex hormones, increases stress hormones, impairs fertility, inhibits copulation, reduces oxytocin-the love and protection hormone.

    https://www.ncbi.nlm.nih.gov/pubmed/19045957 The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent. lateral hypothalamus or dorsal raphe nuclei, which are wake-inducing brain areas which cannabidiol enhances wakefulness and decreases slow wave sleep and REM sleep. Furthermore, cannabidiol increases alpha and theta power spectra but diminishes delta power spectra. Additionally, cannabidiol increases c-Fos expression in lateral hypothalamus or dorsal raphe nueclei. These findings suggest that cannabidiol is a wake-inducing compound that presumably activates neurons in lateral hypothalamus and dorsal raphe nuclei.

    https://en.wikipedia.org/wiki/Delta_wave Delta waves sleep releases growth hormone and prolactin

    https://en.wikipedia.org/wiki/Glymphatic_system Delta sleep needed for function of glymphatic system.

    https://www.ncbi.nlm.nih.gov/pubmed/24096965 Growth hormone and Klotho. Growth hormone increases klotho for proper kidney function and calcium regulation.
    (Reduced klotho is involved in kidney stones, chronic kidney failure, tumors, dementia, arteriosclerosis, skin atrophy, and more.)

    https://www.ncbi.nlm.nih.gov/pubmed/26408166 Endocannabinoids and the Endocrine System in Health and Disease.

    In this review, the effects of cannabinoids in the regulation of the following endocrine systems are discussed: the hypothalamic-pituitary-gonadal axis and hypothalamic-pituitary-adrenal cortex axis. Cannabis users have reduced levels of gonadotropins, reduced prolactin and growth hormone. Cannabis affects corticotropin-releasing hormone-, thyrotropin-releasing hormone-, vasopressin-, and oxytocin-expressing neurons. Therefore, our findings reveal a mechanism of rapid glucocorticoid feedback inhibition of hypothalamic hormone secretion via endocannabinoid release in the paraventricular nucleus of the hypothalamus and provide a link between the actions of glucocorticoids and cannabinoids in the hypothalamus that regulate stress and energy homeostasis. Glucocorticoid negative feedback in the brain controls stress, feeding, and neural-immune interactions by regulating the hypothalamic-pituitary-adrenal axis. Cannabis increases dopamine which decreases prolactin. Cannabis decreases oxytocin, thyroid hormone and growth hormone, and disrupts the hypothalamic-pituitary-adrenal axis. Cannabinoids suppress fertility via reducing hypothalamic gonadotropin- releasing hormone output. γ-Aminobutyric acid (GABA)(A) receptor (GABA(A)-R)-mediated transmission is a major input to gonadotropin releasing hormone cells that can be excitatory. Cannabinoids act via inhibiting GABAergic input. Cannabis disregulates the hypothalamic-pituitary-adrenal axis circadian rhythm. Cannabis decreases serum concentrations of pituitary gonadotropins. Cannabis raises cortisol and ACTH which increases cortisol which uses up progesterone reducing testosterone and estrogen. Cannabis lowers testosterone in men by inhibiting testosterone secretion and impairs fertility in males through alteration in the testicular endocannabinoid system. Cannabis suppresses copulatory behavior even when testosterone levels are maintained. It decreases sperm concentration, causes defective sperm function or alteration of sperm morphology. Endocannabinoids control male reproduction acting at central and local level via cannabinoid receptors. The cannabinoid receptor CB1 has been characterized in the testis, in somatic and germ cells of mammalian and non-mammalian animal models, and its activity related to Leydig cell differentiation, steroidogenesis, spermiogenesis, sperm quality, and maturation. Testicular degeneration and necrosis is induced by chronic administration of cannabis. In both ovulating and menopausal women, cannabis can alter pituitary gonadotropin release and alter metabolism or target tissue response to gonadal steroids, leading to reduced estrogen and progesterone production and anovulatory menstrual cycles. Cannabis presents abnormal longer ovulatory cycle lengths in females. Cannabis suppresses luteinizing hormone when sex hormones are initially high, but, chronic cannabis lowers progesterone and testosterone in men, and lowers estrogen and progesterone in women, so luteinizing hormone significantly increases which raises night time core temperature for disrupted sleep. Cannabis increases hypothalamic nitric oxide which inhibits oxytocin. Cannabis is detrimental for lactating moms. Cannabis decreases maternal care, decreases aggressive instinctual behaviors for protection of young, suppresses maternal anxiolysis, decreases plasma oxytocin levels and milk consumption and decreases activation of oxytocinergic neurons in hypothalamic nuclei. Changes in the behavioral responses of lactating mothers treated with cannabis can be related to disruption in the neuroendocrine control of oxytocin secretion. Cannabis causes impairment of glucocorticoid feedback which either enhances or decreases performance on various tasks. Cannibis can cause a decrease in thyroid which negatively affects cerebellar development and motor performance involved in adult brain function. It induces consistent behavioral changes in adults, leading to severe anxiety and morphological changes in the hippocampus, however, it shows improvements for schizophrenia: improvement in cognitive function and reduction of antipsychotic-side. Cannabis and Δ(9) -THC are anticonvulsant in most animal models but can be proconvulsant in some healthy animals. The simultaneous rapid stimulation of nitric oxide and endocannabinoid synthesis by glucocorticoids has important implications for the impact of stress on the brain as well as on neural-immune interactions in the hypothalamus. Cannabis has implications for psychosis. There are blunted psychotomimetic and amnestic effects with cannabis. Lithium increases oxytocin and helps in cannabis withdrawal, and pregnenolone/progesterone help in cannabis withdrawal as estrogen generally increases and progesterone decreases sensitivity to marijuana.

  • Dave

    great articel. I’m using the Elixinol and its really effective for my anxiety. Glad to read all
    the benefits!

  • Hemp cbd

    I use the CBD (Elixinol) which helps me, I feel great! I believe this product.

  • Lisa

    Thanks Emily. I had a bad reaction as well. I felt fantastic on a minuscule dose ( 3 drops, Biologix) , but a few hours later I destabilized and was in bed for about 3 hours before I could get up. Happened 2 days in a row. I was so happy about how great I felt, but it is not worth the crash.

  • gwen

    Joe, which product do you take? 3600mg, 300mg? what about the liposomal version? which one would be the most cost-effective?

  • Mr. sick

    Sorry to hear that it didn’t work out well for you, Emily, but what you are describing here isn’t a cannabis high. It’s a bad reaction though.

  • MMJ Canada

    Hi Nattha! Been reading a lot about the benefits of CBD Oil, I’m just wondering if you could use the oil directly on an inflamed muscle or skin? I mean, does it always work best when ingested?

    1. Nattha Wannissorn, PhD

      I don’t know. CB2 receptors are present in muscle cells. You could try it and see how it’s like. There are transdermal CBD products on the market so that’s likely to work.

  • Emily Porter

    For the record, for all the super sensitive people out there, I want to comment that CBD oil CAN get you high. NO REALLY. It can. And I’m talking about Elixinol. the recommended brand here, not some random adulterated stuff, not some high cbd marijuana, actual purified, tested, industrial hemp oil. I have chronic fatigue syndrome and experienced with my own body all the same effects from Elixinol, that I have gotten from eating a weed cookie (less intense, but still unpleasant). For me these side effects include full body convulsions and tremors lasting over an hour, anxiety and panic, disturbing disassociative and repetitive/confusing thought patterns, cottonmouth, and intense emotions and weeping. This was from 90mg CBD content at once. Which is more than recommended on the bottle but still well within the realm of a reasonable dose. Like an edible the effects took many hours to kick in, and then the high came on fast. I am also largely intolerant of caffeine and alcohol. However I never have any noticeable effects from most vitamins and herbal products. Not against CBD. Just saying it is possible, even if no one believes you.

  • greenroads

    CBD has played a major role in treating numerous health care problems such as cancer, diabetes, chronic pain, and many other. Research has found that a 600mg dose of CBD helped people in reducing their anxiety to give their speech. It is safe to use if proper medication has been done and does not cause any side effects.

  • Jhodson

    Really? Really? I’m not trying to be rude, but this statement is ridiculous: “Many CBD products on the market don’t actually contain CBD (based on me observing no results at all from using them)”
    You can’t make such claim based on your subjectivism. Go test these CBD, show us the result and THEN you are able to make this kind of statement.

  • tony

    What information or evidence do you base this statement on? “Many CBD products on the market don’t contain any CBD”

    1. Nattha Wannissorn

      He observed no effect from them.

      1. tony

        Oh so an assumption/guess based on a single anecdote is thrown in there as a factually worded statement on a blog about evidence based health info?

        1. Nattha Wannissorn

          It’s a blog that shares both science and personal experimentation results. I’ll edit that to make it clearer.

  • Mike Mills

    What are your thoughts on vaping an eliquid and its effects related to ingestion of an oil compared to water vapor? Would I essentially be able to take more CBD into the blood stream that way compared to taking it sublingually?

    1. Nattha Wannissorn

      They just reach your bloodstream and get eliminated at different speeds.

  • Claire Higham

    Can you make your own by soaking high CBD Hemp buds in oil?! Seems alot easier and cheaper

    1. Nattha Wannissorn

      No

  • James

    I get my CBD products and have been using them for over 6 months to help with my anxiety. I recently got my best friends mother (who has rheumatoid arthritis) to try the higher strengths and she told me that it has helped her tremendously. Would definitely recommend this company to anyone who is looking at CBD for help!

  • Phillip

    Thanks for the CBD oil recommendation. Do you all know if CDB oil is legal to purchase in states where medical and recreational marijuana is illegal?

    1. Nattha Wannissorn

      We checked with the company and they say that because CBD does not have psychoactive properties, it’s considered a dietary supplement which can be sold in all states.

  • Emily Elson

    I am confused about how you say it can be beneficial for cancer and has anti-tumor effects, but then in the side effects, you say that since it can lower T and B cell activity it can worsen disease progression, tumor growth and mestastases. My mom has early stage multiple myeloma as well as some anxiety/depression and insomnia. Thought this would be good- but now confused whether it’s anti or pro cancer.

    1. Nattha Wannissorn

      It depends on where it is in the process because cancer is a complex disease. The research on this is still coming out. I’m inclined to think that it helps more than hurts in this case, but correct me if I’m wrong.

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