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Cissus Quadrangularis a native to India has been used for ages in Ayurvedic medicine to heal broken bones injured ligaments and tendons. Experimental studies have shown that it regulates hormones, helps weight control and also improves blood health. I have compiled all of my research of the healthiest substances on Earth and how they have personally helped me in my book, SelfHacked Secrets.


Cissus Quadrangularis, a member of the grape family, is a herb used for medicinal purposes in India and South Asia. It has been used for traditional medicine in Ayurvedic culture to heal broken bones and damaged joints and tendons. C. quadrangularis has also been used to treat female disorders, such as menopause. It can be taken as a supplement in capsule form.

Health Benefits of Cissus Quadrangularis

1) Cissus Quadrangularis Helps with Bones and the Skeletal System

Alcohol extract has anabolic and bone formation properties (R).

Quadrangularis in human patients helped reduce pain and swelling in jaw fracture injuries (R).

In arthritic rats treated with C. quadrangularis, hydroalcoholic extract reduced joint swelling and reduced oxidative stress in inflammatory markers (R).

In rats treated with C. quadrangularis, cartilage formation was improved compared to untreated rats (R).

In patients with facial fractures, C. quadrangularis helped increase calcium and phosphatase levels, an indicator of fracture healing (R).

In diabetic pregnant rats, those given C. quadrangularis supplements had improved fetal skeletal formation, where diabetes typically harms fetal skeletal development (R).

In diabetic rats, petroleum-ether-fraction C. quadrangularis improved bone health in high glucose conditions, which improved bone growth (R).

In patients with fractures, patients given C. quadrangularis supplements had improved healing compared to those not given the supplement (R).

In healthy men, C. quadrangularis supplements helped reduce joint pain (R).

In mice, C. quadrangularis helped to prevent bone loss (R).

In patients given C. quadrangularis, patients had an increase in calcium and phosphorus levels (R).

In rats, C. quadrangularis helped increase bone thickness, which helps prevent osteoporosis (R).

2) Cissus Quadrangularis Regulates Hormones and Helps with Weight Control

In a study with rats, C. quadrangularis helped treat low estrogen levels in menopause onset (R).

Quadrangularis stem extract had anti-diabetic activity in rats (R).

In diabetic rats, C. quadrangularis stem extract regulated carbohydrate metabolic enzymes, which contribute to blood glucose levels (R).

In rats, c. quadrangularis stem extract improved insulin sensitivity and reduced liver damage, an indication of anti-diabetic properties (R).

Quadrangularis prevents the repression of steroidogenesis, which prevents male infertility (R).

In rats fed with a high fat-high fructose diet, C. quadrangularis improved insulin sensitivity and reduced liver damage, as well as normalizing antioxidant and lipid levels (R).

300 mg of Cissus Quadrangularis extract helped reduce weight and improve serotonin levels in overweight patients (R).

In patients given C. quadrangularis, blood glucose, cholesterol, triglycerides, and weight was reduced (R).

3) Cissus Quadrangularis Benefits the Gastrointestinal Tract

In rats with induced ulcers, C. quadrangularis decreases gastric secretions and increases gastric mucin content and glycoprotein levels (R).

In rats with aspirin-induced ulcers, C. quadrangularis extract reduced the ulcer size and restored the protective mucus layer (R).

In rats given C. quadrangularis, aspirin did not significantly affect the gastric mucosa in the ulcers of rats (R).

Quadrangularis promotes ulcer healing by promoting cellular reproduction (R).

4) Cissus Quadrangularis Improves Blood Health

In humans, the methanol extract of C. quadrangularis lowered aspartate transaminase, alanine transaminase, alkaline phosphatase, and bilirubin levels. High levels of these are toxic to the blood, lowering these levels show blood-protective properties (R).

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Health Tools I Wish I Had When I Was Sick

At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.

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  • SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
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