DHEA is usually praised for its anti-aging properties. It can protect the heart and improve brain function. However, there are some drawbacks to DHEA supplements as well. Read more below to learn all you need to know about DHEA and DHEA-sulfate.
- Introduction to DHEA and DHEA-S
- The DHEA Supplement That I Take
- Health Benefits of DHEA and DHEA-S
- 1) DHEA Boosts Hormone Levels
- 2) DHEA Improves Brain Function
- 3) DHEA Protects the Heart
- 4) DHEA Helps Increase Pregnancy Rate
- 5) DHEA and DHEA-S Helps With Weight Problems
- 6) DHEA Lowers Insulin Resistance
- 7) DHEA Helps Protect Against Inflammation
- 8) DHEA Improves Sleep
- 9) DHEA Improves Bone Health
- 10) DHEA Protects Muscles
- 11) DHEA Relieves Problems Resulting from Menopause
- 12) DHEA May Protect Against Colon Cancer
- 13) DHEA Helps with Lupus
- Negative Effects of DHEA
- Technical Information
- Buying DHEA
- DHEA on SelfDecode
Introduction to DHEA and DHEA-S
DHEA is a steroid hormone that is produced in the adrenal gland, gonads, and brains. It is a precursor to other hormones, namely estrogen and testosterone. DHEA levels are highest after birth, and continue to lower as you age (R).
DHEA-sulfate (DHEA-S) is a sulfite derivative of DHEA. The body also turns it into androgen hormones. Not a lot of studies have been done on DHEA-S and its long term effects, so it is not recommended for supplementation (R).
The DHEA Supplement That I Take
Health Benefits of DHEA and DHEA-S
1) DHEA Boosts Hormone Levels
Women can take supplements during menopause to increase their level of estrogen (R).
DHEA can be used to help alleviate sexual dysfunctions that are the result of poor hormone levels (R).
2) DHEA Improves Brain Function
DHEA also enhances emotional regulation of memory and the connections between the amygdala and hippocampus (memory center) (R).
DHEA levels in the brain controls visual processing. It is involved with the amygdala-dependent changes of the brain and visual awareness and attention (R).
A meta-analysis (of 22 studies) showed that it improved depressive symptoms in both old and young patients. However, only 3 studies were focused on young patients (R).
3) DHEA Protects the Heart
4) DHEA Helps Increase Pregnancy Rate
Ovarian reserve is the capacity for the ovaries to produce a healthy egg that is ready for fertilization. Women taking DHEA with poor ovarian reserve, who also did not respond well to IVF, had a higher rate of pregnancy and higher ovarian reserve than women who did not take DHEA supplements (R).
5) DHEA and DHEA-S Helps With Weight Problems
DHEA supplementation led to huge weight loss in rats and also increased their energy usage (R).
6) DHEA Lowers Insulin Resistance
7) DHEA Helps Protect Against Inflammation
In the feline model of HIV (called FIV), DHEA also prevented neuron loss (R).
8) DHEA Improves Sleep
9) DHEA Improves Bone Health
10) DHEA Protects Muscles
DHEA helps protect against muscle dystrophy. It helps protect against cell oxidation and prevents cell death. It increased the effects of antioxidants and stops muscle atrophy (R).
11) DHEA Relieves Problems Resulting from Menopause
After menopause, some women experience vaginal pain during sexual intercourse or severe dryness of the vagina. Intravaginal administration of DHEA administered led to improved vaginal health and lessened pain (R).
12) DHEA May Protect Against Colon Cancer
13) DHEA Helps with Lupus
Negative Effects of DHEA
Note: I take DHEA myself, so I’m not concerned about these potential negative effects.
Some side effects of DHEA include acne and excessive hair growth (R).
DHEA-S is not recommended for women because of the lack of studies done on long term effects (R).
1) Excess Levels of DHEA and DHEA-S May Cause Cancer
An overdose of DHEA leads to high incidence of cancer of the prostate gland, breast, colon, lung, and stomach (R – unreliable study).
2) DHEA Is Related to Mental Disorders
A high level might be a risk factor for psychotic symptoms. It was found that a higher number of patients with high levels was found to have a family history of major depressive disorder or psychotic symptoms (R).
3) DHEA Increases Addiction
DHEA might contribute to substance abuse. By responding to emotional and behavioral circumstances, DHEA increases addiction (R).
4) DHEA Aggravates Stress
- Inhibited proliferation of spleen cells and IFN-у production, therefore it’s a Th1 suppressant (R).
- Decreased expression of IL-6 and TGF-β (R).
- Augmented frequency of CD4+IL-4+ cells (Th2), decreased CD4+IFN-ɣ+ (Th1) in spleen and constrained CD4+IL-17+ (Th17) population in the mesenteric lymph nodes (R).
- Reduces the accumulation of reactive oxygen species (ROS) in response to H2O2 and the H2O2-induced phosphorylation of ERK and p38 in a dose-dependent manner (R).
- stimulated the activation of Nrf2, which led to the expression of an antioxidant response gene, HO-1 (R).
- treatment reduced inflammatory gene transcripts (IL-1β, TNF-α, CD3ε, GFAP) (R).
- increased expression levels of the beta 3 adrenergic receptor (beta(3)AR) and PGC-1a (R).
- Inhibits phosphatase of regenerating liver-3 (PRL-3) (R).
- Inhibits the three recombinant T-channels (Ca(V)3.1, Ca(V)3.2 and Ca(V)3.3) expressed in NG108-15 cell line and native T-channels in pulmonary artery smooth muscle cells (R).
Recommended DHEA supplement:
DHEA on SelfDecode
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