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Epitalon (Epithalamin) is a peptide studied and utilized for its anti-aging effects. It has been shown to be a potent anti-oxidant, comparable to melatonin, and may confer longevity benefits. To discover the secrets of anti-aging and amazing health check out our ebook SelfHacked Secrets.

Keep reading to learn more about Epitalon and its health effects.

Epitalon Peptide

Epitalon is a synthetic peptide made of four amino acids (alanine, glutamic acid, aspartic acid, and glycine), that is based on a natural peptide called Epithalamin extracted from the pineal gland. It was synthesized by Vladimir Khavinson, a Russian professor and gerontologist, whose research focused on the development of peptide preparations used to restore function in various organs in order to prevent and reverse the aging process. He is currently the Director of the Saint Petersburg Institute of Bioregulation and Gerontology.

Khavinson first extracted Epithalamin from the pineal gland of calves, however due to the inherent limitations in production, he formulated a synthetic version of the peptide called Epitalon.

Epitalon is usually administered via intravenous or intramuscular injection or transdermally (through the skin), as peptides are broken down in the digestive tract and therefore unable to enter the bloodstream intact where they can exert their effects.

Most of the research has been conducted in animals, with a few clinical trials, and the results have been, in a word, promising.

What the Research Shows

1) Epitalon Increases Average and Maximal Lifespan in Fruit Flies, Rats and Mice

When the peptide was administered to fruit flies during the larval stage, it was shown to increase the average lifespan by 11-16 percent[R].

In a study on rats exposed to equal amounts of light and darkness, varying amounts of light and darkness, or permanent light illumination, Epitalon increased maximal lifespan in all three groups by 68 days, 95 days, and 24 days, respectively, in comparison to controls [R].

In mice of model of hypertension, injections of Epitalon did not affect average life span of the mice, but did increase the maximal lifespan by 12.3% [R]

3) Epitalon Increases Enzyme Activities

A decrease in pancreatic enzymes has been shown to occur in elderly individuals [R]

In both young and old rats, Epitalon increased the activity of enzymes that digest protein and sugar, with the effect more pronounced in the older rats [R].

Another study found that the peptide increased enzyme activity in the small intestine of aged rats [R].

4) Epitalon Increases Melatonin Secretion and Corrects Circadian Rhythm

As we age, our circadian rhythms becomes disrupted and less pronounced, coinciding with decreased melatonin secretion and altered sleep cycles [R].

In aging monkeys, Epitalon stimulated evening melatonin secretion and reestablished the circadian rhythm of cortisol release. [R]

In 14 elderly people, epithalamin improved melatonin production and altered its cycle and peak concentrations to resemble those of young people [R].

5) Epitalon Fights Cancer


Many studies in rats and mice have shown that Epitalon strongly inhibits the development of cancer and tumors and induces cancer cell death.

When Epitalon was given to rats with colon cancer, Epitalon increased lymph flow (containing white blood cells) and apoptosis (programmed cell death), and slowed cancer growth [R].

In mice with mammary tumors, Epitalon significantly decreased the number of mice with multiple tumors and decreased the maximum size of tumors in comparison to control mice [R]. The researchers also found that the peptide reduced the expression of certain genes that, when over-expressed, play a key role in the development of breast cancer in both mice and humans.

Another study in mice found that treatment with Epitalon reduced the number of mice with malignant tumors (cancerous tumors) and prevented the cancer from metastasizing (moving to another location in the body) in all of the treated rats [R] In contrast, 3 out of the 9 mice that did not receive treatment with Epitalon saw metastases.

6) Epitalon May Treat Retinitis Pigmentosa and Improve Retinal Health


Retinitis pigmentosa is genetic, degenerative eye disease that results in the degeneration of the rods in the retina. Rods are one of two types of receptors in the eye (the other one being cones) that convert light into chemical signals that can be processed by the brain.

In a rats, Epitalon improves the function of retina cells by preserving their structure and preventing degeneration [R]. In a clinical trial,  improved degenerative damage to the retina (due to retinitis pigmentosa) in 90% of the patients [R].

7) Epitalon Improves Antioxidant Status

Oxidate stress, which occurs when the body has a deficit in antioxidant to counteract the effects of free radicals (molecules that are missing electrons), has been shown to play a causative role in many diseases, including heart disease, cancer, diabetes, and even neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases [R]

One of the most potent antioxidants produced by the human body (endogenous antioxidants) is melatonin [R]

Epitalon’s antioxidant effects are thought to be in part due to its ability to stimulate melatonin production as well as mechanisms other than through the action of melatonin [R]. In male rats, epithalamin increases total antioxidant capacity by 36% and superoxide dismutase (SOD, a powerful endogenous antioxidant) by 19%  [R].

When epithalamin was incubated with blood taken from breast cancer patients increased the activity of antioxidant enzymes and increasing levels of antioxidative vitamins [R]


While the preclinical studies on Epitalon look very promising, there is still a lot of research that needs to be conducted in healthy and diseased individuals.

Note: Epitalon has not been approved by the FDA.

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.


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  • Flavius Iuliaan

    Hi Jason you can let my you email adreess thanks

  • Bruce

    How long before you test your biological age again? Is it strictly a test of telomere length? I wonder how long the results will last without follow up treatments. There needs to be a lot more testing.

  • Jason

    So I’m just going to throw this out there to the world and see what happens. This is my own personal experience. I ordered a 2 test kit from teloyears in February 2017. The test result came back as I was a 63 year old man. I’m 37 and I’ve always tried to eat healthy and take care of myself and it came as a complete shock to me. I ordered 5 vials of various epitalon preparations. (2) of straight epitalon 100mg, (2) N-Acetyl Epitalon 100mg, (1) N-Acetyl Epitalon Amidate. I did 10 days of epitalon and took a week off. Next I did 10 days of the n-acetyl and took a week off. I then did 10 days of tbe amidate and took a week off. Then I worked my way backwards and did 10 days of the n-acetyl, took a week off. Lastly I did 10 days of the straight epitalon. After that, I waited 3 months and had myself retested. It took about 6 weeks to get the results and one day it showed up in the mail and my heart sunk. All I could think was I’ve wasted almost 500 bucks on supplies and had to give myself 50 injections. Why would I do something so foolish? I then opened the test results and staring back at me was an age of 18 and I’m now im the 97th percentile. Mu guess puts me closer to 11-15 because they won’t say less than 18 because that is a minor and I ran the charts. Do I feel any different? No, but I can tell you that my wife noticed that my hair is becoming darker. It’s taking time but mu hair is slowly coming in darker. It’s weird.

    1. Evguenia Alechine

      Thanks for sharing your story, Jason! 🙂

  • Ginger Adams

    So if one was to administer it, at their own risk for their own research, IM or subcutaneously, what is the dosing and would you use 30 ML bacteriostatic water? Comments on storage and optimal dosing?
    website with this info?

  • Neferius Nexus
  • Nathan

    I’m guessing there is zero research regarding its effects on telomeres? The dominant claim out there is that it stimulates telomerase.

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