Erythropoietin (EPO) is a hormone that helps treat Anemia, kidney diseases. It helps improve muscular performance, aids with bone regeneration.

Erythropoietin is a very important marker to monitor, especially if you haven’t been leading the best lifestyle or you have chronic health issues. With Lab Test Analyzer you can track erythropoietin levels and make sure they are always in the optimal range. Why wait until issues get out of hand and interfere with your work and daily life? Lab Test Analyzer has got you covered – it tracks your health and gives you actionable advice on how to improve it.

What is Erythropoietin?

Erythropoietin is also known as EPO, hematopoietin or hemopoietin is a glycoprotein hormone which controls erythropoiesis or red blood cell production. It is a protein signaling molecule for red blood cell (erythrocyte) precursors in the bone marrow.

Erythropoietin (EPO) levels in the blood are quite low in the absence of anemia, but in the condition of hypoxic stress, EPO production may increase up to 1000-fold.  Tissue hypoxia is the only physiological mechanism for increasing erythropoietin production (R).

Erythropoietin controls the proliferation, differentiation, and survival of red blood cell precursors (R).

Erythropoietin (EPO) is produced by the kidney in the adult and by the liver in the fetus, also by the brain in very little quantities (R).

Production of EPO

Loss of red blood cells in a normal individual due to bleeding or hemolysis reduce the delivery of oxygen to the tissues. When cells in the kidney and liver find this low oxygen level in tissues, they produce EPO (R).

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Health Benefits of Erythropoietin

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1) Erythropoietin is an Anti-inflammatory

In a randomized controlled trial, 94 patients with necrotizing enterocolitis were treated with recombinant EPO, results showed that EPO was able to reduce the levels of inflammatory response of TNF-α and IL-6 (R).

EPO increases the production of some cytokines (Th2 cytokines: IL-2, IL-4, and IL-10) by activated T cells. It could directly reduce the regulation of pro-inflammatory T cell responses and it cannot affect the T cell activation status (R).

Inflammation is said to play a key role in meconium aspiration syndrome (MAS). Recombinant human EPO is associated with improved BAL (bronchoalveolar lavage) fluid and serum cytokine levels. Pretreatment might also reduce the risk of developing MAS (R).

2) Erythropoietin Helps Treat Anemia

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The approved clinical uses of EPO are the anemias associated with end-stage kidney disease, cancer chemotherapeutic agents and patients with HIV infection (R).

A prospective observational case series study in Chronic kidney failure (CKD) patients with anemia suggested the use of erythropoietin along with iron as an effective and beneficial treatment especially in patients with low hemoglobin (R).

EPO treatment reduced the number of blood transfusions in preterm infants with anemia (R).

For the treatment of anemia in patients receiving cytotoxic chemotherapy, administered EPO shortens the period of symptomatic anemia (R).

3) Erythropoietin Enhances Muscular Performance

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EPO as blood doping improved the athletes’ long-duration muscular performances much more than expected by increasing red blood cells which carry the oxygen to tissues (R).

Experimental evidence and clinical experience show that erythropoietin has a positive effect on skeletal and cardiac muscle. Mice lacking EPO or its receptor suffer from incomplete development of heart and have a reduced number of proliferating cardiac muscle cells (R).

4) Erythropoietin Protects the Brain

EPO is a promising neuroprotective agent and is currently in Phase III clinical trials for the treatment of traumatic brain injury. It has a bimodal effect on cell death, glial reactivity, and oxidative stress (R).

5) Erythropoietin Could Prevent Eye Damage

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Studies showed that treatment with EPO protects the retina after trauma. Either intraocular delivery of EPO or treatment with non-erythropoietic forms of EPO may be more effective (R).

6) Erythropoietin for Bone Regeneration

Studies in animals showed that EPO has significant effects on bone formation and angiogenesis (development of new blood vessels) and has the capacity to promote the repair of bone defects (R).

7) Erythropoietin for Wound Healing

A Phase II clinical study states that low doses of EPO promoted wound healing of ulcers in diabetics (R).

In a Double-blind, randomized, placebo-controlled trial EPO mouthwash when given to patients with Oral mucositis (OM) and undergoing autologous hematopoietic stem cell transplantation reduced the incidence and duration of OM (R).

Other

The use of recombinant human erythropoietin as a performance-enhancing agent is dangerous particularly in the less fit athlete (R).

Elevation of red cell mass by recombinant human EPO  is associated with the reduction in plasma level and also hypertension is induced in some patients (R).

Technical

  • EPO receptor activation induces the stimulation of JAK2, which leads to tyrosine phosphorylation of several proteins including EPO receptor itself (R).
  • EPO receptor binding leads to intracellular activation of Ras/MAPK and other pathways, which have a role in cell proliferation (R).

Increasing Erythropoietin

Everyone is different and our bodies can be complex. If you want to increase your erythropoietin levels, it’s best to analyze them with Lab Test Analyzer. This tool will compute, based on this and your other results, the best steps you can take that will bring you back to optimal.

  • Sauna (R)
  • Rhodiola (Salidroside) (R)
  • Rehmannia (Catalpol) (R)
  • Astragalus (R)
  • Spirulina (Phycocyanin)
  • Emodin (R)
  • Interval Exercise
  • Arachidonic acid
  • Echinacea
  • Cobalt (R)
  • Kidney glandular
  • HIF-1a
  • Echinacea (R)
  • Astragalus (R)
  • Beetroot juice (RR2)
  • Spirulina (R)
  • Dietary protein (R)
  • Portulaca oleracea L. (R)
  • Altitude training (R)

Irregular Eryhtropoietin Levels?

If you have not yet tested your erythropoietin levels, I recommend that you ask your doctor to do it. If you already have your blood test results and you’re not sure what to make of them, you need to check out Lab Test Analyzer. It does all the heavy lifting for you. No need to do thousands of hours of research on what to make of your various blood tests.

People don’t realize that their blood test results contain a gold mine of information that’s waiting to be unearthed. Unfortunately, not everyone has the time or the inclination to sift through dozens of research papers.

It’s super-simple, so that even if you don’t have any background in science, you will understand what your results mean and what you can do to get them in the optimal range.

Lab Test Analyzer gives you up-to-date scientific information about your lab results. In addition, you will get both lifestyle tips and natural solutions to help you optimize your health. You can also rely on our science-based Optimal Ranges to prevent potential health issues and maximize your overall well-being.

All of the content is backed by science and researched by a team of PhDs, professors, and scientists.

We’re all unique, so we deserve solutions that treat us that way.

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

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