- Introduction: What is Glucosamine?
- Health Benefits of Glucosamine
- Technical Section
- Side Effects
- Buying Glucosamine
- Health Tools I Wish I Had When I Was Sick
Introduction: What is Glucosamine?
Glucosamine (GluN, 2-amino-2-deoxy-β-d-glucopyranose) and its acetylated derivative, N-acetyl glucosamine, are naturally occurring amino sugars found in the human body (R).
It is also an essential noncellular component of connective tissue, cartilage, ligaments and other structures in humans (R).
There are three salt forms:
- Glucosamine Hydrochloride (HCI).
- Glucosamine Sulfate (better absorbed than glucosamine HCI).
- N-acetyl Glucosamine
In the US, it is the most common non-vitamin, non-mineral, dietary supplements used by adults (R).
Health Benefits of Glucosamine
1) Glucosamine Relieves Symptoms of Osteoarthritis
Glucosamine improves symptoms and decreases structural progression in osteoarthritis (OA) when compared to the NSAIDs (Non-Steroidal Anti-Inflammatory drugs) and placebo (R).
Several clinical trials have demonstrated the symptom-modifying and joint space narrowing effects in OA patients (R).
In one study osteoarthritis patients given a combination of glucosamine hydrochloride and chondroitin sulfate for 6 months had a decrease in pain, stiffness, functional limitation and joint swelling (R1, R2).
It is one of the most common nutritional supplement used by athletes (R).
It is also used by athletes with osteoarthritis (R).
Glucosamine administration in athletes with acute knee injury demonstrated a significant improvement in knee flexion and extension after 28 days when compared to the placebo (R).
2) Glucosamine Exerts an Anti-Inflammatory Action
Glucosamine inhibits the production of inflammatory mediators such as cytokines (R).
It suppresses inflammatory cell activation in animals (R).
Children with chronic inflammatory bowel disease, given N-acetyl glucosamine orally, showed a clear improvement in their symptoms (R).
3) Glucosamine Reduces the Risk of Lung Cancer
One study has revealed that there was the greatest reduction (51%) of lung cancer associated with high use of Glucosamine (R).
In another study, it was found to arrest lung cancer cells in the G1/S phase (by the inhibition of cyclin E and Skp2 protein expression) (R).
4) Glucosamine Suppresses the Formation of Fat Accumulation
Glucosamine administration inhibits the formation of atherosclerotic lesion (fat accumulation) and infiltration of inflammatory cells into the lesion (R).
5) Glucosamine is an Antioxidant
6) Glucosamine is Good for the Skin
Glucosamine compounds have been reported to have several beneficial effects on the skin and the skin cells. It has been shown to accelerate wound healing, improve skin hydration and decrease wrinkles (R1, R2).
An anti-aging neck and decolletage cream containing N-acetyl glucosamine delivered significant firming and smoothing effects with reduced hyperpigmentation in women seeking rejuvenation (R).
- Synthesized in the body via the Hexosamine biosynthetic pathway (HBP) (R).
- Exerts its therapeutic effect in osteoarthritis by inhibition of the COX-2 enzyme (R).
- Suppresses the TNF-α-induced production of MCP-1, expression of ICAM-1, and abrogated the phosphorylation of p38MAPK and NF-κB (R).
- Increases glutathione biosynthesis and effects transcription regulation (R).
- Efficiently promotes cell death by inhibiting TGase 2 (transglutaminase 2)-mediated NF-kappaB activation in drug-resistant breast cancer cells (R).
- Specific glucose transporters – GLUT 1, 2 and 4 – transport the extracellular glucosamine into muscle and adipose tissues (R).
- Suppressed the TNF-α-induced activation of intestinal epithelial and endothelial cells, improved the clinical symptoms, colonic inflammation and tissue injury in dextran sulfate sodium-induced colitis in rats, suppressed the IL-1β-induced activation of synovial cells.
- Activates endothelial cells possibly via O-GlcNAc modification (R).
- It stimulates hyaluronic acid synthesis (R).
Coadministration with paracetamol and statin may inhibit the metabolism of these drugs by lowering the concentration of paracetamol metabolites, which may have an influence on the side effects of these drugs (R).
Increased levels also impair insulin secretion. Although there is some evidence for worsening glucose parameters especially in pre-diabetic subsets, the majority of evidence suggests that there is no severe effect in either healthy or pre-diabetic people (R).
External use could increase the activity of Hexosamine biosynthetic pathway (HBP) (R).
Reports from the FDA and WHO suggest that the use of Warfarin and Glucosamine was associated with an altered coagulation (manifested by increased bleeding or bruising) (R).
Glucosamine at a dosage of 1500 mg per day is said to be safe as in many clinical studies.
In most clinical studies on treating osteoarthritis the typical dose used was 500 mg three times a day (or) 1500 mg once-a-day (R).
Steady-state peak concentrations at the therapeutic dose of 15oo mg in humans were in line with those found to be effective in selected lab studies (R).
Injected into muscles for osteoarthritis: 400 mg of glucosamine sulfate has been injected twice weekly (R). N-acetyl-glucosamine is also available as an enema.
It is not recommended for children since its safety in children has not been studied.
Health Tools I Wish I Had When I Was Sick
At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.
That’s why I decided to create tools that will help others cut down the guesswork:
- Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
- SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
- SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
- SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
- Selfhacked Inflammation course – a video course on inflammation and how to bring it down
- Biohacking insomnia – an ebook on how to get great sleep
- Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
- BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
- SelfHacked VIP – an area where you can ask me (Joe) questions about health topics
The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.
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