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Palmitoylethanolamide (PEA) is a natural substance that has many health benefits. It stops pain and inflammation, protects the heart, and improves brain function. Read more below to learn about its effects and be sure to check out our ebook SelfHacked Secrets for a comprehensive guide to biohacking your way to health. Download the first chapter for free by clicking here.
Palmitoylethanolamide, or PEA, is a substance produced in the body naturally to combat inflammation. Outside the body, it can be found in soybean lecithin, egg yolk, peanut meal and other foods (R).
In addition, PEA is available as a supplement in tablet, capsule, and powder form to help with chronic and neuropathic pain relief. It is commonly used in Italy and Spain as a food supplement.
Since its discovery in the 1950’s, it has been widely researched as a pain suppressant and anti-inflammatory. It has found to have little to no known side effects (R).
Health Benefits of Palmitoylethanolamide
1) PEA Reduces Pain and Inflammation
In humans, PEA reduced the pain intensity in patients given a PEA supplement than those without a PEA supplement (R).
PEA reduced pain levels in patients with back pain better than in patients not given PEA (R).
In women with pelvic pain, PEA improved the pain and sexual function symptoms in 6 months (R).
PEA decreased pain intensities in patients with fibromyalgia syndrome (R).
In chemotherapy-caused pain, PEA can help treat nerve pain in cancer patients (R).
In animals, adelmidrol, a PEA equivalent, reduced acute and chronic inflammation (R).
PEA-treated mice had less inflammation and lung damage than those treated without PEA (R).
PEA has an anti-inflammatory effect on mice with collagen-induced arthritis (R).
In mice, PEA helped reduced spinal cord injury-induced inflammation (R).
2) PEA Protects the Brain
In stroke patients given PEA, recovery outcomes, such as cognitive skills and brain status, improved compared to stroke patients not given PEA (R).
PEA improved cognitive and social behaviors in autistic children (R).
In mice, PEA helps preserve brain cells and reduces the expression of pro-inflammatory enzymes. PEA may reduce brain inflammation and brain cell death (R).
Mice given PEA had improved results in neuron regeneration after spinal cord injury (R).
In rats, a pre-treatment of PEA reduced seizure duration, indicating PEA may also have anti-epileptic properties (R).
In mice injected with neurotoxins, PEA reduced some of the neurotoxic and neuroinflammatory effects (R).
3) PEA Benefits the Heart
In mice with induced heart attacks, PEA reduced heart tissue injury, levels of inflammatory cytokines, and cell death (R).
Rats treated with PEA for 5 weeks had lower blood pressure than rats not treated with PEA (R).
4) PEA is Good for Eye Health
In patients with eye diseases, PEA has anti-inflammatory benefits in eye cells and may be used as a treatment supplement, especially for those with glaucoma and diabetic nerve damage (R).
Additionally, PEA counteracted eye pressure that occurred after eye surgery (R).
In human patients with normal tension glaucoma, PEA treatment improved the visual field (R).
In diabetic rats, PEA reduced inflammation in eye cells but preserved the blood-retinal barrier (R).
Also, PEA reduced inflammation in rats’ eyes and reduced damage (R).
5) PEA Helps Gut Function
Adelmidrol, a PEA equivalent, is anti-inflammatory and can help manage inflammatory bowel disease (R).
In rats, PEA lowered blood pressure and helped protected against kidney injury (R).
PEA also normalized intestinal movement in mice with irritable bowel syndrome (R).
- Palmitoylethanolamide exerts neuroprotection and reduces inflammatory secondary events associated with brain ischemia-reperfusion injury (middle cerebral artery occlusion (MCAo)) (R).
- In one pivotal, double-blind, placebo-controlled trial in 636 sciatic pain patients, the number needed to treat to reach 50% pain reduction compared to baseline was 1.5 after 3 weeks of treatment (R).
- Interestingly, Palmitoylethanolamide also showed protective scavenging effect, through superoxide dismutase induction, and dampened unfolding protein response, interfering with glucose-regulated protein 78 expression and PERK-eIF2α pathway (R).
- Palmitoylethanolamide treatment reduces myocardial tissue injury, neutrophil infiltration, adhesion molecules (ICAM-1, P-selectin) expression, proinflammatory cytokines (TNF-α, IL-1β) production, nitrotyrosine and PAR formation, nuclear factor kB expression, and apoptosis (Fas-L, Bcl-2) activation (R).
Health Tools I Wish I Had When I Was Sick
At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.
That’s why I decided to create tools that will help others cut down the guesswork:
- Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
- SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
- SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
- SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
- Selfhacked Inflammation course – a video course on inflammation and how to bring it down
- Biohacking insomnia – an ebook on how to get great sleep
- Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
- BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
- SelfHacked VIP – an area where you can ask me (Joe) questions about health topics
The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.
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