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Phosphatidylserine is an amino acid derivative and is found in high amounts in the brain. It helps cells keep intact and is proven to improve mental focus, memory, mood, and bone health. Read this article to know more about the other amazing health benefits of phosphatidylserine.



Phosphatidylserine (PS) is a phospholipid and is a component of the cell membrane.

Health Benefits of Phosphatidylserine

1) Phosphatidylserine Improves Memory


Phosphatidylserine supplementation increased the speed of calculations done in short-term memory by 20% in a group of healthy adult volunteers [R].

Children with ADHD also saw in improvement in short-term memory after supplementing phosphatidylserine [R].

Senior citizens who supplemented phosphatidylserine had a lower incidence of short-term memory complaints following supplementation [RR].

2) Phosphatidylserine Improves Stress Response

Supplementing phosphatidylserine lowered the release of cortisol, the hormone which is associated with many of the negative effects of stress [R].    

Studies also found that subjective responses to stress, measured in a survey known as the Trier Social Stress Test (TSST), were improved with the supplementation of phosphatidylserine [RR].

3) Phosphatidylserine Aids Athletic Performance

Phosphatidylserine may also increase the time that it takes for people who are exercising to become tired [R].  This could help athletes gain more of the positive effects of exercising by exercising more.

While exercise brings a huge number of benefits, it can also cause a temporary increase of stress hormones [R]. Phosphatidylserine measurably reduced the negative hormonal response to exercise in multiple studies, which could be beneficial to athletes [R, R].   

One study also found a correlation with increased performance in subjective athletic ability in trained golfers following supplementation [R].

4) Phosphatidylserine Helps Relieve ADHD Symptoms in Children

Phosphatidylserine supplementation improved ADHD symptoms in children with ADHD. More research may be needed to see if the same efficacy is seen in adults [R].

A DB-RCT showed Phosphatidylserine supplementation (300mg PS-Omega3/day for 15 weeks) was safe and tolerated well [R].

5) Phosphatidylserine Helps Prevent and Treat Alzheimer’s Disease

The hereditary form of Alzheimer’s is associated with an accumulation of a  chemical waste substance called amyloid beta in the brain.  Studies have shown that phosphatidylserine prevents  amyloid beta from accumulating in the brain, which could help prevent or slow the progression of the disease  [R].

6) Phosphatidylserine Aids Recovery From Injury

Due to the many roles that it plays as an integral part of cell structure, there is evidence that phosphatidylserine may aid recovery from physical injury.

Phosphatidylserine may contribute to recovery from reduced blood flow.

Due to phospatidylserine’s integral role in cell membranes, researchers have suggested that phosphatidylserine could aid in recovery after situations resulting in impaired blood flow, such as heart disease [R].

Phosphatidylserine also aids in the formation of bones from minerals in the body, and researchers have suggested potential applications for phosphatidylserine as a bone repairing molecule for use in recovery from surgery [R].

Buy Phosphatidylserine

Potential Negative Effects

Historically, phosphatidylserine has been sourced from cow brain tissue [R], which carries a risk of contamination and disease transmission [R].   

Phosphatidylserine is now more commonly sourced from soy extracts, which is not associated with the same risks [R].


  • Phosphatidylserine decreases ACTH secretion in response to social stress  [R, R].
  • Phosphatidylserine decreases ACTH secretion in response to physical exertion [R, R].
  • Phosphatidylserine normalizes the disturbed glucose metabolism associated with Alzheimer’s disease [R].
  • Phosphatidylserine in cell membranes is disrupted by progesterone. Thin liquid films containing phosphatidylserine were encouraged to rupture when progesterone was added to cell cultures [R].
  • Mice exposed to phosphatidylserine and factor VIII showed less of an immune response to the clotting factor FVIII and increased the response to other antigens [R].

Health Tools I Wish I Had When I Was Sick

At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on PubMed to figure out how the body worked and how to fix it.

That’s why I decided to create tools that will help others cut down the guesswork:

  • Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
  • SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and Ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
  • SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
  • SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
  • Selfhacked Inflammation course – a video course on inflammation and how to bring it down
  • Biohacking insomnia – an ebook on how to get great sleep
  • Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
  • BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
  • SelfHacked VIP – an area where you can ask me (Joe) questions about health topics

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  • Jeffrey

    Link to study on PS+DHA in ADHD children only says that it’s safe to use, nothing about whether it helped ADHD symptoms.

  • Laura

    I would also like to know od ot can lower your cortisil too much!!

  • Constance Jean Stieger

    Can you take too much phosphatidylserine and lower cortisol too much?

  • Ana Smith

    Loriann, here is the soy-free product I take.
    PS150 Phospatidylserine (Soy-free) by Designs

  • Joe

    PS can also be sourced from sunflower. Swanson does one. Also Viridian, called Cogniserine if i remember well

  • Loriann Rivard

    I am interested in taking phosphatidylserine. Would you happen to know if a product that does not contain soy in phosphatidylserine?

  • David Planz

    Has PS been studied re: its affect on pulmonary disease (emphysema, asthma, etc.)?

  • Caylan


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