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Phosphatidylserine is an amino acid derivative and is found in high amounts in the brain. It helps cells keep intact and is proven to improve mental focus, memory, mood, and bone health. Read this article to know more about the other amazing health benefits of phosphatidylserine.



Phosphatidylserine (PS) is a phospholipid and is a component of the cell membrane.

Health Benefits of Phosphatidylserine

1) Phosphatidylserine Improves Memory


Phosphatidylserine supplementation increased the speed of calculations done in short-term memory by 20% in a group of healthy adult volunteers [R].

Children with ADHD also saw in improvement in short-term memory after supplementing phosphatidylserine  [R].

Senior citizens who supplemented phosphatidylserine had a lower incidence of short-term memory complaints following supplementation [R], [R1].

2) Phosphatidylserine Improves Stress Response

Supplementing phosphatidylserine lowered the release of cortisol, the hormone which is associated with many of the negative effects of stress [R].    

Studies also found that subjective responses to stress, measured in a survey known as the Trier Social Stress Test (TSST), were improved with the supplementation of phosphatidylserine [R], [R1].

3) Phosphatidylserine Aids Athletic Performance

Phosphatidylserine may also increase the time that it takes for people who are exercising to become tired [R].  This could help athletes gain more of the positive effects of exercising by exercising more.

While exercise brings a huge number of benefits, it can also cause a temporary increase of stress hormones [R]. Phosphatidylserine measurably reduced the negative hormonal response to exercise in multiple studies, which could be beneficial to athletes [R], [R1].   

One study also found a correlation with increased performance in subjective athletic ability in trained golfers following supplementation [R].

4) Phosphatidylserine Helps Relieve ADHD Symptoms in Children

Phosphatidylserine supplementation significantly improved short-term auditory memory in children with ADHD  [R].

Phosphatidylserine combined with DHA also helped improve the memory and behavioral symptoms of ADHD in children more than DHA alone [R].  More research may be needed to see if the same efficacy is seen in adults.

5) Phosphatidylserine Helps Prevent and Treat Alzheimer’s Disease

The hereditary form of Alzheimer’s is associated with an accumulation of a  chemical waste substance called amyloid beta in the brain.  Studies have shown that phosphatidylserine prevents  amyloid beta from accumulating in the brain, which could help prevent or slow the progression of the disease  [R], [R1].

Alzheimer’s Disease causes the brain to use glucose less efficiently [R]. Phosphatidylserine supplementation improved glucose metabolism in brains affected by this condition [R].

6) Phosphatidylserine Aids Recovery From Injury

Due to the many roles that it plays as an integral part of cell structure, there is evidence that phosphatidylserine may aid recovery from physical injury.

Phosphatidylserine may contribute to recovery from reduced blood flow.

Due to phospatidylserine’s integral role in cell membranes, researchers have suggested that phosphatidylserine could aid in recovery after situations resulting in impaired blood flow, such as heart disease [R].

Phosphatidylserine also aids in the formation of bones from minerals in the body, and researchers have suggested potential applications for phosphatidylserine as a bone repairing molecule for use in recovery from surgery [R].

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Potential Negative Effects

Historically, phosphatidylserine has been sourced from cow brain tissue [R], which carries a risk of contamination and disease transmission [R].   

Phosphatidylserine is now more commonly sourced from soy extracts, which is not associated with the same risks [R].


  • Phosphatidylserine decreases ACTH secretion in response to social stress  [R], [R1].
  • Phosphatidylserine decreases ACTH secretion in response to physical exertion [R], [R1].
  • Phosphatidylserine normalizes the disturbed glucose metabolism associated with Alzheimer’s disease [R].
  • Phosphatidylserine in cell membranes is disrupted by progesterone. Thin liquid films containing phosphatidylserine were encouraged to rupture when progesterone was added to cell cultures [R].
  • Mice exposed to phosphatidylserine and factor VIII showed less of an immune response to the clotting factor FVIII and increased the response to other antigens [R].

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.


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  • David Planz

    Has PS been studied re: its affect on pulmonary disease (emphysema, asthma, etc.)?

  • Caylan


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