This post for pterostilbene is not up to the quality of Selfhacked Articles. Please be patient while it’s improved.
Pterostilbene is a powerful antioxidant that can help with everyday health by improving brain, heart, and immune system function. Since it has no known toxicity level, this is a good supplement to use. Read more below to learn more about its advantages.
- Introduction: What is Pterostilbene?
- The Pterostilbene That I Recommend
- Health Benefits of Pterostilbene:
- Sources of Pterostilbene
- Side Effects
- Buy Pterostilbene
- Health Tools I Wish I Had When I Was Sick
Introduction: What is Pterostilbene?
Pterostilbene is an antioxidant found in almonds, grape leaves and vines, and especially blueberries. It is chemically similar to Resveratrol, a chemical found in wine. The supplement is linked to improved cognition, reduced cholesterol and glucose, and increased insulin sensitivity (R).
It is currently being studied as the “better,” more effective version of resveratrol because it is more easily absorbed into the body (R).
The Pterostilbene That I Recommend
Health Benefits of Pterostilbene:
1) Pterostilbene Improves Brain Function
Working memory and dopamine release is related to pterostilbene levels in the hippocampus (memory center) (R).
Pterostilbene reduces the effect of glutamate-caused injuries in brain cells (R).
It also reduced brain cell death rate and increased cell viability in cells related to the development of Alzheimer’s disease (R).
When given supplements in their diet, rats had improved cognition in a 12-13 week time span (R).
In smaller doses, the antioxidant helps reduce anxiety and improve mood in mice subjected to cognitive tests (R).
2) Pterostilbene Reduces Blood Sugar
In hamsters with high cholesterol, daily dosages lowered blood glucose (R).
In normal and diabetic rats, blood sugar levels decreased and insulin levels increased (R).
Pterostilbene increased the activity of a blood sugar regulator in the liver tissue in diabetic mice (R).
3) Pterostilbene Has Anti-Cancer Effects
Pterostilbene increased cell death and decreased cell reproduction (R).
It prevents the development of blood vessels, an important role in tumor growth and cancer cell movement (R).
The antioxidant decreased cancer cell metastasis and increased the rate of cancer cell death. In human lung cancer, cancer cell migration also decreased (R).
Doses of this supplement lowered the rate of melanoma and pancreatic cancer cell growth by decreasing glucocorticoid production (R).
When fed this supplement, the level of pinostilbene increased in mice, which may play a significant role in causing cell death in colon cancer cells (R).
4) Pterostilbene Benefits the Muscular and Heart System
Pterostilbene helps restriction of blood reperfusion injuries by activating a certain pathway involved in injury response (R).
Blood pressure was lowered in adults with high cholesterol, but LDL or “bad cholesterol” increased (R).
When given a pterostilbene-caffeine supplement, resistance-trainer body builders’ quadricep muscles increased in thickness (R).
5) Pterostilbene Helps You Lose Weight
Middle-aged patients, who were not on cholesterol medication, lost weight after taking daily supplements. However, if the supplements were taken in addition with GSE, none of the weight loss effects were seen (R).
6) Pterostilbene Has Anti-Inflammatory Effects
It also reduced inflammation in human eye cells in a high sugar environment (R).
Additionally, endothelial cells have reduced inflammation (R).
7) Pterostilbene May Lengthen Your Lifespan
- Reactivates estrogen receptor-alpha receptor production in breast cancer cells (R).
- Suppresses self-renewal ability in lung cancer cells (R).
- Decreases MUC1, NF-κB, CD133, β-catenin,and Sox2 production (R).
- Activates the SIRT1-FOXO1/p53 pathway (R).
- Inactivates the NF-κB pathway regulated by TLR5 down-regulation (R).
- Suppresses inflammatory response via NF-κB inactivity in LPS or TNF-α-induced VSMCs by decreasing TLR5 production (R).
- Increases nuclear Nrf2 and HO-1 and NQO1 levels, increases production of anti-oxidants glutathione and superoxide dismutase (R).
- Reduced production of reactive oxygen species (R).
- Decreased tumor cell adhesion, migration and intracellular GSH levels (R).
- Increased the production of endoplasmic reticulum stress signaling-related molecules (GRP78, ATF6, p-PERK, p-eIF2α and CHOP) (R).
- Promoted the translocation of cytochrome c from mitochondria to cytosol and the activation of Caspase 9 and Caspase 12 (R).
- Stimulates and enhances sirt1 activity and production (R).
- Increases TSP-1 protein production levels (R).
- Decreases levels of oxidative damage biomarkers, malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), aconitase-2 and 8-hydroxydeoxyguanosine (8-OHdG) (R).
- Increases activity of superoxide dismutase 1 (SOD1) and peroxiredoxin-4 (PRDX4) during stress (R).
- Promotes phosphorylation of Akt and affects different PI3K/Akt pathway (R).
- Suppress human retinal endothelial cells, decrease TNF-α and IL-1β, inhibit NF-κB protein expression, reduce ROS production, and increase SOD activity (R).
- Decreases glucocorticoid receptor- and nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-dependent levels (R).
- Decreased the production levels of TRAP, cathepsin K (CTSK), matrix metalloproteinase 9 (MMP9) and proteins that turn genes on c-Fos, and nuclear factor of activated T cells cytoplasmic 1 (NFATc1) (R).
Sources of Pterostilbene
- Pterocarpus marsupium (Indian Kino tree) (R)
- Blueberry and deerberry (R)
- Grapes (R)
- Peanuts (R)
- Dracaena plants (R)
High dosages of pterostilbene can cause LDL cholesterol to increase. There are no other known side effects (R).
Health Tools I Wish I Had When I Was Sick
At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.
That’s why I decided to create tools that will help others cut down the guesswork:
- Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
- SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
- SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
- SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
- Selfhacked Inflammation course – a video course on inflammation and how to bring it down
- Biohacking insomnia – an ebook on how to get great sleep
- Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
- BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
- SelfHacked VIP – an area where you can ask me (Joe) questions about health topics
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