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This one mushroom offers immune support, reduces stress and anxiety, is anti-inflammatory, anti-cancer, and much more. Read more about Reishi mushroom to learn why it is traditionally called “The God of Fungi.” 


Ganoderma lucidum/“Lingzhi” (soul/spirit) mushroom, commonly known as “Reishi mushroom”, is a potent fungus which has been used for thousands of years in Chinese medicine. It is especially good at modifying the immune system by increasing it when weakened, or lowering it when it is too active (R).

It has 400 different bioactive compounds and these have been reported in scientific studies to have a number of effects including modification of the immune system, anti-inflammatory, anti-tumor, sleep promoting, antibacterial, antiviral, anti-diabetic, anti-oxidative, anti-aging and anti-ulcer to name a few (R)

My Experience With Reishi

Reishi is a Th1 stimulant and I’m Th1 dominant, so I don’t take it.  Reishi is great for people with cancer, chronic infections, and immunodeficiency but not for those with autoimmune issues.

Reishi Snapshot


  • Is anti-inflammatory
  • Helps reduce tumors
  • Lowers blood pressure
  • Helps you sleep
  • Reduces anxiety


  • Might overactivate immune system

Health Benefits of Reishi

1) Reishi Reduces Inflammation and Acts as an Antioxidant

Studies have shown reishi to reduce inflammation in rheumatism, asthma, inflammation of the membrane that lines the eye and eyelids without notable side effects (R).

14 days of reishi increased anti-inflammatory/antioxidant markers and protected the blood from oxidative damage. Researchers say this justifies the traditional use of Reishi by African and Chinese medicine as an anti-inflammatory agent (R).

Multiple kinds of extracts showed anti-inflammatory and antioxidant activity and can be considered a useful approach to various inflammation-related diseases (RR).

A study on people with advanced-stage cancer showed a decrease in TNF-alpha and IL-1 which are inflammatory cytokines (R).

2) Reishi Improves Anxiety and Depression

Breast cancer patients reported reduced anxiety and depression, as well as increased quality of life when they received reishi along with their cancer treatment. The group not receiving reishi did not report these effects (R).

3) Reishi Enhances the Immune System

Most people know about reishi for balancing immunity. G. lucidum can activate or deactivate certain parts of the immune system which is why it has a modulating role instead of a specific one area of action (R).

It contains high amounts of organic compounds that are proven to strengthen our immune cells and improve general immune system health (R).

It inhibits fungus growth up to 58% in 5 different fungal pathogens (R).

Reishi combined with antibiotics increased the antimicrobial activity much more than synthetic antibiotics alone (R).

The extract showed significantly enhanced wound healing activity (R).

Reishi extract has potent anti-malaria activity while at the same time protecting against liver damage (R).

4) Reishi Relieves Allergies

Studies have shown reishi extract to reduce and inhibit all four kinds of allergic responses (R).

Reishi has been used for various conditions, including chronic bronchitis because it reduces histamine. Studies reveal compounds found in reishi effectively inhibits the release of histamine from mast cells and stabilized mast cells at the same time (RRR).

5) Reishi Benefits the Heart

An extract of its protein has been shown to potently lower blood pressure with effects lasting up to 8 hours (R).

It also reduced damage to the cells that line blood vessels (R).

In people with diabetes, reishi can help reduce both cholesterol and insulin resistance (R).

6) Reishi Helps Prevent Cancer

It has significant benefits for multiple types of cancer including prostate and breast cancer. It does this via various mechanisms: inflammation reduction, and inhibition of cell and tumor growth. G. lucidum is useful for both prevention and possible treatment (RRR).

Reishi suppressed cell adhesion and cell migration of highly invasive breast and prostate cancer cells, which means it can be potent at reducing tumor growth (R).

Also, it is an alternative way to aid the treatment of leukemia (R).

Reishi has been found to significantly decrease fatigue, anxiety, and depression and improve the subjective well-being of breast cancer survivors and patients (R).

Treatment with reishi for 13 weeks showed reduced tumor growth and weight by roughly 50% and potent inhibition of things like mTOR which promote cancer (R).

Preclinical studies have shown that reishi has potent anti-tumor activity and strengthens the immune system in advanced-stage cancer (R).

7) Reishi Helps You Sleep

Chinese and Japanese herbalists traditionally recommend it for insomnia due to its sleep-promoting ability (R).

Modern science has found that it is useful for sleep (R).

8) Reishi Heals the Liver and Kidneys

14 patients with proteinuria, a sign of kidney disease, used reishi.  All 14 patients got rid of the proteinuria after using reishi and restored their immune system to proper balance (R).

Reishi protected against the damage done by moderate daily alcohol consumption on the liver in rats (R).

In malaria-infected animals, Reishi protected against liver damage while also potently suppressing the malaria infection (R).

9) Reishi Enhances Your Brain

Reishi also improved the brain function of the alcohol-consuming rats, both increasing the energy supply to the brain as well as decreased the amount of mind slowing neurotransmitters that alcohol increases (R).

G. lucidum protects the brain against seizures. It reduced IL-1B and TNF-a, which are compounds that can cause seizures (R).

10) Reishi Aids Gut Health

It helps prevent ulcers from forming and lowers fat in the body as well  (R).


  • Serum malondialdehyde content decreased with a corresponding significant (P<0.05) increase in superoxide dismutase, glutathione peroxidase, glutathione S-transferase, and glucose 6-phosphate dehydrogenase activities in the extract-treated groups compared to the infected but untreated group (R).
  • G. lucidum is the most effective inhibitor, with the lowest half maximal inhibitory concentration (64.09 ± 6.29 μg/mL) of the Nitric Oxide production (R).
  • The experimental group showed statistically significant improvements in the domains of physical well-being and fatigue subscale after intervention with TNF-a, IL-6 (R).
  • After 4 h administration of Reishi, the systolic pressure significantly decreased to 34.3 mmHg (19.5% change) and the effect was maintained up to 8 h of administration, with the decrease reaching as low as 26.8 mmHg (15% reduction-compare to base line a decrease of 26.8 mmHg is less than a decrease of 34.3 mmHg so it should give a smaller % reduction) (R).
  • Additionally, our results show that Reishi inhibited convulsions in rats from Kainic Acid-induced seizures, reduced the degeneration pattern, decreased astrocytic reactivity, and reduced the expression of IL-1β and TNF-α induced by KA (R).


1-2 caps per day of this extract, taken at night or afternoon depending on your response to it:

Reishi most commonly helps you relax, thus promoting sleep, but for some, it can also increase energy and wakefulness. Try it out to see how it affects you.

Side Effects

Most studies suggest none or no noticeable side effects noted by biological markers or subjective experiences (RR).

One study showed no evidence for liver, kidney or DNA toxicity with reishi intake (R).

Although very rare, it may make some autoimmune conditions worse by activating/increasing the already overactive immune system.

In general reishi aids in so many situations/conditions that it has landed a permanent spot in my favorite supplement list (RR).

Notes of caution: Some studies show it reduces NF-kB (inflammation) and some show an increase, so individual responses to it may vary. It might be most useful for balance/reduction of Th2 dominance and as an immune booster for Th1 dominance (RR).

Buy Reishi

Are You Struggling With a Chronic Health Issue?

If you are struggling with chronic health issues – the way I used to – you probably have piles of lab tests that can potentially tell you a lot about your health. However, doctors never had enough time to explain it properly. They will only notice it if the lab flags your test results as outside of normal. But what if all your results are coming back normal, yet you know you are feeling nowhere near healthy? They may even tell you there is nothing wrong with you, and that it’s all in your head – I’ve been there.

Lab Test Analyzer is the tool I wish I had when I was dealing with all my health issues. Instead of normal, it will tell you the optimal values for lab tests. And if you are outside the optimal range, it will give you actionable tips and recommendations that will help you get there.

However, most of the time, people’s issues cannot solely be detected by their labs.

The combination of environment, diet and genetics is the main reason why people come down with chronic health issues.

If you’ve gotten your genes sequenced, SelfDecode can help you determine if your health issues may be as a result of your genes, and then pinpoint what you can do about it.

In SelfHacked Secrets, we dissect the big 8 environmental factors that cause disease. It’s a great place to start your journey if you want to learn the basics of getting your health to be optimal.

Disclaimer and Caveats

See Disclaimer and Caveats

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.


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  • Joe

    “1-2 caps per day of this extract, taken at night or afternoon depending on your response to it:”

    Which extract? Shouldn’t this be listing an amount by quantity of active ingredients? Or at minimum by amount of substance?


    Can i add lemon juice to the said product to cure uterine fibroid?
    Should it be dry in room or outside?
    Can i utilize it in powder form or otherwise?

  • Francis teds

    Great information.. on

  • Håkon Martin Nilsen Bjerke

    Crawler Oz:

    According to Dr. Axe it converts excessive testosterone to dihydrotestosterone.

  • Tony

    I have been using Reishi for a decade so I consider myself as a well informed user. First and foremost, if you decide to consume reishi, always choose a hot water extraction type from full grown red reishi. Avoid biomass, fermented, mycelium based reishi as they are byproducts and tend to be much cheaper with little benefits. Beware of vendors that give you full of marketing talks or materials on their websites without really describing their products. I have personally been taking GanoPrime and ProFormula from Reishi Essence for 8 years. They are excellent choices, but not the cheapest. They have been in business for more than a decade so that alone should tell you they are here to stay and have been offering quality products. I have done my homework and spent a lot of money trying different ones at the beginning. I hope my lessons will help you get started with reishi without trials and errors.

  • crawloer oz

    I heard it reduces testosterone

    1. giuseppe

      what about testosterone and 5 alpha reductase? is it antiandrogenic? if it is antiandrogenic when one stop to take reishi 5 alpha reductase return to the normal levels?

  • Isabel

    May I ask for the location of the BIotech Lingzhi farm? I wonder if it´s the one in Taiwan, I´m also taking their ganoderma as well.

  • Ganoderma Lucidum Geek

    I visited a Bio Tech lingzhi farm and factory last year 2017 and their lingzhi extracts have both polysaccharides and triterpenes. The crude and fastest way to know if the lingzhi capsule contains triterpenes is by opening the capsule and taste it. It should be bitter in taste if there is triterpenes presence in the capsule (aka extracts).This company have been in operation for 3 decades. The chief researcher or scientist is our tour guide for our factory visit. We are very privilege and touched by his kind hospitality.

  • Shakeh

    I have a normal blood pressure, I want to use reishi but don’t want to get low blood pressure from using this . What should I do? Please use my e-mail so I know what to do.
    Thanks, Shakeh

  • Leanne

    Does this help anxiety and depression

  • Luke

    My father had pancreatic cancer and forewent chemo as he only had six months to live. The doctors were correct, that he would not be able to recover from it. However, he took Reishi Mushroom, brown rice, Barley Grass, seaweed, and many other herbal remedies and he managed to have great success in purging much of the cancer from his body. However, the damage had already been done to his body and even the dead cancer still had to filter through his overloaded pancreas.

    Though he still died, I never forgot the joy on his face when he “stuck it to the doctor” that his holistic medicine got rid of significant amounts of cancer without chemo. The doctor admitted it, but also reaffirmed that it had not removed the damage to the pancreas and it was still going to fail, and no extension to his life had been added.

    This does not disprove Reishi Mushroom’s benefits at all. Reishi Mushrooms were my first experience with herbal medicine that actually works and I can say I am grateful to have learned about it from my father. Because of Reishi, I have begun to approach herbal remedies.

    I’m still young… I’m definitely going to take Reishi Mushroom till I die.

  • Marc

    At the beginning of the above reishi scientific summary, you mention that you don’t take reishi as you’Re TH1 dominant. However, at the bottom of the page you mention how reishi has landed a permanent spot in your regimen.

    Which is accurate ?


  • Mark Kaylor

    The one that I have used for the last few years is Super Reishi from Mushroom Wisdom.
    They do a dual extraction, one with hot water, the other with alcohol. I also like the fact that they grow their Reishi on logs, the natural food source for this mushroom.

  • Mark Kaylor

    Thank you for this article but the Reishi you recommend doesn’t seem to contain the alcohol soluble triterpenes which are responsible for many of the action that you write about. A fully effective Reishi extract should be extract in alcohol and hot water in order to contain the array of active constituents.

    1. Natcha M

      Thank you. I added the Herb Pharm Reishi tincture to the suggestions. Do you have one in mind that you have great results with? ~Team SelfHacked

      1. Chance Isham

        Tonictinctures does a great job

      2. Mark Kaylor

        I use the Mushroom Wisdom Reishi since it is log grown and they extract in hot water and in alcohol.

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