Sceletium tortuosum is a plant commonly found in South Africa and is traditionally used to relieve pain and reduce hunger. Numerous scientific studies have also mentioned that it decreases anxiety, stress, and tension. If you are looking to improve your emotional resilience, lower stress levels, and feel better than ever check out our ebook, SelfHacked Secrets. Download the first chapter absolutely free here.
- Introduction: What is it?
- Where to Buy Scleretium
- Health Benefits of Sceletium Tortuosum
- Technical Section
- Health Tools I Wish I Had When I Was Sick
Introduction: What is it?
Sceletium tortuosum is a South African succulent plant known as Kanna which is traditionally known as a psychoactive herb. It is not known to be hallucinogenic or habit forming but is taken prior to stressing events such as hunting (traditional use) for its cognitive effects.
Sceletium tortuosum has been reported to elevate mood, reduce anxiety and stress and alleviate pain (R).
Where to Buy Scleretium
Health Benefits of Sceletium Tortuosum
1) Mesembrine Has Antidepressant Effects
Mesembrine present in Sceletium tortuosum has antidepressant property in animal studies. Its antidepressant activity has been observed in mice exposed to both chronic and acute stress. It caused a significant change in both immobility and swimming times. Mesembrine an alkaloid elicited its antidepressant effect by inhibiting 5HT reuptake. Piperine is reported to increase the serotonin level in the cerebral cortex and limbic areas and thus produced the antidepressant-like activity. However, further investigations about precise underlying mechanism are still required (R).
2) Mesembrine Has Analgesic Properties
Mesembrine appears to have analgesic properties without abuse liabilities or ataxia. This botanical has shown activity at δ2- and µ- opioid receptors; agonists at these sites show analgesic effects. These findings suggest that mesembrine may be a useful analgesic (R).
3) Sceletium Tortuosum May Have Anti-Anxiety and Anti-Stress Effects
Sceletium tortuosum, a member of the family Mesembryanthemaceae, is one of the plants traditionally claimed to have sedative and anti-anxiety properties. In a recent review, the anecdotally reported anti-stress effects of Sceletium tortuosum was ascribed to the alkaloids contained in the plant, which includes mesembrine, mesembrenone, Δ7 mesembrenone, mesembranol, and epi-mesembranol. Sceletium exhibits some promising anti-anxiety effects, much more research of a species-specific nature is required to define the dosage to be used, since there seems to be a fine line between therapeutic and detrimental dosage range (R).
4) Sceletium Tortuosum May Improve Cognition
One study in 16 otherwise cognitively healthy middle-aged adults (45-65yrs) found supplementation of 25mg of a 2:1 Kanna extract containing 0.4% total alkaloids (mesembrenone, mesembrenol, mesembrine, and mesembranol) was able to improve executive function and cognitively flexibility when compared to control.
- One main mechanism of Kanna is inhibition of PDE4, which would promote the accumulation of cAMP in the regions where PDE4 is inhibited. As this enzyme and its isoforms are present in numerous brain regions it is thought to contribute to the psychoactive effects of Kanna.
- The mechanisms of action of the central nervous system (CNS) of a standardized extract of S. tortuosum(Zembrin) were recently identified as comprising blockade of the serotonin (5-HT) transporter and selective inhibition of the phosphodiesterase-4 (PDE4) enzyme (R).
Health Tools I Wish I Had When I Was Sick
At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.
That’s why I decided to create tools that will help others cut down the guesswork:
- Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
- SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
- SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
- SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
- Selfhacked Inflammation course – a video course on inflammation and how to bring it down
- Biohacking insomnia – an ebook on how to get great sleep
- Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
- BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
- SelfHacked VIP – an area where you can ask me (Joe) questions about health topics
The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.
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