Print Friendly, PDF & Email

Proline Rich Polypeptides (PRPs) are important parts of the immune and nervous systems. They are crucial for the development of newborns and are equally beneficial for the health of the elderly. In this article we will explore 10 key, scientific reasons why PRPs are an important addition to your supplement toolkit.


Proline rich polypeptides (PRPs), also known as Colostrinin, are a derived from Colostrum – the milk given to a newborn mammal as its first nourishment (R).

PRPs are not species-specific i.e PRPs derived from cow milk works on all mammals (R).

Since the immune system of a newborn is not fully developed, PRPs play an important role in immunity; showing antiviral, antibacterial, anti-tumor, and immunoregulatory activity (R).

PRPs could be important, not only for the development of the immune and nervous systems of newborns, but also in improving the health status of elderly persons (R).

As we will discuss, PRPs influence a wide variety of biological functions, such as the regulation of cell and tissue processes and the interactions of signal and regulatory proteins (R). They have also been shown to improve cognitive activity and behavior of old rats, humans, and chickens (R).

The PRP Supplement That I Take

Below, I give a few good sources of PRP, but some people want to to know exactly which one I take:

PRP Snapshot

  • Longevity7.5/10
  • Inflammation8.5/10
  • Mood7.5/10
  • Cognition8.5/10
  • Energy8.0/10


  • Improves brain function and memory
  • Mitigates food sensitivities by binding to tannins
  • Great immune system booster
  • Powerful anti-viral properties
  • Limits allergies
  • Protects brain from toxins
  • Has anti-tumor properties


  • Can cause mild insomnia and anxiety
  • Colostrum may cause reaction in some with dairy intolerance
  • Not recommended for pregnant woman

Benefits of Proline Rich Polypeptides (PRPs)

1) PRPs Regulate the Immune System

PRPs encourage the growth of white blood cells before stimulating the white blood cells to become either helper T-cells or suppressor T-cells (RR1).

  • Helper T-cells activate B-cells, another part of the immune system that produces antibodies to fight infections (R).
  • Helper T-cells also help produce memory T-cells, which help the immune system react quickly when new infections occur (R).
  • Suppressor T-cells turn off the immune response to avoid damage to healthy tissue (R).

Administration of PRP to AIDS sufferers was effective at returning T-cell (CD4+) count to normal or relatively normal levels. Within just a couple of days the patients symptoms (nausea, vomiting and diarrhea) had decreased dramatically (R).

PRPs promote appropriate responses to microbial invaders, toxins or allergens by regulating the immune system and natural killer cell activity (R).

PRPs behave as hormones in the thymus gland by stimulating young lymphocytes to grow into either helper T-cells or suppressor T-cells, depending on what is needed (R).

The net immune system effect of PRPs depend on the actual state of the animals studied. But broadly speaking, PRPs seem to restore the balance in cellular immune functions (R).

2) PRPs Regulate Inflammation


Chronic inflammation that we might get from a food intolerance or exposure to constant stress is a bad thing. However, sometimes inflammation is a healthy response – as is the case with an infection.

PRPs can stimulate the production of pro-inflammatory cytokines, like TNF-a and Interferon gamma (Th1 cytokine), in white blood cells, peritoneal cells, and placental and amniotic membranes (R, R1, R2).

PRP can increase the production of IL-6 and IL-10 in blood cell cultures (R).

PRP’s raise the permeability of blood vessels in the skin in order to allow the passage of blood cells and cytokines into the infected area in which they are needed – this is a vital step in the inflammatory response (R).

PRPs are able to stimulate the production of inflammatory cytokines by peripheral blood cells. PRPs will stimulate different cytokines depending on whether the immune system is under active or overactive (R).

PRPs decrease the severity of inflammatory diseases by altering genetic expression (R).

In a study on Alzheimer’s patients, PRPs defended against oxidative stress and lowered the expression of inflammatory chemokines and cytokines – thereby interrupting the processes that precede Alzheimer’s and other neurological diseases.

3) PRPs are Good for Cognition and Mood


One study discovered that PRPs had beneficial effects on the cognitive functioning of older rats (R).

While a different study found them to be effective in enhancing pro-cognitive functions in animal models and Alzheimer patients (R).

PRPs have also shown the ability to improve mood and cognitive abilities in humans (R).

They delayed the extinction of spatial memory and enhanced long-term memory in rats (R).

Chicks who had PRP-rich Colostrin injected into a part of their brain responsible for learning showed a marked improvement in memory function (R).

PRPs could also prevent or decrease the symptoms of neurodegenerative disorders like Alzheimer’s, Huntington’s, sporadic ALS, epilepsy and post-stroke neurodegeneration (R).

4) PRPs are Antiviral and May Treat Chronic Fatigue Syndrome


PRPs have been experimentally shown to provide immunity against several viruses, including:

Of particular note is PRPs ability to inhibit the replication of the Epstein-Barr virus and the human herpes virus-6 (HHV-6) – both of which have been linked with autoimmune conditions and chronic fatigue syndrome (R, R1).

5) PRPs May Prevent Age-related Loss of Brain Function

Alzheimer’s disease may be caused by age-related changes in the immune system (R). A hallmark of the disease is the formation of amyloid plaques in the patient’s brain.  PRPs have been shown to prevent the formation of these destructive brain plaques (R, R2).

One study showed that orally administered tablets containing PRP prevented overproduction of nitric oxide and improved the outcome of patients with Alzheimer’s disease (R).

Another study of 105 individuals with mild to moderate Alzheimer’s showed that 40% of participants treated with PRPs stabilized or improved (R).

One study gave PRPs to rats. The aged rats showed improved spatial learning. The young rats (<3 months) did not show the same benefits suggesting that PRPs are most beneficial for the elderly brain (R).

6) PRPs May Prevent Tumors

PRPs Stimulate the activity of natural killer cells, the cells that actually attack and kill pathogens, as well as cancerous cells (R).

They also stimulate the production of tumor necrosis factor-alpha (TNF-a), which causes cell death and prevents the formation of tumors (R).

7) PRPs Prevent Cellular Damage & Slow Aging


PRP acts as an antioxidant (R, R2).

When studied in mice, PRPs lowered reactive oxygen species (ROS), which cause cellular stress and damage (R).

PRPs reduce the chance of random mutations and mutations caused by ROS and toxins (R).

PRPs induce changes in cell signaling pathways involved in growth and maturation, and are important for suppressing uncontrolled activation of cells (R, R1).

One study found that PRPs can prevent mitochondrial dysfunction and limit brain cell death (R).

When introduced to a cellular model, PRPs increased lifespan, suggesting that they may delay the development of cellular aging for organism (R).

8) PRPs Prevent Allergic Responses

PRPs decreased immune response, airway constriction, mucus production and hypersensitivity caused by pollen and dust mites (R).

9) PRPs Protect Against Tannins

I believe tannins are second to lectins when it comes to harmful food agents that contribute to autoimmunity.

Tannins are found in many plant foods and are considered anti-nutritional because they can cause problems with digestion and absorption of nutrients (R).

Proline rich polypeptides provide protection against dietary tannins (R).

10) PRPs Can Protect the Brain Against Toxins

One experiment showed that PRPs possessed neuroprotective properties in mice with aluminum toxicity or neuronal damage from venom and toxins (R).

Potential Risks and Side Effects

Only one study reported any adverse side effects to PRP supplementation. These included very mild anxiety, excessive talkativeness, and insomnia that only lasted for 3 to 4 days (R).

During pregnancy the mother’s immune system is in a very delicate balance. She shifts to TH2 dominance to stop the her immune system from over reacting to the unfamiliar DNA of the child growing inside her. Because PRPs have such a dramatic impact on the immune system I recommend that pregnant women and women trying to get pregnant should avoid PRP products, or at least ask their doctor first.

Buy PRP Supplements

There are only a few good quality supplements on the market that contain extracted PRPs:

Even so, one of the best ways to get PRP is through taking whole colostrum products. These are ones I often recommend:


Health Tools I Wish I Had When I Was Sick

At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.

That’s why I decided to create tools that will help others cut down the guesswork:

  • Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
  • SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
  • SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
  • SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
  • Selfhacked Inflammation course – a video course on inflammation and how to bring it down
  • Biohacking insomnia – an ebook on how to get great sleep
  • Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
  • BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
  • SelfHacked VIP – an area where you can ask me (Joe) questions about health topics

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.


1 Star2 Stars3 Stars4 Stars5 Stars (3 votes, average: 4.00 out of 5)


  • Sean

    Joseph! I just started taking Colostrum and am having bad reactions. How do I tell if it’s die off, or if it is also a immune stimulant/allergen for me as well? What exactly do you personally feel when you take it?

  • prioris

    Because of the CFS/CFIDS/ME, I rarely ever had colds and flu’s and like you if my health got better, I would be more prone to them.

  • Whisper

    Goats Colostrum does work.

  • Whisper

    Joesph it was for me for a while. Not now. Have you tried the PRP Cytokines Colostrum Messenger Molecules. Or the Lactofferin?
    Lactoferrin stimulated me easy, but does not effect my Son. He said it stimulates his hormones. So he prefers Colostrum with Lactofferin to help the Immune stystem. They both can cause a Insomnia with me or interrupted sleep. I believe my Immune system is weaker and maybe this is the reason. Although I have heard many guys say Lactofferin effects the male hormones to much. JMHO

  • Barb

    Have you tried Goats Colostrum?

  • Sam

    Joe, when you first took PRP, did you notice benefits (especially from a cognitive perspective) within the first week or two?
    I wonder if something like PRP is going to serve greater benefit from a long term perspective, like growth hormone’s effects on cellular regeneration. I have tried colostrum in the past and have been mostly disappointed except for one (expensive) brand, but the health boost came 3 mths after first starting it so it was not conclusively responsible. I was looking at PRP (that colostrum brand claimed high levels) as a cheaper alternative, but people naturally what to see a beneficial change in their health asap when taking a new supplement to make the connection it has been worthwhile especially when they have limited funds.

    I am Th2 dominant and ma focusing on your Th1/Th2 balancing recommendations. I have CFS and am rundown/bad brain fog and have low immunity markers but never get colds/flu except for when my health/vitality levels pickup then ironically I pick up the colds/flu going around. Thanks

  • th

    How do you find colostrum from a casein point of view, do you find it an issue?

    1. Joseph M. Cohen

      Colostrum is too much of an immune stimulant and allergen for me

  • Leave a Reply

    Your email address will not be published. Required fields are marked *

    This site uses Akismet to reduce spam. Learn how your comment data is processed.