Pregnenolone is a supplement that everyone should read about.
It can help by increasing mood, motivation, and brain function. Pregnenolone feels like a steroid for the brain.
Our Lab Test Analyzer can help you keep your pregnenolone in the optimum range by allowing you to keep track of your levels, identifying causes of low or high levels, and giving you evidence-based lifestyle, diet, and supplement recommendations.
- About Pregnenolone
- My Experience and What I Use
- Pregnenolone Snapshot
- Pregnenolone Benefits
- 1) Pregnenolone Is a Nootropic and Boosts Cognitive Function
- 2) Pregnenolone Improves Learning and Memory
- 3) Pregnenolone Stimulates Deep Sleep
- 4) Pregnenolone Relieves Schizophrenia Symptoms
- 5) Pregnenolone Boosts Mood and Relieves Depression
- 6) Pregnenolone is Anti-anxiety
- 7) Pregnenolone Balances the Immune System
- 8) Pregnenolone Reduces Alcohol Preference and Intake
- 9) Pregnenolone Kills Brain Cancer Cells
- 10) Pregnenolone Protects from Cannabis Intoxication
- 11) Other Benefits
- Measuring Pregnenolone in the Blood
- Pregnenolone Side Effects
- Safety of Pregnenolone
- Pregnenolone Dosage
- Pregnenolone and Weight Loss
- What Else Increases Pregnenolone?
- Pregnenolone Goes Well With:
- When to Take Pregnenolone
- Pregnenolone on SelfDecode
- Buying Pregnenolone
- Health Tools I Wish I Had When I Was Sick
Pregnenolone and its sulfate (pregnenolone sulfate) are excitatory neurosteroids – they stimulate the brain [R].
Pregnenolone is the main steroid produced from cholesterol [R].
Ever since the 1940s, pregnenolone was reported to have anti-stress and mood-elevating effects on factory workers, students, and pilots.
Pregnenolone is the main precursor of many other steroid hormones [R].
For example, pregnenolone increases the level of other neurosteroids, such as pregnenolone sulfate and allopregnanolone.
Allopregnanolone is another molecule that increases the growth of neurons and decreases cell death and inflammation [R].
Like most products that can’t be patented, pregnenolone doesn’t have large clinical trials for various conditions. This is where self-hacking comes in – testing out if pregnenolone works for you.
My Experience and What I Use
I’ve been taking pregnenolone for 3 to 4 years, on and off and I really love it. However, it can take some time to figure out the right dosage. Pregnenolone doesn’t work for a lot of my clients. The most common issues with pregnenolone are that it gives people anxiety and they have more trouble sleeping.
For me, it will cause sleep issues if 1) I take too much, 2) I don’t exercise enough, or 3) I don’t exercise enough earlier in the day. Exercise makes pregnenolone convert to other hormones to produce cortisol. If I exercise later in the day with pregnenolone, it makes me more wired than usual (perhaps I have a larger cortisol spike).
I find when I was having chronic inflammation, I was deficient in pregnenolone. I’m not deficient now, but since I have a very heavy workload, I use more up, so in these times it’s useful.
- Great for cognitive enhancement
- Is relaxing and stimulating at the same time
- Increases motivation
- Increases wakefulness
- Increase hormones
- Good for libido
- Good for longevity
- May increase anxiety for some
- Can cause some sleep issues
1) Pregnenolone Is a Nootropic and Boosts Cognitive Function
Pregnenolone increases the growth of neurons [R].
Pregnenolone enhances myelination, enhances the formation of new synapses, and has neuroprotective properties. Myelin is a fatty layer that electrically insulates nerves, and is essential for their proper functioning [R].
Pregnenolone sulfate enhanced the survival of newborn neurons in adult mice [R].
Pregnenolone also improves neurological recovery [R].
Low blood levels of pregnenolone are found in the elderly, including those with dementia [R].
Pregnenolone sulfate decreases the activity of GABAA receptors, kainate, and AMPA receptors, and increases the activity of NMDA receptors [R].
This might be why pregnenolone increases anxiety in some.
By regulating microtubules, pregnenolone may increase neuronal development and plasticity of neurons during aging [R].
Pregnenolone boosts cognitive function for me and is one of my favorite nootropics. It goes well with infrared therapy/LLLT.
2) Pregnenolone Improves Learning and Memory
Pregnenolone/pregnenolone sulfate resulted in better performance of mice and rats in various mazes [R].
Pregnenolone sulfate prevented learning and memory deficits induced by certain drugs [R].
Pregnenolone boosts learning and memory for me.
3) Pregnenolone Stimulates Deep Sleep
Pregnenolone and its derivative allopregnanolone stimulated deep sleep in animal studies [R].
Low concentration of pregnenolone sulfate increased the amount of REM (paradoxical sleep), while high concentrations increased both REM and slow wave sleep (deep sleep) [R].
Pregnenolone increased the amount of time spent in deep sleep in human volunteers [R].
Deep sleep, in turn, helps consolidate memories.
Pregnenolone is more likely to worsen your sleep than benefit it. I have found pregnenolone (at 50 mg) delays sleep onset and results in less sleep for me. Other people also report insomnia from these doses.
4) Pregnenolone Relieves Schizophrenia Symptoms
Elevations in pregnenolone and allopregnanolone after pregnenolone treatment in schizophrenia were correlated with cognitive improvements [R].
Treatment with pregnenolone sulfate reduced schizophrenia-like symptoms and rescued the cognitive deficits in mice [R].
Pregnenolone reduced symptoms in patients with schizophrenia and schizoaffective disorder [R].
Low-dose pregnenolone together with antipsychotics reduced drug-induced side effects in schizophrenic patients [R].
5) Pregnenolone Boosts Mood and Relieves Depression
Pregnenolone has significant mood-stabilizing effects [R].
It also enhanced the activation of neurocircuits that control emotion [R].
Blocking allopregnanolone impaired social and emotional functioning [R].
A synthetic pregnenolone derivative acts as an antidepressant in rats [R].
Depressive disorders are associated with neuronal abnormalities in brain microtubule function [R].
By increasing formation and stability of tubules, pregnenolone increases neurite growth and can combat depression [R].
Pregnenolone boosts mood and motivation quite a bit. In fact, it increases mood and motivation more than anything else I’ve tried.
6) Pregnenolone is Anti-anxiety
Patients with general anxiety disorder have significantly lower levels of pregnenolone sulfate [R].
Pregnenolone does have anti-anxiety effects, but I’ve had some clients tell me it increases their anxiety. For me, it makes me more emotional and more passionate. This includes good and bad emotions. For example, a breakup would feel worse if I’m taking pregnenolone, but you are more likely to fall in love, in my experience.
7) Pregnenolone Balances the Immune System
Synthetic pregnenolone derivatives act as antiviral agents against the herpes simplex virus [R].
Pregnenolone suppresses immune cells to restore immune balance (homeostasis) [R].
8) Pregnenolone Reduces Alcohol Preference and Intake
Also, pregnenolone treatment significantly reduced alcohol self-administration in rats [R].
9) Pregnenolone Kills Brain Cancer Cells
Pregnenolone induced glioma cell death [R].
10) Pregnenolone Protects from Cannabis Intoxication
Pregnenolone protects the brain from cannabis intoxication [R].
11) Other Benefits
Pregnenolone has anti-arthritic, anti-aging, and anti-fatigue properties. It also lowers cholesterol [R].
Measuring Pregnenolone in the Blood
You can take a blood test to measure pregnenolone levels. High or low pregnenolone numbers can indicate that certain processes in the body aren’t optimal.
Pregnenolone Side Effects
1) Pregnenolone Can Impair Memory
Allopregnanolone impaired learning in rats [R].
2) Pregnenolone Can Reduce Wakefulness
Pregnenolone sulfate promotes sleep and can impair wakefulness [R].
3) Pregnenolone Can Cause Anxiety
I haven’t seen this in studies, but in some clients, pregnenolone can increase anxiety, even though it also has anti-anxiety actions.
Safety of Pregnenolone
Studies conducted in the 1940s and 1950s showed that pregnenolone at 25 to 500 mg/day was safe and well tolerated in humans, with minimal side effects, and did not affect weight, heart rate, blood pressure, menstrual cycle, or glucose levels [R].
Pregnenolone is very safe as far as toxicity.
Generally, if you do get a side effect from pregnenolone, you can stop taking it and it will go away. I’ve never heard of permanent negative effects.
I recommend starting out with 5 mg if you’re healthy and make sure to pay attention to your sleep.
If you have schizophrenia or chronic inflammation, you will want to take 25 mg a day (if your doctor thinks it’s a good idea).
Pregnenolone and Weight Loss
Pregnenolone inhibits the production of cortisol. This has the effect of causing fat loss since cortisol increases stomach fat (R).
By inhibiting cortisol, pregnenolone is naturally boosting testosterone levels, which is associated with a higher metabolic rate (R). This is another way pregnenolone may promote weight loss.
What Else Increases Pregnenolone?
- THC, the main active component of marijuana, substantially increased the production of pregnenolone [R]
- Stress [R]
- SSRIs and antipsychotic drugs used for treating depression and bipolar disorder: Clozapine, olanzapine and fluoxetine (Prozac) elevated pregnenolone levels in the brain and blood of rats [R]
Pregnenolone Goes Well With:
Pregnenolone goes well with aromatase inhibitors so that it doesn’t convert to estradiol.
My favorite aromatase inhibitors include:
Inhibiting cortisol production may also help.
When to Take Pregnenolone
I recommend taking it right upon awakening and exercising in the morning, and on an empty stomach – so that it gets absorbed more quickly.
Pregnenolone on SelfDecode
There are many dosages of pregnenolone you can buy. You can either buy a smaller amount or larger amount and break up the capsule.
Health Tools I Wish I Had When I Was Sick
At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.
That’s why I decided to create tools that will help others cut down the guesswork:
- Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
- SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
- SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
- SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
- Selfhacked Inflammation course – a video course on inflammation and how to bring it down
- Biohacking insomnia – an ebook on how to get great sleep
- Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
- BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
- SelfHacked VIP – an area where you can ask me (Joe) questions about health topics
The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.
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