Resveratrol is one of my favorite supplements. I use this for increasing the amplitude of my circadian rhythm, increasing energy production and for anti-inflammatory effects. Resveratrol makes me feel like I have excess energy.
- What is Resveratrol?
- Resveratrol Snapshot
- Resveratrol Benefits
- 1) Resveratrol is Anti-Aging
- 2) Resveratrol is Neuroprotective
- 3) Resveratrol Contributes to Heart Health
- 4) Resveratrol Benefits Glucose Balance
- 5) Resveratrol Combats Obesity
- 6) Resveratrol Helps Bones
- 7) Resveratrol May Prevent Cancer
- 8) Resveratrol Helps With Liver Health
- 9) Resveratrol Helps Muscle Growth
- 10) Resveratrol Protects Against Radiation
- 11) Resveratrol Prevents Hearing Loss
- 12) Resveratrol Increase Sex Hormones
- 13) Resveratrol Induces Autophagy
- 14) Resveratrol for Acne Treatment
- 15) Resveratrol Helps Fight Infections
- 16) Resveratrol Increases Sensitivity to Vitamin D
- When to Take Resveratrol
- What I Use Resveratrol For
- Resveratrol Synergies
- Food Sources of Resveratrol
- Side Effects
- Technical Information on Resveratrol
- Buy Resveratrol
What is Resveratrol?
Resveratrol came to scientific attention during the mid-1990s. Since then, it has been touted by manufacturers and examined by scientific researchers as an antioxidant (R), an anti-cancer agent, and a phytoestrogen. Commonly called “The French Paradox in a bottle.”
Resveratrol is a beneficial compound found in red wine that is associated with life extension and some of the health benefits in wine. It is produced in grapes as a defense against toxins and is abundant in the skins.
- Anti-aging and protects the brain.
- Reduces risk for heart disease.
- Anti-cancer and protects against radiation
- Helps fight infections: bacterial, fungal, and viral.
- Resveratrol binds to iron, so if you’re anemic that could be a problem.
- Certain medications and nutritional supplements are contraindicated.
- Taking over 5 grams may cause nausea or intestinal upset.
1) Resveratrol is Anti-Aging
2) Resveratrol is Neuroprotective
3) Resveratrol Contributes to Heart Health
Resveratrol has been investigated for its contribution to heart health after a meta-analysis first found a significant risk reduction associated with 1-2 glasses (150-300 ml) of wine daily (R).
Resveratrol is anti-atherogenic (reduces the formation of plaque in arteries) (R).
4) Resveratrol Benefits Glucose Balance
5) Resveratrol Combats Obesity
Resveratrol can cause the death of fat cells (R).
6) Resveratrol Helps Bones
Resveratrol increases bone cells by redirecting stem cells from becoming fat cells (R), which may increase bone health.
Resveratrol synergizes with Vitamin D for bone health (R).
7) Resveratrol May Prevent Cancer
It has shown promise on skin cancers when used on the body surface of mice (R).
Resveratrol is effective against esophageal cancer when ingested orally in rats (R).
Resveratrol’s anti-cancer effects come, in part, from its regulation of the topoisomerase II enzyme (R).
8) Resveratrol Helps With Liver Health
9) Resveratrol Helps Muscle Growth
Resveratrol has positive effects on muscle growth (R).
Resveratrol supplementation enhances aerobic performance (R).
10) Resveratrol Protects Against Radiation
Resveratrol has a good anti-radiation effect (at 100 and 300 mg/Kg concentration) (R).
11) Resveratrol Prevents Hearing Loss
Resveratrol has a protective effect on noise-induced hearing loss (R).
12) Resveratrol Increase Sex Hormones
High doses of Resveratrol can increase Testosterone.
13) Resveratrol Induces Autophagy
14) Resveratrol for Acne Treatment
15) Resveratrol Helps Fight Infections
Antiviral Activity of Resveratrol
Resveratrol inhibited herpes virus infection of ducks, geese etc. (R).
Resveratrol has shown to inhibit Herpes simplex virus-1 and Herpes simplex virus-2 (HSV-1 and HSV-2) (R).
Resveratrol has shown to inhibit the Respiratory Syncytial virus in mice (R).
Resveratrol also inhibited Varicella zoster and Enterovirus 71 (EV 71) (R).
Resveratrol inhibited African swine fever virus in-vitro (R).
Resveratrol inhibited Human rhinovirus (HRV) and Cytomegalovirus (R).
Anti-fungal Activity of Resveratrol
Antibacterial Activity of Resveratrol
Resveratrol showed antibacterial activity against MRSA in humans (Methicillin-Resistant Staphylococcus aureus) (R).
Resveratrol showed antibacterial activity against E.Coli (R).
Resveratrol inhibited the growth of Propionibacterium acnes, the bacteria which causes acne (R).
Resveratrol had an antibacterial effect on Haemophilus ducreyi (R).
Resveratrol inhibited Arcobacter butzleri and Arcobacter cryaerophilusa (R).
16) Resveratrol Increases Sensitivity to Vitamin D
When to Take Resveratrol
You must take resveratrol first thing in the morning.
What I Use Resveratrol For
I use resveratrol to improve circadian rhythm amplitude. Increasing your circadian amplitude results in increased energy in the daytime and increased tiredness at night.
When I take resveratrol first thing in the morning, I feel much more energetic that day.
Resveratrol, when taken along with few compounds, shows enhanced functioning.
Resveratrol, Genistein, and Quercetin together showed further synergism, and low dosing of these three can provide cumulatively similar benefits at cheaper costs (R).
This synergism has also been noted in regards to preventing skin cancer in mice (R).
Resveratrol Works with Quercetin to Increase Its Effects
The combination of resveratrol and quercetin, a flavonoid from certain foods, can also have more health benefits. For example, they combine their effects together to inhibit colon cancer and increase cancer cell death (apoptosis) in human cell culture [R].
In rats, this combination also significantly reduced fat tissue. In contrast, resveratrol or quercetin alone did not have any effect on the fat tissue. The combination of resveratrol and quercetin is synergistic [R].
Most supplements contain 50-500 mg of Resveratrol, but to get the dose equivalent in some animal studies people will have to consume 2 gm or more per day.
Many leading Resveratrol researchers believe that 5 mg of Resveratrol per Kg of body weight is the suitable amount for human intake. So for a 150-pound person (68 kg), this translates to 340 mg of resveratrol per day (R).
I personally take about 500 mg of resveratrol (I’m about 70 kg), which equates to roughly 3 teaspoons or 15 gm of the liposomal form.
Some studies showed that taking 150 mg of Resveratrol once daily for 30 days significantly lowered sleeping and resting metabolic rate (R).
Resveratrol Effectiveness Depends on its Delivery
The delivery of resveratrol might influence how effective it is on health.
In mice, scientists tested resveratrol’s effects when supplemented in a normal diet, a high-fat diet, and through a pump. They found that a high-fat diet helped increase antioxidant levels and mitochondrial activity in the brain [R].
Meanwhile, a normal diet did not show these same effects. A high-fat diet can help deliver resveratrol to different parts of the body and increase its effectiveness [R].
Food Sources of Resveratrol
Resveratrol can’t be found in meaningful concentrations in food. However, here are some foods which have resveratrol:
Resveratrol is found in the skin of red grapes. The richest source of resveratrol comes from the red grapes of Spain (1.89 mg per five-ounce glass) (R).
One cup of Boiled Peanuts contains 1.28 mg of Resveratrol.
Peanut Butter contains up to 13 mg per cup of Resveratrol.
A study revealed that 500 mg tablets are well tolerated by healthy men and women (R).
Resveratrol binds to iron, so if you’re anemic that could be a problem.
If taking medications that change the liver such as Mevacor, Nizoral, Sporanox, Allegra, and Halcion avoid this supplement.
HIV protease inhibitors and immunosuppressants.
Erectile dysfunction medications
Anti-viral or Anti-fungal medications
If taking any medications that slow blood clotting like Aspirin, Clopidogrel (Plavix), Diclofenac (Voltaren, Cataflam), Ibuprofen (Advil, Motrin), Naproxen (Anaprox, Naprosyn), Dalteparin (Fragmin), Enoxaparin (Lovenox), Heparin and Warfarin (Coumadin).
Resveratrol should be stopped at least two weeks before surgery.
Resveratrol Shows Conflicting Effects Based on Dosage Amount
Hormesis is when a chemical has harmful effects at high doses but can be beneficial at low doses. In various trials, resveratrol consistently showed hormetic responses, and opposite effects occur at low and high doses [R].
For example, at low doses in tumor cell lines, resveratrol increases estrogen activity (as an agonist) but stops estrogen activity at higher doses. At low concentrations, resveratrol can stimulate human tumor cell formation [R, R].
But in other diseases, low doses of resveratrol protects our health. It can benefit patients that have heart disease, osteoporosis, and Alzheimer’s. However, high doses can potentially be harmful [R].
People who take resveratrol for its health benefits need to be careful with their dosage [R].
Technical Information on Resveratrol
- Resveratrol induces Superoxide Dismutase (SOD) (R).
- Resveratrol increases Glutathione peroxidase (R).
- Resveratrol induces Heme-oxygenase 1 (R).
- Resveratrol induces Catalase (R).
- Resveratrol decreases iNOS (R).
- Resveratrol decreases Myeloperoxidase (R).
- Resveratrol induces Heme-oxygenase 1 (R).
- Resveratrol increases Glutathione reductase (R).
- Resveratrol increases the activity of NRF2 (R).
- Resveratrol decreases NADPH oxidase (R).
- Resveratrol decreases Lipid peroxides (R).
- Resveratrol inhibits cyclooxygenases and lipoxygenases (R).
- Resveratrol inhibits the NF-kB pathway (R).
- Inhibits HMGB1 (R).
- Resveratrol inhibits STAT3 and STAT5 (R).
- Resveratrol stimulates Endothelial nitric oxide synthase (eNOS) (R).
- Resveratrol increases PON1 (R).
- Resveratrol inhibits PDE (R)
Antimicrobial Activity of Resveratrol
- Resveratrol regulates PML-NBs (R).
- Resveratrol inhibits DNA gyrase (R).
- Resveratrol induces ROS (Reactive Oxygen Species) (R).
Resveratrol and Hormonal Effects
Increases the activity of Steroidogenesis acute regulatory protein (StAR), which increases hormone production.
Activities Related to Neurological Disease/Alzheimer’s
- Resveratrol downregulates Poly ADP-ribose (R).
- Resveratrol increases Glucose 6 phosphate dehydrogenase (G6PD) (R).
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