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Progesterone has a lot of benefits. People often have an imbalance of their progesterone and estrogen ratio – with too much estrogen and not enough progesterone.

What is Progesterone?

Progesterone belongs to a group of hormones called progestogens and these are involved in the menstrual cycle, embryo creation, and pregnancy of humans and other species (R).

Progesterone is produced and released by the ovaries and maintains fertility in women.

Progesterone and Fertility

Progesterone prepares the uterus for egg attachment and maintains pregnancy and prevents further ovulation during pregnancy.

Progesterone is required for ovulation, fertilization, and production of hormonal cells of endometrial glands.


Progesterone stimulates the growth of maternal breast tissue and milk glands. Progesterone needs estrogen to affect the breasts since estrogen induces the production of the progesterone receptors in breast tissue to prime the breasts (R).

Progesterone, estrogen, prolactin and other hormones work together during pregnancy to prepare the breast for lactation (R).

Too Little Progesterone

According to research, low levels of progesterone cause definite abnormalities (R).

Low progesterone may cause irregular or absent menstrual bleeding.

Low progesterone may be due to amenorrhea (no periods), failure to ovulate or possible miscarriage (R).

Low progesterone blood levels are associated with a low percentage of ovulation in infertile women. It can prevent women from getting pregnant (R).

Even in pregnant women, progesterone is still required to maintain the uterus. If it is at a low level, the uterus may not be able to carry the fetus and can result in a miscarriage (R).

Low progesterone level may result in or pregnancy that occurs outside of the uterus (R).

Too Much Progesterone

If the progesterone level is higher than normal level, this may be due to pregnancy, adrenal cancer, ovarian cancer, or congenital adrenal hyperplasia (R).

Congenital adrenal hyperplasia is a disorder that affects the adrenal gland by lacking an enzyme which the adrenal gland needs to make the hormones (R).

Progesterone pills, either alone or in combination with estrogen, prevent ovulation, as well as pregnancy.

Progesterone in Males

Although progesterone is thought as female sex hormone, it is also produced in the adrenal cortex in both sexes and in the testes of males (R).

The amount of progesterone is less in males than in females. It balances against the overactivity of testosterone and estrogen.

In some research, a higher level of progesterone receptors was found in prostate cancer cells, suggesting that progesterone has a role in this cancer (R).

Progesterone is also associated with fewer markers of obesity in men. Obese men with lower progesterone levels have higher BMI and waist circumference (R).

Progesterone in Hormone Therapy

Hormone therapy is used to treat certain symptoms of menopause. It works by replacing the estrogen that is no longer produced by the body (R).

Studies show that using synthetic progesterone (progestin) with estrogen increases the breast cancer risk compared to estrogen alone. By contrast, using natural progesterone with estrogen does not affect breast cancer risk (R).

Before the menopause years, cells from the endometrium are shed during menstruation. When the endometrium is no longer shed, cells are overgrowth in the uterus by estrogen, which can lead to cancerProgesterone decreases the risk of endometrial cancer by making endometrium thin.

Progesterone Snapshot


  • Great for weight loss: helps the thyroid, reduces cravings, and reduces water retention.
  • Reduces stress & anxiety.
  • Improves energy and sleep.
  • Helps PMS and Menopause.


  • May a cause headache and painful/tender breasts.
  • Prevents ovulation (causing missed periods), as well as pregnancy.
  • May increase risk for heart disease, and ovarian and prostate cancers.

Progesterone: The Good

1) Progesterone is an Anti-Inflammatory

Progesterone has anti-inflammatory actions (R).

It suppresses NF-κB and MAPK  activation, which then inhibits proinflammatory markers (like TNF-α, iNOS, and COX-2) (R).

2) Progesterone May Help Lower Weight 

Progesterone is also associated with fewer markers of obesity in men. This means that men with higher progesterone levels have lower BMI and waist circumference (R).

In hamsters, the combination of progesterone and 17 beta-estradiol interact to lower their fat (lipid) stores. This causes them to lose weight (R).

3) Progesterone Reduces Blood Pressure

Women’s blood pressure can rise after they go through menopause. Progestin, a synthetic version of progesterone, slightly lowers blood pressure in women with menopause. The combination of progestin and estrogen administration in 12 postmenopausal women lowered blood pressure by  6 to 7 mm Hg (R).

4) Progesterone Protects Bone Health

Progesterone stimulates bone growth. In human bone cells, progesterone administration promotes bone cell formation. It activates osteoblast (bone forming cells) activity (R).

Although progesterone does not prevent bone loss, it can work with other drugs as co-therapy to decrease fractures in postmenopausal women (R).

5) Progesterone Protects Against Cancer

In the endometrium, progesterone stops estrogen-driven cell growth. This helps protect against endometrial cancer (R).

In obese women, a progesterone deficiency can increase their risk for endometrial cancer (R).

6) Progesterone May Reduce Anxiety

Progesterone and progestin (synthetic progesterone) might help decrease anxiety in women. However, there does not seem to be a correlation between progesterone levels and anxiety in women with the menstrual dysphoric disorder (R, R).

In mice, progesterone administration helped reduce anxiety (R).

7) Progesterone Helps Sleep

Progesterone helps induce sleep (R).

In a study (DB-RCT) of 8 postmenopausal women, progesterone administration restored normal sleep when sleep was disturbed (R).

8) Progesterone Improves Mood

There are progesterone receptors located in the areas of the brain that are involved in thinking and emotion (hippocampus and amygdala). Progesterone increases serotonin transmission, which helps improve mood (R).

9) Progesterone Helps With Common Symptoms of Menopause

Estrogens levels fall by half during menopause. Progesterone levels reach zero (R).

The high ratio between estrogen and progesterone causes the problems of menopause.

Giving people progesterone cream can help with hot flushes, mood swings, insomnia, night sweats, vaginal dryness and restlessness (R).

10) Progesterone Causes Relief From Menstruation and PMS Symptoms

Causes of PMS include cyclical changes in hormones, changes in the brain, and depression.

Symptoms include anxiety, depression, joint or muscle pain, and feeling tired.

Progesterone along with other drugs called diuretics, NSAIDs, and antidepressants can help with these conditions (R).

14 days after ovulation, if there is no pregnancy, the uterus presses in and this causes bleeding.

Low progesterone causes uncontrolled menstrual bleeding, so progesterone administration can limit bleeding (R).

11) Progesterone Helps Maintain Fertility

Women with low progesterone levels can have otherwise unexplained miscarriages (R).

Progesterone is an important hormone during pregnancy. It decreases inflammation, which helps maintain early pregnancy (R).

In a review, progesterone administration helped improve pregnancy outcome in women that had miscarriages before (R).

12) Progesterone Improves Muscle Mass

In postmenopausal women, progesterone improves muscle mass by promoting muscle protein synthesis. It also increased MYOD1 gene activity, which helps increase muscle mass (R).

Progestin (synthetic progesterone) also increases muscle strength in postmenopausal women (R).

13) Progesterone Helps Reverse Baldness

At high doses, progesterone inhibits the enzyme 5-alpha reductase and prevents the conversion of testosterone to dihydrotestosterone (DHT) (R).

DHT is considered to be responsible for damaging hair follicles and an important factor in hair loss (R).

14) Progesterone Improves the Skin

Progesterone cream application can improve skin health in women. It slows down the skin aging process (R).

In a study (DB-RT) of 40 postmenopausal women, a progesterone cream improved elasticity and reduced more wrinkles than the control (R).

15) Progesterone Protects Nerve Cells

Progesterone improves the integrity and function of cell membranes. In the brain, progesterone receptors help protect nerve tissue (R).

Progesterone: The Bad

1) Synthetic Progesterone May Increase Heart Disease Risk

Synthetic Progesterone is associated with congestive heart failure (R).

2) Progesterone Might Causes Missed Periods

Progesterone causes mice not to ovulate or have periods (R).

Progesterone stops cells at the surface of the uterus from dividing and causes sores on the surface of the uterus. This causes the uterus to bleed (R).

3) Progesterone Increases Breast Cancer Risk

Progesterone can activate progesterone receptor target genes and increase cell formation/replication in breast cancer cells (R).

In a study of one million women, a treatment with estrogen and synthetic progesterone caused an increase in breast cancer risk (R).


Progesterone blocks the action of oxytocin.

Irregular Progesterone Levels?

If you have not yet tested your progesterone levels, I recommend that you ask your doctor for it. If you already have your blood test results and you’re not sure what to make of them, you need to check out Lab Test Analyzer. It does all the heavy lifting for you. No need to do thousands of hours of research on what to make of your various blood tests.

People don’t realize that their blood test results contain a gold mine of information that’s waiting to be unearthed. Unfortunately, not everyone has the time or the inclination to sift through dozens of research papers.

It’s super-simple so that even if you don’t have any background in science, you will understand what your results mean, and what you can do to get them in the optimal range.

Lab Test Analyzer gives you up-to-date scientific information about your lab results. In addition, you will get both lifestyle tips and natural solutions to help you optimize your health. You can also rely on our science-based Optimal Ranges to prevent potential health issues and maximize your overall wellbeing.

All of the content is backed by science and researched by a team of PhDs, professors, and scientists.

We’re all unique, so we deserve solutions that treat us that way.

Buy Progesterone Cream

Progesterone tablets can be taken orally.

Progesterone cream taken on the skin can be 5-7 times more powerful than progesterone taken orally.

Progesterone cream can also be taken through vaginal or anal routes.

Preferred progesterone cream:

Other potentially good progesterone creams:

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The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.


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