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Low Dose Naltrexone is a beneficial drug used for fighting cancer and autoimmune diseases.  It helps alleviate pain and inflammation caused by various conditions, and it can be beneficial for many with chronic illnesses.

Introduction to Low Dose Naltrexone (LDN)

Low Dose Naltrexone (LDN) is a drug which can help treat an array of cancers, central nervous system disorders, autoimmune diseases, and a variety of other issues. 

Originally, Naltrexone was prescribed and FDA approved in much higher doses (50 mg to 300 mg) to treat drug and alcohol addiction.  This article focuses on lower doses of Naltrexone (1.5 mg to 4.5 mg) and its multiple medicinal benefits (R).

How Does LDN Work?

LDN works by blocking the opioid growth factor and opioid growth factor receptor pathway in your body, which in turn helps to boost your body’s immune system and natural defenses.

By blocking this pathway temporarily, the body then tries to compensate by producing more beta-endorphin and met-enkephalin (your body’s natural opioids).  Many body tissues have receptors for these endorphins and enkephalins, including every cell of the body’s immune system (R1,R2).

Cancer and autoimmune diseases are triggered by low blood levels of endorphins, contributing to the disease-associated immune deficiencies.  Similarly, HIV/AIDS is accelerated by a deficiency of endorphins (R).

Bottom Line: LDN has the ability to correct the endorphin and enkephalin deficiencies, boost the immune system, and fight the inflammation and sickness responses to diseases.

Uses of Low Dose Naltrexone

1) LDN May Reduce Pain and Inflammation in Many Conditions

LDN is also known to block activation of microglia, a type of white blood cells found in the central nervous system. Activation of microglia causes common symptoms associated with sickness such as fatigue, fever, inflammation, and pain (R).

Blocking activation of microglial cells results in a reduction of proinflammatory cytokines as well as neurotoxic superoxides by blocking Toll-like receptor 4 (TLR4), which can control the body’s response to inflammation (R).

 LDN Treats Fibromyalgia Symptoms

Various studies on Fibromyalgia performed at Stanford University found that the drug can significantly help with pain, fatigue, stress levels, mood, general satisfaction, and inflammation.  LDN is able to fix these symptoms because it improves immune functioning and increases endorphin neurotransmitters (R).

LDN improved pain tolerance in cold pressor tests (CPT) and the ability for fibromyalgia patients to relate interpersonally with others and participate in human relationships (R).

LDN Reduces Pain and Swelling in Rheumatoid Arthritis


Ten patients with this disease have been treated with LDN.  In all ten patients, the joint pain and swelling cleared.  When patients stopped taking LDN for a few weeks or experienced periods of severe stress, it resulted in exacerbation of the condition (R).

LDN Amplifies Anticonvulsant and Anti-Pain Effects of Drugs

When low doses of naltrexone were combined with cannabinoids or opioids such as morphine or buprenorphine, their ability to reduce seizure risk and feelings of pain were amplified.

In one study with 10 patients, a buprenorphine:naltrexone ratio of 166:1 was found to have the greatest effect on pain tolerance for patients in a cold pressor pain test (R).

The anticonvulsant effects of opioids and cannabinoids were greatly increased when combined with low dose naltrexone in a study with mice.  This means patients with diseases like epilepsy are less likely to have new seizures (R).

In addition, LDN was able to help patients avoid a buildup of tolerance to the anticonvulsant effects of morphine in another study done with mice (R).

LDN Helps with CRPS Symptoms


Complex regional pain syndrome (CRPS) is evoked/aggravated by symptoms that may be associated with local small intestinal bacterial overgrowth, obstructive sleep apnea, and potential increased microglial activity (R).

Since  low dose naltrexone can block microglial toll-like receptors and induce production of endorphins, it is able to significantly reduce inflammation.  The improvement provides relief to CRPS patients (R).

Low dose naltrexone can enhance the pain relieving properties of acupuncture which can also be helpful for CRPS patients (R).

A common symptom of patients with CRPS is dystonia.  In this study, two patients were treated with low dose naltrexone in the hope that it would block the Toll-like receptor 4 (TLR4) to decrease neuroinflammation.  After treatment, both patients had a decrease in pain, fixed dystonia, and dystonic spasms in their extremities (R).

LDN Helps with Pain in Transverse Myelitis

Transverse myelitis (TM) is characterized by inflammation of the spinal cord with varying degrees of motor, sensory and autonomic dysfunction (R).

This study followed one patient with TM who was unresponsive to multiple pain medications and immune-modulation therapies but noticed an improvement in neuropathic pain with low dose (3-4.5 mg) Naltrexone (R).

This occurred because LDN is a TLR4 antagonist and therefore stops the microglial activation and sensitization process (R).

In addition, low doses of Naltrexone do not inhibit other opioid receptors in the central nervous system, thereby allowing endogenous anti-pain pathways to continue operating (R).

2) LDN Effectively Treats Irritable Bowel Syndrome

This pre-clinical study assessed 42 Irritable Bowel Syndrome (IBS) patients. Participants received 0.5 mg per day for 4 weeks and were evaluated during baseline, treatment, and at a 4-week follow-up (R).

Patients initially reported degrees of abdominal pain, stool urgency, consistency, and frequency (R).

Treatment with LDN resulted in a number of pain-free days and overall symptom relief, evaluated by a global assessment score.  Global assessment improved in 76% of 42 patients. During treatment, the mean weekly number of pain-free days increased from 0.5+/-1 to 1.25+/-2.14 (P=0.011) (R).

There were no significant side effects (R).

Overall, patients noticed improvements in pain and relief from symptoms (R).

3) LDN Effectively Treats Inflammatory Bowel Disease 


Multiple studies have shown that low dose naltrexone was able to treat patients with Irritable Bowel Disease (IBD). Crohn’s disease and Ulcerative Colitis are two common examples of this chronic relapsing bowel disorder (R).

In this study, Dr. Bihari followed eight patients who had Crohn’s Disease and were on LDN. In all eight cases, within 2-3 weeks the signs and symptoms of disease activity stopped. All eight remained stable anywhere from 2 months to multiple years afterward (R).

In a study with 14 children with Crohn’s, LDN was used to treat their condition.  After an 8-week course of naltrexone therapy, twenty-five percent were considered in remission, and 67% had improved with mild disease activity.  The systemic and social quality of life improved with naltrexone treatment as well (R).

Patients with ulcerative colitis that don’t notice improvements in symptoms from other medications may find relief with LDN.  A study of 40 ulcerative colitis patients found that 30% of the severe cases responded to treatment, and 20% showed lasting benefits (R).

Amongst the long-term responders, many went into remission.  Most of them are still in remission today, but 3 patients relapsed at 11, 12, and 21 months (R).

4) LDN May Help Fight Cancer


LDN has been known to treat cancers such as bladder cancer, breast cancer, carcinoid tumors, colorectal cancer, glioblastoma, liver cancer, lung cancer (non-small cell), leukemia, lymphoma, melanoma, myeloma, neuroblastoma, ovarian cancer, pancreatic cancer, prostate cancer, renal cell carcinoma, throat cancer, thyroid cancer, and uterine cancer (R).

Some patients treated with LDN who were deemed terminal with little time left are still alive and doing well years later.  

This study in mice found that LDN can be coupled with chemotherapy and radiotherapy; it is a unique, non-toxic, cancer therapy (R).  

LDN increases the number and density of opiate receptors on the tumor cell membranes, making them more responsive to the growth-inhibiting effects of endorphins.  It also increases the amount of cytotoxic T cells, natural killer cells, and both of their activities.  All these factors cause cancer cells to die (R1,R2).

In a study having approximately 450 cancer patients directed by Dr. Bihari, nearly a quarter of his patients had at least a 75% reduction in tumor size, and nearly 60% of his patients demonstrated disease stability (R).

A study on ovarian cancer found that LDN reduced DNA synthesis, blood vessel development, and cell replication (R).

Exposure to LDN in combination with cancer drugs enhanced anti-cancer action (R).  

LDN combined with a chemotherapy drug, cisplatin, alleviated the toxicity associated with cisplatin (R).  

It increased the production of the opioid growth factor which inhibits ovarian cancer cell growth (R).

LDN May Enhance Maturation of Bone Marrow Dendritic Cells

This study evaluated both phenotypic and functional maturation of bone marrow dendritic cells (BMDCs). They found that LDN enhances maturation of BMDCs by increasing the expression of Costimulatory Molecules including MHC II, CD40, CD83, CD80 and CD86 molecules (R).

It also decreased the rates of pinocytosis and phagocytosis.  This was accompanied by the results of decreased ACP, and FITC-dextran bioassay (R).

The study confirmed that LDN plays a role in immune system management, enhances host immunity in cancer therapy, and can be used in the design of dendritic cell-based vaccines. (R).

5) LDN May Help With Degenerative Brain Disorders


Naltrexone and Alzheimer’s Disease

In patients with degenerative illnesses like Alzheimer’s, the illness progression is slowed. People with Alzheimer’s disease do not regain already lost function, so it is crucial to begin the treatment as early as possible (R).

Improvements in symptoms from naltrexone (high dose) include better mood and behavior, less confusion, and stronger memory (R).  The same may not hold true for low dose naltrexone.

LDN Alleviates Symptoms in Parkinson’s Disease

In Dr. Bihari’s study of seven Parkinson’s patients, LDN was able to stop the progression of the condition, and the signs and symptoms subsided.  One patient was not seeing improvement in his condition so he discontinued LDN, but his symptoms immediately worsened.  After resuming LDN, he experienced a reversal of the progression that had occurred while off of the drug. His symptoms subsided, and even his depression subsided (R).

In another patient, taking low dose Naltrexone resulted in the disappearance of the glabellar sign, a common symptom in PD patients (R).  

Other symptoms which improved include tremors, sleep issues, and ability to smell, just to name a few (R).

LDN May Treat ALS and PLS

In patients with degenerative illnesses such as Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig’s Disease) and Primary Lateral Sclerosis (PLS), the illness progression is slowed. People with ALS may even regain already lost function.

Patients notice improvements in muscle weakness, spasms, physical and speech coordination, ability to breathe, and fatigue (R).

In one small study, two patients showed significant improvement in their breathing, as measured by a forced vital capacity (FVC). One had a 25% improvement within two months of beginning LDN and the other an 11% improvement. A third patient had improvement in his ability to breathe and a reduction in his resting pulse from 96 to the low 80’s (R).

6) LDN May Treat Patients with Autism

In one study of autistic children, behavioral improvements were observed as early as half an hour after dosing. LDN also increased verbal production and decreased autistic stereotypies (repetitive or ritualistic movement, posture, or utterance) (R).

Other studies found improvements in focus, mood, and behavior due to decreased anxiety and hyperactivity.  LDN is unable to completely bridge the learning disadvantage for children with autism, but it is a start (R).

Dr. Jaquelyn McCandless has found a very positive effect of LDN in appropriately reduced dosage and applied as a transdermal cream, in children with autism (R).

7) LDN May Improve PTSD Symptoms

In one study, 11 out of 15 patients with post-traumatic stress disorder (PTSD) who were treated with LDN felt multiple positive effects.

They reported a clearer perception of both their surroundings and their inner life. Their assessment of reality and dealing with it improved.  Lastly, their perception of their own body, effects on others, and self-control got better (R).

8) LDN May Improve Mood and Quality of Life

Low dose naltrexone plays a role in promoting healthy immune system control which reduces various cancerous and inflammatory autoimmune processes.  This, in turn, results in less pain in patients.

In addition, LDN can increase opioid activity which promotes stress resilience, exercise, social bonding, and emotional well-being, as well as an improvement in psychiatric problems such as autism and depression.  These benefits are attributed to its ability to impact both the immune system and the brain’s neurochemistries (R).

9) LDN May Decrease Nausea in Trauma Patients

When LDN was used in conjunction with morphine in patients with trauma to their upper and lower extremities, it did not decrease pain any more than morphine alone.  However, it did lower the risk of nausea in the trauma patients (R).

10) LDN May Alleviate Itchiness (and Possibly Histamine Intolerance)

In this study, patients were put in a functional magnetic resonance imaging (fMRI) machine to observe the central nervous system processing of itch caused by histamine and capsaicin.  Histamine and capsaicin cause itching, burning, stinging, or prickling feelings in patients.  However, when the patients were treated with LDN, they noticed a reduction in the itching sensation.  This was confirmed by significantly less fMRI activation (R).

Itchiness is also a common symptom associated with conditions like systemic sclerosis/scleroderma and psoriasis, and LDN may be able to help (R1,R2).

This study found that 3 female patients with systemic sclerosis all noticed significant improvements in the pruritus symptom (severe itching of the skin).  It is believed that this symptom of these illnesses is increased by the inflammation from autoimmune gastrointestinal disorders which these patients often have as well (R).

11) LDN Can Help Patients Struggling with Drug Problems

LDN Can Help Treat Opioid Withdrawal and Detox Patients

LDN improved pain tolerance in cold pressor tests (CPT) and the ability for post-detoxification patients to relate interpersonally with others and participate in human relationships (R).

In a study of 127 patients undergoing a 6-day methadone taper, very low dose naltrexone (VLNTX) and clonidine were used to decrease withdrawal intensity and noradrenaline release.

Withdrawal symptoms and treatment completion were compared following VLNTX (.125 or .25 mg/day) and clonidine (.1-.2 mg).  Both medicines used together resulted in a reduction of withdrawal symptoms such as shaking, anxiety, bone and muscle aches, restlessness, and craving, as well as lacrimation, rhinorrhea, and sweating (R).

Of the four groups in the study, the group that took both medications had the highest study retention at 85.3%; the average of the four was 66.9%.  This shows that taking both medications had a significant effect on treatment completion and success (R).

LDN Reduces Craving and Drug Response in Heavy-Drinking Smokers

In one study with 130 heavy-drinking daily smokers, a combination of LDN and Varenicline was able to reduce cigarette and alcohol cravings, as well as the strength of the “high” feeling associated with both drugs (Varenicline; 1 mg twice daily, LDN; 25 mg once daily) (R).

LDN Can Help Prevent Cocaine Relapse

This study on rats used a combination of levo-tetrahydropalmatine (l-THP) and low dose naltrexone (LDN), targeting primarily dopaminergic and endogenous opioid systems as a cocaine-relapse-prevention treatment (R).

The combination of the medicines reduced the drug-seeking tendencies of the rats in various scenarios. Locomotion (movement) in the rats was increased on the two drugs as well (R).

These effects can be attributed to the increase of beta-endorphin and increased POMC expression in the rats (R).

12) LDN Alleviates Symptoms in Multiple Sclerosis

People with Multiple Sclerosis (MS) may find relief from their condition by taking LDN.  Some patients report up to 90% improvement in their symptoms.  MS patients often note relief from spasticity, fatigue, and bladder problems (R).

In Dr. Bihari’s study, less than 1% of MS patients ever experienced a new attack of the disease while taking LDN (R).

For MS patients that experience muscle spasms at the 4.5 mg dosage, lowering the medicine to 3 mg per day may help reduce this symptom (R).  


Dr. Bihari has been treating hundreds of AIDS patients with LDN and accepted AIDS therapies for over 7 years, and claims that 85% of the patients had no detectable levels of the virus in their systems.  This is a much higher success rate compared to most AIDS treatments, and with no side effects (R).  

Many HIV/AIDS patients are living symptom-free for years while taking only LDN (R).

In patients with HIV/AIDS, low levels of beta-endorphin are found in the bloodstream.  LDN is able to correct this deficiency when blocking the opioid receptors and then allowing them to open back up again (R).

LDN successfully treats HIV/AIDS due to its ability to stop the deterioration of Helper T cells (R).

The abnormal buildup of fat caused by HIV drugs usually improves significantly with LDN (R).

Other Information


Consult with your physician before taking LDN to see if it is safe and the correct medication for your condition.

LDN is a prescription drug and should be taken once a day, usually at bedtime (R).  

Depending on what your doctor prescribes for you, dosages can range from 1.5 mg to 3 mg to 4.5 mg (R).  

Avoid slow/timed-release naltrexone and LDN capsules which contain calcium carbonate filters (R).

LDN is usually taken as a pill, but topical creams have successfully been developed as well.

Side Effects

In the clinical trials that have been done to date, most patients don’t experience any side effects, but those who do tend to find that their symptoms subside within a few days to a week.  Symptoms include trouble sleeping, increased vivid dreams, nausea, gas, bloating, upset stomach, hunger pangs, and increased spasticity (R).  

LDN shouldn’t be taken with narcotic painkillers or immunosuppressive drugs (R).

I have been informed that there are anecdotes on the web about some people with CFS and mold illness who don’t react well to LDN.  If you’re getting side effects, you should speak to your healthcare practitioner.

Cautionary Warnings

  1. Because LDN blocks opioid receptors throughout the body, a person using medicine that is an opioid activator (narcotic medication) should not take LDN until such medicine is completely out of one’s system. Patients who have become dependent on the daily use of narcotic-containing pain medication may require 10 days to 2 weeks before being able to begin LDN safely (R).
  2. Full-dose naltrexone carries a cautionary warning against its use in those with liver disease. However, LDN will not produce impairment of liver function (R).
  3. People who have had organ transplants and are taking immunosuppressive medication permanently are cautioned against the use of LDN (R).

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.


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  • MarleneVar

    For how long can we take LDN? It is not a cure as I have read so in order to control symptoms with LDN I imagine we have to take it forever in case of autoimmune diseases.

  • Supplemania

    i’ve been tired since i start with LDN. Now this tips is easier for me.

  • Nellie

    Do you have another source for LDN since irc . bio is closing?

  • Andreas Voglreiter

    Hallo ! Es freut mich, daß das LDN bei dir für eine Bessere Stimmung sorgt ! Kannst du mir bitte sagen, in welcher Dosierung bei dir die gute Stimmung gekommen ist und ob bei dir am Anfang, in der Einschleichphase Nebenwirkungen aufgetreten sind (Wenn JA – Welche Nebenwirkungen) und ob die Nebenwirkungen dann verschwunden sind ? Ich nehme jetzt seit 2 Wochen eine Dosis von 1 mg und habe seit 3 Tagen Nebenwirkungen von schwachen Bändern (pampiges schwaches Gefühl der Fingergelenke und Knie) und Muskeln. Kannst du mir bitte sagen, ob du auch diese Nebenwirkungen hattest und ob diese Nebenwirkungen wieder verschwunden sind ?
    Ich leide seit ca 20 Jahre an Stimmungsabhängigen Nackenerspannunen und hoffe, diese mit der Hilfe von LDN wegzubekommen.
    Über eine hilfreiche Antwort von dir würde ich mich sehr freuen.

  • Dolores Hendricks

    Addendum to my comments…The pharmaceutical link has prices that seem unreasonably low. I use a compounding pharmacy that that Dr. Berkson recommended and have had no issues. The one time I tried a different pharmacy I had a setback so fair warning… If it’s not working for you it may be the pharmacy.

  • Dolores Hendricks

    I have been on 3mg of LDN for about 3 years under the care of Dr. Berkson (integrative medicine) of Las Cruces NM for psoriatic arthritis. LDN works! No more pain and fatigue. Ran out once and by the third day I was sick again. Google Dr. Berkson. Recommend him 100%. My sister was diagnosed with Lupus and she on LDN under Dr. Berkson as well. She’s doing great as well.

  • Paula

    Started taking sublingual LDN about 10 days ago. I continue to have insomnia and wonder if this will improve.

  • Anthony

    I have severe Haemophilia “A” with >1% clotting factor in my system which is controlled by administering via intravenous factor 8 which is done profolaxis.
    I was 13 years old when clotting factor was made available but all the damage has been done with many years of joint bleeds which has left me with chronic pain daily. Also suffered from hep B &C with very high liver functions. Been taking opiods for several years in low doses which has worked fine but want to get off them.
    Will LDN provide pain relief ?

  • Cassie

    I have MS and take LDN since 2010. My liver enzymes have continued to increase for the last 8 years (did not occur while on MS meds and even cyclophosphamide). Since MS drugs made me just sicker I began LDN and have some stability. Ccsvi angioplasty got me my health and legs back. Upshot is: no junk food, good diet, regular exercise, no alcohol, no more nasty meds and both levels are up to 44 and 43 when they were under 20 for years. Very frustrating. Some docs say quit and others say to continue. Anyone with this issue? I have gluten intolerance but do not think it matters that much.

  • Cedra

    I have food histamine intolerance with Mast Involvement, lupus, sjogrens, and fibromyalgia. Would LDN cause allergic reaction or cause an increase in histamine? My dose is 1.5mg.

  • Judi Smith

    I am currently in a great deal of pain from low back injury/sciatica, that electrifyingly radiates down both legs, which makes my feet vibrate. I am on tramadol, hydrocodone and flexeral. I have been prescribed LDN 4.5 to be taken at night. Do I have to quit all these drugs to take LDN? If so, how long? What will happen if I still take these drugs with LDN? Please and thank you for your response.

  • kita

    how long have you been taking it

  • Tarkita

    Could you email and explain more about how it worked for you.

  • Jeff Fowler

    Boston Children’s Hospital is conducting a clinical trial of LDN for NDPH. New Daily Persistent Headache the most refractory headache

  • Sally Godfrey

    Have been taking 1mg each night since mid Feb’18 – much less Raynaud’s symptoms, skin on fingers much better – even have fingerprints again! Still occasional oesophageal paralysis … but whatever the cause of joint pain in my fingers – its completely gone! Vivid dreams – but not nightmares or anything. I was to start taking 1mg/night and increase it after a couple of weeks, but I don’t feel the need to increase it as I’ve had such a good response 🙂

  • Josie

    I just started taking LDN and I have had nonstop nose runnin and itchy hives. However, I also ran out of my nightly Zyrtec I take every night. So I’m not sure if I am ultra sensitive because I have been taking allergy meds for years and then stopped when I ran out…?

  • Susan

    I started taking LDN a year and a half ago for autoimmune symptoms related to celiac disease. Even though I’d eliminated gluten from my diet for a couple of years by then, I still experienced intermittent joint pain, neuropathic pain, depression, and general ill health. The summer before I started taking LDN I was constantly ill with respiratory and flu-like viruses. I began on a dose of 3 mg LDN, which cleared up my illnesses and pain within weeks. Six months ago I went up to 4.5 mg for breakthrough symptoms of depression and anxiety due to major life stressors. I feel as if this medication has transformed my life, and particularly my health. I haven’t contracted a virus (despite having a young child in public school) or experienced joint or neuropathic pain to any significant degree in well over a year. (Indeed, the only time I’ve fallen ill since beginning LDN was when I aggravated my immune system by taking so-called immune boosting supplements.) It does stimulate vivid dreams and seems to dampen the intoxicating effects of alcohol, but those are small prices to pay for vastly improved health. I regularly recommend LDN to people with autoimmune complaints and regularly receive blank (or worse) stares in response! Thanks for your very helpful coverage here.

  • Kaylyn

    Can LDN be used at the same time as RSO? It’s a concentrated cannabis oil with higher THC to help kill cancer.

  • Sue Sanchez

    Has anyone with Sclerodrema used this? I have limited scleroderma, Raynaud’s and Im hypothyroid. I have been on so many different meds and I am at my wits end.

  • an

    what time of the day are you taking it please?

  • Lynn

    Just started on ldn 2 months ago for fibromyalgia. I’ve failed all drugs in the past. Can’t use TENS unit because of pacemaker. Also have IBS, CFS, thyroid issues, generalized granuloma annulare and arthritis. I’m hopeful after reading these posts that this could be an answer to my prayers. Thank you.

    1. Keena M Pratt

      I have Fibro and CFS. Let me know how it works. Thx

  • DElise

    That’s me.. I tend to have the opposite expected reaction. This med is definitely on my “most likely to try” list for suspected fibro (or some other muscle specific issue.. not sure what that would be).

    1. Dede

      I also usually respond opposite of any drugs intention. Benadryl I’m wired, Xanax wide awake. I started LDN 4 months ago. Started at 1 and now on 3. I still don’t Sleep well, but sleep more than I did. Psoriatic Arthritic pain has calmed down. IBS, Fibro, and pancreatitis also is not an issue since going to 3. I also have hypothyroidism and take specific compounded T3& T4 . It’s very well worth the try My Dr prescribed from compounding pharmacy.

  • Amanda Bloom

    Hi you sound exactly like me been doing this for 7 years would love to know if you took it in scared to start I can’t even tolerate food it’s too painful

  • Lisa

    Could we please talk

    1. Helen

      Hi, you can ask Joe inside of VIP: or over at

  • David B. Stebelton OD

    Ultram(Tramadol) is close enough to an Opiod that it will cause LDN not to work. They operate on the same receptors. You’ll have to go off the pain meds for at least one week before LDN can start to be effective. Try CBD oil capsules and Advil for pain.

  • Roe

    I am taking tramadol for RLS. I also have multiple auto immune including Addisons, hashimotos, and lupus. Will the LDN affect the tramadol?

  • Marie

    Tried 0.25 mg to start with for a week. My sleep problems worsened a lot so I took it in the morning which didn’t help. Stopped after 2 weeks with feeling more miserable than ever and it worsened also muscle pain. Didn’t take more than 0.50 mg.

  • Y.A

    I have been taking 4.5 mg low dose naltrexone for about a year and it has helped me tremendously. Before LDN I was having difficulty using my hands because of the pain I was in. I could not lose the 25 pounds I had gained. I was run down, tired, losing hair and depressed. My antibodies were thru the roof. Since taking the LDN my hands stopped hurting, I lost the weight without diet or excersise, my hair stopped falling, my energy level is back, I am no longer depressed and my antibodies have been cut by more than half. I highly recommend it to everyone. The patent ran out for it a long time ago, so that is why it is not pushed by pharmaceutical companies and that is why most doctors know nothing about it.

  • Susan

    I use 50mg Naltrexone for severe binge eating disorder. It is God sent. Why don’t we just scrape all medications in the world and only treat people with Naltrexone because it’s certainly a wonder drug right?!? ☺

  • Nicole Zook

    I have horrible reactions to medicine’s, I usually have the reverse reaction to most medicine.
    I highly recommend LDN, no side effects at all for me. I started out very low and worked up as I was ready. I am feeling so much better.
    Good luck to you ❤️

  • Mallory

    Anyone have any experience buying from the link provided?

  • Monica

    Hi did you try the LDN yet? I’m very much like you and get adverse reactions even in small doses to meds or even supplements. I’m also considering starting in a small side of maybe .20.

  • Gabby

    I’ve been taking LDN for almost a year to treat dissociative disorder. I felt better after the first dose -which could never be said of all the ineffective antidepressants I’ve taken over my life. This article does a great job of summing up the literature. I’ve shared this article with numerous friends and colleagues

  • Alexandria Martinez

    I was having a conversation with a friend of mine who mentioned the medicine Low-Dose Naltrexone. I have never heard of this drug before and decided to learn more about it. It is amazing that it can help HIV?AIDS patients live symptom-free lives. That is an awesome use, thanks for the educating post!

  • Yessie

    Wow….for how you have been taking it? Did you have any side effects? I am so happy for you, Elizabeth! Are you still feeling good?

    I do have Lyme, but my gastroenterologist prescribed it to me because I do have severe gut issues and pain. Too much inflammation, and many allergies. The problem is that I am extremely sensitive to ALL drugs and supplements. For years I haven’t been able to tolerate anything. I am too sick and without any treatment because I feel even worse when I take something that suppose to help me.

    I haven’t started this med yet. I am too scared. I am already enduring an incredible amount of pain, and I am afraid after taking it will be too too much for me to bear. My doctor told me to take 0.5mg and then increase the dose…but I’ll start with even less…..I always do that and still get TOO sick :(.

  • K

    This is a good place for research and resources about LDN:

  • Jill

    Could you provide a list of resources for the studies? It would be really helpful.

  • K

    Johny Joseph did you mean to say 0.5mg or 0.5ml?

  • Daphne

    I find that my brain feels “less foggy” overall with LDN. Marijuana still gives the same effects, although I feel less “high/foggy” from weed now.

  • Elizabeth K Davis

    I have been taking LDN for 10 months and am in remission from Lyme, coinfections and mold illness. I just started having strong histimine reaction (possible mast cell activation syndrome) in the form of bone pain and breathlessness that takes me to the ER. Is it possible that this could be caused by LDN?

  • deejayvj

    Noticed that Ldn causes my sibo and candida to flare. Because it reduces th 17?

  • anna

    I’m wondering, does ldn increase t1, or t2, or is it more a modulator? I ask because I have an immune deficiency (very low t2) so of course high t1. I am trying to be mindful of avoiding t1 stimulants. I have been using ldn for years with the hopes that I have some benefit from it on
    the immune deficiency and the lupus that has resulted from the immune deficiency. I have no idea if it is helping or hurting. The only way to know for sure is to stop taking it. I would appreciate clarification. thanks, Anna

    1. Nattha Wannissorn, PhD

      Check with your doctor.

      1. anna burns

        So, you don’t know if ldn increases t1 or t2? I would have thought that you or Joseph would have known the answer to that question.

        1. Nattha Wannissorn, PhD

          It reduces inflammation, likely without going through the Th1 or Th2, so it can help with both. However, I’m not about to recommend medications for you on a blog comment, especially with your health situation. You need to speak to your doctor, or a doctor who is well-versed with the use of LDN in clinical practice.

          1. anna

            I do appreciate your reply. The only info that wanted was what you answered. I do not need a medication recommendation from you. I do that for myself.

            reply icon
  • Philippa

    In answer to the question about Hashimoto’s if you go to Amazon they have a book called The Root Cause by Dr.Izabella Wentz a young pharmacist who has an amazing website site and documentary series. Google her. I hope you or anyone else who might benefit sees these message. LDN is good for all forms of autoimmune disease both psychological and pathological.

    I have diagnosed myself Hashimoto as genetic inheritance and symptomology would indicate it and have obtained LDN to start this Saturday.

    Hope this helps any one who visits this site.

    Self-Hacked is great by the way; only one thing your free chapter link isn’t working and I’d love to read it.


    1. Nattha Wannissorn

      Hi Philippa,
      Thank you for pointing out that the link isn’t working. Try this link for the time being.

      1. Philippa

        Thank you very much; it worked. I also hope my comment will help others.

        I am doing a lot of research on Thyroid at the moment and it just occurred to me…could the surge in Thyroid Abnormalities be also due to TMI. In other words, our brains are still adjusting to the speed of modern life and especially the amount of sensory input and information and “Thyropause” to coin Mary Shomon’s phrase, is just another attempt by our bodies to respond and/or control our environment.

        Hence the need for RRR, Rest, Relaxation, Restoration.

        Just a thought!


  • deejayvj

    I have CFS / mold. Causes me and others candida flares and possibly sibo. Careful if you are immunosuppressed.

  • Eppuliukko


    I just started using LDN 4 days ago, dosage being 1mg, 1mg, 2mg and 2mg and will up the dosage to 3mg in 2 week perioid countin from the first pill.

    Iv diagnosed MS in 2008 but really it started 2001, between that i was diagnosed as a nutcase and was in at psych care. Cruel diagnosis as MS is it was huge releaf to get it.

    I have never writted to anywhere about my illnes but now when on LDN i feel like responsebility to do so. Atleast write something.

    Sorry for my bad eanglish writing 🙂

    Im on a very early stage but feels like LDN has given my life back, atleast living on this planet is not that bad anymore. I use to have huge head/neck pains, fatigue and, nubness, severe depression (and i mean severe!). All those symphtomes makes me not want to be here at all. My 8y boy is all that keeps me still going on.

    Okey back to start, my pain is nearly gone, 15years opioid painkiller history has stopped, im sleeping again and when waking up feel rested, not depressed and fatigue.

    If you have MS, cut you dairy and gluten products to zero. Do not care what anyone (doctors) say, just cut them off and save your self. Also try to find a doctor that prescribe you LDN.

  • johny joseph

    I started using LDN for primary sjogren’s syndrome. The result is amazing. I started just 15 days ago with 0.5 ml and now am at 1.6 ml.

  • Barbara

    Is this a miss print? Do you really mean “increased”
    “The anticonvulsant effects of opioids and cannabinoids were greatly decreased when combined with low dose naltrexone in a study with mice. This means patients with diseases like epilepsy are less likely to have new seizures (R).I looked up the reference

    1. Joseph M. Cohen

      Misprint 🙂

  • Brennan

    Is it still effective when taken in the morning.

    1. Lynette sullivan

      I have sleep apnua is it best to take in the morning not night because of my sleep apnia

  • Gina

    Is there any information about LDN treating Hashimoto’s Disease

  • Razonilov Égor

    i’ve been tired since i start with LDN. i mean, really really tired. what could it be?

  • Jessica

    Will taking LDN effect the relief I get from medical marijuana?

    1. Joseph M. Cohen

      Shouldn’t, or at least not that I know of

  • koane

    Is widely reported that LDN inhibits glial cells which produce glutamate. However, LDN increases levels of beta endorphins drastically…which have been shown to enhance glutamate neurotoxicity in the hypothalamus by disrupting the calcium balance.

    What’s the answer? LDN reduce or increases glutamate levels?

    1. beakstealer

      I’d also be interested to know, if anyone has insights on this.

  • Padalino

    Excellent, i´ve been using it for years as a mood enhancer and it´s just great!

  • Karin

    Is it pissible to combine LDN with medicinal marihuana oil?

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