Ursolic Acid (UA) is a substance that comes from a variety of plants and herbs. It is part of a class of chemicals known as pentacyclic triterpenoids. It is primarily recognized for its potential role in cell growth regulation. Continue to read to learn more about the health benefits of ursolic acid.
This post has a lot of links to SelfDecode, so that people can see which SNPs affect a given pathway – and then if these pathways are working in them. You need to log in and upload in order to see your genotype. SelfDecode will be heavily integrated into SelfHacked, so I suggest you get your genes sequenced by 23andme and upload them to SelfDecode.
- Introduction to Ursolic Acid
- My Experience With Ursolic Acid
- Health Benefits of Ursolic Acid
- 1) Ursolic Acid Has Anti-inflammatory Properties
- 2) Ursolic Acid Prevents Memory Impairment
- 3) Ursolic Acid May Have Anti-Cancer Properties
- 4) Ursolic Acid Has Antimicrobial Properties
- 5) Ursolic Acid Reduces Post-stroke Damage
- 6) Ursolic Acid has Liver-Protective Properties
- 7) Ursolic Acid Combinations Increase Insulin sensitivity
- 8) Ursolic Acid Stimulates Muscle Growth
- 9) Ursolic Acid Causes Weight loss by Increasing Bodily energy expenditure
- Potential Risks/Negatives
- Buy Ursolic Acid
- Health Tools I Wish I Had When I Was Sick
Introduction to Ursolic Acid
Ursolic Acid (UA) is a substance that comes from a variety of plants and herbs. It is part of a class of chemicals known as pentacyclic triterpenoids. It is primarily recognized for its potential role in cell growth regulation.
My Experience With Ursolic Acid
This is a supplement I like to take, but the issue is getting quality ones. I tried the Labrada Nutrition one and I didn’t feel anything. I then tried a higher quality one and it was very good.
Health Benefits of Ursolic Acid
1) Ursolic Acid Has Anti-inflammatory Properties
2) Ursolic Acid Prevents Memory Impairment
One of the potential mechanisms of the neuroprotective effect was by lessening the accumulation of malondialdehyde (MDA) and depletion of glutathione (GSH) in the hippocampus (memory center).
Malondialdehyde (MDA) is one of the better-known indicators of cell membrane injury [R].
3) Ursolic Acid May Have Anti-Cancer Properties
Ursolic Acid at high doses decreased the following cancer markers: MMP-2, Ki-67, and CD34 (adhesion factor).
UA treatment strongly blocked the cancer survival AKT – GSK3b – β-catenin pathway, resulting in cell destruction.
UA at low concentrations enhanced the anti-tumoral effects of one cancer drug by up to 2-fold. Ursolic Acid is able to induce cell destruction in human gut cancer cells by blocking the AKT pathway [R].
Epigenetic effects of Ursolic Acid could potentially contribute to its beneficial effects, including the prevention of skin cancer [R].
4) Ursolic Acid Has Antimicrobial Properties
Mycobacterial infections are controlled by the activation of macrophages through type 1 cytokine production by T cells.
5) Ursolic Acid Reduces Post-stroke Damage
Abrupt reoxygenation due to the rapid restoration of blood flow is frequently associated with an exacerbation of tissue injury and an intense inflammatory response that is triggered by inflammatory mediators, such as MMPs.
PPARy activation suppressed the inflammatory response in brain ischemia, and this finding suggests that PPARy might be critical in cases where the brain is restricted to blood (ischemia).
PPARy protein levels were increased after Ursolic Acid treatment in a dose-dependent manner [R].
6) Ursolic Acid has Liver-Protective Properties
UA inhibited growth and induced cell destruction of liver cancer cells through AMPK -mediated inhibition of DNA methyltransferase 1 (through SP1).
UA inhibited the growth of liver cancer cells through induction of IGFBP1 and FOXO3a. Increasing evidence suggests an important role of IGFBP in the development and progression of several types of cancers [R].
7) Ursolic Acid Combinations Increase Insulin sensitivity
Ursolic acid was demonstrated to be an effective insulin-mimetic agent at doses above 50 μg/ml and as an insulin-sensitizer at doses as low as 1 μg/ml [R].
8) Ursolic Acid Stimulates Muscle Growth
Ursolic acid increases muscle at least in part by enhancing the IGF-I and insulin receptors [R].
One human study which gave healthy participants 150mg ursolic acid three times a day with meals for eight weeks alongside resistance training noted that supplementation was able to increase circulating IGF-1 concentrations by 22.8% relative to placebo (also given resistance training) [R].
Ursolic acid enhanced the production of myoglobin (∼2 folds) in concert with a remodeling of muscle fibers to mainly fast IIA (∼30%) and slow-twitch (∼4%) types [R].
Ursolic acid indirectly mimicked beneficial effects of short-term calorie restriction and exercise (fast-oxidative) by directing the muscle composition toward oxidative metabolism [R].
Ursolic acid appears to have weak activity as an aromatase inhibitor (which would increase testosterone slightly) [R].
9) Ursolic Acid Causes Weight loss by Increasing Bodily energy expenditure
Ursolic acid increased muscle Akt activity in high fat-fed mice. Muscle Akt activity is known to increase energy expenditure and reduce obesity and its complications.
Another possibility is that ursolic acid increases fight or flight activity, which is known to expand brown fat [R].
Due to the potent endothelial cell death-inducing the activity of UA, a systemic application of UA in the treatment of heart diseases seems unfavorable. The DNA damaging activity of UA may, however, constitute a serious problem [R].
A previous study has revealed that UA has the potential of sperm motility inhibition. Specifically, it causes breaking of bridges in between cells that are soon to be sperm, and the damaged cells then collect to form symplasts in the seminiferous tubules that are associated with male infertility [R].
Buy Ursolic Acid
Health Tools I Wish I Had When I Was Sick
At SelfHacked, it’s our goal to offer our readers all the tools possible to get optimally healthy. When I was struggling with chronic health issues I felt stuck because I didn’t have any tools to help me get better. I had to spend literally thousands of hours trying to read through studies on pubmed to figure out how the body worked and how to fix it.
That’s why I decided to create tools that will help others cut down the guesswork:
- Lab Test Analyzer – a software tool that will analyze your labs and tell you what the optimal values are for each marker — as well as provide you with actionable tips and personalized health and lifestyle recommendations to help you get there.
- SelfDecode – a software tool that will help you analyze your genetic data from companies such as 23andme and ancestry. You will learn how your health is being impacted by your genes, and how to use this knowledge to your advantage.
- SelfHacked Secrets – an ebook where we examine and explain the biggest overlooked environmental factors that cause disease. This ebook is a great place to start your journey if you want to learn the essential steps to optimizing your health.
- SelfHacked Elimination Diet course – a video course that will help you figure out which diet works best for you
- Selfhacked Inflammation course – a video course on inflammation and how to bring it down
- Biohacking insomnia – an ebook on how to get great sleep
- Lectin Avoidance Cookbook – an e-cookbook for people with food sensitivities
- BrainGauge – a device that detects subtle brain changes and allows you to test what’s working for you
- SelfHacked VIP – an area where you can ask me (Joe) questions about health topics
The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.
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